{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T20:24:25Z","timestamp":1782332665627,"version":"3.54.5"},"reference-count":78,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ITT"],"DOI":"10.2147\/itt.s267077","type":"journal-article","created":{"date-parts":[[2020,11,26]],"date-time":"2020-11-26T19:53:41Z","timestamp":1606420421000},"page":"299-316","source":"Crossref","is-referenced-by-count":11,"title":["&lt;p&gt;Development of Anti-&lt;em&gt;Yersinia pestis&lt;\/em&gt; Human Antibodies with Features Required for Diagnostic and Therapeutic Applications&lt;\/p&gt;"],"prefix":"10.2147","volume":"Volume 9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0457-6598","authenticated-orcid":true,"given":"Antonietta M","family":"Lillo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4488-9126","authenticated-orcid":true,"given":"Nileena","family":"Velappan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4100-9119","authenticated-orcid":true,"given":"Julia M","family":"Kelliher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4329-1309","authenticated-orcid":true,"given":"Austin J","family":"Watts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel P","family":"Merriman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Vuyisich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura M","family":"Lilley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0761-3670","authenticated-orcid":true,"given":"Kent E","family":"Coombs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara","family":"Mastren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8133-7411","authenticated-orcid":true,"given":"Munehiro","family":"Teshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0366-5476","authenticated-orcid":true,"given":"Benjamin W","family":"Stein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory L","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srinivas","family":"Iyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5567-8172","authenticated-orcid":true,"given":"Andrew RM","family":"Bradbury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7406-1904","authenticated-orcid":true,"given":"Jennifer Foster","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0640-6629","authenticated-orcid":true,"given":"Armand E","family":"Dichosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stosh A","family":"Kozimor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2020,11]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Riedel S. Biological warfare and bioterrorism: a historical review. Paper presented at: Baylor University Medical Center Proceedings; 2004.","DOI":"10.1080\/08998280.2004.11928002"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"778","DOI":"10.3201\/eid1705.100029","volume":"17","author":"Bertherat","year":"2011","journal-title":"Emerg Infect Dis"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1128\/IAI.00950-08","volume":"77","author":"Sebbane","year":"2009","journal-title":"Infect Immun"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"2025","DOI":"10.1128\/IAI.00105-08","volume":"76","author":"Quenee","year":"2008","journal-title":"Infect Immun"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1128\/IAI.70.3.1453-1460.2002","volume":"70","author":"Du","year":"2002","journal-title":"Infect Immun"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/S1438-4221(00)80126-5","volume":"290","author":"Chanteau","year":"2000","journal-title":"Int J Med Microbiol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.femsim.2004.02.005","volume":"41","author":"Splettstoesser","year":"2004","journal-title":"FEMS Immunol Med Mic"},{"key":"ref8","volume-title":"Foodborne Microbial Pathogens","year":"2018"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"106","DOI":"10.3389\/fcimb.2013.00106","volume":"3","author":"Ke","year":"2013","journal-title":"Front Cell Infect Microbiol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1128\/IAI.00981-10","volume":"79","author":"Weening","year":"2011","journal-title":"Infect Immun"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1708","DOI":"10.1128\/JCM.00064-11","volume":"49","author":"Sha","year":"2011","journal-title":"J Clin Microbiol"},{"key":"ref12","first-page":"156","volume":"120","author":"Davis","year":"1996","journal-title":"Arch Pathol Lab Med"},{"key":"ref13","first-page":"408","volume":"23","author":"Winter","year":"1960","journal-title":"Bull World Health Organ"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1128\/CMR.17.2.434-464.2004","volume":"17","author":"Anisimov","year":"2004","journal-title":"Clin Microbiol Rev"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"2234","DOI":"10.1128\/IAI.71.4.2234-2238.2003","volume":"71","author":"Hill","year":"2003","journal-title":"Infect Immun"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"3068","DOI":"10.1128\/IAI.74.5.3068-3070.2006","volume":"74","author":"Hill","year":"2006","journal-title":"Infect Immun"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"471","DOI":"10.4269\/ajtmh.1997.56.471","volume":"56","author":"Anderson","year":"1997","journal-title":"Am J Trop Med Hyg"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"e0177012","DOI":"10.1371\/journal.pone.0177012","volume":"12","author":"Liu","year":"2017","journal-title":"PLoS One"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"4476","DOI":"10.1128\/IAI.65.11.4476-4482.1997","volume":"65","author":"Hill","year":"1997","journal-title":"Infect Immun"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/S0140-6736(03)12270-2","volume":"361","author":"Chanteau","year":"2003","journal-title":"Lancet"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"3404","DOI":"10.1128\/JCM.00458-07","volume":"45","author":"Tomaso","year":"2007","journal-title":"J Clin Microbiol"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"e309","DOI":"10.1371\/journal.pone.0000309","volume":"2","author":"Welch","year":"2007","journal-title":"PLoS One"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1515\/pac-2013-1027","volume":"86","author":"Gubala","year":"2014","journal-title":"Pure Appl Chem"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1038\/nrclinonc.2016.211","volume":"14","author":"Weichselbaum","year":"2017","journal-title":"Nat Rev Clin Oncol"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1038\/nrc3236","volume":"12","author":"Scott","year":"2012","journal-title":"Nat Rev Cancer"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1038\/nrd1957","volume":"5","author":"Schrama","year":"2006","journal-title":"Nat Rev Drug Discov"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.tibtech.2018.05.014","volume":"37","author":"Grilo","year":"2019","journal-title":"Trends Biotechnol"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1086\/524891","volume":"46","author":"Spellberg","year":"2008","journal-title":"Clin Infect Dis"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1016\/S0192-0561(00)00074-6","volume":"22","author":"Masihi","year":"2000","journal-title":"Int J Immunopharmacol"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1016\/j.drudis.2019.03.002","volume":"24","author":"McConnell","year":"2019","journal-title":"Drug Discov Today"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"5","DOI":"10.3390\/antib7010005","volume":"7","author":"Wang-Lin","year":"2018","journal-title":"Antibodies"},{"key":"ref32","unstructured":"Inc. HGS. A study to evaluate the safety and tolerability of raxibacumab in healthy subjects. NLM; 2018. Available from: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT00639678."},{"key":"ref33","unstructured":"Therapeutics E. An open label field study of anthim (obiltoxaximab) in subjects exposed to B. anthracis. NLM; 2020. Available from: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03088111."},{"key":"ref34","unstructured":"Corp MSD. Bezlotoxumab (MK-6072) versus placebo in children with clostridium difficile infection (CDI) (MK-6072-001) (MODIFY III); 2020. Available from: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03182907."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1016\/j.copbio.2008.10.002","volume":"19","author":"Bebbington","year":"2008","journal-title":"Curr Opin Biotechnol"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1038\/nbt.1480","volume":"26","author":"Junutula","year":"2008","journal-title":"Nat Biotechnol"},{"key":"ref37","doi-asserted-by":"crossref","unstructured":"Panowski S, Bhakta S, Raab H, Polakis P, Junutula JR. Site-specific antibody drug conjugates for cancer therapy. Paper presented at: MAbs; 2014.","DOI":"10.4161\/mabs.27022"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"16101","DOI":"10.1073\/pnas.1211023109","volume":"109","author":"Axup","year":"2012","journal-title":"PNAS"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1016\/S0021-9258(19)77935-6","volume":"263","author":"Posnett","year":"1988","journal-title":"J Biol Chem"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"194","DOI":"10.3390\/ijms17020194","volume":"17","author":"Yao","year":"2016","journal-title":"Int J Mol Sci"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"197","DOI":"10.3390\/antib4030197","volume":"4","author":"Dennler","year":"2015","journal-title":"Antibodies"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"25894","DOI":"10.1016\/S0021-9258(19)74471-8","volume":"268","author":"Di Marzo Veronese","year":"1993","journal-title":"J Biol Chem"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1093\/protein\/gzq027","volume":"23","author":"Ivanenkov","year":"2010","journal-title":"Protein Eng Des Sel"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1086\/599794","volume":"200","author":"Zhang","year":"2009","journal-title":"J Infect Dis"},{"key":"ref45","doi-asserted-by":"crossref","unstructured":"Reslan L, Dalle S, Dumontet C. Understanding and circumventing resistance to anticancer monoclonal antibodies. Paper presented at: MAbs; 2009.","DOI":"10.4161\/mabs.1.3.8292"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.tibtech.2012.12.006","volume":"31","author":"Worthington","year":"2013","journal-title":"Trends Biotechnol"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.4155\/fmc.13.58","volume":"5","author":"Worthington","year":"2013","journal-title":"Future Med Chem"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1038\/nbt.1791","volume":"29","author":"Bradbury","year":"2011","journal-title":"Nat Biotechnol"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1021\/cr960065d","volume":"97","author":"Smith","year":"1997","journal-title":"Chem Rev"},{"key":"ref50","volume-title":"Cell Biology","year":"2006"},{"key":"ref51","volume-title":"Methods in Enzymology","year":"2000"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"9434","DOI":"10.1021\/bi060264j","volume":"45","author":"Kim","year":"2006","journal-title":"Biochemistry"},{"key":"ref53","unstructured":"Martinez JS, Close DW, Lillo AM, et al. Genetically engineered polymer libraries and methods of using them. United States patent US20170029812A1. In: Google Patents. 2017."},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0160940","volume":"11","author":"Phipps","year":"2016","journal-title":"PLoS One"},{"key":"ref55","doi-asserted-by":"crossref","unstructured":"Velappan N, Mahajan A, Naranjo L, et al. Selection and characterization of Fc\u03b5RI phospho-ITAM specific antibodies. Paper presented at: MAbs; 2019.","DOI":"10.1080\/19420862.2019.1632113"},{"key":"ref56","doi-asserted-by":"crossref","unstructured":"Li B, Fouts AE, Stengel K, et al. In vitro affinity maturation of a natural human antibody overcomes a barrier to in vivo affinity maturation. Paper presented at: MAbs; 2014.","DOI":"10.4161\/mabs.27875"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1038\/71958","volume":"18","author":"Sblattero","year":"2000","journal-title":"Nat Biotechnol"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"e27756","DOI":"10.1371\/journal.pone.0027756","volume":"6","author":"Lillo","year":"2011","journal-title":"PLoS One"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.antiviral.2008.06.002","volume":"80","author":"Wang","year":"2008","journal-title":"Antiviral Res"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1021\/bp970144q","volume":"14","author":"Boder","year":"1998","journal-title":"Biotechnol Prog"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"e49535","DOI":"10.1371\/journal.pone.0049535","volume":"7","author":"Ferrara","year":"2012","journal-title":"PLoS One"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1186\/1471-2180-13-270","volume":"13","author":"Close","year":"2013","journal-title":"BMC Microbiol"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1038\/nprot.2014.034","volume":"9","author":"Dichosa","year":"2014","journal-title":"Nat Protoc"},{"key":"ref64","first-page":"e50635","author":"Signor","year":"2013","journal-title":"J Vis Exp"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1016\/S0969-8043(98)00151-1","volume":"50","author":"McDevitt","year":"1999","journal-title":"Appl Radiat Isot"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"6288","DOI":"10.1021\/ac0580114","volume":"77","author":"Apostolidis","year":"2005","journal-title":"Anal Chem"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/ncomms12312","volume":"7","author":"Ferrier","year":"2016","journal-title":"Nat Commun"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"e13047","DOI":"10.1371\/journal.pone.0013047","volume":"5","author":"Xiao","year":"2010","journal-title":"PLoS One"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"3832","DOI":"10.1016\/j.molimm.2008.05.022","volume":"45","author":"Abhinandan","year":"2008","journal-title":"Mol Immunol"},{"key":"ref70","volume-title":"Yeast Surface Display","year":"2015"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1093\/infdis\/73.2.124","volume":"73","author":"Jawetz","year":"1943","journal-title":"J Infect Dis"},{"key":"ref72","unstructured":"Available from: https:\/\/www.biocompare.com\/pfu\/110447\/soids\/598\/Antibodies\/Yersinia_pestis."},{"key":"ref73","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/S0022-1759(96)00227-X","volume":"201","author":"Benedict","year":"1997","journal-title":"J Immunol Methods"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1128\/MMBR.00031-15","volume":"80","author":"Yang","year":"2016","journal-title":"Microbiol Mol Biol Rev"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1038\/mi.2014.55","volume":"8","author":"Roche","year":"2015","journal-title":"Mucosal Immunol"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1016\/j.chom.2011.09.009","volume":"10","author":"Dalia","year":"2011","journal-title":"Cell Host Microbe"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"334","DOI":"10.3390\/ijms12010334","volume":"12","author":"Spooner","year":"2011","journal-title":"Int J Mol Sci"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.molmed.2016.12.008","volume":"23","author":"Mariathasan","year":"2017","journal-title":"Trends Mol Med"}],"container-title":["ImmunoTargets and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=64210","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=64210","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T12:57:38Z","timestamp":1618491458000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/development-of-anti-yersinia-pestis-human-antibodies-with-features-req-peer-reviewed-article-ITT"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":78,"URL":"https:\/\/doi.org\/10.2147\/itt.s267077","relation":{},"ISSN":["2253-1556"],"issn-type":[{"value":"2253-1556","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11]]}}}