{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T21:43:40Z","timestamp":1792014220793,"version":"4.4.0"},"reference-count":81,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ITT"],"DOI":"10.2147\/itt.s260429","type":"journal-article","created":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T00:31:25Z","timestamp":1624321885000},"page":"185-200","source":"Crossref","is-referenced-by-count":58,"title":["VISTA: A Promising Target for Cancer Immunotherapy?"],"prefix":"10.2147","volume":"Volume 10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7461-023X","authenticated-orcid":true,"given":"Marco","family":"Tagliamento","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Agostinetto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5403-0916","authenticated-orcid":true,"given":"Roberto","family":"Borea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Brand\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Poggio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0988-0828","authenticated-orcid":true,"given":"Alfredo","family":"Addeo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1797-5296","authenticated-orcid":true,"given":"Matteo","family":"Lambertini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2021,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1038\/s41422-020-0343-4","volume":"30","author":"He","year":"2020","journal-title":"Cell Res"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s12276-018-0191-1","volume":"50","author":"Darvin","year":"2018","journal-title":"Exp Mol Med"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1038\/cmi.2017.148","volume":"15","author":"Xu","year":"2018","journal-title":"Cell Mol Immunol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1909","DOI":"10.3389\/fimmu.2018.01909","volume":"9","author":"De Sousa Linhares","year":"2018","journal-title":"Front Immunol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"2642","DOI":"10.3390\/ijms18122642","volume":"18","author":"Torphy","year":"2017","journal-title":"Int J Mol Sci"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"e000501","DOI":"10.1136\/esmoopen-2019-000501","volume":"4","author":"Lambertini","year":"2019","journal-title":"ESMO Open"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.3390\/cancers12051125","volume":"12","author":"Rossi","year":"2020","journal-title":"Cancers"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"2625","DOI":"10.3390\/ijms22052625","volume":"22","author":"Rebuzzi","year":"2021","journal-title":"Int J Mol Sci"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"101305","DOI":"10.1016\/j.smim.2019.101305","volume":"42","author":"Ruffo","year":"2019","journal-title":"Semin Immunol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"100811","DOI":"10.1016\/j.tranon.2020.100811","volume":"13","author":"Solinas","year":"2020","journal-title":"Transl Oncol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1038\/nrc3239","volume":"12","author":"Pardoll","year":"2012","journal-title":"Nat Rev Cancer"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"e000497","DOI":"10.1136\/esmoopen-2019-000497","volume":"4","author":"Friedlaender","year":"2019","journal-title":"ESMO Open"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"e000911","DOI":"10.1136\/jitc-2020-000911","volume":"8","author":"Acharya","year":"2020","journal-title":"J Immunother Cancer"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"e000957","DOI":"10.1136\/jitc-2020-000957","volume":"8","author":"Chauvin","year":"2020","journal-title":"J Immunother Cancer"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1767","DOI":"10.7150\/ijbs.41105","volume":"16","author":"Yang","year":"2020","journal-title":"Int J Biol Sci"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1566","DOI":"10.3390\/jcm8101566","volume":"8","author":"Genova","year":"2019","journal-title":"J Clin Med"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"e000683","DOI":"10.1136\/esmoopen-2020-000683","volume":"4","author":"Tagliamento","year":"2019","journal-title":"ESMO Open"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"e000684","DOI":"10.1136\/esmoopen-2020-000684","volume":"4","author":"De Mattos-arruda","year":"2019","journal-title":"ESMO Open"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1111\/cei.13415","volume":"200","author":"ElTanbouly","year":"2020","journal-title":"Clin Exp Immunol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1186\/s13045-020-00917-y","volume":"13","author":"Huang","year":"2020","journal-title":"J Hematol Oncol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1084\/jem.20100619","volume":"208","author":"Wang","year":"2011","journal-title":"J Exp Med"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"7776","DOI":"10.1074\/jbc.M109.077156","volume":"285","author":"Aloia","year":"2010","journal-title":"J Biol Chem"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"13482","DOI":"10.3390\/ijms140713482","volume":"14","author":"Battista","year":"2013","journal-title":"Int J Mol Sci"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.4049\/jimmunol.1100660","volume":"187","author":"Flies","year":"2011","journal-title":"J Immunol"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1924","DOI":"10.1158\/0008-5472.CAN-13-1504","volume":"74","author":"Lines","year":"2014","journal-title":"Cancer Res"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"e109103","DOI":"10.1371\/journal.pone.0109103","volume":"9","author":"Bharaj","year":"2014","journal-title":"PLoS One"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"14846","DOI":"10.1073\/pnas.1407447111","volume":"111","author":"Wang","year":"2014","journal-title":"Proc Natl Acad Sci"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"1966","DOI":"10.1172\/JCI74589","volume":"124","author":"Flies","year":"2014","journal-title":"J Clin Invest"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"5294","DOI":"10.4049\/jimmunol.1402648","volume":"194","author":"Flies","year":"2015","journal-title":"J Immunol"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"6682LP","DOI":"10.1073\/pnas.1420370112","volume":"112","author":"Liu","year":"2015","journal-title":"Proc Natl Acad Sci"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"102501","DOI":"10.1016\/j.jaut.2020.102501","volume":"113","author":"Tham","year":"2020","journal-title":"J Autoimmun"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"1638","DOI":"10.3389\/fimmu.2019.01638","volume":"10","author":"Hid Cadena","year":"2019","journal-title":"Front Immunol"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"2645","DOI":"10.1002\/glia.23517","volume":"66","author":"Borggrewe","year":"2018","journal-title":"Glia"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"580187","DOI":"10.3389\/fimmu.2020.580187","volume":"11","author":"ElTanbouly","year":"2020","journal-title":"Front Immunol"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1111\/imm.13001","volume":"156","author":"Wang","year":"2019","journal-title":"Immunology"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.hoc.2020.08.013","volume":"35","author":"Buchbinder","year":"2021","journal-title":"Hematol Oncol Clin North Am"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1016\/j.celrep.2019.12.036","volume":"30","author":"Rosenbaum","year":"2020","journal-title":"Cell Rep"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"1497LP","DOI":"10.1158\/2326-6066.CIR-18-0489","volume":"7","author":"Xu","year":"2019","journal-title":"Cancer Immunol Res"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"1666","DOI":"10.1038\/modpathol.2017.89","volume":"30","author":"Kakavand","year":"2017","journal-title":"Mod Pathol off J U S Can Acad Pathol Inc"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1007\/s00262-018-2169-1","volume":"67","author":"Kuklinski","year":"2018","journal-title":"Cancer Immunol Immunother"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"1562","DOI":"10.1158\/1078-0432.CCR-17-2542","volume":"24","author":"Villarroel-Espindola","year":"2018","journal-title":"Clin Cancer Res"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1007\/s00428-018-2326-0","volume":"472","author":"Brcic","year":"2018","journal-title":"Virchows Arch"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"8516","DOI":"10.1200\/JCO.2018.36.15_suppl.8516","volume":"36","author":"Ladanyi","year":"2018","journal-title":"J Clin Oncol"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1038\/s41379-019-0364-z","volume":"33","author":"Muller","year":"2020","journal-title":"Mod Pathol"},{"key":"ref45","doi-asserted-by":"publisher","volume-title":"Novel Insights into Malignant Pleural Disease","year":"2019","DOI":"10.1136\/thorax-2019-BTSabstracts2019.51"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1097\/mpa.0000000000001059","volume":"47","author":"Liu","year":"2018","journal-title":"Pancreas"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1245\/s10434-014-4293-2","volume":"22","author":"Byers","year":"2015","journal-title":"Ann Surg Oncol"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"1692","DOI":"10.1073\/pnas.1811067116","volume":"116","author":"Blando","year":"2019","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.1007\/s00262-018-2227-8","volume":"67","author":"Xie","year":"2018","journal-title":"Cancer Immunol Immunother"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1186\/s13046-019-1372-z","volume":"38","author":"Zaravinos","year":"2019","journal-title":"J Exp Clin Cancer Res"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1038\/nature12477","volume":"500","author":"Alexandrov","year":"2013","journal-title":"Nature"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"2808","DOI":"10.3389\/fimmu.2020.563044","volume":"11","author":"Xie","year":"2020","journal-title":"Front Immunol"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1007\/s00262-020-02554-3","volume":"69","author":"Zong","year":"2020","journal-title":"Cancer Immunol Immunother"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.1001\/jamaoncol.2016.1061","volume":"2","author":"Stanton","year":"2016","journal-title":"JAMA Oncol"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.breast.2017.07.005","volume":"35","author":"Solinas","year":"2017","journal-title":"Breast"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"20100","DOI":"10.1038\/s41598-020-77043-9","volume":"10","author":"Losurdo","year":"2020","journal-title":"Sci Rep"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/s11912-021-01038-6","volume":"23","author":"Agostinetto","year":"2021","journal-title":"Curr Oncol Rep"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"3010","DOI":"10.3389\/fonc.2020.583966","volume":"10","author":"Cao","year":"2021","journal-title":"Front Oncol"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"1830524","DOI":"10.1080\/2162402X.2020.1830524","volume":"9","author":"Pilones","year":"2020","journal-title":"OncoImmunology"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1007\/s13238-019-0642-z","volume":"10","author":"Hong","year":"2019","journal-title":"Protein Cell"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1111\/imr.12524","volume":"276","author":"Ni","year":"2017","journal-title":"Immunol Rev"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/s00262-019-02434-5","volume":"69","author":"Zong","year":"2020","journal-title":"Cancer Immunol Immunother"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1038\/s41416-018-0313-5","volume":"120","author":"Mulati","year":"2019","journal-title":"Br J Cancer"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"2658","DOI":"10.1182\/blood.V130.Suppl_1.2658.2658","volume":"130","author":"Kim","year":"2017","journal-title":"Blood"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"e1469594","DOI":"10.1080\/2162402X.2018.1469594","volume":"7","author":"Wang","year":"2018","journal-title":"Oncoimmunology"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"2804","DOI":"10.3390\/molecules24152804","volume":"24","author":"Musielak","year":"2019","journal-title":"Molecules"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1186\/s40425-016-0190-5","volume":"4","author":"Deng","year":"2016","journal-title":"J Immunother Cancer"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"TPS3099","DOI":"10.1200\/JCO.2017.35.15_suppl.TPS3099","volume":"35","author":"Lee","year":"2017","journal-title":"J Clin Oncol"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"v405","DOI":"10.1093\/annonc\/mdx376.007","volume":"28","author":"Powderly","year":"2017","journal-title":"Ann Oncol"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-018-0422-y","volume":"6","author":"Bang","year":"2018","journal-title":"J Immunother Cancer"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"S757","DOI":"10.1016\/j.jtho.2019.08.1625","volume":"14","author":"Zauderer","year":"2019","journal-title":"J Thorac Oncol"},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-019-0764-0","volume":"7","author":"Zauderer","year":"2019","journal-title":"J Immunother Cancer"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40425-018-0434-7","volume":"6","author":"Radhakrishnan","year":"2018","journal-title":"J Immunother Cancer"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"2662","DOI":"10.1038\/s41598-020-59608-w","volume":"10","author":"He","year":"2020","journal-title":"Sci Rep"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1158\/2326-6066.CIR-15-0110","volume":"4","author":"Gabrielson","year":"2016","journal-title":"Cancer Immunol Res"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1186\/s13000-018-0770-4","volume":"13","author":"Liang","year":"2018","journal-title":"Diagn Pathol"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"15621","DOI":"10.18632\/oncotarget.14919","volume":"8","author":"Li","year":"2017","journal-title":"Oncotarget"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"e173290","DOI":"10.1001\/jamaoncol.2017.3290","volume":"3","author":"Goode","year":"2017","journal-title":"JAMA Oncol"},{"key":"ref79","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1002\/hed.24406","volume":"38","author":"Nguyen","year":"2016","journal-title":"Head Neck"},{"key":"ref80","doi-asserted-by":"publisher","first-page":"e6472","DOI":"10.1097\/MD.0000000000006472","volume":"96","author":"Ye","year":"2017","journal-title":"Medicine"},{"key":"ref81","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1038\/s41379-019-0328-3","volume":"33","author":"Chung","year":"2020","journal-title":"Mod Pathol"}],"container-title":["ImmunoTargets and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=70843","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=70843","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T00:31:36Z","timestamp":1624321896000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/vista-a-promising-target-for-cancer-immunotherapy-peer-reviewed-fulltext-article-ITT"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":81,"URL":"https:\/\/doi.org\/10.2147\/itt.s260429","relation":{},"ISSN":["2253-1556"],"issn-type":[{"value":"2253-1556","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6]]}}}