{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T01:53:50Z","timestamp":1777514030416,"version":"3.51.4"},"reference-count":63,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JEP"],"DOI":"10.2147\/jep.s267375","type":"journal-article","created":{"date-parts":[[2020,12,16]],"date-time":"2020-12-16T21:18:30Z","timestamp":1608153510000},"page":"643-652","source":"Crossref","is-referenced-by-count":7,"title":["&lt;p&gt;Experimental Pharmacological Agents for the Treatment of Primary Biliary Cholangitis&lt;\/p&gt;"],"prefix":"10.2147","volume":"Volume 12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2630-7054","authenticated-orcid":true,"given":"Annarosa","family":"Floreani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2020,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1016\/S0140-6736(15)00154-3","volume":"386","author":"Carey","year":"2015","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-37186-2","volume":"9","author":"Marchall","year":"2019","journal-title":"Sci Rep"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1097\/MEG.0b013e328353753d","volume":"24","author":"Baldursdottir","year":"2012","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1920","DOI":"10.1002\/hep.29717","volume":"67","author":"Murillo Perez","year":"2018","journal-title":"Hepatology"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"European Association for the Study of the Liver. EASL clinical practice guidelines: the diagnosis and management of patients with primary biliary cholangitis. J Hepatol. 2017;67:145\u2013172.","DOI":"10.1016\/j.jhep.2017.03.022"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1053\/j.gastro.2005.12.029","volume":"130","author":"Pares","year":"2006","journal-title":"Gastroenterology"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1002\/hep.22428","volume":"48","author":"Corpechot","year":"2008","journal-title":"Hepatology"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1053\/j.gastro.2009.01.003","volume":"136","author":"Kuiper","year":"2009","journal-title":"Gastroenterology"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"2186","DOI":"10.1038\/ajg.2010.216","volume":"105","author":"Kumagi","year":"2010","journal-title":"Am J Gastroenterol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1016\/j.jhep.2011.02.031","volume":"55","author":"Corpechot","year":"2011","journal-title":"J Hepatol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.1053\/j.gastro.2014.08.029","volume":"147","author":"Lammers","year":"2014","journal-title":"Gastroenterology"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.14309\/01.ajg.0000710184.43839.1d","volume":"115","author":"Murillo Perez","year":"2020","journal-title":"Am J Gastroenterol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.jhep.2019.04.001","volume":"71","author":"Harm","year":"2019","journal-title":"J Hepatol"},{"key":"ref14","first-page":"683","volume":"19","author":"Harm","year":"2018","journal-title":"Hepatol Commun"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1600","DOI":"10.1016\/S0140-6736(10)61965-4","volume":"377","author":"Selmi","year":"2011","journal-title":"Lancet"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.00117","author":"Gerussi","year":"2020","journal-title":"Frontiers Med"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1053\/j.gastro.2011.10.028","volume":"142","author":"Modica","year":"2012","journal-title":"Gastroenterology"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"1890","DOI":"10.1002\/hep.29569","volume":"67","author":"Kowdley","year":"2018","journal-title":"Hepatology"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1056\/NEJMoa1509840","volume":"375","author":"Nevens","year":"2016","journal-title":"N Engl J Med"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S2468-1253(19)30094-9","volume":"4","author":"Trauner","year":"2019","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1111\/liv.14429","volume":"40","author":"Pares","year":"2020","journal-title":"Liver Int"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1016\/j.cgh.2019.09.050","volume":"18","author":"Bowlus","year":"2020","journal-title":"Clin Gastroenterol Hepatol"},{"key":"ref23","first-page":"A98","volume":"66","author":"Hirschfield","year":"2017","journal-title":"Gut"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.1002\/hep4.1518","volume":"4","author":"Roberts","year":"2020","journal-title":"Hepatol Commun"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1002\/hep.26894","volume":"59","author":"Ghonem","year":"2014","journal-title":"Hepatology"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"1931","DOI":"10.1002\/hep.26018","volume":"57","author":"Honda","year":"2013","journal-title":"Hepatology"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"2171","DOI":"10.1056\/NEJMoa1714519","volume":"378","author":"Corpechot","year":"2018","journal-title":"N Engl J Med"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1016\/S0016-5085(19)32419-9","volume":"69","author":"Summerfield","year":"1975","journal-title":"Gastroenterology"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(20)31404-5","volume":"73","author":"Reig","year":"2020","journal-title":"J Hepatol"},{"key":"ref30","first-page":"770A","volume":"suppl.1","author":"Culver","year":"2019","journal-title":"Hepatology"},{"key":"ref31","author":"Sorel","year":"2019","journal-title":"Hepatology"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.10.001","author":"De Vries","year":"2020","journal-title":"Gastroenterology"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"9960","DOI":"10.1021\/acs.jmedchem.7b00907","volume":"60","author":"Tully","year":"2017","journal-title":"J Med Chem"},{"key":"ref34","first-page":"LB0","volume":"suppl. 1","author":"Schramm","year":"2018","journal-title":"J Hepatol"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1002\/hep.30509","volume":"70","author":"Trauner","year":"2019","journal-title":"Hepatology"},{"key":"ref36","first-page":"LBO","volume":"suppl 1S","author":"Schattenberg","year":"2019","journal-title":"J Hepatol"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1016\/S2468-1253(17)30246-7","volume":"2","author":"Jones","year":"2017","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(20)31411-2","volume":"73","author":"Levy","year":"2020","journal-title":"J Hepatol"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"S120","DOI":"10.1194\/jlr.R800026-JLR200","volume":"50","author":"Russell","year":"2009","journal-title":"J Lipid Res"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/hep4.1090","volume":"2","author":"May","year":"2018","journal-title":"Hepatol Commun"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/j.jhep.2019.04.012","volume":"71","author":"Nishio","year":"2019","journal-title":"J Hepatol"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1016\/S0618-8278(19)30002-7","volume":"70","author":"Dalekos","year":"2019","journal-title":"J Hepatol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1002\/hep.24748","volume":"55","author":"Tsuda","year":"2012","journal-title":"Hepatology"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1038\/ajg.2013.51","volume":"108","author":"Myers","year":"2013","journal-title":"Am J Gastroenterol"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"1646","DOI":"10.1002\/hep.30099","volume":"70","author":"Khanna","year":"2019","journal-title":"Hepatology"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2005.08.009","volume":"25","author":"Chuang","year":"2005","journal-title":"J Autoimmun"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1046\/j.1365-2249.2001.01391.x","volume":"123","author":"Nishioji","year":"2001","journal-title":"Clin Exp Immunol"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1002\/hep4.1170","volume":"2","author":"De Graaf","year":"2018","journal-title":"Hepatol Commun"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1002\/hep.28359","volume":"64","author":"Hirschfield","year":"2016","journal-title":"Hepatology"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.jaut.2019.04.005","volume":"101","author":"Bowlus","year":"2019","journal-title":"J Autoimmun"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"7492836","DOI":"10.1155\/2017\/7492836","volume":"2017","author":"Arsenijevic","year":"2017","journal-title":"Anal Cell Pathol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1016\/j.jhep.2018.01.030","volume":"68","author":"Alfaif","year":"2018","journal-title":"J Hepatol"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1111\/jgh.12029","volume":"28","author":"Wang","year":"2013","journal-title":"J Gastroenterol Hepatol"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"2482","DOI":"10.1089\/scd.2013.0500","volume":"23","author":"Wang","year":"2014","journal-title":"Stem Cell Dev"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"1620","DOI":"10.1016\/S0140-6736(97)10290-2","volume":"35","author":"Mason","year":"1998","journal-title":"Lancet"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.3138\/canlivj.2018-0020","author":"Lytvyak","year":"2019","journal-title":"Can Liver J"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1002\/hep4.1305","volume":"3","author":"Mayo","year":"2019","journal-title":"Hepatol Commun"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1016\/S0140-6736(17)30319-7","volume":"389","author":"Hegade","year":"2017","journal-title":"Lancet"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"6658","DOI":"10.1038\/s41598-018-25214-0","volume":"8","author":"Al-Dury","year":"2018","journal-title":"Sci Rep"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1016\/j.jhep.2013.05.037","volume":"59","author":"Zenouzi","year":"2013","journal-title":"J Hepatol"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1016\/j.cgh.2008.04.013","volume":"6","author":"Hollingsworth","year":"2008","journal-title":"Clin Gastroenterol Hepatol"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1111\/j.1365-2036.2006.03223.x","volume":"25","author":"Jones","year":"2007","journal-title":"Aliment Pharmacol Ther"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"FR396","DOI":"10.1016\/S0168-8278(17)31070-X","volume":"66","author":"Millar","year":"2017","journal-title":"J Hepatol"}],"container-title":["Journal of Experimental Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=64936","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=64936","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,16]],"date-time":"2020-12-16T21:18:39Z","timestamp":1608153519000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/experimental-pharmacological-agents-for-the-treatment-of-primary-bilia-peer-reviewed-article-JEP"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":63,"URL":"https:\/\/doi.org\/10.2147\/jep.s267375","relation":{},"ISSN":["1179-1454"],"issn-type":[{"value":"1179-1454","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12]]}}}