{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T23:53:17Z","timestamp":1790034797344,"version":"4.0.1"},"reference-count":67,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJN"],"DOI":"10.2147\/ijn.s599472","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T13:50:11Z","timestamp":1781185811000},"page":"1-21","source":"Crossref","is-referenced-by-count":1,"title":["Gold Nanoparticle Radiosensitization for High-Dose-Rate Brachytherapy: Differential Efficacy of PEG- and RGD-Functionalized Gold Nanoparticles Across 2-Dimensional, 3-Dimensional, and in vivo Prostate Cancer Models"],"prefix":"10.2147","volume":"Volume 21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2947-6052","authenticated-orcid":true,"given":"Daniel","family":"Cecchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nolan","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitri","family":"Karaman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne","family":"Beckham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Johnstone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Lloyd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devika","family":"Chithrani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2026,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/j.euo.2023.11.018","volume":"7","author":"Slevin","year":"2024","journal-title":"Eur Urol Oncol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1016\/j.brachy.2020.10.007","volume":"20","author":"Martell","year":"2021","journal-title":"Brachytherapy"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"250","DOI":"10.4111\/icu.2020.61.3.250","volume":"61","author":"Huang-Tiel","year":"2020","journal-title":"Investig Clin Urol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1186\/s12645-016-0018-5","volume":"7","author":"Nicolae","year":"2016","journal-title":"Cancer Nanotechnol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/cancers12082021","volume":"12","author":"Penninckx","year":"2020","journal-title":"Cancers"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.3390\/nano13061011","volume":"13","author":"Chuang","year":"2023","journal-title":"Nanomaterials"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.radonc.2021.04.021","volume":"160","author":"Verry","year":"2021","journal-title":"Radiother Oncol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1556-276X-6-440","volume":"6","author":"Li","year":"2011","journal-title":"Nanoscale Res Lett"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"771","DOI":"10.2147\/IJN.S8428","volume":"5","author":"Zhang","year":"2010","journal-title":"Int J Nanomed"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1021\/acs.chemrestox.9b00368","volume":"33","author":"Zhang","year":"2020","journal-title":"Chem Res Toxicol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"2125","DOI":"10.1166\/JNN.2015.10321","volume":"15","author":"Cruje","year":"2015","journal-title":"J Nanosci Nanotechnol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1039\/c8nr07769j","volume":"11","author":"Han","year":"2019","journal-title":"Nanoscale"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1080\/10717544.2022.2039804","volume":"29","author":"Xu","year":"2022","journal-title":"Drug Deliv"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1088\/1361-6560\/ab9159","volume":"65","author":"Schuemann","year":"2020","journal-title":"Phys Med Biol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"6139","DOI":"10.1158\/1078-0432.CCR-10-0978","volume":"16","author":"Libutti","year":"2010","journal-title":"Clin Cancer Res"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"5733","DOI":"10.2147\/IJN.S174624","volume":"13","author":"Shahhoseini","year":"2018","journal-title":"Int J Nanomed"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/mp.18006","volume":"52","author":"Cecchi","year":"2025","journal-title":"Med Phys"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"359","DOI":"10.2147\/IJN.S292105","volume":"16","author":"Yogo","year":"2021","journal-title":"Int J Nanomed"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1088\/1361-6560\/ab9502","volume":"65","author":"Gray","year":"2020","journal-title":"Phys Med Biol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1021\/acsanm.4c05460","volume":"8","author":"Jackson","year":"2024","journal-title":"ACS Appl Nano Mater"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"22308","DOI":"10.1021\/ACSANM.5C04161","volume":"8","author":"Cecchi","year":"2025","journal-title":"ACS Appl Nano Mater"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"2168","DOI":"10.1021\/mp300016p","volume":"9","author":"Chattopadhyay","year":"2012","journal-title":"Mol Pharm"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1560","DOI":"10.1100\/TSW.2011.145","volume":"11","author":"Rosevear","year":"2011","journal-title":"Sci World J"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.ctro.2021.12.012","volume":"33","author":"Bagley","year":"2022","journal-title":"Clin Transl Radiat Oncol"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/cam4.6800","volume":"13","author":"Javid","year":"2024","journal-title":"Cancer Med"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"7565","DOI":"10.1021\/acs.jmedchem.1c00264","volume":"64","author":"Gambino","year":"2021","journal-title":"J Med Chem"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"5889","DOI":"10.2147\/ijn.s36847","volume":"7","author":"Rangger","year":"2012","journal-title":"Int J Nanomed"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"5069","DOI":"10.2147\/IJN.S137833","volume":"12","author":"Wu","year":"2017","journal-title":"Int J Nanomed"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"13","DOI":"10.3390\/ijms23136887","volume":"23","author":"Tabatabaie","year":"2022","journal-title":"Int J Mol Sci"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1118\/1.4906192","volume":"42","author":"Kirkby","year":"2015","journal-title":"Med Phys"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"269","DOI":"10.3978\/j.issn.2218-676X.2013.08.03","volume":"2","author":"Butterworth","year":"2013","journal-title":"Transl Cancer Res"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12645-023-00228-0","volume":"14","author":"Jackson","year":"2023","journal-title":"Cancer Nanotechnol"},{"key":"ref33","unstructured":"Polydimethylsiloxane - Ataman Kimya. Available from: https:\/\/www.atamanchemicals.com\/polydimethylsiloxane_u33115\/. Accessed December 01, 2025."},{"key":"ref34","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1016\/j.brachy.2020.12.007","volume":"20","author":"Berumen","year":"2021","journal-title":"Brachytherapy"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1166\/rnn.2014.1042","volume":"3","author":"Cruje","year":"2014","journal-title":"Rev Nanosci Nanotechnol"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.addr.2015.09.012","volume":"99","author":"Suk","year":"2016","journal-title":"Adv Drug Delivery Rev"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"2139","DOI":"10.1021\/ja2084338","volume":"134","author":"Walkey","year":"2012","journal-title":"J Am Chem Soc"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3390\/cancers10030084","volume":"10","author":"Yang","year":"2018","journal-title":"Cancers"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"3157","DOI":"10.3390\/cancers13133157","volume":"13","author":"Alhussan","year":"2021","journal-title":"Cancers"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"4215","DOI":"10.1021\/ac0702084","volume":"79","author":"Haiss","year":"2007","journal-title":"Analy Chem"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-020-68994-0","volume":"10","author":"Bromma","year":"2020","journal-title":"Sci Rep"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"1542","DOI":"10.1021\/nl070363y","volume":"7","author":"Chithrani","year":"2007","journal-title":"Nano Lett"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"299","DOI":"10.3109\/09687688.2010.507787","volume":"27","author":"Chithrani","year":"2010","journal-title":"Mol Member Biol"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1007\/s10549-012-2338-4","volume":"137","author":"Chattopadhyay","year":"2013","journal-title":"Breast Cancer Res Treat"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1016\/j.nano.2014.12.016","volume":"11","author":"Wolfe","year":"2015","journal-title":"Nanomedicine Nanotechnology Biol Med"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/srep39805","volume":"7","author":"Kapp","year":"2017","journal-title":"Sci Rep"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"101525","DOI":"10.1039\/c5ra19104a","volume":"5","author":"Cruje","year":"2015","journal-title":"RSC Adv"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"15","DOI":"10.3390\/nano13152215","volume":"13","author":"Liu","year":"2023","journal-title":"Nanomaterials"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-025-22151-7","volume":"15","author":"Jackson","year":"2025","journal-title":"Sci Rep"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1002\/jcp.22356","volume":"226","author":"Antonov","year":"2011","journal-title":"J Cell Physiol"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"e13571","DOI":"10.1002\/acm2.13571","volume":"23","author":"Huang","year":"2022","journal-title":"J Appl Clin Med Phys"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2407-10-4\/FIGURES\/6","volume":"10","author":"Ban\u00e1th","year":"2010","journal-title":"BMC Cancer"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"3338","DOI":"10.1002\/smll.201400110","volume":"10","author":"Sicard-Roselli","year":"2014","journal-title":"Small"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3390\/ijms23031429","volume":"23","author":"Zdrowowicz","year":"2022","journal-title":"Int J Mol Sci"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"e70372","DOI":"10.1002\/MP.70372","volume":"53","author":"Cecchi","year":"2026","journal-title":"Med Phys"},{"key":"ref56","doi-asserted-by":"publisher","volume-title":"Tzumor Microenvironment. Advances in Experimental Medicine and Biology","year":"2016","DOI":"10.1007\/978-3-319-26666-4_10"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1186\/s12645-023-00231-5","volume":"14","author":"Bromma","year":"2023","journal-title":"Cancer Nanotechnol"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1088\/0031-9155\/49\/18\/N03","volume":"49","author":"Hainfeld","year":"2004","journal-title":"Phys Med Biol"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"105014","DOI":"10.1063\/5.0121239","volume":"12","author":"Alanazi","year":"2022","journal-title":"AIP Adv"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"2073","DOI":"10.1007\/s10103-017-2329-0","volume":"32","author":"Al-Musywel","year":"2017","journal-title":"Lasers Med Sci"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"4889","DOI":"10.1088\/0031-9155\/54\/16\/004","volume":"54","author":"Cho","year":"2009","journal-title":"Phys Med Biol"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"1950","DOI":"10.1021\/ja210239k","volume":"134","author":"Cheng","year":"2012","journal-title":"J Am Chem Soc"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"952","DOI":"10.3390\/nano10050952","volume":"10","author":"Morozov","year":"2020","journal-title":"Nanomaterials"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"9","DOI":"10.3390\/ijms23095279","volume":"23","author":"Marques","year":"2022","journal-title":"Int J Mol Sci"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"4103","DOI":"10.2147\/IJN.S443168","volume":"19","author":"Jakic","year":"2024","journal-title":"Int J Nanomed"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1667\/RADE-22-00197.1","volume":"200","author":"Cassatt","year":"2023","journal-title":"Radiat Res"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"e29620","DOI":"10.7759\/CUREUS.29620","volume":"14","author":"Nabrinsky","year":"2022","journal-title":"Cureus"}],"container-title":["International Journal of Nanomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/116264","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/116264","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T13:50:14Z","timestamp":1781185814000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/gold-nanoparticle-radiosensitization-for-high-dose-rate-brachytherapy--peer-reviewed-fulltext-article-IJN"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":67,"URL":"https:\/\/doi.org\/10.2147\/ijn.s599472","relation":{},"ISSN":["1178-2013"],"issn-type":[{"value":"1178-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]}}}