{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T00:41:06Z","timestamp":1775263266516,"version":"3.50.1"},"reference-count":53,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JEP"],"DOI":"10.2147\/jep.s254818","type":"journal-article","created":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T02:53:05Z","timestamp":1594695185000},"page":"203-211","source":"Crossref","is-referenced-by-count":1,"title":["<p>Multiple Pathway\u2013Mediated Gut-Modulatory Effects of <em>Maerua subcordata<\/em> (Gilg) DeWolf<\/p>"],"prefix":"10.2147","volume":"Volume 12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7296-4074","authenticated-orcid":true,"given":"Amber Hanif","family":"Palla","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gereziher Gebremedhin","family":"Sibhat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6198-1664","authenticated-orcid":true,"given":"Aman","family":"Karim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6925-7697","authenticated-orcid":true,"given":"Najeeb Ur","family":"Rehman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6525-4103","authenticated-orcid":true,"given":"Mebrahtom Gebrelibanos","family":"Hiben","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2020,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"046","DOI":"10.1055\/s-0032-1301759","volume":"25","author":"Occhipinti","year":"2012","journal-title":"Clin Colon Rectal Surg"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"6031","DOI":"10.3748\/wjg.v20.i20.6031","volume":"20","author":"Annah\u00e1zi","year":"2014","journal-title":"World J Gastroenterol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.jep.2014.10.014","volume":"158","author":"Rokaya","year":"2014","journal-title":"J Ethnopharmacol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.jep.2005.06.001","volume":"100","author":"Gilani","year":"2005","journal-title":"J Ethnopharmacol"},{"key":"ref5","first-page":"789","volume":"86","author":"Patwardhan","year":"2004","journal-title":"Curr Sci"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/0378-8741(89)90038-X","volume":"25","author":"Chhabra","year":"1989","journal-title":"J Ethnopharmacol"},{"key":"ref7","unstructured":"Mabogo DEN, van Wyk AE The Ethnobotany of the Vhavenda. Master\u2019s Thesis, University of Pretoria, Pretoria\u2013South Africa; 1990."},{"key":"ref8","first-page":"108","volume":"7","author":"Magaji","year":"2008","journal-title":"Nigerian J Pharmaceut Sci"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/S0378-8741(02)00191-5","volume":"83","author":"Geissler","year":"2002","journal-title":"J Ethnopharmacol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1076\/phbi.37.1.80.6313","volume":"37","author":"Diallo","year":"1999","journal-title":"Pharmaceut Biol"},{"key":"ref11","first-page":"099","volume":"1","author":"Abouri","year":"2012","journal-title":"Int J Med Plant Res"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.9734\/EJMP\/2014\/11246","volume":"4","author":"Akuodor","year":"2014","journal-title":"Europ J Med Plants"},{"key":"ref13","first-page":"32","volume":"14","author":"Heuz\u00e9","year":"2015"},{"key":"ref14","first-page":"194","volume":"2","author":"Agize","year":"2013","journal-title":"Topclass J Herbal Med"},{"key":"ref15","first-page":"330","volume":"4","author":"Andarge","year":"2015","journal-title":"Int J Med Plant Res"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/1746-4269-6-23","volume":"6","author":"Teklehaymanot","year":"2010","journal-title":"J Ethnobiol Ethnomed"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1016\/j.jep.2013.05.033","volume":"148","author":"Hassan-Abdallah","year":"2013","journal-title":"J Ethnopharmacol"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.bse.2015.01.020","volume":"59","author":"Morgan","year":"2015","journal-title":"Biochem Systematics Ecol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s42779-019-0032-4","volume":"6","author":"Hiben","year":"2019a","journal-title":"J Ethnic Foods"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"190","DOI":"10.3923\/ijp.2013.190.196","volume":"9","author":"Rehman","year":"2013","journal-title":"Int J Pharmacol"},{"key":"ref21","unstructured":"NRC (National Research Council). Guide for the Care and Use of Laboratory Animals. Washington: National Academy Press; 1996:1\u20137."},{"key":"ref22","unstructured":"NRC (National Research Council). Guide for the Care and Use of Laboratory Animals. National Academies Press; 2010."},{"key":"ref23","volume-title":"Guide for the Care and Use of Laboratory Animals","year":"2012"},{"key":"ref24","unstructured":"OECD\/OCDE. OECD Guideline for the Testing of Chemicals. Acute Oral Toxicity; Up-And-Down Procedure (UDP). Paris, France: OECD; 2008."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"289","DOI":"10.3329\/bjp.v7i4.12873","volume":"7","author":"Khan","year":"2012","journal-title":"Bangladesh J Pharmacol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"82","DOI":"10.3923\/ijp.2014.82.89","volume":"10","author":"Mandukhail","year":"2014","journal-title":"Int J Pharmacol"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/0306-3623(91)90331-Y","volume":"22","author":"Farre","year":"1991","journal-title":"Gen Pharmacol"},{"key":"ref28","first-page":"321","volume":"38","author":"Godfraind","year":"1986","journal-title":"Pharmacol Rev"},{"key":"ref29","first-page":"424","volume":"23","author":"Lorenz","year":"1983","journal-title":"Mol Pharmacol"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/0165-6147(88)90238-6","volume":"9","author":"Cook","year":"1989","journal-title":"Trends in Pharmacol Sci"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1016\/0277-9536(82)90167-8","volume":"16","author":"Etkin","year":"1982","journal-title":"Soc Sci Med"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1016\/j.jep.2009.11.025","volume":"127","author":"Waterman","year":"2010","journal-title":"J Ethnopharmacol"},{"key":"ref33","first-page":"628","volume":"231","author":"Reynolds","year":"1984","journal-title":"J Pharmacol Exper Ther"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1254\/jjp.12.137","volume":"12","author":"Iwao","year":"1962","journal-title":"Jap J Pharmacol"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1038\/sj.bjp.0701130","volume":"121","author":"Croci","year":"1997","journal-title":"Br J Pharmacol"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"627","DOI":"10.3329\/bjp.v10i3.23714","volume":"10","author":"Ali","year":"2015","journal-title":"Bangladesh J Pharmacol"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/S0024-3205(96)00691-1","volume":"60","author":"Gilani","year":"1997","journal-title":"Life Sci"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/0305-1978(96)00044-0","volume":"24","author":"McLean","year":"1996","journal-title":"Biochem Systematics Ecol"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"e0215155","DOI":"10.1371\/journal.pone.0215155","volume":"14","author":"Hiben","year":"2019","journal-title":"PLoS One"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1111\/j.1476-5381.1969.tb08303.x","volume":"36","author":"Hobbiger","year":"1969","journal-title":"Br J Pharmacol"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1146\/annurev.pa.17.040177.001053","volume":"17","author":"Fleckenstein","year":"1977","journal-title":"Ann Rev Pharmacol"},{"key":"ref42","volume-title":"Textbook of Pharmacology","year":"1999"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1254\/jphs.FPJ05013X","volume":"98","author":"Kaneda","year":"2005","journal-title":"J Pharmacol Sci"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1254\/jjp.22.869","volume":"22","author":"Takayanagi","year":"1972","journal-title":"Jap J Pharmacol"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/0014-2999(94)90797-8","volume":"271","author":"Frank","year":"1994","journal-title":"Europ J Pharmacol"},{"key":"ref46","first-page":"23","volume":"6","author":"Empfield","year":"1995","journal-title":"Pharmaceut News"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1002\/med.10060","volume":"24","author":"Mannhold","year":"2004","journal-title":"Med Res Rev"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1111\/j.1472-8206.1992.tb00122.x","volume":"6","author":"Quast","year":"1992","journal-title":"Fundam Clin Pharmacol"},{"key":"ref49","volume-title":"Potential Role of Potassium Channel Openers for the Treatment of Cardiovascular Disease","year":"1995"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1097\/00045391-199605000-00009","volume":"3","author":"Findling","year":"1996","journal-title":"Am J Ther"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1038\/sj.ijir.3901491","volume":"19","author":"Schwarz","year":"2007","journal-title":"Int J Impot Res"},{"key":"ref52","first-page":"544","volume":"218","author":"Nawrath","year":"1981","journal-title":"J Pharmacol Exper Therapeut"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"S107","DOI":"10.1097\/00005344-199118101-00019","volume":"18","author":"Billman","year":"1991","journal-title":"J Cardiovas Pharmacol"}],"container-title":["Journal of Experimental Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=59698","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=59698","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T02:53:14Z","timestamp":1594695194000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/multiple-pathwayndashmediated-gut-modulatory-effects-of-maerua-subcord-peer-reviewed-article-JEP"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":53,"URL":"https:\/\/doi.org\/10.2147\/jep.s254818","relation":{},"ISSN":["1179-1454"],"issn-type":[{"value":"1179-1454","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7]]}}}