{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:15:36Z","timestamp":1792588536267,"version":"4.5.0"},"reference-count":87,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ITT"],"DOI":"10.2147\/itt.s261414","type":"journal-article","created":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T14:54:24Z","timestamp":1607957664000},"page":"317-331","source":"Crossref","is-referenced-by-count":57,"title":["&lt;p&gt;Complement Inhibition for the Treatment of Myasthenia Gravis&lt;\/p&gt;"],"prefix":"10.2147","volume":"Volume 9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9810-5737","authenticated-orcid":true,"given":"Renato","family":"Mantegazza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiammetta","family":"Vanoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Frangiamore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Cavalcante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2020,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1111\/nyas.13592","volume":"1413","author":"Vincent","year":"2018","journal-title":"Ann N Y Acad Sci"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/s41572-019-0079-y","volume":"5","author":"Gilhus","year":"2019","journal-title":"Nat Rev Dis Primers"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1016\/j.autrev.2013.03.003","volume":"12","author":"T\u00fcz\u00fcn","year":"2013","journal-title":"Autoimmun Rev"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"20783","DOI":"10.1073\/pnas.1313944110","volume":"110","author":"Huijbers","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1016\/S1474-4422(17)30363-0","volume":"16","author":"Gilhus","year":"2017","journal-title":"Lancet Neurol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1212\/WNL.0000000000002790","volume":"87","author":"Sanders","year":"2016","journal-title":"Neurology"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1111\/nyas.13537","volume":"1412","author":"Sanders","year":"2018","journal-title":"Ann N Y Acad Sci"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"151","DOI":"10.2147\/NDT.S8915","volume":"7","author":"Mantegazza","year":"2011","journal-title":"Neuropsychiatr Dis Treat"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1756285617749134","DOI":"10.1177\/1756285617749134","volume":"11","author":"Mantegazza","year":"2018","journal-title":"Ther Adv Neurol Disord"},{"key":"ref10","volume":"3","author":"Chamberlain","year":"2019","journal-title":"J Neurol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1078\/0171-2985-00141","volume":"205","author":"Botto","year":"2002","journal-title":"Immunobiology"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1084\/jem.20030374","volume":"198","author":"Strey","year":"2003","journal-title":"J Exp Med"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1146\/annurev-neuro-061010-113810","volume":"35","author":"Stephan","year":"2012","journal-title":"Ann Rev Neurosci"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1038\/nri3761","volume":"14","author":"Kolev","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/ncomms10587","volume":"7","author":"Serna","year":"2016","journal-title":"Nat Commun"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1038\/nrneph.2016.70","volume":"12","author":"Ricklin","year":"2016","journal-title":"Nat Rev Nephrol"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1111\/nyas.13522","volume":"1412","author":"Howard","year":"2018","journal-title":"Ann N Y Acad Sci"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.clim.2005.10.014","volume":"118","author":"Kim","year":"2006","journal-title":"Clin Immunol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1074\/jbc.M109322200","volume":"277","author":"Hourcade","year":"2002","journal-title":"J Biol Chem"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1002\/(SICI)1097-4598(199701)20:1<92::AID-MUS12>3.0.CO;2-3","volume":"20","author":"Navenot","year":"1997","journal-title":"Muscle Nerve"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.expneurol.2004.06.005","volume":"189","author":"Kaminski","year":"2004","journal-title":"Exp Neurol"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1056\/NEJM197805182982004","volume":"298","author":"Drachman","year":"1978","journal-title":"N Engl J Med"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"2053","DOI":"10.1093\/clinchem\/39.10.2053","volume":"39","author":"Hara","year":"1993","journal-title":"Clin Chem"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1126\/science.186.4158.55","volume":"186","author":"Almon","year":"1974","journal-title":"Science"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/0165-5728(88)90043-4","volume":"19","author":"Lang","year":"1988","journal-title":"J Neuroimmunol"},{"key":"ref26","first-page":"82","volume":"67","author":"R\u00f8dgaard","year":"1987","journal-title":"Clin Exp Immunol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"3847","DOI":"10.4049\/jimmunol.171.7.3847","volume":"171","author":"T\u00fcz\u00fcn","year":"2003","journal-title":"J Immunol"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1002\/ana.410010403","volume":"1","author":"Engel","year":"1977","journal-title":"Ann Neurol"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1097\/00005072-197803000-00008","volume":"37","author":"Sahashi","year":"1978","journal-title":"J Neuropathol Exp Neurol"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1212\/WNL.43.6.1167","volume":"43","author":"Nakano","year":"1993","journal-title":"Neurology"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.jneuroim.2004.08.002","volume":"158","author":"Romi","year":"2005","journal-title":"J Neuroimmunol"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/0303-8467(93)90103-N","volume":"95","author":"Barohn","year":"1993","journal-title":"Clin Neurol Neurosurg"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1748","DOI":"10.1212\/WNL.35.12.1748","volume":"35","author":"Ashizawa","year":"1985","journal-title":"Neurology"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1111\/nyas.13555","volume":"1413","author":"Kusner","year":"2018","journal-title":"Ann N Y Acad Sci"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.expneurol.2015.02.009","volume":"270","author":"T\u00fcz\u00fcn","year":"2015","journal-title":"Exp Neurol"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.expneurol.2015.03.010","volume":"270","author":"Losen","year":"2015","journal-title":"Exp Neurol"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"2697","DOI":"10.4049\/jimmunol.172.4.2697","volume":"172","author":"Baggi","year":"2004","journal-title":"J Immunol"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"30836","DOI":"10.1074\/jbc.M403196200","volume":"279","author":"Kock","year":"2004","journal-title":"J Biol Chem"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.molimm.2017.05.012","volume":"89","author":"Arbore","year":"2017","journal-title":"Mol Immunol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.4049\/jimmunol.140.8.2589","volume":"140","author":"Christadoss","year":"1988","journal-title":"J Immunol"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1111\/j.1365-2249.2006.03198.x","volume":"146","author":"Chamberlain-Banoub","year":"2006","journal-title":"Clin Exp Immunol"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.expneurol.2006.06.003","volume":"202","author":"Kaminski","year":"2006","journal-title":"Exp Neurol"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1172\/JCI0216086","volume":"110","author":"Lin","year":"2002","journal-title":"J Clin Invest"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"2654","DOI":"10.4049\/jimmunol.142.8.2654","volume":"142","author":"Biesecker","year":"1989","journal-title":"J Immunol"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"8562","DOI":"10.4049\/jimmunol.179.12.8562","volume":"179","author":"Zhou","year":"2007","journal-title":"J Immunol"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1002\/ana.21536","volume":"65","author":"Soltys","year":"2009","journal-title":"Ann Neurol"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1016\/j.omtm.2019.04.009","volume":"13","author":"Kusner","year":"2019","journal-title":"Mol Ther Methods Clin Dev"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.jneuroim.2006.10.014","volume":"182","author":"T\u00fcz\u00fcn","year":"2007","journal-title":"J Neuroimmunol"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1046\/j.1365-3083.2000.00752.x","volume":"52","author":"Klint","year":"2000","journal-title":"Scand J Immunol"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.jaut.2013.01.003","volume":"42","author":"Huda","year":"2013","journal-title":"J Autoimmun"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/S0165-5728(96)00144-0","volume":"71","author":"Piddlesden","year":"1996","journal-title":"J Neuroimmunol"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1016\/j.molimm.2007.06.144","volume":"45","author":"Hepburn","year":"2008","journal-title":"Mol Immunol"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1002\/mus.24057","volume":"49","author":"Kusner","year":"2014","journal-title":"Muscle Nerve"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1634\/theoncologist.2008-0086","volume":"13","author":"Dmytrijuk","year":"2008","journal-title":"Oncologist"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"2169","DOI":"10.1056\/NEJMoa1208981","volume":"368","author":"Legendre","year":"2013","journal-title":"N Engl J Med"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1056\/NEJMoa1900866","volume":"381","author":"Pittock","year":"2019","journal-title":"N Engl J Med"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1002\/mus.23839","volume":"48","author":"Howard","year":"2013","journal-title":"Muscle Nerve"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/S1474-4422(17)30369-1","volume":"16","author":"Howard","year":"2017","journal-title":"Lancet Neurol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/mus.26447","volume":"60","author":"Muppidi","year":"2019","journal-title":"Muscle Nerve"},{"key":"ref60","first-page":"S133","volume":"60","author":"Howard","year":"2019","journal-title":"Muscle Nerve"},{"key":"ref61","unstructured":"Alexion Pharmaceuticals Inc. Soliris (eculizumab): US prescribing information; 2015. Available from: https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2017\/125166s422lbl.pdf. Accessed December 02, 2020."},{"key":"ref62","unstructured":"Alexion Europe SAS. Soliris (eculizumab): summary of product characteristics; 2017. Available from: http:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/EPAR_Product_Information\/human\/000791\/WC500054208.pdf. Accessed December 02, 2020."},{"key":"ref63","unstructured":"Japan Ministry of Health Labour and Welfare. Soliris (eculizumab): Japanese prescribing information; 2017. Available from: https:\/\/www.businesswire.com\/news\/home\/20171226005046\/en\/Soliris%C2%AE-Eculizumab-Receives-Marketing-Authorization-Japan-Treatment. Accessed December 02, 2020."},{"key":"ref64","doi-asserted-by":"publisher","first-page":"116419","DOI":"10.1016\/j.jns.2019.08.004","volume":"407","author":"Murai","year":"2019","journal-title":"J Neurol Sci"},{"key":"ref65","first-page":"1756286420932035","author":"V\u00e9lez-Santamar\u00eda","year":"2020","journal-title":"Ther Adv Neurol Disord"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.ensci.2019.01.006","volume":"14","author":"Amano","year":"2019","journal-title":"eNeurologicalSci"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"e0195909","DOI":"10.1371\/journal.pone.0195909","volume":"13","author":"Sheridan","year":"2018","journal-title":"PLoS One"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1001\/jamaneurol.2019.5125","volume":"77","author":"Howard","year":"2020","journal-title":"JAMA Neurol"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"2237","DOI":"10.3389\/fimmu.2018.02237","volume":"9","author":"Ekdahl","year":"2018","journal-title":"Front Immunol"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"2539","DOI":"10.3389\/fimmu.2019.02539","volume":"10","author":"Mohebnasab","year":"2019","journal-title":"Front Immunol"},{"key":"ref71","volume-title":"Experimental Immunochemistry","year":"1961"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1093\/ajcp\/79.1.65","volume":"79","author":"Joiner","year":"1983","journal-title":"Am J Clin Pathol"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.jim.2018.06.010","volume":"460","author":"Willrich","year":"2018","journal-title":"J Immunol Methods"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1007\/s40262-019-00742-8","volume":"58","author":"Wijnsma","year":"2019","journal-title":"Clin Pharmacokinet"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1080\/15321819.2016.1234485","volume":"38","author":"Kerboua","year":"2017","journal-title":"J Immunoassay Immunochem"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1002\/mus.21398","volume":"40","author":"Liu","year":"2009","journal-title":"Muscle Nerve"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"105630","DOI":"10.1016\/j.clineuro.2019.105630","volume":"189","author":"Yanagidaira","year":"2020","journal-title":"Clin Neurol Neurosurg"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.it.2012.06.001","volume":"33","author":"Harris","year":"2012","journal-title":"Trends Immunol"},{"key":"ref79","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1056\/NEJMoa1311084","volume":"370","author":"Nishimura","year":"2014","journal-title":"N Engl J Med"},{"key":"ref80","doi-asserted-by":"publisher","first-page":"337","DOI":"10.4049\/jimmunol.1600280","volume":"197","author":"Schatz-Jakobsen","year":"2016","journal-title":"J Immunol"},{"key":"ref81","doi-asserted-by":"publisher","first-page":"262","DOI":"10.3324\/haematol.2013.090001","volume":"99","author":"Rondelli","year":"2014","journal-title":"Haematologica"},{"key":"ref82","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.mrfmmm.2011.03.004","volume":"717","author":"Etheridge","year":"2011","journal-title":"Mutat Res"},{"key":"ref83","doi-asserted-by":"publisher","first-page":"5156","DOI":"10.4049\/jimmunol.1502701","volume":"196","author":"Hillman","year":"2016","journal-title":"J Immunol"},{"key":"ref84","doi-asserted-by":"publisher","first-page":"1970","DOI":"10.1158\/2326-6066.CIR-18-0818","volume":"7","author":"Hillman","year":"2019","journal-title":"Cancer Immunol Res"},{"key":"ref85","doi-asserted-by":"publisher","first-page":"e0172131","DOI":"10.1371\/journal.pone.0172131","volume":"12","author":"Tan","year":"2017","journal-title":"PLoS One"},{"key":"ref86","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1080\/23808993.2020.1804865","volume":"5","author":"Cavalcante","year":"2020","journal-title":"Expert Rev Precis Med Drug Dev"},{"key":"ref87","doi-asserted-by":"publisher","first-page":"104388","DOI":"10.1016\/j.phrs.2019.104388","volume":"148","author":"Cavalcante","year":"2019","journal-title":"Pharmacol Res"}],"container-title":["ImmunoTargets and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=64829","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=64829","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T03:44:47Z","timestamp":1697341487000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/complement-inhibition-for-the-treatment-of-myasthenia-gravis-peer-reviewed-article-ITT"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":87,"URL":"https:\/\/doi.org\/10.2147\/itt.s261414","relation":{},"ISSN":["2253-1556"],"issn-type":[{"value":"2253-1556","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12]]}}}