{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T05:00:29Z","timestamp":1777870829667,"version":"3.51.4"},"reference-count":69,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ITT"],"DOI":"10.2147\/itt.s577364","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T16:45:11Z","timestamp":1777567511000},"page":"1-19","source":"Crossref","is-referenced-by-count":0,"title":["B7-H3 (CD276) as Target for T Cell-Based Bispecific Antibody Therapy of Penile Cancer"],"prefix":"10.2147","volume":"Volume 15","author":[{"given":"Aleksander","family":"Kielbik","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronika","family":"Bahlinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1792-1768","authenticated-orcid":true,"given":"Christian","family":"Sch\u00fcrch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Luisa","family":"Barcena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olesya","family":"Vakhrusheva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Igor","family":"Tsaur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonas","family":"Heitmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helmut","family":"Salih","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilona","family":"Hagelstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2026,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1007\/s11912-011-0163-2","volume":"13","author":"Guimar\u00e3es","year":"2011","journal-title":"Curr Oncol Rep"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"891623","DOI":"10.3389\/fonc.2022.891623","volume":"12","author":"Deng","year":"2022","journal-title":"Front Oncol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1590\/S1677-5538.IBJU.2020.0959","volume":"47","author":"Zekan","year":"2021","journal-title":"Int Braz J Urol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1007\/s00345-008-0310-z","volume":"27","author":"Pagliaro","year":"2009","journal-title":"World J Urol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.juro.2013.07.088","volume":"191","author":"Djajadiningrat","year":"2014","journal-title":"J Urol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"4085","DOI":"10.21037\/tau-20-945","volume":"10","author":"Thomas","year":"2021","journal-title":"Transl Androlo Urol"},{"key":"ref7","unstructured":"Brouwer OR, Tagawa ST, Albersen M, et al. EAU-ASCO Collaborative Guidelines on. Arnhem. Report. 2025."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"S720","DOI":"10.1016\/j.annonc.2021.08.110","volume":"32","author":"Pouessel","year":"2021","journal-title":"Ann Oncol"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Bahl A, Challapalli A, Venugopal B, et al. EPIC-A: Phase II trial of cemiplimab plus standard of care chemotherapy followed by maintenance cemiplimab in locally advanced or metastatic penile carcinoma. Report. 2025.","DOI":"10.1200\/JCO.2025.43.5_suppl.1"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1007\/s00428-022-03271-1","volume":"480","author":"Hladek","year":"2022","journal-title":"Virchows Archiv"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1007\/s00428-014-1713-4","volume":"466","author":"Lohneis","year":"2015","journal-title":"Virchows Archiv"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01253","volume":"9","author":"Ottenhof","year":"2018","journal-title":"Front Immunol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"22050","DOI":"10.1038\/s41598-024-70855-z","volume":"14","author":"Lohse","year":"2024","journal-title":"Sci Rep"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"2785","DOI":"10.3390\/ijms26062785","volume":"26","author":"Czajkowski","year":"2025","journal-title":"Int J Mol Sci"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1002\/cac2.12001","volume":"40","author":"Zhou","year":"2020","journal-title":"Cancer Commun"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-89760-0","volume":"15","author":"Miyagi","year":"2025","journal-title":"Sci Rep"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"2220","DOI":"10.1056\/nejmoa2206913","volume":"387","author":"Dickinson","year":"2022","journal-title":"N Engl J Med"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"2259","DOI":"10.1038\/s41591-023-02528-9","volume":"29","author":"Lesokhin","year":"2023","journal-title":"Nat Med"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"2063","DOI":"10.1056\/nejmoa2307980","volume":"389","author":"Ahn","year":"2023","journal-title":"N Engl J Med"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"2256","DOI":"10.1056\/nejmoa2304753","volume":"389","author":"Hassel","year":"2023","journal-title":"N Engl J Med"},{"key":"ref21","first-page":"4048","volume":"61","author":"Modak","year":"2001","journal-title":"Cancer Res"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-9-463","volume":"9","author":"Loos","year":"2009","journal-title":"BMC Cancer"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"457","DOI":"10.3748\/wjg.v12.i3.457","volume":"12","author":"Wu","year":"2006","journal-title":"World J Gastroenterol"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1879","DOI":"10.1002\/cam4.522","volume":"4","author":"Guery","year":"2015","journal-title":"Cancer Med"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"Shi W, Wang Y, Zhao Y, et al. Immune checkpoint B7-H3 is a therapeutic vulnerability in prostate cancer harboring PTEN and TP53 deficiencies. Report. 2023. Available from: https:\/\/www.science.org.","DOI":"10.1126\/scitranslmed.adf6724"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.trecan.2018.03.010","volume":"4","author":"Flem-Karlsen","year":"2018","journal-title":"Trends Cancer"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-023-01751-9","volume":"22","author":"Getu","year":"2023","journal-title":"Mol Cancer"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/j.ccell.2017.03.005","volume":"31","author":"Seaman","year":"2017","journal-title":"Cancer Cell"},{"key":"ref29","first-page":"2646","volume":"7","author":"Chen","year":"2015","journal-title":"Am J Transl Res"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1016\/j.ymthe.2023.02.010","volume":"31","author":"Zekri","year":"2023","journal-title":"Mol Ther"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1186\/s12967-024-05689-4","volume":"22","author":"Hagelstein","year":"2024","journal-title":"J Transl Med"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1163136","volume":"14","author":"Lutz","year":"2023","journal-title":"Front Immunol"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2024.1351901","volume":"14","author":"Jung","year":"2024","journal-title":"Front Oncol"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"EMMM201911902","DOI":"10.15252\/emmm.201911902","volume":"13","author":"Zekri","year":"2021","journal-title":"EMBO Mol Med"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"100045","DOI":"10.1016\/j.cpccr.2020.100045","volume":"3","author":"Steck","year":"2021","journal-title":"Curr Problems Cancer"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"113360","DOI":"10.1016\/j.ejca.2023.113360","volume":"194","author":"Tan","year":"2023","journal-title":"Eur J Cancer"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.urolonc.2018.10.016","volume":"37","author":"Huang","year":"2019","journal-title":"J Urol Oncol"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1111\/bju.16442","volume":"134","author":"Weiten","year":"2024","journal-title":"BJU Int"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.humpath.2023.10.003","volume":"142","author":"Tekin","year":"2023","journal-title":"Hum Pathol"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"e006680","DOI":"10.1136\/jitc-2023-006680","volume":"11","author":"Park","year":"2023","journal-title":"J Immunother Cancer"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1126\/science.275.5299.547","volume":"275","author":"Huang","year":"1996","journal-title":"Science"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/S0168-3659(99)00137-6","volume":"64","author":"Molema","year":"2000","journal-title":"J Control Release"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1111\/j.1398-9995.1997.tb01031.x","volume":"52","author":"Werfel","year":"1997","journal-title":"Allergy"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1038\/ni.2035","volume":"12","author":"Wherry","year":"2011","journal-title":"Nat Immunol"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/j.ccell.2018.03.012","volume":"33","author":"Thommen","year":"2018","journal-title":"Cancer Cell"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"2162","DOI":"10.1158\/0008-5472.CAN-11-3687","volume":"72","author":"Facciabene","year":"2012","journal-title":"Cancer Res"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1158\/2159-8290.CD-23-0964","volume":"14","author":"Kelly","year":"2024","journal-title":"Cancer Discov"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"2536","DOI":"10.1200\/JCO.2024.42.16_suppl.2536","volume":"42","author":"Heitmann","year":"2025","journal-title":"JCO"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1056\/nejmoa1814213","volume":"380","author":"Bardia","year":"2019","journal-title":"N Engl J Med"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"3834","DOI":"10.1158\/1078-0432.CCR-12-0715","volume":"18","author":"Loo","year":"2012","journal-title":"Clin Cancer Res"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"S995","DOI":"10.1016\/j.annonc.2024.08.1733","volume":"35","author":"de Bono","year":"2024","journal-title":"Ann Oncol"},{"key":"ref52","first-page":"1","volume":"2025","author":"Wang","year":"2025","journal-title":"Am Soc Clin Oncol"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"1949","DOI":"10.1038\/s41591-025-03600-2","volume":"31","author":"Ma","year":"2025","journal-title":"Nat Med"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.ccell.2019.01.002","volume":"35","author":"Du","year":"2019","journal-title":"Cancer Cell"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.omto.2020.03.019","volume":"17","author":"Zhang","year":"2020","journal-title":"Mol Ther Oncolytics"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"53","DOI":"10.36401\/JIPO-23-18","volume":"2024","author":"Feustel","year":"2024","journal-title":"J Immunother Precis Oncol"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-021-01209-9","volume":"14","author":"Lemoine","year":"2021","journal-title":"J Hematol Oncol"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"2113","DOI":"10.1038\/s12276-024-01317-9","volume":"56","author":"Jo","year":"2024","journal-title":"Exp Mol Med"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"e002222","DOI":"10.1136\/jitc-2020-002222","volume":"9","author":"Park","year":"2021","journal-title":"J Immunother Cancer"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1002\/eji.202451589","volume":"55","author":"Liao","year":"2025","journal-title":"Eur J Immunol"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.coi.2015.01.011","volume":"33","author":"Lanitis","year":"2015","journal-title":"Curr Opin Immunol"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-018-0343-9","volume":"6","author":"Shimabukuro-Vornhagen","year":"2018","journal-title":"J Immunother Cancer"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1038\/nrc798","volume":"2022","author":"Zur Hausen","year":"2002","journal-title":"Nat Rev Cancer"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1038\/s41585-022-00617-x","volume":"19","author":"Joshi","year":"2022","journal-title":"Nat Rev Urol"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1038\/s41591-020-01225-1","volume":"27","author":"Nagarsheth","year":"2021","journal-title":"Nat Med"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"2759","DOI":"10.1200\/JCO.18","volume":"37","author":"Doran","year":"2019","journal-title":"J Clin Oncol"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"1605","DOI":"10.1093\/jnci\/djad155","volume":"115","author":"El Zarif","year":"2023","journal-title":"J Natl Cancer Inst"},{"key":"ref68","doi-asserted-by":"crossref","unstructured":"Cotait Maluf F, Trindade K, Almeida Preto DD, et al. A phase II trial of pembrolizumab plus platinum-based chemotherapy as first-line systemic therapy in advanced penile cancer: HERCULES (LACOG 0218) trial. Report. 2025.","DOI":"10.2139\/ssrn.4794430"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1016\/j.trecan.2024.07.002","volume":"10","author":"Herrera","year":"2024","journal-title":"Trends Cancer"}],"container-title":["ImmunoTargets and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/114695","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/114695","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T16:45:13Z","timestamp":1777567513000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/b7-h3-cd276-as-target-for-t-cell-based-bispecific-antibody-therapy-of--peer-reviewed-fulltext-article-ITT"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":69,"URL":"https:\/\/doi.org\/10.2147\/itt.s577364","relation":{},"ISSN":["2253-1556"],"issn-type":[{"value":"2253-1556","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]}}}