{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T16:22:48Z","timestamp":1790353368924,"version":"4.1.0"},"reference-count":125,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJN"],"DOI":"10.2147\/ijn.s610406","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T07:25:26Z","timestamp":1780039526000},"page":"1-24","source":"Crossref","is-referenced-by-count":2,"title":["Diabetes-Related Metabolic Osteoarthritis: Advanced Glycation\u2013Collagen Axis, Cartilage Stiffening, and Biomaterials-Based Therapeutic Strategies"],"prefix":"10.2147","volume":"Volume 21","author":[{"given":"Jiayao","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binhao","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuxia","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengjin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7680-8834","authenticated-orcid":true,"given":"Mengen","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiqi","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengzheng","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0355-7889","authenticated-orcid":true,"given":"Zhipeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chongqiang","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2026,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"e508","DOI":"10.1016\/S2665-9913(23)00163-7","volume":"5","author":"Steinmetz","year":"2023","journal-title":"Lancet Rheumatol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1038\/s41413-023-00301-9","volume":"11","author":"Wei","year":"2023","journal-title":"Bone Res"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"e000077","DOI":"10.1136\/rmdopen-2015-000077","volume":"1","author":"Louati","year":"2015","journal-title":"RMD Open"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"496","DOI":"10.23736\/S1973-9087.24.08034-1","volume":"60","author":"Alenazi","year":"2024","journal-title":"Eur J Phys Rehabil Med"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1016\/j.jbspin.2013.09.007","volume":"80","author":"Sellam","year":"2013","journal-title":"Joint Bone Spine"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.joca.2024.10.008","volume":"33","author":"Jenei-Lanzl","year":"2025","journal-title":"Osteoarthritis Cartilage"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1302\/2046-3758.115.BJR-2021-0334.R1","volume":"11","author":"He","year":"2022","journal-title":"Bone Joint Res"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"111813","DOI":"10.4239\/wjd.v16.i10.111813","volume":"16","author":"Li","year":"2025","journal-title":"World J Diabetes"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1186\/s12986-018-0306-7","volume":"15","author":"Chen","year":"2018","journal-title":"Nutr Metab"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.3390\/biomedicines12061262","volume":"12","author":"Mocanu","year":"2024","journal-title":"Biomedicines"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1488481","DOI":"10.3389\/fendo.2024.1488481","volume":"15","author":"Yu","year":"2024","journal-title":"Front Endocrinol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1578","DOI":"10.1016\/j.joca.2019.06.011","volume":"27","author":"Bannuru","year":"2019","journal-title":"Osteoarthritis Cartilage"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.joca.2022.09.005","volume":"31","author":"Rocha","year":"2023","journal-title":"Osteoarthritis Cartilage"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1644222","DOI":"10.3389\/fbioe.2025.1644222","volume":"13","author":"Chen","year":"2025","journal-title":"Front Bioeng Biotechnol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"021503","DOI":"10.1063\/5.0255473","volume":"9","author":"Yokoyama","year":"2025","journal-title":"APL Bioeng"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"BSR20231730","DOI":"10.1042\/BSR20231730","volume":"44","author":"Song","year":"2024","journal-title":"Biosci Rep"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"2103","DOI":"10.3390\/foods12112103","volume":"12","author":"Li","year":"2023","journal-title":"Foods"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.joca.2011.12.007","volume":"20","author":"Vos","year":"2012","journal-title":"Osteoarthritis Cartilage"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1720","DOI":"10.1021\/acs.chemrestox.2c00160","volume":"35","author":"Lai","year":"2022","journal-title":"Chem Res Toxicol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"461","DOI":"10.3945\/an.115.008433","volume":"6","author":"Uribarri","year":"2015","journal-title":"Adv Nutr"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/ar380","volume":"4","author":"Eyre","year":"2002","journal-title":"Arthritis Res"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"R136","DOI":"10.1186\/ar2807","volume":"11","author":"Franke","year":"2009","journal-title":"Arthritis Res Ther"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"3212","DOI":"10.1002\/art.10627","volume":"46","author":"Chen","year":"2002","journal-title":"Arthritis Rheum"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1053\/joca.2001.0469","volume":"9","author":"DeGroot","year":"2001","journal-title":"Osteoarthritis Cartilage"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1002\/jor.23719","volume":"36","author":"Ozawa","year":"2018","journal-title":"J Orthop Res"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"499","DOI":"10.3724\/abbs.2024017","volume":"56","author":"Chen","year":"2024","journal-title":"Acta Biochim Biophys Sin"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"105870","DOI":"10.1016\/j.jmbbm.2023.105870","volume":"143","author":"Kamml","year":"2023","journal-title":"J Mech Behav Biomed Mater"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"2376","DOI":"10.1002\/art.21199","volume":"52","author":"Loeser","year":"2005","journal-title":"Arthritis Rheum"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"734","DOI":"10.3390\/cells8070734","volume":"8","author":"Choi","year":"2019","journal-title":"Cells"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"e2308599","DOI":"10.1002\/smll.202308599","volume":"20","author":"Zhou","year":"2024","journal-title":"Small"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1002\/jor.23083","volume":"34","author":"Chen","year":"2016","journal-title":"J Orthop Res"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"3005","DOI":"10.3390\/jcm13103005","volume":"13","author":"Lee","year":"2024","journal-title":"J Clin Med"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13018-024-05055-6","volume":"19","author":"Guan","year":"2024","journal-title":"J Orthop Surg Res"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.matbio.2014.08.007","volume":"39","author":"Loeser","year":"2014","journal-title":"Matrix Biol"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"4564","DOI":"10.1038\/s41467-018-07022-2","volume":"9","author":"Deng","year":"2018","journal-title":"Nat Commun"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"e23636","DOI":"10.1096\/fj.202302273RR","volume":"38","author":"Lu","year":"2024","journal-title":"FASEB J"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1186\/s13287-024-04011-9","volume":"15","author":"Han","year":"2024","journal-title":"Stem Cell Res Ther"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1038\/s41584-024-01130-8","volume":"20","author":"Miao","year":"2024","journal-title":"Nat Rev Rheumatol"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"338","DOI":"10.5114\/ceji.2023.134217","volume":"48","author":"Li","year":"2023","journal-title":"Cent Eur J Immunol"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"1799","DOI":"10.1210\/js.2019-00160","volume":"3","author":"Asadipooya","year":"2019","journal-title":"J Endocr Soc"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"e14","DOI":"10.1017\/erm.2021.16","volume":"23","author":"Dieterle","year":"2021","journal-title":"Expert Rev Mol Med"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1038\/s41413-023-00248-x","volume":"11","author":"Wang","year":"2023","journal-title":"Bone Res"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"105936","DOI":"10.1016\/j.isci.2023.105936","volume":"26","author":"Lu","year":"2023","journal-title":"iScience"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"C236","DOI":"10.1152\/ajpcell.00135.2022","volume":"323","author":"Williantarra","year":"2022","journal-title":"Am J Physiol Cell Physiol"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bioactmat.2024.09.005","volume":"43","author":"Hashemi-Afzal","year":"2025","journal-title":"Bioact Mater"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"100682","DOI":"10.1016\/j.mtbio.2023.100682","volume":"20","author":"Duan","year":"2023","journal-title":"Mater Today Bio"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1016\/j.bioactmat.2022.07.013","volume":"25","author":"Zhou","year":"2023","journal-title":"Bioact Mater"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"1648","DOI":"10.3390\/healthcare12161648","volume":"12","author":"Krakowski","year":"2024","journal-title":"Healthcare"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"1630","DOI":"10.3390\/biomedicines12081630","volume":"12","author":"Halabitska","year":"2024","journal-title":"Biomedicines"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"1536341","DOI":"10.3389\/fendo.2025.1536341","volume":"16","author":"Que","year":"2025","journal-title":"Front Endocrinol"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"403","DOI":"10.2337\/dc12-0924","volume":"36","author":"Schett","year":"2013","journal-title":"Diabetes Care"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"e001030","DOI":"10.1136\/rmdopen-2019-001030","volume":"6","author":"Khor","year":"2020","journal-title":"RMD Open"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1016\/j.joca.2015.01.013","volume":"23","author":"Eymard","year":"2015","journal-title":"Osteoarthritis Cartilage"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"3985","DOI":"10.1038\/s41598-020-60989-1","volume":"10","author":"Alenazi","year":"2020","journal-title":"Sci Rep"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"1631","DOI":"10.1016\/j.joca.2022.08.014","volume":"30","author":"Waqas","year":"2022","journal-title":"Osteoarthritis Cartilage"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/s13075-017-1226-z","volume":"19","author":"Eaton","year":"2017","journal-title":"Arthritis Res Ther"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/j.ymeth.2021.02.016","volume":"203","author":"Atzeni","year":"2022","journal-title":"Methods"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1136\/ard.2004.029140","volume":"64","author":"Senolt","year":"2005","journal-title":"Ann Rheum Dis"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1016\/j.clinbiochem.2010.07.007","volume":"43","author":"Chayanupatkul","year":"2010","journal-title":"Clin Biochem"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"931","DOI":"10.7150\/thno.78639","volume":"13","author":"Li","year":"2023","journal-title":"Theranostics"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"1539566","DOI":"10.3389\/fbioe.2025.1539566","volume":"13","author":"Xu","year":"2025","journal-title":"Front Bioeng Biotechnol"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"2372","DOI":"10.1016\/j.bioactmat.2021.01.017","volume":"6","author":"Xue","year":"2021","journal-title":"Bioact Mater"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"111542","DOI":"10.1016\/j.matdes.2022.111542","volume":"225","author":"Chen","year":"2023","journal-title":"Mater Des"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.bioactmat.2024.08.018","volume":"42","author":"Yang","year":"2024","journal-title":"Bioact Mater"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"1339916","DOI":"10.3389\/fbioe.2024.1339916","volume":"12","author":"Liu","year":"2024","journal-title":"Front Bioeng Biotechnol"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.1161\/hc3801.097806","volume":"104","author":"Kass","year":"2001","journal-title":"Circulation"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"8504","DOI":"10.1039\/d2sm00004k","volume":"18","author":"Rowe","year":"2022","journal-title":"Soft Matter"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"8981","DOI":"10.3390\/ijms24108981","volume":"24","author":"De Decker","year":"2023","journal-title":"Int J Mol Sci"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s13075-018-1801-y","volume":"21","author":"Trellu","year":"2019","journal-title":"Arthritis Res Ther"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"4779","DOI":"10.3390\/ijms25094779","volume":"25","author":"Delanghe","year":"2024","journal-title":"Int J Mol Sci"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"492","DOI":"10.3390\/antiox14040492","volume":"14","author":"Zhang","year":"2025","journal-title":"Antioxidants"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"1426794","DOI":"10.3389\/fbioe.2024.1426794","volume":"12","author":"Liao","year":"2024","journal-title":"Front Bioeng Biotechnol"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"e12078","DOI":"10.1002\/bmm2.12078","volume":"2","author":"Jiang","year":"2024","journal-title":"BMEMat"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.3390\/biomedicines9091113","volume":"9","author":"P\u00e9rez","year":"2021","journal-title":"Biomedicines"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"101353","DOI":"10.1016\/j.mtbio.2024.101353","volume":"29","author":"Wu","year":"2024","journal-title":"Mater Today Bio"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"4054","DOI":"10.7150\/thno.104551","volume":"15","author":"Said","year":"2025","journal-title":"Theranostics"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"1605","DOI":"10.3390\/cells14201605","volume":"14","author":"Martin","year":"2025","journal-title":"Cells"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s12951-024-03046-7","volume":"23","author":"Wang","year":"2025","journal-title":"J Nanobiotechnology"},{"key":"ref79","doi-asserted-by":"publisher","first-page":"5325","DOI":"10.1039\/d3tb02871b","volume":"12","author":"Roy","year":"2024","journal-title":"J Mater Chem B"},{"key":"ref80","doi-asserted-by":"publisher","first-page":"105682","DOI":"10.1016\/j.jff.2023.105682","volume":"107","author":"Wu","year":"2023","journal-title":"J Funct Foods"},{"key":"ref81","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.jot.2022.02.001","volume":"32","author":"Meurot","year":"2022","journal-title":"J Orthop Translat"},{"key":"ref82","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.joca.2022.09.010","volume":"31","author":"He","year":"2023","journal-title":"Osteoarthritis Cartilage"},{"key":"ref83","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.actbio.2018.12.004","volume":"93","author":"Vedadghavami","year":"2019","journal-title":"Acta Biomater"},{"key":"ref84","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/j.jconrel.2016.01.007","volume":"240","author":"Wahyudi","year":"2016","journal-title":"J Control Release"},{"key":"ref85","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1007\/s40820-021-00670-y","volume":"13","author":"Li","year":"2021","journal-title":"Nanomicro Lett"},{"key":"ref86","doi-asserted-by":"publisher","first-page":"102945","DOI":"10.4252\/wjsc.v17.i4.102945","volume":"17","author":"Li","year":"2025","journal-title":"World J Stem Cells"},{"key":"ref87","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1186\/s12951-023-02050-7","volume":"21","author":"Wan","year":"2023","journal-title":"J Nanobiotechnology"},{"key":"ref88","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1080\/10717544.2022.2048130","volume":"29","author":"Huang","year":"2022","journal-title":"Drug Deliv"},{"key":"ref89","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.semarthrit.2019.01.005","volume":"49","author":"Veronese","year":"2019","journal-title":"Semin Arthritis Rheum"},{"key":"ref90","doi-asserted-by":"publisher","first-page":"724","DOI":"10.18063\/ijb.724","volume":"9","author":"Du","year":"2023","journal-title":"Int J Bioprint"},{"key":"ref91","doi-asserted-by":"publisher","first-page":"101340","DOI":"10.1016\/j.mtbio.2024.101340","volume":"29","author":"Chen","year":"2024","journal-title":"Mater Today Bio"},{"key":"ref92","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1038\/s41536-024-00368-w","volume":"9","author":"Qiu","year":"2024","journal-title":"NPJ Regen Med"},{"key":"ref93","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1186\/s12951-022-01422-9","volume":"20","author":"Zhu","year":"2022","journal-title":"J Nanobiotechnology"},{"key":"ref94","doi-asserted-by":"publisher","first-page":"106720","DOI":"10.4239\/wjd.v16.i6.106720","volume":"16","author":"Wang","year":"2025","journal-title":"World J Diabetes"},{"key":"ref95","doi-asserted-by":"publisher","first-page":"1611718","DOI":"10.3389\/fimmu.2025.1611718","volume":"16","author":"Lan","year":"2025","journal-title":"Front Immunol"},{"key":"ref96","doi-asserted-by":"publisher","first-page":"419","DOI":"10.3390\/cells9020419","volume":"9","author":"Koh","year":"2020","journal-title":"Cells"},{"key":"ref97","doi-asserted-by":"publisher","first-page":"1573","DOI":"10.1056\/NEJMoa2403664","volume":"391","author":"Bliddal","year":"2024","journal-title":"N Engl J Med"},{"key":"ref98","doi-asserted-by":"publisher","first-page":"100298","DOI":"10.1016\/j.ocarto.2022.100298","volume":"4","author":"Lim","year":"2022","journal-title":"Osteoarthr Cartil Open"},{"key":"ref99","first-page":"1833","volume":"15","author":"Bellamy","year":"1988","journal-title":"J Rheumatol"},{"key":"ref100","doi-asserted-by":"publisher","first-page":"1379189","DOI":"10.3389\/fcvm.2024.1379189","volume":"11","author":"Masson","year":"2024","journal-title":"Front Cardiovasc Med"},{"key":"ref101","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1038\/s41598-022-05323-7","volume":"12","author":"Meurot","year":"2022","journal-title":"Sci Rep"},{"key":"ref102","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1186\/s12891-024-07640-6","volume":"25","author":"Zhang","year":"2024","journal-title":"BMC Musculoskelet Disord"},{"key":"ref103","doi-asserted-by":"publisher","first-page":"e3000410","DOI":"10.1371\/journal.pbio.3000410","volume":"18","author":"Percie du Sert","year":"2020","journal-title":"PLoS Biol"},{"key":"ref104","doi-asserted-by":"publisher","first-page":"R198","DOI":"10.1186\/ar3529","volume":"13","author":"Mooney","year":"2011","journal-title":"Arthritis Res Ther"},{"key":"ref105","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1016\/j.joca.2007.03.006","volume":"15","author":"Glasson","year":"2007","journal-title":"Osteoarthritis Cartilage"},{"key":"ref106","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1016\/j.joca.2024.06.002","volume":"32","author":"Ol\u00e1h","year":"2024","journal-title":"Osteoarthritis Cartilage"},{"key":"ref107","doi-asserted-by":"publisher","first-page":"S17","DOI":"10.1016\/j.joca.2010.05.025","volume":"18 Suppl 3","author":"Glasson","year":"2010","journal-title":"Osteoarthritis Cartilage"},{"key":"ref108","doi-asserted-by":"publisher","first-page":"e0174294","DOI":"10.1371\/journal.pone.0174294","volume":"12","author":"Das Neves Borges","year":"2017","journal-title":"PLoS One"},{"key":"ref109","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1016\/j.jbiomech.2008.12.010","volume":"42","author":"Julkunen","year":"2009","journal-title":"J Biomech"},{"key":"ref110","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1089\/ten.TEC.2019.0116","volume":"25","author":"Patel","year":"2019","journal-title":"Tissue Eng Part C Methods"},{"key":"ref111","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.bbapap.2011.06.020","volume":"1824","author":"Troeberg","year":"2012","journal-title":"Biochim Biophys Acta"},{"key":"ref112","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1016\/s1063-4584(03)00163-8","volume":"11","author":"Bove","year":"2003","journal-title":"Osteoarthritis Cartilage"},{"key":"ref113","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1016\/j.joca.2006.01.013","volume":"14","author":"Castro","year":"2006","journal-title":"Osteoarthritis Cartilage"},{"key":"ref114","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1302\/2046-3758.118.BJR-2021-0575.R1","volume":"11","author":"Hu","year":"2022","journal-title":"Bone Joint Res"},{"key":"ref115","doi-asserted-by":"publisher","first-page":"1468","DOI":"10.1002\/jbmr.141","volume":"25","author":"Bouxsein","year":"2010","journal-title":"J Bone Miner Res"},{"key":"ref116","doi-asserted-by":"publisher","first-page":"MS10","DOI":"10.1097\/00005650-199905001-00002","volume":"37","author":"Kosinski","year":"1999","journal-title":"Med Care"},{"key":"ref117","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/1477-7525-1-17","volume":"1","author":"Roos","year":"2003","journal-title":"Health Qual Life Outcomes"},{"key":"ref118","unstructured":"Food US, Drug A. Use of international standard iso 10993-1, \u201cbiological evaluation of medical devices \u2013 part 1: evaluation and testing within a risk management process\u201d guidance for industry and fda staff. U.S. Food & Drug Administration; 2023."},{"key":"ref119","unstructured":"European Medicines A. Ich q8, q9 and q10 \u2013 questions and answers (r5). Eur Med Agen. 2025."},{"key":"ref120","unstructured":"Food US, Drug A. Public safety notification on exosome products. U.S. Food & Drug Administration; 2019."},{"key":"ref121","doi-asserted-by":"publisher","first-page":"981","DOI":"10.3899\/jrheum.181194","volume":"46","author":"Smith","year":"2019","journal-title":"J Rheumatol"},{"key":"ref122","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.cardfail.2004.09.010","volume":"11","author":"Little","year":"2005","journal-title":"J Card Fail"},{"key":"ref123","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1016\/j.joca.2011.02.018","volume":"19","author":"Conaghan","year":"2011","journal-title":"Osteoarthritis Cartilage"},{"key":"ref124","doi-asserted-by":"publisher","first-page":"e12404","DOI":"10.1002\/jev2.12404","volume":"13","author":"Welsh","year":"2024","journal-title":"J Extracell Vesicles"},{"key":"ref125","unstructured":"Food US, Drug A. Osteoarthritis: structural endpoints for the development of drugs, devices, and biological products for treatment \u2014 guidance for industry (draft). US Food & Drug Administration; 2018."}],"container-title":["International Journal of Nanomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/115789","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/115789","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T07:25:28Z","timestamp":1780039528000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/diabetes-related-metabolic-osteoarthritis-advanced-glycationcollagen-a-peer-reviewed-fulltext-article-IJN"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":125,"URL":"https:\/\/doi.org\/10.2147\/ijn.s610406","relation":{},"ISSN":["1178-2013"],"issn-type":[{"value":"1178-2013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]}}}