{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T11:05:54Z","timestamp":1777028754072,"version":"3.51.4"},"reference-count":72,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JEP"],"DOI":"10.2147\/jep.s261403","type":"journal-article","created":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T00:36:11Z","timestamp":1618446971000},"page":"441-459","source":"Crossref","is-referenced-by-count":8,"title":["Experimental Drugs for Panic Disorder: An Updated Systematic Review"],"prefix":"10.2147","volume":"Volume 13","author":[{"given":"Daniela","family":"Caldirola","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Alciati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6145-2137","authenticated-orcid":true,"given":"Francesco","family":"Cuniberti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giampaolo","family":"Perna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2021,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1002\/mpr.1359","volume":"21","author":"Kessler","year":"2012","journal-title":"Int J Methods Psychiatr Res"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1002\/da.22572","volume":"33","author":"de Jonge","year":"2016","journal-title":"Depress Anxiety"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/j.eurpsy.2010.06.004","volume":"26","author":"Skapinakis","year":"2011","journal-title":"Eur Psychiatry"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.jad.2007.03.013","volume":"104","author":"Batelaan","year":"2007","journal-title":"J Affect Disord"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s12962-019-0177-4","volume":"17","author":"Brettschneider","year":"2019","journal-title":"Cost Eff Resour Alloc"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 5th ed. American Psychiatric Association; 2013. doi:10.1176\/appi.books.9780890425596","DOI":"10.1176\/appi.books.9780890425596"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1957","DOI":"10.2147\/NDT.S174433","volume":"15","author":"Caldirola","year":"2019","journal-title":"Neuropsychiatr Dis Treat"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1708\/1228.13618","volume":"48","author":"Perna","year":"2013","journal-title":"Riv Psichiatr"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/j.neubiorev.2014.07.027","volume":"46","author":"Johnson","year":"2014","journal-title":"Neurosci Biobehav Rev"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1001\/archpsyc.1993.01820160076009","volume":"50","author":"Klein","year":"1993","journal-title":"Arch Gen Psychiatry"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1326","DOI":"10.1016\/j.neubiorev.2008.05.017","volume":"32","author":"Graeff","year":"2008","journal-title":"Neurosci Biobehav Rev"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/j.neubiorev.2014.03.020","volume":"46","author":"Canteras","year":"2014","journal-title":"Neurosci Biobehav Rev"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/j.neubiorev.2014.03.025","volume":"46","author":"Preter","year":"2014","journal-title":"Neurosci Biobehav Rev"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1111\/j.0924-2708.2004.0080.x","volume":"16","author":"Perna","year":"2004","journal-title":"Acta Neuropsychiatr"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1177\/0269881109104847","volume":"24","author":"Esquivel","year":"2010","journal-title":"J Psychopharmacol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"294","DOI":"10.12688\/f1000research.12788.1","volume":"7","author":"Perna","year":"2018","journal-title":"F1000Research"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/j.neubiorev.2014.03.010","volume":"46","author":"Paul","year":"2014","journal-title":"Neurosci Biobehav Rev"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s00702-012-0811-1","volume":"120","author":"Dresler","year":"2013","journal-title":"J Neural Transm"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1038\/nn.3323","volume":"16","author":"Feinstein","year":"2013","journal-title":"Nat Neurosci"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1176\/appi.ajp.157.4.493","volume":"157","author":"Gorman","year":"2000","journal-title":"Am J Psychiatry"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.2174\/1871527313666140612112923","volume":"13","author":"Perna","year":"2014","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1177\/0269881114527363","volume":"28","author":"Goossens","year":"2014","journal-title":"J Psychopharmacol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1080\/14656566.2018.1504921","volume":"19","author":"Caldirola","year":"2018","journal-title":"Expert Opin Pharmacother"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.1080\/14656566.2020.1779220","volume":"21","author":"Caldirola","year":"2020","journal-title":"Expert Opin Pharmacother"},{"key":"ref25","unstructured":"American Psychiatric Association. Practice Guideline for the Treatment of Patients with Panic Disorder. 2nd ed. 2010;1\u201390. Available from: http:\/\/www.psychiatryonline.com\/pracGuide\/pracGuideTopic_9.aspx. Accessed June 1, 2020."},{"key":"ref26","unstructured":"National Institute for Health and Care Excellence. Generalised anxiety disorder and panic disorder (with or without agoraphobia) in adults: management. NICE. 2011. Available from:https:\/\/www.nice.org.uk\/guidance\/cg113. Accessed June 1, 2020."},{"key":"ref27","doi-asserted-by":"crossref","first-page":"93","DOI":"10.31887\/DCNS.2017.19.2\/bbandelow","volume":"19","author":"Bandelow","year":"2017","journal-title":"Dialogues Clin Neurosci"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1007\/s40501-017-0128-7","volume":"4","author":"Perna","year":"2017","journal-title":"Curr Treat Options Psychiatry"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1007\/978-981-32-9705-0_19","volume":"1191","author":"Bandelow","year":"2020","journal-title":"Adv Exp Med Biol"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"50","DOI":"10.30773\/pi.2018.12.21.1","volume":"16","author":"Zugliani","year":"2019","journal-title":"Psychiatry Investig"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"551","DOI":"10.3390\/ijms17040551","volume":"17","author":"Perna","year":"2016","journal-title":"Int J Mol Sci"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1186\/s12991-018-0190-6","volume":"17","author":"Shah","year":"2018","journal-title":"Ann Gen Psychiatry"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1517\/13543784.2014.996286","volume":"24","author":"Perna","year":"2015","journal-title":"Expert Opin Investig Drugs"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"107402","DOI":"10.1016\/j.pharmthera.2019.107402","volume":"204","author":"Sartori","year":"2019","journal-title":"Pharmacol Ther"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1016\/j.jclinepi.2009.06.006","volume":"62","author":"Liberati","year":"2009","journal-title":"J Clin Epidemiol"},{"key":"ref36","unstructured":"European Medicines Agency. EU Clinical Trials Register. Available from: https:\/\/www.clinicaltrialsregister.eu\/. Accessed February 1, 2021."},{"key":"ref37","unstructured":"US National Library of Medicine. ClinicalTrials.gov. Available from: http:\/\/clinicaltrials.gov\/. Accessed February 1, 2021."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"e885","DOI":"10.1038\/tp.2016.162","volume":"6","author":"Leibold","year":"2016","journal-title":"Transl Psychiatry"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1016\/j.physbeh.2012.03.016","volume":"107","author":"Johnson","year":"2012","journal-title":"Physiol Behav"},{"key":"ref40","unstructured":"World Health Organisation. International Statistical Classification of Diseases and Related Health Problems. 9th ed. 1979. https:\/\/www.cdc.gov\/nchs\/icd\/icd9.htm."},{"key":"ref41","unstructured":"World Health Organisation. ICD-10: International Statistical Classification of Diseases and Related Health Problems: Tenth Revision. 2nd ed. 2004."},{"key":"ref42","unstructured":"World Health Organisation. International Statistical Classification of Diseases and Related Health Problems. 10th ed. 2016. Available from: https:\/\/icd.who.int\/browse10\/2016\/en. Accessed April 1, 2021."},{"key":"ref43","unstructured":"American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed. 1994."},{"key":"ref44","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders 4th ed. American Psychiatric Association;2000. doi:10.1176\/appi.books.9780890423349","DOI":"10.1176\/appi.books.9780890423349"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1124\/jpet.114.220392","volume":"352","author":"Bonaventure","year":"2015","journal-title":"J Pharmacol Exp Ther"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1002\/da.22403","volume":"32","author":"Johnson","year":"2015","journal-title":"Depress Anxiety"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"6661","DOI":"10.1016\/j.bmcl.2012.08.109","volume":"22","author":"McElhinny","year":"2012","journal-title":"Bioorganic Med Chem Lett"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fphar.2017.00357","volume":"8","author":"Bonaventure","year":"2017","journal-title":"Front Pharmacol"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41398-020-00937-9","volume":"10","author":"Salvadore","year":"2020","journal-title":"Transl Psychiatry"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"110166","DOI":"10.1016\/j.pnpbp.2020.110166","author":"Kaufmann","year":"2020","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1177\/0269881112443742","volume":"27","author":"Diaper","year":"2013","journal-title":"J Psychopharmacol"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"103607","DOI":"10.1016\/j.brat.2020.103607","volume":"129","author":"Reinecke","year":"2020","journal-title":"Behav Res Ther"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1186\/s12967-017-1237-1","volume":"15","author":"Dobrovolsky","year":"2017","journal-title":"J Transl Med"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1016\/j.biopsych.2011.05.027","volume":"70","author":"Meuret","year":"2011","journal-title":"Biol Psychiatry"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41398-020-01076-x","volume":"10","author":"Tenorio-Lopes","year":"2020","journal-title":"Transl Psychiatry"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"145893","DOI":"10.1016\/j.brainres.2018.07.026","volume":"1731","author":"Grafe","year":"2020","journal-title":"Brain Res"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1177\/0269881109353464","volume":"25","author":"Johnson","year":"2011","journal-title":"J Psychopharmacol"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"1911","DOI":"10.1038\/npp.2012.38","volume":"37","author":"Johnson","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1038\/nm.2075","volume":"16","author":"Johnson","year":"2010","journal-title":"Nat Med"},{"key":"ref60","doi-asserted-by":"publisher","volume-title":"Progress in Brain Research","year":"2012","DOI":"10.1016\/B978-0-444-59489-1.00004-5"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1016\/j.physbeh.2012.04.016","volume":"107","author":"Johnson","year":"2012","journal-title":"Physiol Behav"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1097\/YPG.0b013e328341a3db","volume":"21","author":"Annerbrink","year":"2011","journal-title":"Psychiatr Genet"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1038\/s41398-019-0415-8","volume":"9","author":"Gottschalk","year":"2019","journal-title":"Transl Psychiatry"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/S0006-3223(02)01740-7","volume":"54","author":"Salomon","year":"2003","journal-title":"Biol Psychiatry"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2018.09.010","volume":"1731","author":"Abreu","year":"2020","journal-title":"Brain Res"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"146037","DOI":"10.1016\/j.brainres.2018.11.032","volume":"1731","author":"Soya","year":"2020","journal-title":"Brain Res"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-017-01782-z","volume":"8","author":"Soya","year":"2017","journal-title":"Nat Commun"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"80","DOI":"10.5492\/wjccm.v1.i3.80","volume":"1","author":"Zhou","year":"2012","journal-title":"World J Crit Care Med"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1016\/j.pbb.2011.06.014","volume":"100","author":"Harvey","year":"2012","journal-title":"Pharmacol Biochem Behav"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1038\/sj.mp.4001845","volume":"11","author":"Hettema","year":"2006","journal-title":"Mol Psychiatry"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.pnpbp.2013.01.020","volume":"44","author":"Long","year":"2013","journal-title":"Prog Neuro Psychopharmacol Biol Psychiatry"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1002\/da.22257","volume":"31","author":"Hofmann","year":"2014","journal-title":"Depress Anxiety"}],"container-title":["Journal of Experimental Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=68541","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=68541","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T00:36:35Z","timestamp":1618446995000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/experimental-drugs-for-panic-disorder-an-updated-systematic-review-peer-reviewed-article-JEP"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":72,"URL":"https:\/\/doi.org\/10.2147\/jep.s261403","relation":{},"ISSN":["1179-1454"],"issn-type":[{"value":"1179-1454","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4]]}}}