{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T11:39:47Z","timestamp":1793965187859,"version":"4.8.0"},"reference-count":117,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JBM"],"DOI":"10.2147\/jbm.s389241","type":"journal-article","created":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T10:55:24Z","timestamp":1677754524000},"page":"189-208","source":"Crossref","is-referenced-by-count":57,"title":["Von Willebrand Disease Epidemiology, Burden of Illness and Management: A Systematic Review"],"prefix":"10.2147","volume":"Volume 14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1329-790X","authenticated-orcid":true,"given":"Ping","family":"Du","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurore","family":"Bergamasco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yola","family":"Moride","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Truong Berthoz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fclden","family":"\u00d6zen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spiros","family":"Tzivelekis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2023,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"7880","DOI":"10.1073\/pnas.89.17.7880","volume":"89","author":"Gralnick","year":"1992","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"2103","DOI":"10.1111\/j.1538-7836.2006.02146.x","volume":"4","author":"Sadler","year":"2006","journal-title":"J Thromb Haemost"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1172\/JCI108788","volume":"60","author":"Weiss","year":"1977","journal-title":"J Clin Invest"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1182\/bloodadvances.2020003264","volume":"5","author":"Connell","year":"2021","journal-title":"Blood Adv"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"2067","DOI":"10.1056\/NEJMra1601561","volume":"375","author":"Leebeek","year":"2016","journal-title":"N Engl J Med"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1111\/j.1538-7836.2009.03661.x","volume":"8","author":"Bowman","year":"2010","journal-title":"J Thromb Haemost"},{"key":"ref7","unstructured":"Cochrane group. Cochrane handbook for systematic reviews of interventions. Available from: http:\/\/training.cochrane.org\/handbook. Accessed March 21, 2018."},{"key":"ref8","unstructured":"Institute of Medicine (IOM). Standards for systematic reviews. Available from: https:\/\/iom.nationalacademies.org\/Reports\/2011\/Finding-What-Works-in-Health-Care-Standards-for-Systematic-Reviews\/Standards.aspx. Accessed March 21, 2018."},{"key":"ref9","unstructured":"Orphanet. Von Willebrand disease. Available from: https:\/\/www.orpha.net\/consor\/cgi-bin\/OC_Exp.php?Lng=EN&Expert=903. Accessed May 31, 2022."},{"key":"ref10","unstructured":"World Federation of Hemophilia. Report on the annual global survey; 2019. Available from: http:\/\/www1.wfh.org\/publications\/files\/pdf-1806.pdf. Accessed May 31, 2022."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1111\/j.1365-2141.1984.tb02876.x","volume":"57","author":"Mannucci","year":"1984","journal-title":"Br J Haematol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"58","DOI":"10.2450\/2019.0211-18","volume":"18","author":"Abbonizio","year":"2020","journal-title":"Blood Transfus"},{"key":"ref13","unstructured":"FranceCoag. National statistics: von Willebrand disease. Available from: https:\/\/www.francecoag.org\/SiteWebPublic\/public\/stats\/stats_page.jsp?stat1=on&stat4=on. Accessed March 31, 2021."},{"key":"ref14","first-page":"s30","volume":"18","author":"Giampaolo","year":"2020","journal-title":"Blood Transfus"},{"key":"ref15","unstructured":"United Kingdom Haemophilia Centre Doctors\u2019 Organisation (UKHCDO). UKHCDO annual report 2020 & bleeding disorder statistics for the financial year 2019\/2020; 2020."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"34","DOI":"10.3390\/jcm6030034","volume":"6","author":"Giampaolo","year":"2017","journal-title":"J Clin Med"},{"key":"ref17","unstructured":"Korea Hemophilia Foundation (KHF). Current Status. Available from: http:\/\/www.kohem.org\/eng\/load.asp?subPage=310. Accessed December 31, 2020."},{"key":"ref18","unstructured":"National Blood Authority of Australia. Australian bleeding disorders registry: annual report 2018-19; 2019. Available from: https:\/\/www.blood.gov.au\/system\/files\/ABDR-Annual-Report-2018-19-FINAL.pdf. Accessed November 23, 2021."},{"key":"ref19","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/j.1365-2516.2012.02761.x","volume":"18","author":"Tatsunami","year":"2012","journal-title":"Haemophilia"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"e350","DOI":"10.3346\/jkms.2020.35.e350","volume":"35","author":"Yoon","year":"2020","journal-title":"J Korean Med Sci"},{"key":"ref21","first-page":"455","volume":"45","author":"Qu","year":"2014","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/hae.13880","volume":"26","author":"Alkaabi","year":"2020","journal-title":"Haemophilia"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"233","DOI":"10.2450\/2012.0023-12","volume":"11","author":"Mansouritorghabeh","year":"2013","journal-title":"Blood Transfus"},{"key":"ref24","unstructured":"Blatn\u00fd J, Ovesn\u00e1 P The status of care for persons with von Willebrand disease registered within CNHP registry annual report; 2019. Available from: https:\/\/www.cnhp.cz\/res\/file\/vysledky\/cnhp_2019_vwd_print.pdf. Accessed August 19, 2022."},{"key":"ref25","unstructured":"Centers for Disease Control and Prevention. HTC population profile patient characteristics. Available from: https:\/\/www.cdc.gov\/ncbddd\/hemophilia\/communitycounts\/data-reports\/2020-9\/table-1-patient-characteristics-by-calendar.html. Accessed August 19, 2022."},{"key":"ref26","unstructured":"The World Bank. Population, Total \u2013 Australia; 2019. Available from: https:\/\/data.worldbank.org\/indicator\/SP.POP.TOTL?locations=AU. Accessed November 23, 2021."},{"key":"ref27","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1182\/blood.V69.2.454.454","volume":"69","author":"Rodeghiero","year":"1987","journal-title":"Blood"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"40","DOI":"10.4274\/tjh.2011.0020","volume":"30","author":"Sap","year":"2013","journal-title":"Turk J Haematol"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"136","DOI":"10.4103\/joah.joah_63_18","volume":"9","author":"Abu-Douleh","year":"2018","journal-title":"J Appl Hematol"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1002\/pbc.22429","volume":"55","author":"Bowman","year":"2010","journal-title":"Pediatr Blood Cancer"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1016\/s0022-3476(05)80384-1","volume":"123","author":"Werner","year":"1993","journal-title":"J Pediatr"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"e7789","DOI":"10.4236\/oalib.1107789","volume":"8","author":"Shonde-Adebola","year":"2021","journal-title":"OALib"},{"key":"ref33","unstructured":"Orphanet. Von Willebrand disease type 3. Available from: https:\/\/www.orpha.net\/consor\/cgi-bin\/OC_Exp.php?lng=en&Expert=166096. Accessed April 19, 2021."},{"key":"ref34","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1055\/s-0031-1281037","volume":"37","author":"Federici","year":"2011","journal-title":"Semin Thromb Hemost"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"4037","DOI":"10.1182\/blood-2014-02-557264","volume":"123","author":"Federici","year":"2014","journal-title":"Blood"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1111\/hae.13642","volume":"25","author":"Holm","year":"2019","journal-title":"Haemophilia"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1111\/jth.12586","volume":"12","author":"Sanders","year":"2014","journal-title":"J Thromb Haemost"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1111\/hae.12900","volume":"22","author":"Siboni","year":"2016","journal-title":"Haemophilia"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"e185","DOI":"10.1111\/hae.12670","volume":"21","author":"van Galen","year":"2015","journal-title":"Haemophilia"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1002\/ajh.25656","volume":"95","author":"Abe","year":"2020","journal-title":"Am J Hematol"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1177\/1076029616670258","volume":"24","author":"Apostolova","year":"2018","journal-title":"Clin Appl Thromb Hemost"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"486","DOI":"10.4103\/0377-4929.68287","volume":"53","author":"Kumar","year":"2010","journal-title":"Indian J Pathol Microbiol"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1097\/MBC.0b013e3283540bf8","volume":"23","author":"Mokhtar","year":"2012","journal-title":"Blood Coagul Fibrinolysis"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"102728","DOI":"10.1016\/j.transci.2020.102728","volume":"59","author":"\u00d6ner","year":"2020","journal-title":"Transfus Apher Sci"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1007\/s12288-019-01233-3","volume":"36","author":"Sahoo","year":"2020","journal-title":"Indian J Hematol Blood Transfus"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"1999","DOI":"10.1111\/jth.13142","volume":"13","author":"Seaman","year":"2015","journal-title":"J Thromb Haemost"},{"key":"ref47","first-page":"653","volume":"121","author":"Trasi","year":"2005","journal-title":"Indian J Med Res"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"e255","DOI":"10.1016\/j.thromres.2012.09.005","volume":"130","author":"Qureshi","year":"2012","journal-title":"Thromb Res"},{"key":"ref49","first-page":"222","volume":"9","author":"Henriksson","year":"2011","journal-title":"J Thromb Haemost"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"e442","DOI":"10.1111\/hae.12739","volume":"21","author":"Malec","year":"2015","journal-title":"Haemophilia"},{"key":"ref51","first-page":"3373","volume":"130","author":"Mittal","year":"2017","journal-title":"Blood"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1111\/hae.13292","volume":"23","author":"Sidonio","year":"2017","journal-title":"Haemophilia"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1111\/j.1538-7836.2006.01847.x","volume":"4","author":"Tosetto","year":"2006","journal-title":"J Thromb Haemost"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1007\/s00277-011-1266-4","volume":"90","author":"Chen","year":"2011","journal-title":"Ann Hematol"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1160\/TH12-04-0244","volume":"108","author":"de Wee","year":"2012","journal-title":"Thromb Haemost"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1046\/j.1365-2141.2000.02507.x","volume":"111","author":"Lak","year":"2000","journal-title":"Br J Haematol"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1002\/ajh.24195","volume":"90","author":"Sanders","year":"2015","journal-title":"Am J Hematol"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"2145","DOI":"10.1111\/jth.14886","volume":"18","author":"Tosetto","year":"2020","journal-title":"J Thromb Haemost"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1111\/hae.12065","volume":"19","author":"Hassan","year":"2013","journal-title":"Haemophilia"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1111\/jth.14696","volume":"18","author":"O\u2019Brien","year":"2020","journal-title":"J Thromb Haemost"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"e54","DOI":"10.1111\/hae.13653","volume":"25","author":"Xu","year":"2019","journal-title":"Haemophilia"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1111\/hae.12016","volume":"19","author":"Majluf-Cruz","year":"2013","journal-title":"Haemophilia"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1111\/ejh.13562","volume":"106","author":"Wilson","year":"2021","journal-title":"Eur J Haematol"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1097\/MBC.0000000000000620","volume":"28","author":"Skeith","year":"2017","journal-title":"Blood Coagul Fibrinolysis"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"E155","DOI":"10.1016\/j.ejogrb.2018.08.499","volume":"234","author":"Sladic","year":"2019","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1182\/blood.V130.Suppl_1.1086.1086","volume":"130","author":"Yousuf","year":"2017","journal-title":"Blood"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1111\/hae.12014","volume":"19","author":"Rae","year":"2013","journal-title":"Haemophilia"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"E31","DOI":"10.1002\/ajh.24928","volume":"93","author":"Kaur","year":"2018","journal-title":"Am J Hematol"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"175","DOI":"10.18553\/jmcp.2020.20327","volume":"27","author":"Lu","year":"2021","journal-title":"J Manag Care Spec Pharm"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.thromres.2019.04.017","volume":"178","author":"Tsagianni","year":"2019","journal-title":"Thromb Res"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1089\/jwh.2019.7930","volume":"29","author":"Haley","year":"2020","journal-title":"J Womens Health"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"e35","DOI":"10.1111\/hae.13632","volume":"25","author":"van Deukeren","year":"2019","journal-title":"Haemophilia"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1111\/hae.12834","volume":"22","author":"van Galen","year":"2016","journal-title":"Haemophilia"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1111\/j.1538-7836.2010.03796.x","volume":"8","author":"Biss","year":"2010","journal-title":"J Thromb Haemost"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1111\/bjh.15277","volume":"182","author":"Atiq","year":"2018","journal-title":"Br J Haematol"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1055\/s-0035-1564844","volume":"42","author":"Franchini","year":"2016","journal-title":"Semin Thromb Hemost"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1111\/j.1538-7836.2010.04175.x","volume":"9","author":"de Wee","year":"2011","journal-title":"J Thromb Haemost"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1186\/s12955-017-0643-7","volume":"15","author":"McLaughlin","year":"2017","journal-title":"Health Qual Life Outcomes"},{"key":"ref79","doi-asserted-by":"publisher","first-page":"1486","DOI":"10.3324\/haematol.2017.168617","volume":"102","author":"van Galen","year":"2017","journal-title":"Haematologica"},{"key":"ref80","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1111\/hae.13062","volume":"23","author":"Xu","year":"2017","journal-title":"Haemophilia"},{"key":"ref81","doi-asserted-by":"publisher","first-page":"1690","DOI":"10.1055\/s-0038-1670704","volume":"118","author":"van Galen","year":"2018","journal-title":"Thromb Haemost"},{"key":"ref82","doi-asserted-by":"publisher","first-page":"1923","DOI":"10.3892\/etm.2016.3144","volume":"11","author":"Govorov","year":"2016","journal-title":"Exp Ther Med"},{"key":"ref83","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1111\/hae.13473","volume":"24","author":"Holm","year":"2018","journal-title":"Haemophilia"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"4692","DOI":"10.1182\/blood-2019-122749","volume":"134","author":"Oladapo","year":"2019","journal-title":"Blood"},{"key":"ref85","doi-asserted-by":"publisher","first-page":"e300","DOI":"10.1111\/hae.13779","volume":"25","author":"Boban","year":"2019","journal-title":"Haemophilia"},{"key":"ref86","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1160\/TH11-03-0180","volume":"106","author":"De Wee","year":"2011","journal-title":"Thromb Haemost"},{"key":"ref87","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1111\/hae.12496","volume":"20","author":"Batty","year":"2014","journal-title":"Haemophilia"},{"key":"ref88","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1111\/j.1365-2516.2010.02445.x","volume":"17","author":"Howman","year":"2011","journal-title":"Haemophilia"},{"key":"ref89","doi-asserted-by":"publisher","first-page":"e44","DOI":"10.1111\/hae.12497","volume":"21","author":"Khair","year":"2015","journal-title":"Haemophilia"},{"key":"ref90","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1111\/hae.12841","volume":"22","author":"Livesey","year":"2016","journal-title":"Haemophilia"},{"key":"ref91","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/j.thromres.2014.12.017","volume":"135","author":"Miesbach","year":"2015","journal-title":"Thromb Res"},{"key":"ref92","doi-asserted-by":"publisher","first-page":"1922","DOI":"10.1111\/jth.14928","volume":"18","author":"Goudemand","year":"2020","journal-title":"J Thromb Haemost"},{"key":"ref93","doi-asserted-by":"publisher","first-page":"e0164683","DOI":"10.1371\/journal.pone.0164683","volume":"11","author":"Govorov","year":"2016","journal-title":"PLoS One"},{"key":"ref94","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1111\/hae.12568","volume":"21","author":"James","year":"2015","journal-title":"Haemophilia"},{"key":"ref95","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1111\/j.1365-2516.2012.02916.x","volume":"19","author":"Abshire","year":"2013","journal-title":"Haemophilia"},{"key":"ref96","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1111\/hae.12005","volume":"19","author":"Castaman","year":"2013","journal-title":"Haemophilia"},{"key":"ref97","doi-asserted-by":"publisher","first-page":"6","DOI":"10.4081\/hmr.v1i6.270","volume":"1","author":"Federici","year":"2005","journal-title":"Hematology Meeting Reports"},{"key":"ref98","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1111\/j.1365-2516.2009.02088.x","volume":"16","author":"Federici","year":"2010","journal-title":"Haemophilia"},{"key":"ref99","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1097\/MBC.0000000000000257","volume":"26","author":"Holm","year":"2015","journal-title":"Blood Coagul Fibrinolysis"},{"key":"ref100","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1160\/TH10-09-0616","volume":"105","author":"Halimeh","year":"2011","journal-title":"Thromb Haemost"},{"key":"ref101","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1055\/s-2006-949667","volume":"32","author":"Berntorp","year":"2006","journal-title":"Semin Thromb Hemost"},{"key":"ref102","doi-asserted-by":"publisher","first-page":"2511","DOI":"10.1111\/j.1538-7836.2006.02179.x","volume":"4","author":"Berntorp","year":"2006","journal-title":"J Thromb Haemost"},{"key":"ref103","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1182\/bloodadvances.2020003265","volume":"5","author":"James","year":"2021","journal-title":"Blood Adv"},{"key":"ref104","doi-asserted-by":"publisher","first-page":"17","DOI":"10.2147\/CEOR.S71892","volume":"7","author":"Schinco","year":"2015","journal-title":"Clinicoecon Outcomes Res"},{"key":"ref105","unstructured":"Population Estimate as of January 1, 2021. Institut national de statistique et des \u00e9tudes \u00e9conomiques (INSEE); 2021. Available from: https:\/\/www.insee.fr\/fr\/statistiques\/1893198. Accessed November 23, 2021."},{"key":"ref106","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1056\/NEJM198207083070222","volume":"307","author":"Weiss","year":"1982","journal-title":"N Engl J Med"},{"key":"ref107","unstructured":"The World Bank. Population, total - Japan. Available from: https:\/\/data.worldbank.org\/indicator\/SP.POP.TOTL?locations=JP. Accessed November 23, 2021."},{"key":"ref108","unstructured":"The World Bank. Population, Total - Korea, Republic. Available from: https:\/\/data.worldbank.org\/indicator\/SP.POP.TOTL?locations=KR. Accessed April 27, 2022."},{"key":"ref109","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1182\/blood-2018-99-113293","volume":"132","author":"Lu","year":"2018","journal-title":"Blood"},{"key":"ref110","first-page":"139","volume":"26","author":"Turan","year":"2020","journal-title":"Haemophilia"},{"key":"ref111","first-page":"667","volume":"9","author":"Borel-Derlon","year":"2011","journal-title":"J Thromb Haemost"},{"key":"ref112","first-page":"A42","volume":"33","author":"Boyer-Neumann","year":"2013","journal-title":"Hamostaseologie"},{"key":"ref113","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1111\/hae.14242","volume":"27","author":"Desprez","year":"2021","journal-title":"Haemophilia"},{"key":"ref114","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1111\/hae.12075","volume":"19","author":"Auerswald","year":"2013","journal-title":"Haemophilia"},{"key":"ref115","doi-asserted-by":"publisher","first-page":"e199","DOI":"10.1111\/hae.13718","volume":"25","author":"Seaman","year":"2019","journal-title":"Haemophilia"},{"key":"ref116","first-page":"550","volume":"11","author":"O\u2019Connell","year":"2013","journal-title":"J Thromb Haemost"},{"key":"ref117","first-page":"389","volume":"3","author":"Proulle","year":"2019","journal-title":"Res Pract Thromb Haemost"}],"container-title":["Journal of Blood Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=87876","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=87876","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T10:55:49Z","timestamp":1677754549000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/von-willebrand-disease-epidemiology-burden-of-illness-and-management-a-peer-reviewed-fulltext-article-JBM"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":117,"URL":"https:\/\/doi.org\/10.2147\/jbm.s389241","relation":{},"ISSN":["1179-2736"],"issn-type":[{"value":"1179-2736","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3]]}}}