{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T05:57:19Z","timestamp":1789192639925,"version":"build-2803163510"},"reference-count":100,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JBM"],"DOI":"10.2147\/jbm.s431493","type":"journal-article","created":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T04:35:17Z","timestamp":1701837317000},"page":"613-628","source":"Crossref","is-referenced-by-count":41,"title":["Paroxysmal Nocturnal Hemoglobinuria: Current Management, Unmet Needs, and Recommendations"],"prefix":"10.2147","volume":"Volume 14","author":[{"given":"Monika","family":"Oliver","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2089-8650","authenticated-orcid":true,"given":"Christopher","family":"Patriquin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2023,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1056\/NEJM199511093331904","volume":"333","author":"Hillmen","year":"1995","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"587","DOI":"10.7326\/0003-4819-148-8-200804150-00003","volume":"148","author":"Brodsky","year":"2008","journal-title":"Ann Intern Med"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"922","DOI":"10.3324\/haematol.2013.093161","volume":"99","author":"Schrezenmeier","year":"2014","journal-title":"Haematologica"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1111\/ejh.13176","volume":"102","author":"Patriquin","year":"2019","journal-title":"Eur J Haematol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1002\/cyto.b.20525","volume":"78","author":"Borowitz","year":"2010","journal-title":"Cytometry B Clin Cytom"},{"key":"ref6","unstructured":"Partnering4PNH. A global policy consensus paper to address remaining unmet medical needs for people living with PNH; 2022. Available from: https:\/\/pnh.sobi.com\/sites\/default\/files\/P4PNH-consensus-paper-short-version%20-%2015.12.2022%20.pdf. Accessed December 02, 2023."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"855","DOI":"10.3324\/haematol.2010.023176","volume":"95","author":"Brodsky","year":"2010","journal-title":"Haematologica"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1666","DOI":"10.3324\/haematol.2012.062828","volume":"97","author":"Peffault de Latour","year":"2012","journal-title":"Haematologica"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1111\/bjh.17753","volume":"196","author":"Risitano","year":"2022","journal-title":"Br J Haematol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"e103","DOI":"10.3324\/haematol.2017.182360","volume":"103","author":"Vallet","year":"2018","journal-title":"Haematologica"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1727","DOI":"10.1007\/s40265-022-01809-w","volume":"82","author":"Heo","year":"2022","journal-title":"Drugs"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"2979","DOI":"10.1007\/s00277-023-05402-3","volume":"102","author":"Hochsmann","year":"2023","journal-title":"Ann Hematol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1177\/2040620716681748","volume":"8","author":"Griffin","year":"2017","journal-title":"Ther Adv Hematol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1182\/blood-2018-09-876136","volume":"133","author":"Lee","year":"2019","journal-title":"Blood"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1182\/blood-2018-09-876805","volume":"133","author":"Kulasekararaj","year":"2019","journal-title":"Blood"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"E232","DOI":"10.1002\/ajh.26176","volume":"96","author":"Kulasekararaj","year":"2021","journal-title":"Am J Hematol"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1056\/NEJMra2201664","volume":"387","author":"Notaro","year":"2022","journal-title":"N Engl J Med"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1182\/blood.2019003812","volume":"137","author":"Brodsky","year":"2021","journal-title":"Blood"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.3389\/fimmu.2019.01157","volume":"10","author":"Risitano","year":"2019","journal-title":"Front Immunol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"4094","DOI":"10.1182\/blood-2008-11-189944","volume":"113","author":"Risitano","year":"2009","journal-title":"Blood"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"230","DOI":"10.3324\/haematol.2019.236877","volume":"106","author":"Brodsky","year":"2021","journal-title":"Haematologica"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1182\/blood-2016-08-732800","volume":"129","author":"Harder","year":"2017","journal-title":"Blood"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1007\/s12185-016-1946-x","volume":"103","author":"Miyasaka","year":"2016","journal-title":"Int J Hematol"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1056\/NEJMoa1502950","volume":"373","author":"Kelly","year":"2015","journal-title":"N Engl J Med"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1248\/bpb.b15-00703","volume":"39","author":"Nakayama","year":"2016","journal-title":"Biol Pharm Bull"},{"key":"ref26","first-page":"3471","volume":"130","author":"McKinley","year":"2017","journal-title":"Blood"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"567","DOI":"10.3324\/haematol.2009.007229","volume":"95","author":"Hill","year":"2010","journal-title":"Haematologica"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"262","DOI":"10.3324\/haematol.2013.090001","volume":"99","author":"Rondelli","year":"2014","journal-title":"Haematologica"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1812","DOI":"10.1182\/blood.2022017019","volume":"141","author":"Prata","year":"2023","journal-title":"Blood"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1056\/NEJMoa1311084","volume":"370","author":"Nishimura","year":"2014","journal-title":"N Engl J Med"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1111\/bjh.15790","volume":"185","author":"Socie","year":"2019","journal-title":"Br J Haematol"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"734","DOI":"10.15585\/mmwr.mm6627e1","volume":"66","author":"McNamara","year":"2017","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1093\/cid\/ciy958","volume":"69","author":"Crew","year":"2019","journal-title":"Clin Infect Dis"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1159\/000491439","volume":"10","author":"Heesterbeek","year":"2018","journal-title":"J Innate Immun"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1056\/NEJMoa2029073","volume":"384","author":"Hillmen","year":"2021","journal-title":"N Engl J Med"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1007\/s12325-022-02339-3","volume":"40","author":"Yenerel","year":"2023","journal-title":"Adv Ther"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1002\/ajh.26998","volume":"98","author":"Liu","year":"2023","journal-title":"Am J Hematol"},{"key":"ref38","doi-asserted-by":"crossref","unstructured":"R\u00f6th A, He G, Brodsky A, et al. The Phase III, randomized commodore 2 trial: results from a multicenter study of crovalimab vs eculizumab in paroxysmal nocturnal hemoglobinuria (pnh) patients na\u00efve to complement inhibitors. presented at: European Hematology Association; 2023; Frankfurt, Germany. Available from: https:\/\/s3.eu-central-1.amazonaws.com\/m-anage.com.storage.eha\/temp\/eha23_abstract_bodies\/S181.pdf. Accessed December 02, 2023.","DOI":"10.1097\/01.HS9.0000967636.72750.f1"},{"key":"ref39","doi-asserted-by":"crossref","unstructured":"Scheinberg P, Cle D, Edwards J, et al. PHASE III randomized, multicenter, open-label commodore 1 trial: comparison of crovalimab vs eculizumab in complement inhibitor-experienced patients with Paroxysmal Nocturnal Hemoglobinuria (PNH). presented at: European Hematology Association; 2023. Available from: https:\/\/s3.eu-central-1.amazonaws.com\/m-anage.com.storage.eha\/temp\/eha23_abstract_bodies\/S183.pdf. Accessed December 02, 2023.","DOI":"10.1097\/01.HS9.0000967644.45540.d8"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"e0269749","DOI":"10.1371\/journal.pone.0269749","volume":"17","author":"Devalaraja-Narashimha","year":"2022","journal-title":"PLoS One"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1182\/blood-2022-169301","volume":"140","author":"Browett","year":"2022","journal-title":"Blood"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2022-171469","volume":"140","author":"de Latour","year":"2022","journal-title":"Blood"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"S33","DOI":"10.1002\/ajh.26882","volume":"98 Suppl 4","author":"Kulasekararaj","year":"2023","journal-title":"Am J Hematol"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"S8","DOI":"10.18553\/jmcp.2020.26.12-b.s8","volume":"26","author":"Bektas","year":"2020","journal-title":"J Manag Care Spec Pharm"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1016\/j.jval.2018.08.008","volume":"22","author":"Rizzardo","year":"2019","journal-title":"Value Health"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"e456","DOI":"10.1016\/S2352-3026(15)00229-X","volume":"2","author":"Lancet Haematology","year":"2015","journal-title":"Lancet Haematol"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.tmrv.2019.09.004","volume":"33","author":"Patriquin","year":"2019","journal-title":"Transfus Med Rev"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"2689","DOI":"10.1007\/s00277-021-04624-7","volume":"100","author":"Kulagin","year":"2021","journal-title":"Ann Hematol"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1002\/jha2.632","volume":"4","author":"Jang","year":"2023","journal-title":"EJHaem"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"2468","DOI":"10.1182\/bloodadvances.2022009129","volume":"7","author":"Wong","year":"2023","journal-title":"Blood Adv"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1056\/NEJMoa031688","volume":"350","author":"Hillmen","year":"2004","journal-title":"N Engl J Med"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"20406207221091046","DOI":"10.1177\/20406207221091046","volume":"13","author":"Kulasekararaj","year":"2022","journal-title":"Ther Adv Hematol"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"2600","DOI":"10.1038\/s41409-021-01372-0","volume":"56","author":"Debureaux","year":"2021","journal-title":"Bone Marrow Transplant"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"6786","DOI":"10.1182\/blood-2011-02-333997","volume":"117","author":"Kelly","year":"2011","journal-title":"Blood"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1002\/ajh.24278","volume":"91","author":"Loschi","year":"2016","journal-title":"Am J Hematol"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"4123","DOI":"10.1182\/blood-2007-06-095646","volume":"110","author":"Hillmen","year":"2007","journal-title":"Blood"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1056\/NEJMoa061648","volume":"355","author":"Hillmen","year":"2006","journal-title":"N Engl J Med"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"1840","DOI":"10.1182\/blood-2007-06-094136","volume":"111","author":"Brodsky","year":"2008","journal-title":"Blood"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1111\/bjh.16711","volume":"191","author":"Peffault de Latour","year":"2020","journal-title":"Br J Haematol"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1097\/01.HS9.0000846132.33920.32","volume":"6","author":"Kulasekararaj","year":"2022","journal-title":"Hemasphere"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1182\/blood.2019003399","volume":"135","author":"Roth","year":"2020","journal-title":"Blood"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1111\/ejh.14011","volume":"111","author":"Roth","year":"2023","journal-title":"Eur J Haematol"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"e0231892","DOI":"10.1371\/journal.pone.0231892","volume":"15","author":"Latuszek","year":"2020","journal-title":"PLoS One"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1007\/s40262-020-00940-9","volume":"60","author":"Badri","year":"2021","journal-title":"Clin Pharmacokinet"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.3324\/haematol.2020.265868","volume":"107","author":"Nishimura","year":"2022","journal-title":"Haematologica"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.3324\/haematol.2022.281562","volume":"108","author":"Kulasekararaj","year":"2023","journal-title":"Haematologica"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"8660","DOI":"10.1182\/blood-2022-166722","volume":"140","author":"Kulasekararaj","year":"2022","journal-title":"Blood"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1111\/ejh.13411","volume":"105","author":"Chow","year":"2020","journal-title":"Eur J Haematol"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"269","DOI":"10.5414\/CP204176","volume":"60","author":"Lee","year":"2022","journal-title":"Int J Clin Pharmacol Ther"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"115004","DOI":"10.1016\/j.jpba.2022.115004","volume":"220","author":"Gusarova","year":"2022","journal-title":"J Pharm Biomed Anal"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1111\/eci.12419","volume":"45","author":"Mastellos","year":"2015","journal-title":"Eur J Clin Invest"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1080\/17512433.2022.2109462","volume":"15","author":"Lee","year":"2022","journal-title":"Expert Rev Clin Pharmacol"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1111\/ejh.13969","volume":"111","author":"Panse","year":"2023","journal-title":"Eur J Haematol"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"2921","DOI":"10.1182\/blood-2022-163625","volume":"140","author":"Patriquin","year":"2022","journal-title":"Blood"},{"key":"ref75","doi-asserted-by":"crossref","unstructured":"M G, Kelly R, Deeren D, et al. Intensive pegcetacoplan dosing in the management of acute hemolysis as part of the 307 open-label extension study. presented at: American Society of Hematology; 2022; New Orleans. Available from: https:\/\/ashpublications.org\/blood\/article\/140\/Supplement%201\/2937\/492951\/Intensive-Pegcetacoplan-Dosing-in-the-Management. Accessed December 02, 2023.","DOI":"10.1182\/blood-2022-163117"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1182\/blood.2022017266","volume":"141","author":"Griffin","year":"2023","journal-title":"Blood"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"e344","DOI":"10.1016\/S2352-3026(21)00028-4","volume":"8","author":"Risitano","year":"2021","journal-title":"Lancet Haematol"},{"key":"ref78","unstructured":"Novartis Phase III APPOINT-PNH trial shows investigational oral monotherapy iptacopan improves hemoglobin to near-normal levels, leading to transfusion Independence in all treatment-na\u00efve PNH patients. 2023. Available from: https:\/\/www.novartis.com\/news\/media-releases\/novartis-phase-iii-appoint-pnh-trial-shows-investigational-oral-monotherapy-iptacopan-improves-hemoglobin-near-normal-levels-leading-transfusion-independence-all-treatment-naive-pnh-patients. Accessed December 02, 2023."},{"key":"ref79","unstructured":"Risitano A, Han B, Ueda Y, et al. Oral complement factor B inhibitor iptacopan monotherapy improves hemoglobin to normal\/near-normal levels in paroxysmal nocturnal hemoglobinuria patients na\u00efve to complement inhibitors: phase III APPOINT-PNH trial; 2023."},{"key":"ref80","doi-asserted-by":"publisher","first-page":"712572","DOI":"10.3389\/fimmu.2021.712572","volume":"12","author":"Barratt","year":"2021","journal-title":"Front Immunol"},{"key":"ref81","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1097\/01.HS9.0000846188.51290.75","volume":"6","author":"Kulasekararaj","year":"2022","journal-title":"Hemasphere"},{"key":"ref82","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1097\/01.HS9.0000846184.35066.7a","volume":"6","author":"McDonald","year":"2022","journal-title":"Hemasphere"},{"key":"ref83","unstructured":"BioCryst discontinues development of BCX9930 and shifts focus to potential once-daily, oral factor D inhibitor, BCX10013; 2022. Available from: https:\/\/ir.biocryst.com\/news-releases\/news-release-details\/biocryst-discontinues-development-bcx9930-and-shifts-focus. Accessed December 02, 2023."},{"key":"ref84","doi-asserted-by":"publisher","first-page":"1928","DOI":"10.1182\/blood.2021011388","volume":"138","author":"Kulasekararaj","year":"2021","journal-title":"Blood"},{"key":"ref85","unstructured":"Kira pharmaceuticals announces first cohort of patients dosed in phase 2 study of KP104 in paroxysmal nocturnal hemoglobinuria (PNH); 2022. Available from: https:\/\/www.prnewswire.com\/news-releases\/kira-pharmaceuticals-announces-first-cohort-of-patients-dosed-in-phase-2-study-of-kp104-in-paroxysmal-nocturnal-hemoglobinuria-pnh-301689797.html. Accessed December 02, 2023."},{"key":"ref86","doi-asserted-by":"publisher","first-page":"e94","DOI":"10.3324\/haematol.2018.198846","volume":"104","author":"Griffin","year":"2019","journal-title":"Haematologica"},{"key":"ref87","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1111\/imj.13523","volume":"47","author":"Almeida","year":"2017","journal-title":"Intern Med J"},{"key":"ref88","unstructured":"CADTH. Ravulizumab; 2022. Available from: https:\/\/www.cadth.ca\/ravulizumab-0. Accessed 04 December 2023."},{"key":"ref89","doi-asserted-by":"publisher","first-page":"1334","DOI":"10.1002\/ajh.25960","volume":"95","author":"de Castro","year":"2020","journal-title":"Am J Hematol"},{"key":"ref90","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1111\/bjh.17860","volume":"196","author":"Brodsky","year":"2022","journal-title":"Br J Haematol"},{"key":"ref91","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1007\/s12185-013-1346-4","volume":"97","author":"Lee","year":"2013","journal-title":"Int J Hematol"},{"key":"ref92","doi-asserted-by":"publisher","first-page":"3188","DOI":"10.3324\/haematol.2020.261826","volume":"106","author":"Risitano","year":"2021","journal-title":"Haematologica"},{"key":"ref93","doi-asserted-by":"crossref","unstructured":"Jang JH, Pavani R, Aurand L, et al. A phase 2, randomized trial evaluating the safety and efficacy of pozelimab and cemdisiran in patients with paroxysmal nocturnal hemoglobinuria. Presented at: European Hematology Association; 2023; Frankfurt, Germany. Available from: https:\/\/s3.eu-central-1.amazonaws.com\/m-anage.com.storage.eha\/temp\/eha23_abstract_bodies\/P782.pdf. Accessed December 02, 2023.","DOI":"10.1097\/01.HS9.0000970032.01817.07"},{"key":"ref94","unstructured":"Summary Safety Review - SOLIRIS (eculizumab) and BEXSERO (Multicomponent Meningococcal B Vaccine [recombinant, adsorbed]) - Assessing the Potential Risk of Hemolysis and Low Hemoglobin in Patients Treated with Soliris and Vaccinated with Bexsero; 2016."},{"key":"ref95","doi-asserted-by":"publisher","first-page":"e340","DOI":"10.3324\/haematol.2018.209692","volume":"104","author":"Granoff","year":"2019","journal-title":"Haematologica"},{"key":"ref96","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1182\/blood-2017-05-781450","volume":"130","author":"Konar","year":"2017","journal-title":"Blood"},{"key":"ref97","doi-asserted-by":"publisher","first-page":"4802","DOI":"10.1182\/blood-2019-127005","volume":"134","author":"Patriquin","year":"2019","journal-title":"Blood"},{"key":"ref98","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1016\/j.bbmt.2016.03.032","volume":"22","author":"Jodele","year":"2016","journal-title":"Biol Blood Marrow Transplant"},{"key":"ref99","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1016\/S0140-6736(18)31069-9","volume":"392","author":"Luzzatto","year":"2018","journal-title":"Lancet"},{"key":"ref100","doi-asserted-by":"publisher","first-page":"101041","DOI":"10.1016\/j.blre.2023.101041","volume":"59","author":"Kulasekararaj","year":"2023","journal-title":"Blood Rev"}],"container-title":["Journal of Blood Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=94983","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=94983","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T04:35:23Z","timestamp":1701837323000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/paroxysmal-nocturnal-hemoglobinuria-current-management-unmet-needs-and-peer-reviewed-fulltext-article-JBM"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":100,"URL":"https:\/\/doi.org\/10.2147\/jbm.s431493","relation":{},"ISSN":["1179-2736"],"issn-type":[{"value":"1179-2736","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12]]}}}