{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T07:11:27Z","timestamp":1775545887479,"version":"3.50.1"},"reference-count":80,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ITT"],"DOI":"10.2147\/itt.s581990","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T06:20:11Z","timestamp":1775542811000},"page":"1-22","source":"Crossref","is-referenced-by-count":0,"title":["Cryoablation Plus Immune Checkpoint Inhibitors Enhanced Dendritic Cell and T Cell Activation in TNBC Murine Model"],"prefix":"10.2147","volume":"Volume 15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7335-6567","authenticated-orcid":true,"given":"Flavia","family":"Sardela de Miranda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Babcock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Mahecha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prrishti","family":"Gukhool","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geetha","family":"Boligala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dalia","family":"Martinez-Marin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ava","family":"Oliver","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Hintelmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn","family":"Furr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chhanda","family":"Bose","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharilyn","family":"Almodovar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharda","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Pruitt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Melkus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rakhshanda","family":"Layeequr Rahman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2026,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"113365","DOI":"10.1016\/j.intimp.2024.113365","volume":"143","author":"Arafat Hossain","year":"2024","journal-title":"Int Immunopharmacol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1038\/nm1100","volume":"10","author":"Rosenberg","year":"2004","journal-title":"Nat Med"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"3801","DOI":"10.1038\/s41467-020-17670-y","volume":"11","author":"Robert","year":"2020","journal-title":"Nat Commun"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"S87","DOI":"10.3747\/co.27.5223","volume":"27","author":"Esfahani","year":"2020","journal-title":"Curr Oncol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1038\/nri3405","volume":"13","author":"Chen","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1615\/critrevimmunol.v29.i3.10","volume":"29","author":"Redmond","year":"2009","journal-title":"Crit Rev Immunol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1111\/j.1600-065X.2009.00770.x","volume":"229","author":"Rudd","year":"2009","journal-title":"Immunol Rev"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1126\/science.1160062","volume":"322","author":"Wing","year":"2008","journal-title":"Science"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1093\/intimm\/8.5.765","volume":"8","author":"Agata","year":"1996","journal-title":"Int Immunol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/s1074-7613(04)00051-2","volume":"20","author":"Zhang","year":"2004","journal-title":"Immunity"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1084\/jem.20112741","volume":"209","author":"Yokosuka","year":"2012","journal-title":"J Exp Med"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"945","DOI":"10.4049\/jimmunol.173.2.945","volume":"173","author":"Chemnitz","year":"2004","journal-title":"J Immunol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1002\/emmm.201100165","volume":"3","author":"Karwacz","year":"2011","journal-title":"EMBO Mol Med"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1038\/nrc3239","volume":"12","author":"Pardoll","year":"2012","journal-title":"Nat Rev Cancer"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.2217\/fon.15.52","volume":"11","author":"Brahmer","year":"2015","journal-title":"Future Oncol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1007\/s10555-021-09976-0","volume":"40","author":"Wojtukiewicz","year":"2021","journal-title":"Cancer Metastasis Rev"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/S1470-2045(19)30689-8","volume":"21","author":"Schmid","year":"2020","journal-title":"Lancet Oncol"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"5249","DOI":"10.1158\/1078-0432.CCR-22-1110","volume":"28","author":"Shah","year":"2022","journal-title":"Clin Cancer Res"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1038\/nrclinonc.2016.66","volume":"13","author":"Bianchini","year":"2016","journal-title":"Nat Rev Clin Oncol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1007\/s10549-012-2315-y","volume":"136","author":"Malorni","year":"2012","journal-title":"Breast Cancer Res Treat"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"2750","DOI":"10.1172\/JCI45014","volume":"121","author":"Lehmann","year":"2011","journal-title":"J Clin Invest"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"4429","DOI":"10.1158\/1078-0432.CCR-06-3045","volume":"13","author":"Dent","year":"2007","journal-title":"Clin Cancer Res"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1358","DOI":"10.1080\/07853890.2021.1966086","volume":"53","author":"Wang","year":"2021","journal-title":"Ann Med"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1038\/s41571-021-00565-2","volume":"19","author":"Bianchini","year":"2022","journal-title":"Nat Rev Clin Oncol"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.soc.2017.08.004","volume":"27","author":"Chaudhary","year":"2018","journal-title":"Surg Oncol Clin N Am"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"600573","DOI":"10.3389\/fonc.2020.600573","volume":"10","author":"Thomas","year":"2020","journal-title":"Front Oncol"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"85","DOI":"10.3389\/fonc.2018.00085","volume":"8","author":"Abdo","year":"2018","journal-title":"Front Oncol"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1111\/j.1464-410X.2005.05502.x","volume":"95","author":"Baust","year":"2005","journal-title":"BJU Int"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"283","DOI":"10.2147\/BCTT.S197406","volume":"11","author":"Pusceddu","year":"2019","journal-title":"Breast Cancer"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"e200134","DOI":"10.1148\/rycan.2021200134","volume":"3","author":"Regen-Tuero","year":"2021","journal-title":"Radiol Imaging Cancer"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.amjsurg.2020.07.028","volume":"221","author":"Habrawi","year":"2021","journal-title":"Am J Surg"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"128","DOI":"10.3978\/j.issn.2227-684X.2012.08.02","volume":"1","author":"Niu","year":"2012","journal-title":"Gland Surg"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1111\/j.1075-122X.2005.21700.x","volume":"11","author":"Kaufman","year":"2005","journal-title":"Breast J"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1016\/j.jvir.2009.06.029","volume":"20","author":"Littrup","year":"2009","journal-title":"J Vasc Interv Radiol"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1159\/000495919","volume":"13","author":"Paepke","year":"2018","journal-title":"Breast Care"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"2914","DOI":"10.1245\/s10434-021-11157-w","volume":"29","author":"Khan","year":"2022","journal-title":"Ann Surg Oncol"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/s10549-004-3289-1","volume":"90","author":"Sabel","year":"2005","journal-title":"Breast Cancer Res Treat"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"930461","DOI":"10.3389\/fimmu.2022.930461","volume":"13","author":"Wu","year":"2022","journal-title":"Front Immunol"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"1498942","DOI":"10.3389\/fimmu.2024.1498942","volume":"15","author":"de Miranda F","year":"2024","journal-title":"Front Immunol"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.it.2015.02.008","volume":"36","author":"Pauken","year":"2015","journal-title":"Trends Immunol"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1158\/2159-8290.CD-18-0367","volume":"8","author":"Wei","year":"2018","journal-title":"Cancer Discov"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"8509","DOI":"10.1002\/jcp.27782","volume":"234","author":"Farhood","year":"2019","journal-title":"J Cell Physiol"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1038\/sj.bjc.6603341","volume":"95","author":"den Brok","year":"2006","journal-title":"Br J Cancer"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1038\/ni.2039","volume":"12","author":"Pulendran","year":"2011","journal-title":"Nat Immunol"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1126\/science.aaa8172","volume":"348","author":"Sharma","year":"2015","journal-title":"Science"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"1258873","DOI":"10.3389\/fimmu.2023.1258873","volume":"14","author":"de Miranda F","year":"2023","journal-title":"Front Immunol"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1186\/1471-2407-8-228","volume":"8","author":"Tao","year":"2008","journal-title":"BMC Cancer"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1158\/2326-6066.CIR-13-0031-T","volume":"2","author":"Redmond","year":"2014","journal-title":"Cancer Immunol Res"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1158\/1535-7163.MCT-25-0501","volume":"25","author":"Swancutt","year":"2026","journal-title":"Mol Cancer Ther"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1158\/1078-0432.CCR-18-3486","volume":"26","author":"Kemeny","year":"2020","journal-title":"Clin Cancer Res"},{"key":"ref51","unstructured":"AVMA. AVMA Guidelines for the Euthanasia of Animals: 2020 Edition. American Veterinary Medical Association; 2020."},{"key":"ref52","doi-asserted-by":"publisher","first-page":"1915","DOI":"10.3390\/cancers17121915","volume":"17","author":"Fermanian","year":"2025","journal-title":"Cancers"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1001\/jamaoncol.2018.4224","volume":"5","author":"Emens","year":"2019","journal-title":"JAMA Oncol"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1002\/ijc.33534","volume":"149","author":"Low","year":"2021","journal-title":"Int J Cancer"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1200\/JCO.18.01998","volume":"37","author":"Lebbe","year":"2019","journal-title":"J Clin Oncol"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1016\/S1470-2045(19)30151-2","volume":"20","author":"Rozeman","year":"2019","journal-title":"Lancet Oncol"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"5280","DOI":"10.1158\/1078-0432.CCR-21-0793","volume":"27","author":"Long","year":"2021","journal-title":"Clin Cancer Res"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1056\/NEJMoa2112651","volume":"386","author":"Schmid","year":"2022","journal-title":"N Engl J Med"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"1817","DOI":"10.1016\/S0140-6736(20)32531-9","volume":"396","author":"Cortes","year":"2020","journal-title":"Lancet"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.immuni.2013.07.012","volume":"39","author":"Chen","year":"2013","journal-title":"Immunity"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/s1074-7613(03)00175-4","volume":"19","author":"Itano","year":"2003","journal-title":"Immunity"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1016\/j.trecan.2025.04.008","volume":"11","author":"von Renesse","year":"2025","journal-title":"Trends Cancer"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/j.cell.2016.12.022","volume":"168","author":"Spitzer","year":"2017","journal-title":"Cell"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.124507","volume":"3","author":"Fransen","year":"2018","journal-title":"JCI Insight"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1016\/j.cell.2023.02.021","volume":"186","author":"Rahim","year":"2023","journal-title":"Cell"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.immuni.2022.12.002","volume":"56","author":"Prokhnevska","year":"2023","journal-title":"Immunity"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"4049","DOI":"10.1016\/j.cell.2022.09.020","volume":"185","author":"Huang","year":"2022","journal-title":"Cell"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"2338","DOI":"10.1016\/j.immuni.2021.08.026","volume":"54","author":"Schenkel","year":"2021","journal-title":"Immunity"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1038\/s41467-019-14127-9","volume":"11","author":"Vokali","year":"2020","journal-title":"Nat Commun"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"8065","DOI":"10.1158\/0008-5472.CAN-06-1392","volume":"66","author":"Hoshida","year":"2006","journal-title":"Cancer Res"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"7828","DOI":"10.1158\/0008-5472.CAN-08-1488","volume":"68","author":"Burton","year":"2008","journal-title":"Cancer Res"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1093\/jnci\/94.11.819","volume":"94","author":"He","year":"2002","journal-title":"J Natl Cancer Inst"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"4298","DOI":"10.1038\/s41467-022-31941-w","volume":"13","author":"Saddawi-Konefka","year":"2022","journal-title":"Nat Commun"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"7015","DOI":"10.1038\/s41467-022-34676-w","volume":"13","author":"Darragh","year":"2022","journal-title":"Nat Commun"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1016\/j.ccell.2020.09.001","volume":"38","author":"Dammeijer","year":"2020","journal-title":"Cancer Cell"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"108164","DOI":"10.1016\/j.celrep.2020.108164","volume":"32","author":"Pfirschke","year":"2020","journal-title":"Cell Rep"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"2589","DOI":"10.7150\/thno.93812","volume":"14","author":"Liao","year":"2024","journal-title":"Theranostics"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1084\/jem.20161621","volume":"214","author":"Deniset","year":"2017","journal-title":"J Exp Med"},{"key":"ref79","doi-asserted-by":"publisher","first-page":"349","DOI":"10.3390\/genes12030349","volume":"12","author":"Martins","year":"2021","journal-title":"Genes"},{"key":"ref80","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/s00262-011-1148-6","volume":"61","author":"Malyguine","year":"2012","journal-title":"Cancer Immunol Immunother"}],"container-title":["ImmunoTargets and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/113765","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/113765","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T06:20:14Z","timestamp":1775542814000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/cryoablation-plus-immune-checkpoint-inhibitors-enhanced-dendritic-cell-peer-reviewed-fulltext-article-ITT"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":80,"URL":"https:\/\/doi.org\/10.2147\/itt.s581990","relation":{},"ISSN":["2253-1556"],"issn-type":[{"value":"2253-1556","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]}}}