{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T00:35:51Z","timestamp":1788568551233,"version":"build-2803163510"},"reference-count":43,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JBM"],"DOI":"10.2147\/jbm.s377126","type":"journal-article","created":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T04:20:13Z","timestamp":1668399613000},"page":"649-662","source":"Crossref","is-referenced-by-count":13,"title":["Structure and Function of Recombinant versus Plasma-Derived von Willebrand Factor and Impact on Multimer Pharmacokinetics in von Willebrand Disease"],"prefix":"10.2147","volume":"Volume 13","author":[{"given":"Herbert","family":"Gritsch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Schrenk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Weinhappl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Mellg\u00e5rd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3871-8619","authenticated-orcid":true,"given":"Bruce","family":"Ewenstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6161-1556","authenticated-orcid":true,"given":"Peter L","family":"Turecek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2022,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.1007\/s40265-017-0793-2","volume":"77","author":"Heijdra","year":"2017","journal-title":"Drugs"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1007\/s002770050184","volume":"72","author":"Furlan","year":"1996","journal-title":"Ann Hematol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1055\/s-2006-949668","volume":"32","author":"Budde","year":"2006","journal-title":"Semin Thromb Hemost"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"7503","DOI":"10.1073\/pnas.90.16.7503","volume":"90","author":"Furlan","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1055\/s-2006-947866","volume":"32","author":"Budde","year":"2006","journal-title":"Semin Thromb Hemost"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.blre.2010.03.003","volume":"24","author":"Goodeve","year":"2010","journal-title":"Blood Rev"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1097\/MBC.0000000000000065","volume":"25","author":"Stockschlaeder","year":"2014","journal-title":"Blood Coagul Fibrinolysis"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1111\/j.1365-2141.1989.tb00226.x","volume":"73","author":"Federici","year":"1989","journal-title":"Br J Haematol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/0049-3848(96)00161-2","volume":"84","author":"Fischer","year":"1996","journal-title":"Thromb Res"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.1172\/JCI112736","volume":"78","author":"Moake","year":"1986","journal-title":"J Clin Invest"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1016\/j.thromres.2014.03.024","volume":"133","author":"Kragh","year":"2014","journal-title":"Thromb Res"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1182\/blood.V58.2.387.387","volume":"58","author":"Gralnick","year":"1981","journal-title":"Blood"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"2067","DOI":"10.1056\/NEJMra1601561","volume":"375","author":"Leebeek","year":"2016","journal-title":"N Engl J Med"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1056\/NEJMra040403","volume":"351","author":"Mannucci","year":"2004","journal-title":"N Engl J Med"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1111\/j.1365-2516.2007.01610.x","volume":"14","author":"Federici","year":"2008","journal-title":"Haemophilia"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1136\/pgmj.2006.052118","volume":"83","author":"Ozg\u00f6nenel","year":"2007","journal-title":"Postgrad Med J"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1097\/MBC.0b013e3283254570","volume":"20","author":"Batlle","year":"2009","journal-title":"Blood Coagul Fibrinolysis"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1111\/j.1423-0410.1987.tb02981.x","volume":"52","author":"L\u00f3pez-Fern\u00e1ndez","year":"1987","journal-title":"Vox Sang"},{"key":"ref19","unstructured":"Baxalta US Inc. VONVENDI\u00ae (von Willebrand factor [recombinant]) lyophilized powder for solution for intravenous injection [prescribing information]; 2019. Available from: https:\/\/www.shirecontent.com\/PI\/PDFs\/VONVENDI_USA_ENG.pdf. Accessed May 20, 2021."},{"key":"ref20","unstructured":"Baxalta Innovations GmbH. Veyvondi summary of product characteristics. Available from: https:\/\/www.ema.europa.eu\/en\/documents\/product-information\/veyvondi-epar-product-information_en.pdf. Accessed May 20, 2021."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1080\/17474086.2016.1214070","volume":"9","author":"Franchini","year":"2016","journal-title":"Expert Rev Hematol"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"S32","DOI":"10.1055\/s-0037-1617202","volume":"29","author":"Turecek","year":"2009","journal-title":"Hamostaseologie"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1076029619873976","DOI":"10.1177\/1076029619873976","volume":"25","author":"Colling","year":"2019","journal-title":"Clin Appl Thromb Hemost"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1182\/blood-2013-01-479527","volume":"122","author":"Mannucci","year":"2013","journal-title":"Blood"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1055\/s-0030-1255445","volume":"36","author":"Turecek","year":"2010","journal-title":"Semin Thromb Hemost"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1111\/j.1365-2516.2004.00893.x","volume":"10","author":"Lethagen","year":"2004","journal-title":"Haemophilia"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1182\/blood-2002-03-0814","volume":"101","author":"Reiter","year":"2003","journal-title":"Blood"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.thromres.2021.02.012","volume":"201","author":"Turecek","year":"2021","journal-title":"Thromb Res"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1638","DOI":"10.1111\/j.1538-7836.2011.04365.x","volume":"9","author":"Hubbard","year":"2011","journal-title":"J Thromb Haemost"},{"key":"ref30","unstructured":"European Medicines Agency. Guideline on Reporting the Results of Population Pharmacokinetic Analyses; 2007. Available from: https:\/\/www.ema.europa.eu\/en\/documents\/scientific-guideline\/guideline-reporting-results-population-pharmacokinetic-analyses_en.pdf. Accessed November 4, 2022."},{"key":"ref31","unstructured":"US Food and Drug Administration. Population pharmacokinetics: guidance for industry; 2019. Available from: http:\/\/www.fda.gov\/downloads\/Drugs\/GuidanceComplianceRegulatoryInformation\/Guidances\/ucm072137.pdf. Accessed November 4, 2022."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1111\/j.1538-7836.2008.02945.x","volume":"6","author":"Budde","year":"2008","journal-title":"J Thromb Haemost"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"2038","DOI":"10.1182\/blood-2015-02-629873","volume":"126","author":"Gill","year":"2015","journal-title":"Blood"},{"key":"ref34","first-page":"776","volume":"4","author":"Bauer","year":"2020","journal-title":"Res Pract Thromb Haemost"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1111\/jth.14313","volume":"17","author":"Peyvandi","year":"2019","journal-title":"J Thromb Haemost"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"3481","DOI":"10.1182\/bloodadvances.2019000368","volume":"3","author":"Mannucci","year":"2019","journal-title":"Blood Adv"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1097\/MBC.0000000000000169","volume":"25","author":"Patzke","year":"2014","journal-title":"Blood Coagul Fibrinolysis"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"2939","DOI":"10.1182\/blood.V88.8.2939.bloodjournal8882939","volume":"88","author":"Siedlecki","year":"1996","journal-title":"Blood"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"225","DOI":"10.5482\/HAMO-14-12-0077","volume":"35","author":"Reininger","year":"2015","journal-title":"Hamostaseologie"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1002\/ajh.21739","volume":"85","author":"Ledford-Kraemer","year":"2010","journal-title":"Am J Hematol"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1172\/JCI115376","volume":"88","author":"Dent","year":"1991","journal-title":"J Clin Invest"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/0092-8674(91)90648-i","volume":"64","author":"Wagner","year":"1991","journal-title":"Cell"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"313","DOI":"10.5505\/tjh.2012.39205","volume":"29","author":"Berber","year":"2012","journal-title":"Turk J Haematol"}],"container-title":["Journal of Blood Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=85388","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=85388","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T04:20:18Z","timestamp":1668399618000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/structure-and-function-of-recombinant-versus-plasma-derived-von-willeb-peer-reviewed-fulltext-article-JBM"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":43,"URL":"https:\/\/doi.org\/10.2147\/jbm.s377126","relation":{},"ISSN":["1179-2736"],"issn-type":[{"value":"1179-2736","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11]]}}}