{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T10:56:14Z","timestamp":1762253774681,"version":"3.40.5"},"reference-count":39,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JEP"],"DOI":"10.2147\/jep.s262342","type":"journal-article","created":{"date-parts":[[2021,4,9]],"date-time":"2021-04-09T01:14:21Z","timestamp":1617930861000},"page":"433-440","source":"Crossref","is-referenced-by-count":6,"title":["Emerging and Experimental Agents for Anal Cancer: What is New?"],"prefix":"10.2147","volume":"Volume 13","author":[{"given":"Jo\u00e3o Paulo F","family":"Farias","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Helena C","family":"Rangel da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9070-4383","authenticated-orcid":true,"given":"Alexandre A","family":"J\u00e1come","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2021,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21590","volume":"70","author":"Siegel","year":"2020","journal-title":"CA Cancer J Clin"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21442","volume":"68","author":"Siegel","year":"2018","journal-title":"CA Cancer J Clin"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21551","volume":"69","author":"Siegel","year":"2019","journal-title":"CA Cancer J Clin"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1093\/ije\/dyw276","volume":"46","author":"Islami","year":"2017","journal-title":"Int J Epidemiol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/S1470-2045(13)70086-X","volume":"14","author":"James","year":"2013","journal-title":"Lancet Oncol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1914","DOI":"10.1001\/jama.299.16.1914","volume":"299","author":"Ajani","year":"2008","journal-title":"JAMA"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1007\/BF02586980","volume":"17","author":"Nigro","year":"1974","journal-title":"Dis Colon Rectum"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1941","DOI":"10.1200\/JCO.2011.35.4837","volume":"30","author":"Peiffert","year":"2012","journal-title":"J Clin Oncol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/S1470-2045(17)30071-2","volume":"18","author":"Glynne-Jones","year":"2017","journal-title":"Lancet Oncol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1038\/sj.bjc.6605605","volume":"102","author":"Northover","year":"2010","journal-title":"Br J Cancer"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"4344","DOI":"10.1200\/JCO.2012.43.8085","volume":"30","author":"Gunderson","year":"2012","journal-title":"J Clin Oncol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"JCO1903266","DOI":"10.1200\/JCO.19.03266","author":"Rao","year":"2020","journal-title":"J Clin Oncol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/S1470-2045(17)30104-3","volume":"18","author":"Morris","year":"2017","journal-title":"Lancet Oncol"},{"journal-title":"Am Soc Clin Oncol","year":"2020","author":"Marabelle","key":"ref14"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"852","DOI":"10.6004\/jnccn.2018.0060","volume":"16","author":"Benson","year":"2018","journal-title":"J Nat Comprehen Cancer Network"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1046\/j.1365-2168.1999.01184.x","volume":"86","author":"Brown","year":"1999","journal-title":"Br j Surg"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1016\/S1470-2045(18)30321-8","volume":"19","author":"Kim","year":"2018","journal-title":"Lancet Oncol"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1080\/13543784.2018.1543659","volume":"27","author":"Jacome","year":"2018","journal-title":"Expert Opin Investig Drugs"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1336","DOI":"10.1093\/annonc\/mdw152","volume":"27","author":"Chung","year":"2016","journal-title":"Ann Oncol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"1542","DOI":"10.1158\/1541-7786.MCR-17-0060","volume":"15","author":"Morris","year":"2017","journal-title":"Mol Cancer Res"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1097\/DCR.0000000000000160","volume":"57","author":"Siegel","year":"2014","journal-title":"Dis Colon Rectum"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"43594","DOI":"10.18632\/oncotarget.6202","volume":"6","author":"Smaglo","year":"2015","journal-title":"Oncotarget"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11912-020-00946-3","volume":"22","author":"Phuong","year":"2020","journal-title":"Curr Oncol Rep"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1007\/s00428-019-02530-y","volume":"474","author":"Jiang","year":"2019","journal-title":"Virchows Archiv"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"254","DOI":"10.3390\/v9090254","volume":"9","author":"Smola","year":"2017","journal-title":"Viruses"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.4049\/jimmunol.1100889","volume":"187","author":"Heusinkveld","year":"2011","journal-title":"J Immunol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"6838","DOI":"10.3390\/ijms21186838","volume":"21","author":"Spehner","year":"2020","journal-title":"Int J Mol Sci"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1093\/annonc\/mdx029","volume":"28","author":"Ott","year":"2017","journal-title":"Ann Oncol"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"S1170","DOI":"10.1016\/j.annonc.2020.08.2272","volume":"31","author":"Rao","year":"2020","journal-title":"Ann Oncol"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"S706","DOI":"10.1016\/j.annonc.2020.08.1143","volume":"31","author":"Rajdev","year":"2020","journal-title":"Ann Oncol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"3009","DOI":"10.1200\/JCO.2017.35.15_suppl.3009","volume":"35","author":"Hinrichs","year":"2017","journal-title":"Am Soc Clin Oncol"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1200\/JCO.2020.38.15_suppl.101","volume":"38","author":"Norberg","year":"2020","journal-title":"Am Soc Clin Oncol"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1334","DOI":"10.18632\/oncotarget.27536","volume":"11","author":"Eng","year":"2020","journal-title":"Oncotarget"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"v403","DOI":"10.1093\/annonc\/mdx376.002","volume":"28","author":"Glisson","year":"2017","journal-title":"Ann Oncol"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.soc.2016.07.008","volume":"26","author":"Morris","year":"2017","journal-title":"Surgical Oncol Clin"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1080\/14737140.2020.1810573","volume":"20","author":"Rogers","year":"2020","journal-title":"Expert Rev Anticancer Ther"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"S412","DOI":"10.1016\/j.annonc.2020.08.513","volume":"31","author":"Lonardi","year":"2020","journal-title":"Ann Oncol"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"S412","DOI":"10.1016\/j.annonc.2020.08.514","volume":"31","author":"Morris","year":"2020","journal-title":"Ann Oncol"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"3515","DOI":"10.1200\/JCO.2020.38.15_suppl.3515","volume":"38","author":"Falchook","year":"2020","journal-title":"Am Soc Clin Oncol"}],"container-title":["Journal of Experimental Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=68352","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=68352","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,9]],"date-time":"2021-04-09T01:14:24Z","timestamp":1617930864000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/emerging-and-experimental-agents-for-anal-cancer-what-is-new-peer-reviewed-article-JEP"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":39,"URL":"https:\/\/doi.org\/10.2147\/jep.s262342","relation":{},"ISSN":["1179-1454"],"issn-type":[{"type":"electronic","value":"1179-1454"}],"subject":[],"published":{"date-parts":[[2021,4]]}}}