{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T10:40:10Z","timestamp":1784544010883,"version":"3.55.0"},"reference-count":109,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJNRD"],"DOI":"10.2147\/ijnrd.s334024","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T11:20:05Z","timestamp":1638271205000},"page":"411-420","source":"Crossref","is-referenced-by-count":13,"title":["Novel Treatments from Inhibition of the Intestinal Sodium\u2013Hydrogen Exchanger 3"],"prefix":"10.2147","volume":"Volume 14","author":[{"given":"Csaba P","family":"Kovesdy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7033-1871","authenticated-orcid":true,"given":"Adebowale","family":"Adebiyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Rosenbaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey W","family":"Jacobs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L Darryl","family":"Quarles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2021,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1074\/jbc.M410041200","volume":"280","author":"Nakamura","year":"2005","journal-title":"J Biol Chem"},{"key":"ref2","unstructured":"SLC9A1. The human protein atlas. Available from: https:\/\/www.proteinatlas.org\/ENSG00000090020-SLC9A1\/cell. Accessed April 28, 2021."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1161\/01.RES.0000014966.97486.C0","volume":"90","author":"Engelhardt","year":"2002","journal-title":"Circ Res"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"G29","DOI":"10.1152\/ajpgi.1996.270.1.G29","volume":"270","author":"Hoogerwerf","year":"1996","journal-title":"Am J Physiol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1038\/969","volume":"19","author":"Schultheis","year":"1998","journal-title":"Nat Genet"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"F510","DOI":"10.1152\/ajprenal.1998.275.4.F510","volume":"275","author":"Pizzonia","year":"1998","journal-title":"Am J Physiol Renal Physiol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"4377","DOI":"10.1074\/jbc.274.7.4377","volume":"274","author":"Baird","year":"1999","journal-title":"J Biol Chem"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"17387","DOI":"10.1074\/jbc.M101319200","volume":"276","author":"Numata","year":"2001","journal-title":"J Biol Chem"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"C1031","DOI":"10.1152\/ajpcell.00420.2001","volume":"282","author":"Brett","year":"2002","journal-title":"Am J Physiol Cell Physiol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"F761","DOI":"10.1152\/ajprenal.00117.2007","volume":"293","author":"Zhang","year":"2007","journal-title":"Am J Physiol Renal Physiol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"2035","DOI":"10.1074\/jbc.273.4.2035","volume":"273","author":"D\u2019Souza","year":"1998","journal-title":"J Biol Chem"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1152\/physrev.1997.77.1.51","volume":"77","author":"Wakabayashi","year":"1997","journal-title":"Physiol Rev"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1630","DOI":"10.1242\/jeb.027375","volume":"212","author":"Alexander","year":"2009","journal-title":"J Exp Biol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"8102","DOI":"10.1021\/bi000870t","volume":"39","author":"Zizak","year":"2000","journal-title":"Biochemistry"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1638","DOI":"10.1242\/jeb.028605","volume":"212","author":"Donowitz","year":"2009","journal-title":"J Exp Biol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"13716","DOI":"10.1074\/jbc.270.23.13716","volume":"270","author":"Levine","year":"1995","journal-title":"J Biol Chem"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1113\/jphysiol.2004.060921","volume":"556","author":"Li","year":"2004","journal-title":"J Physiol"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"3353","DOI":"10.1242\/jcs.01180","volume":"117","author":"Cha","year":"2004","journal-title":"J Cell Sci"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"C223","DOI":"10.1152\/ajpcell.00360.2004","volume":"288","author":"Brett","year":"2005","journal-title":"Am J Physiol Cell Physiol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"44657","DOI":"10.1074\/jbc.M307351200","volume":"278","author":"Nehrke","year":"2003","journal-title":"J Biol Chem"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1042\/CS20200065","volume":"134","author":"Xue","year":"2020","journal-title":"Clin Sci (Lond)"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"6614","DOI":"10.1093\/hmg\/ddv367","volume":"24","author":"Janecke","year":"2015","journal-title":"Hum Mol Genet"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/S0022-3476(85)80465-0","volume":"106","author":"Holmberg","year":"1985","journal-title":"J Pediatr"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"238080","DOI":"10.1155\/2010\/238080","volume":"2010","author":"He","year":"2010","journal-title":"J Biomed Biotechnol"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"G539","DOI":"10.1152\/ajpgi.1999.276.2.G539","volume":"276","author":"Ikuma","year":"1999","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"29972","DOI":"10.1074\/jbc.273.45.29972","volume":"273","author":"Lamprecht","year":"1998","journal-title":"J Biol Chem"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"3978","DOI":"10.1074\/jbc.274.7.3978","volume":"274","author":"Zhao","year":"1999","journal-title":"J Biol Chem"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"8790","DOI":"10.1074\/jbc.273.15.8790","volume":"273","author":"Janecki","year":"1998","journal-title":"J Biol Chem"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"C1090","DOI":"10.1152\/ajpcell.1998.274.4.C1090","volume":"274","author":"Zhang","year":"1998","journal-title":"Am J Physiol-Cell Physiol"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"C802","DOI":"10.1152\/ajpcell.00597.2004","volume":"289","author":"Wang","year":"2005","journal-title":"Am J Physiol Cell Physiol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"3010","DOI":"10.1073\/pnas.94.7.3010","volume":"94","author":"Yun","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1172\/JCI119128","volume":"99","author":"Laghmani","year":"1997","journal-title":"J Clin Invest"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1172\/JCI62","volume":"101","author":"Amb\u00fchl","year":"1998","journal-title":"J Clin Invest"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/S0021-9258(18)54135-1","volume":"268","author":"Yun","year":"1993","journal-title":"J Biol Chem"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"C586","DOI":"10.1152\/ajpcell.1998.274.3.C586","volume":"274","author":"Cho","year":"1998","journal-title":"Am J Physiol"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"C887","DOI":"10.1152\/ajpcell.00630.2005","volume":"291","author":"Amin","year":"2006","journal-title":"Am J Physiol-Cell Physiol"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1159\/000343390","volume":"36","author":"Queiroz-Leite","year":"2012","journal-title":"Kidney Blood Press Res"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"e68","DOI":"10.1161\/HYPERTENSIONAHA.113.02564","volume":"63","author":"Cabral","year":"2014","journal-title":"Hypertension"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"F917","DOI":"10.1152\/ajprenal.1996.271.4.F917","volume":"271","author":"Amb\u00fchl","year":"1996","journal-title":"Am J Physiol"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1161\/HYPERTENSIONAHA.113.01094","volume":"62","author":"Chen","year":"2013","journal-title":"Hypertension"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1042\/cs0490433","volume":"49","author":"Lennane","year":"1975","journal-title":"Clin Sci Mol Med"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1007\/s00232-001-0038-9","volume":"182","author":"Abedin","year":"2001","journal-title":"J Membr Biol"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"443","DOI":"10.2133\/dmpk.20.443","volume":"20","author":"Watanabe","year":"2005","journal-title":"Drug Metab Pharmacokinet"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1007\/s00109-013-1015-3","volume":"91","author":"Li","year":"2013","journal-title":"J Mol Med (Berl)"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"2418","DOI":"10.1159\/000480184","volume":"42","author":"Shi","year":"2017","journal-title":"Cell Physiol Biochem"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"G776","DOI":"10.1152\/ajpgi.00297.2001","volume":"282","author":"Gawenis","year":"2002","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1002\/ibd.20743","volume":"15","author":"Sullivan","year":"2009","journal-title":"Inflamm Bowel Dis"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.05.043","volume":"137","author":"Kiela","year":"2009","journal-title":"Gastroenterology"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"G63","DOI":"10.1152\/ajpgi.90207.2008","volume":"295","author":"Laubitz","year":"2008","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1152\/physiolgenomics.00076.2004","volume":"18","author":"Zhou","year":"2004","journal-title":"Physiol Genomics"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1126\/scitranslmed.aam6474","volume":"10","author":"King","year":"2018","journal-title":"Sci Transl Med"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1007\/s40261-017-0614-0","volume":"38","author":"Rosenbaum","year":"2018","journal-title":"Clin Drug Investig"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"1560","DOI":"10.1161\/HYPERTENSIONAHA.112.201590","volume":"60","author":"Linz","year":"2012","journal-title":"Hypertension"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"227ra236","DOI":"10.1126\/scitranslmed.3007790","volume":"6","author":"Spencer","year":"2014","journal-title":"Sci Transl Med"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"F943","DOI":"10.1152\/ajprenal.00504.2010","volume":"302","author":"Pan","year":"2012","journal-title":"Am J Physiol Renal Physiol"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"1691","DOI":"10.1681\/ASN.2011121213","volume":"23","author":"Schiavi","year":"2012","journal-title":"J Am Soc Nephrol"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.ekir.2017.08.003","volume":"3","author":"Larsson","year":"2018","journal-title":"Kidney Int Rep"},{"key":"ref58","unstructured":"Molnar C, Gair J. Concepts of biology: 1st Canadian edition; 2015."},{"key":"ref59","doi-asserted-by":"publisher","first-page":"G886","DOI":"10.1152\/ajpgi.90520.2008","volume":"296","author":"Bradford","year":"2009","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1097\/FJC.0000000000000336","volume":"67","author":"Linz","year":"2016","journal-title":"J Cardiovasc Pharmacol"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1056\/NEJMoa1311989","volume":"371","author":"Mente","year":"2014","journal-title":"N Engl J Med"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1038\/hr.2012.155","volume":"36","author":"Ohta","year":"2013","journal-title":"Hypertens Res"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1111\/jch.12362","volume":"16","author":"Zhao","year":"2014","journal-title":"J Clin Hypertens"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"F712","DOI":"10.1152\/ajprenal.00264.2020","volume":"319","author":"Onishi","year":"2020","journal-title":"Am J Physiol Renal Physiol"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1111\/dom.13151","volume":"20","author":"Chan","year":"2018","journal-title":"Diabetes Obes Metab"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1056\/NEJM200003303421301","volume":"342","author":"Gress","year":"2000","journal-title":"N Engl J Med"},{"key":"ref67","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2007.08.002","volume":"154","author":"Greenberg","year":"2007","journal-title":"Am Heart J"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/S0002-9343(02)01530-9","volume":"114","author":"Tenenbaum","year":"2003","journal-title":"Am J Med"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"2084","DOI":"10.2337\/dc10-0286","volume":"33","author":"van Melle","year":"2010","journal-title":"Diabetes Care"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1093\/ehjci\/jev061","volume":"16","author":"Paolillo","year":"2015","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1016\/j.atherosclerosis.2011.05.035","volume":"217","author":"Ai","year":"2011","journal-title":"Atherosclerosis"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1016\/0026-0495(88)90124-2","volume":"37","author":"Marangou","year":"1988","journal-title":"Metabolism"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1046\/j.1523-1755.2003.00701.x","volume":"63","author":"Hollenberg","year":"2003","journal-title":"Kidney Int"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"1548","DOI":"10.1161\/CIRCULATIONAHA.117.030418","volume":"136","author":"Packer","year":"2017","journal-title":"Circulation"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"R166","DOI":"10.1152\/ajpregu.00127.2011","volume":"302","author":"Inoue","year":"2012","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"4429","DOI":"10.1002\/ehf2.13024","volume":"7","author":"Trum","year":"2020","journal-title":"ESC Heart Failure"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"108050","DOI":"10.1016\/j.diabres.2020.108050","volume":"161","author":"Wu","year":"2020","journal-title":"Diabetes Res Clin Pract"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"F532","DOI":"10.1152\/ajprenal.00365.2001","volume":"283","author":"Klisic","year":"2002","journal-title":"Am J Physiol Renal Physiol"},{"key":"ref79","doi-asserted-by":"publisher","first-page":"2117","DOI":"10.1056\/NEJMoa1504720","volume":"373","author":"Zinman","year":"2015","journal-title":"New Engl J Med"},{"key":"ref80","doi-asserted-by":"publisher","DOI":"10.1101\/2020.07.16.207118","author":"Borges-J\u00fanior","year":"2020","journal-title":"bioRxiv"},{"key":"ref81","doi-asserted-by":"publisher","first-page":"1526","DOI":"10.1093\/eurheartj\/ehv728","volume":"37","author":"Fitchett","year":"2016","journal-title":"Eur Heart J"},{"key":"ref82","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1097\/MNH.0000000000000187","volume":"25","author":"Novikov","year":"2016","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"ref83","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/S0016-5085(69)80071-5","volume":"56","author":"Devroede","year":"1969","journal-title":"Gastroenterology"},{"key":"ref84","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1023\/A:1018805812321","volume":"43","author":"McRorie","year":"1998","journal-title":"Dig Dis Sci"},{"key":"ref85","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1053\/j.gastro.2012.10.029","volume":"144","author":"Bharucha","year":"2013","journal-title":"Gastroenterology"},{"key":"ref86","volume-title":"Avery\u2019s Diseases of the Newborn (Ninth Edition)","year":"2012"},{"key":"ref87","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1038\/ajg.2017.41","volume":"112","author":"Chey","year":"2017","journal-title":"Am J Gastroenterol"},{"key":"ref88","doi-asserted-by":"publisher","first-page":"281","DOI":"10.14309\/ajg.0000000000000516","volume":"115","author":"Chey","year":"2020","journal-title":"Am J Gastroenterol"},{"key":"ref89","unstructured":"IBSRELA\u00ae (tenapanor) tablets, for oral use [prescribing information]. Ardelyx; 2019."},{"key":"ref90","unstructured":"Phosphate binder use, last 3 months. DOPPS practice monitor; 2020. Available from: https:\/\/www.dopps.org\/DPM-HD\/Files\/maxPBINDER_use_c_overallTAB.htm. Accessed March 17, 2021."},{"key":"ref91","doi-asserted-by":"publisher","first-page":"1788","DOI":"10.1681\/ASN.2004040275","volume":"16","author":"Slinin","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"ref92","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1681\/ASN.2004070602","volume":"16","author":"Kestenbaum","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"ref93","volume-title":"StatPearls [Internet]","year":"2020"},{"key":"ref94","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.jacc.2012.03.040","volume":"60","author":"Ix","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"ref95","doi-asserted-by":"publisher","first-page":"2765","DOI":"10.1161\/CIRCULATIONAHA.108.808733","volume":"119","author":"Hagstr\u00f6m","year":"2009","journal-title":"Circulation"},{"key":"ref96","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.2215\/CJN.09050815","volume":"11","author":"Block","year":"2016","journal-title":"Clin J Am Soc Nephrol"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1681\/ASN.2018080832","volume":"30","author":"Block","year":"2019","journal-title":"J Am Soc Nephrol"},{"key":"ref98","unstructured":"Chertow GM, Yang Y, Rosenbaum DP. Long-term safety and efficacy of tenapanor for the control of serum phosphorus in patients with chronic kidney disease on dialysis. American Society of Nephrology (ASN) Kidney Week; October 22\u201325, 2020; Virtual."},{"key":"ref99","unstructured":"Rosenbaum DP, Sprague SM. Tolerability of tenapanor, an investigational, first-in-class, nonbinder therapy for the control of serum phosphorus in patients with chronic kidney disease on dialysis. American Society of Nephrology (ASN) Kidney Week; 2020; October 22\u201325, 2020; Virtual."},{"key":"ref100","doi-asserted-by":"publisher","first-page":"1465","DOI":"10.1681\/ASN.2020101398","volume":"32","author":"Pergola","year":"2021","journal-title":"J Am Soc Nephrol"},{"key":"ref101","volume-title":"Endocrinology: An Integrated Approach","year":"2001"},{"key":"ref102","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1038\/ki.2011.47","volume":"79","author":"Isakova","year":"2011","journal-title":"Kidney Int"},{"key":"ref103","doi-asserted-by":"publisher","first-page":"440","DOI":"10.2215\/CJN.05130610","volume":"6","author":"Martin","year":"2011","journal-title":"Clin J Am Soc Nephrol"},{"key":"ref104","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1681\/ASN.2014030317","volume":"26","author":"Labont\u00e9","year":"2015","journal-title":"J Am Soc Nephrol"},{"key":"ref105","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1177\/2040622315578654","volume":"6","author":"Kraus","year":"2015","journal-title":"Ther Adv Chronic Dis"},{"key":"ref106","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1186\/s12882-019-1367-1","volume":"20","author":"Cano-Meg\u00edas","year":"2019","journal-title":"BMC Nephrol"},{"key":"ref107","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.1056\/NEJMra0912522","volume":"362","author":"Tonelli","year":"2010","journal-title":"N Engl J Med"},{"key":"ref108","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1038\/nrneph.2011.112","volume":"7","author":"Hutchison","year":"2011","journal-title":"Nat Rev Nephrol"},{"key":"ref109","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1177\/1535370219831220","volume":"244","author":"Saurette","year":"2019","journal-title":"Exp Biol Med"}],"container-title":["International Journal of Nephrology and Renovascular Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=76330","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=76330","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T11:20:18Z","timestamp":1638271218000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/novel-treatments-from-inhibition-of-the-intestinal-sodiumhydrogen-exch-peer-reviewed-fulltext-article-IJNRD"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":109,"URL":"https:\/\/doi.org\/10.2147\/ijnrd.s334024","relation":{},"ISSN":["1178-7058"],"issn-type":[{"value":"1178-7058","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12]]}}}