{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T17:31:20Z","timestamp":1784914280369,"version":"3.55.0"},"reference-count":102,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAA"],"DOI":"10.2147\/jaa.s526788","type":"journal-article","created":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T10:55:12Z","timestamp":1747911312000},"page":"769-777","source":"Crossref","is-referenced-by-count":6,"title":["NOD2-NLRP3 Axis and Asthma"],"prefix":"10.2147","volume":"Volume 18","author":[{"given":"Xulong","family":"Cai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2025,5]]},"reference":[{"key":"ref1","unstructured":"Global Initiative for Asthma. Global strategy for asthma management and prevention [Internet]. Available from: http:\/\/www.ginasthma.org. Accessed January 31, 2025."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/s13052-024-01594-0","volume":"50","author":"Klain","year":"2024","journal-title":"Ital J Pediatr"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1016\/j.jaci.2014.07.064","volume":"134","author":"Miller","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1097\/MOP.0000000000000421","volume":"28","author":"Sheehan","year":"2016","journal-title":"Curr Opin Pediatr"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"123","DOI":"10.3390\/ijms20010123","volume":"20","author":"Frati","year":"2019","journal-title":"Int J Mol Sci"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"27984","DOI":"10.3402\/ecrj.v2.27984","volume":"2","author":"Del Giacco","year":"2015","journal-title":"Eur Clin Respir J"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1702","DOI":"10.1016\/j.jaci.2019.02.018","volume":"143","author":"Poole","year":"2019","journal-title":"J Allergy Clin Immunol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1016\/j.cell.2021.02.016","volume":"184","author":"Hammad","year":"2021","journal-title":"Cell"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s13052-023-01492-x","volume":"50","author":"Bisoffi","year":"2024","journal-title":"Ital J Pediatr"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"S2","DOI":"10.1002\/alr.21609","volume":"5","author":"Mims","year":"2015","journal-title":"Int Forum Allergy Rhinol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1007\/s00441-016-2566-8","volume":"367","author":"Fehrenbach","year":"2017","journal-title":"Cell Tissue Res"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1152\/physrev.00009.2014","volume":"95","author":"Motta","year":"2015","journal-title":"Physiol Rev"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1007\/s00011-018-1132-0","volume":"67","author":"Alhazmi","year":"2018","journal-title":"Inflamm Res"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"5","DOI":"10.3349\/ymj.2016.57.1.5","volume":"57","author":"Kim","year":"2016","journal-title":"Yonsei Med J"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1146\/annurev-immunol-081022-021207","volume":"41","author":"Fu","year":"2023","journal-title":"Annu Rev Immunol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1016\/j.biopha.2017.05.126","volume":"92","author":"Patel","year":"2017","journal-title":"Biomed Pharmacother"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1038\/ni.3202","volume":"16","author":"Bruchard","year":"2015","journal-title":"Nat Immunol"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"18","DOI":"10.24875\/RIC.17002327","volume":"70","author":"Dominguez-Martinez","year":"2018","journal-title":"Rev Invest Clin"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1007\/s12026-016-8873-z","volume":"64","author":"Shrivastava","year":"2016","journal-title":"Immunol Res"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.gene.2018.03.061","volume":"660","author":"Gaballah","year":"2018","journal-title":"Gene"},{"key":"ref21","first-page":"1","volume":"2018","author":"Wang","year":"2018","journal-title":"J Immunol Res"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"4812","DOI":"10.1074\/jbc.M008072200","volume":"276","author":"Ogura","year":"2001","journal-title":"J Biol Chem"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1038\/35079114","volume":"411","author":"Ogura","year":"2001","journal-title":"Nature"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1111\/j.1365-2567.2011.03492.x","volume":"134","author":"Kvarnhammar","year":"2011","journal-title":"Immunology"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1111\/j.1365-2567.2009.03212.x","volume":"130","author":"Ekman","year":"2010","journal-title":"Immunology"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"3100","DOI":"10.1016\/j.molimm.2007.02.007","volume":"44","author":"Uehara","year":"2007","journal-title":"Mol Immunol"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1111\/cei.12031","volume":"172","author":"Qiu","year":"2013","journal-title":"Clin Exp Immunol"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1016\/j.chom.2014.05.001","volume":"15","author":"Bonham","year":"2014","journal-title":"Cell Host Microbe"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1038\/nature17631","volume":"532","author":"Keestra-Gounder","year":"2016","journal-title":"Nature"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"2427","DOI":"10.1002\/glia.23482","volume":"66","author":"Singh","year":"2018","journal-title":"Glia"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"1889","DOI":"10.4049\/jimmunol.1700507","volume":"201","author":"Napier","year":"2018","journal-title":"J Immunol"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1038\/s41598-017-00484-2","volume":"7","author":"Rodriguez-Nunez","year":"2017","journal-title":"Sci Rep"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1186\/s12879-014-0648-3","volume":"14","author":"Liu","year":"2014","journal-title":"BMC Infect Dis"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/ni.1823","volume":"11","author":"Travassos","year":"2010","journal-title":"Nat Immunol"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"2727","DOI":"10.1002\/eji.201242396","volume":"42","author":"Vissers","year":"2012","journal-title":"Eur J Immunol"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1038\/cmi.2012.77","volume":"10","author":"Wong","year":"2013","journal-title":"Cell Mol Immunol"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1002\/eji.201847534","volume":"49","author":"Lee","year":"2019","journal-title":"Eur J Immunol"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"8650","DOI":"10.4049\/jimmunol.181.12.8650","volume":"181","author":"Duan","year":"2008","journal-title":"J Immunol"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.coi.2018.06.007","volume":"54","author":"Haspeslagh","year":"2018","journal-title":"Curr Opin Immunol"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1016\/j.jaci.2010.09.021","volume":"126","author":"Duan","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"2254","DOI":"10.4049\/jimmunol.1002503","volume":"186","author":"Lei","year":"2011","journal-title":"J Immunol"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1165\/rcmb.2010-0001OC","volume":"44","author":"Lee","year":"2011","journal-title":"Am J Respir Cell Mol Biol"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"L296","DOI":"10.1152\/ajplung.00086.2011","volume":"301","author":"Poole","year":"2011","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1016\/j.jaci.2015.04.018","volume":"136","author":"Chien","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.pharmthera.2017.08.011","volume":"181","author":"Mishra","year":"2018","journal-title":"Pharmacol Ther"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"5509","DOI":"10.1074\/jbc.C200673200","volume":"278","author":"Inohara","year":"2003","journal-title":"J Biol Chem"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"8869","DOI":"10.1074\/jbc.C200651200","volume":"278","author":"Girardin","year":"2003","journal-title":"J Biol Chem"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"13535","DOI":"10.1021\/ja303883c","volume":"134","author":"Grimes","year":"2012","journal-title":"J Am Chem Soc"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1038\/416194a","volume":"416","author":"Gal\u00e1n","year":"2002","journal-title":"Nature"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"2345","DOI":"10.1248\/bpb.30.2345","volume":"30","author":"Kim","year":"2007","journal-title":"Biol Pharm Bull"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"e00675","DOI":"10.1002\/mgg3.675","volume":"7","author":"Cai","year":"2019","journal-title":"Mol Genet Genomic Med"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1007\/s10753-014-0038-4","volume":"38","author":"Wong","year":"2015","journal-title":"Inflammation"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.cellimm.2016.11.007","volume":"312","author":"Ni","year":"2017","journal-title":"Cell Immunol"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1007\/s00408-019-00209-4","volume":"197","author":"Belhaj","year":"2019","journal-title":"Lung"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1146\/annurev-immunol-031210-101405","volume":"29","author":"Davis","year":"2011","journal-title":"Annu Rev Immunol"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.yexcr.2018.03.002","volume":"366","author":"Li","year":"2018","journal-title":"Exp Cell Res"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/S1097-2765(02)00599-3","volume":"10","author":"Martinon","year":"2002","journal-title":"Mol Cell"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1038\/nri.2016.151","volume":"17","author":"Liston","year":"2017","journal-title":"Nat Rev Immunol"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1038\/nri.2016.58","volume":"16","author":"Broz","year":"2016","journal-title":"Nat Rev Immunol"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1038\/nature16959","volume":"530","author":"He","year":"2016","journal-title":"Nature"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1038\/s41586-019-1295-z","volume":"570","author":"Sharif","year":"2019","journal-title":"Nature"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1111\/imr.12608","volume":"281","author":"Hughes","year":"2018","journal-title":"Immunol Rev"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1038\/nrd.2018.97","volume":"17","author":"Mangan","year":"2018","journal-title":"Nat Rev Drug Discov"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"5974","DOI":"10.4049\/jimmunol.1400368","volume":"192","author":"Grailer","year":"2014","journal-title":"J Immunol"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"C182","DOI":"10.1152\/ajpcell.00086.2013","volume":"305","author":"Fukumoto","year":"2013","journal-title":"Am J Physiol Cell Physiol"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"6574","DOI":"10.1038\/ncomms7574","volume":"6","author":"Dos","year":"2015","journal-title":"Nat Commun"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1111\/jpi.12322","volume":"60","author":"Zhang","year":"2016","journal-title":"J Pineal Res"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.intimp.2014.02.017","volume":"20","author":"Luo","year":"2014","journal-title":"Int Immunopharmacol"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1007\/s00011-016-0973-7","volume":"65","author":"Jiang","year":"2016","journal-title":"Inflamm Res"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"5296","DOI":"10.4049\/jimmunol.1400653","volume":"192","author":"Zhang","year":"2014","journal-title":"J Immunol"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"7360","DOI":"10.1111\/jcmm.14595","volume":"23","author":"Liu","year":"2019","journal-title":"J Cell Mol Med"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"2884","DOI":"10.4049\/jimmunol.1102488","volume":"188","author":"Allen","year":"2012","journal-title":"J Immunol"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.jaut.2018.07.003","volume":"93","author":"Huang","year":"2018","journal-title":"J Autoimmun"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.1111\/1440-1681.13306","volume":"47","author":"Zhu","year":"2020","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"106301","DOI":"10.1016\/j.intimp.2020.106301","volume":"81","author":"Zhao","year":"2020","journal-title":"Int Immunopharmacol"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1183\/09031936.00105013","volume":"43","author":"Simpson","year":"2014","journal-title":"Eur Respir J"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1093\/toxsci\/kfz099","volume":"170","author":"Chen","year":"2019","journal-title":"Toxicol Sci"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1111\/all.13619","volume":"74","author":"Tan","year":"2019","journal-title":"Allergy"},{"key":"ref79","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1016\/j.jaci.2017.02.045","volume":"141","author":"Rossios","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"ref80","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1164\/rccm.201609-1830OC","volume":"196","author":"Kim","year":"2017","journal-title":"Am J Respir Crit Care Med"},{"key":"ref81","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1186\/s12931-020-01374-4","volume":"21","author":"Xu","year":"2020","journal-title":"Respir Res"},{"key":"ref82","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1038\/s41385-019-0172-2","volume":"12","author":"Han","year":"2019","journal-title":"Mucosal Immunol"},{"key":"ref83","doi-asserted-by":"publisher","first-page":"1995","DOI":"10.1042\/BCJ20180086","volume":"475","author":"Liu","year":"2018","journal-title":"Biochem J"},{"key":"ref84","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1016\/j.jaci.2009.07.044","volume":"124","author":"Hitomi","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"ref85","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1189\/jlb.1006627","volume":"82","author":"Pan","year":"2007","journal-title":"J Leukoc Biol"},{"key":"ref86","doi-asserted-by":"publisher","first-page":"e4931","DOI":"10.1371\/journal.pone.0004931","volume":"4","author":"Wagner","year":"2009","journal-title":"PLoS One"},{"key":"ref87","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1038\/ni.2563","volume":"14","author":"Lupfer","year":"2013","journal-title":"Nat Immunol"},{"key":"ref88","doi-asserted-by":"publisher","first-page":"e1004410","DOI":"10.1371\/journal.ppat.1004410","volume":"10","author":"Lupfer","year":"2014","journal-title":"PLoS Pathog"},{"key":"ref89","doi-asserted-by":"publisher","first-page":"2650","DOI":"10.1002\/eji.201243281","volume":"43","author":"Kim","year":"2013","journal-title":"Eur J Immunol"},{"key":"ref90","doi-asserted-by":"publisher","first-page":"e003870","DOI":"10.1161\/CIRCHEARTFAILURE.117.003870","volume":"10","author":"Tsch\u00f6pe","year":"2017","journal-title":"Circ Heart Fail"},{"key":"ref91","doi-asserted-by":"publisher","first-page":"196","DOI":"10.3389\/fcimb.2020.00196","volume":"10","author":"Shi","year":"2020","journal-title":"Front Cell Infect Microbiol"},{"key":"ref92","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1007\/s00784-014-1361-8","volume":"19","author":"Lee","year":"2015","journal-title":"Clin Oral Investig"},{"key":"ref93","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1038\/ni.3704","volume":"18","author":"Mills","year":"2017","journal-title":"Nat Immunol"},{"key":"ref94","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1016\/j.cell.2013.02.054","volume":"153","author":"Subramanian","year":"2013","journal-title":"Cell"},{"key":"ref95","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1165\/rcmb.2014-0009OC","volume":"51","author":"Rynko","year":"2014","journal-title":"Am J Respir Cell Mol Biol"},{"key":"ref96","doi-asserted-by":"publisher","first-page":"1528","DOI":"10.1093\/cid\/civ062","volume":"60","author":"Jackson","year":"2015","journal-title":"Clin Infect Dis"},{"key":"ref97","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/s12931-018-0725-z","volume":"19","author":"Mahmutovic Persson","year":"2018","journal-title":"Respir Res"},{"key":"ref98","doi-asserted-by":"publisher","first-page":"1486780","DOI":"10.3389\/fmed.2024.1486780","volume":"11","author":"Thawanaphong","year":"2024","journal-title":"Front Med"},{"key":"ref99","doi-asserted-by":"publisher","first-page":"4358","DOI":"10.4049\/jimmunol.1301170","volume":"191","author":"Park","year":"2013","journal-title":"J Immunol"},{"key":"ref100","doi-asserted-by":"publisher","first-page":"10365","DOI":"10.1074\/jbc.RA118.007218","volume":"294","author":"Shehat","year":"2019","journal-title":"J Biol Chem"},{"key":"ref101","doi-asserted-by":"publisher","first-page":"927593","DOI":"10.3389\/fimmu.2022.927593","volume":"13","author":"Wang","year":"2022","journal-title":"Front Immunol"},{"key":"ref102","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1038\/ni.1782","volume":"10","author":"Sabbah","year":"2009","journal-title":"Nat Immunol"}],"container-title":["Journal of Asthma and Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/103199","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/103199","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T10:55:13Z","timestamp":1747911313000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/nod2-nlrp3-axis-and-asthma-peer-reviewed-fulltext-article-JAA"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":102,"URL":"https:\/\/doi.org\/10.2147\/jaa.s526788","relation":{},"ISSN":["1178-6965"],"issn-type":[{"value":"1178-6965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5]]}}}