{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:30:20Z","timestamp":1787877020249,"version":"build-2784847793"},"reference-count":65,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JEP"],"DOI":"10.2147\/jep.s555519","type":"journal-article","created":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T06:45:11Z","timestamp":1761547511000},"page":"721-741","source":"Crossref","is-referenced-by-count":1,"title":["Effects of Catha edulis Extract on Atorvastatin-Induced Myotoxicity in Rats: Biochemical and Histopathological Evidence"],"prefix":"10.2147","volume":"Volume 17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-8737-3721","authenticated-orcid":true,"given":"Abdulatef","family":"Abbas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6549-3996","authenticated-orcid":true,"given":"Safia","family":"Alrezami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4131-509X","authenticated-orcid":true,"given":"Butheina Abdulwalli","family":"Al- Amrani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2025,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"101015","DOI":"10.1016\/j.disamonth.2020.101015","volume":"66","author":"Cabral","year":"2020","journal-title":"Disease-a-Month"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"11","DOI":"10.5847\/wjem.j.issn.1920-8642.2012.01.002","volume":"3","author":"Zhang","year":"2012","journal-title":"World J Emerg Med"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1950","DOI":"10.3390\/jcm10091950","volume":"10","author":"Yang","year":"2021","journal-title":"J Clin Med"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1093\/med\/9780199592548.001.0001\/med-9780199592548-chapter-252","volume":"90","author":"Gupta","year":"2021","journal-title":"Ulster Med J"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"6634","DOI":"10.1038\/s41598-024-57185-w","volume":"14","author":"Lapp","year":"2024","journal-title":"Sci Rep"},{"key":"ref6","unstructured":"Farhana A, Lappin SL. Biochemistry, lactate dehydrogenase. 2020."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"763","DOI":"10.2147\/DMSO.S234382","volume":"13","author":"Habte","year":"2020","journal-title":"Diabetes Metabol Syndr Obesity"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2020\/5346483","volume":"2020","author":"Klein","year":"2020","journal-title":"Vet Med Int"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1186\/s12882-020-02104-0","volume":"21","author":"Yang","year":"2020","journal-title":"BMC Nephrol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"e3952","DOI":"10.7717\/peerj.3952","volume":"5","author":"Ko","year":"2017","journal-title":"PeerJ"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1111\/jcpt.13058","volume":"45","author":"Palleria","year":"2020","journal-title":"J Clin Pharm Therapeutics"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1080\/14740338.2020.1747431","volume":"19","author":"Nikolic","year":"2020","journal-title":"Expert Opin Drug Saf"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"211","DOI":"10.2147\/DHPS.S333738","volume":"Volume 13","author":"Safitri","year":"2021","journal-title":"Drug, Healthcare Patient Safety"},{"key":"ref14","first-page":"2","volume":"4","author":"Abebe","year":"2015","journal-title":"Fam Med Med Sci Res"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"110658","DOI":"10.1016\/j.forsciint.2020.110658","volume":"319","author":"Pendl","year":"2021","journal-title":"Forensic Sci Int"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1333556","DOI":"10.3389\/fpsyt.2024.1333556","volume":"15","author":"Wogayehu","year":"2024","journal-title":"Frontiers in Psychiatry"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"024","DOI":"10.30574\/gscbps.2020.11.1.0038","volume":"11","author":"Ademe","year":"2020","journal-title":"GSC Bio Pharmac Sci"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.brainresbull.2018.07.014","volume":"145","author":"Patel","year":"2019","journal-title":"Brain Res Bull"},{"key":"ref19","first-page":"26","volume":"7","author":"Woldamanuel","year":"2019","journal-title":"Science"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"333","DOI":"10.56499\/jppres20.951_9.3.333","volume":"9","author":"Albaser","year":"2021","journal-title":"J Pharm Pharmacogn Res"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1007\/s13318-018-0518-2","volume":"44","author":"Lim","year":"2019","journal-title":"Eur J Drug Metabol Pharmacokinetics"},{"key":"ref22","volume-title":"International Journal of Health Administration and Education Congress (Sanitas Magisterium)","year":"2022"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"33","DOI":"10.2147\/JEP.S46635","author":"Alele","year":"2013","journal-title":"J Exp Pharmacol"},{"key":"ref24","first-page":"971","volume":"2","author":"Ageely","year":"2014","journal-title":"Int J Adv Res"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"603","DOI":"10.22271\/chemi.2020.v8.i2i.8834","volume":"8","author":"Shaikh","year":"2020","journal-title":"Int J Chem Stud"},{"key":"ref26","first-page":"013","volume":"4","author":"Goodies","year":"2015","journal-title":"Sky J Biochem Res"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"Askarian F, Zabihi M, Hekmatimoghaddam S, Nooshabadi MR, Sajjad Zabihi M. Ascorbic acid greatly decreases creatine kinase levels in an animal model of statin\/fibrate-induced myopathy. 2021.","DOI":"10.21203\/rs.3.rs-151070\/v1"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"442","DOI":"10.4172\/2157-7099.1000444","volume":"8","author":"Ahmed","year":"2017","journal-title":"J Cytol Histol"},{"key":"ref29","first-page":"2083","volume":"95","author":"Limenie","year":"2018","journal-title":"East Afr Med J"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.14202\/vetworld.2015.1230-1236","volume":"8","author":"Sarvaiya","year":"2015","journal-title":"Vet World"},{"key":"ref31","first-page":"24","volume":"1","author":"Ikitde","year":"2015","journal-title":"Biosci Res Today\u2019s World"},{"key":"ref32","first-page":"2924","volume":"10","author":"Jabir","year":"2018","journal-title":"J Pharm Sci Res"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2021\/9933389","volume":"2021","author":"Belete","year":"2021","journal-title":"Biomed Res Int"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"S359","DOI":"10.4103\/pm.pm_142_19","volume":"15","author":"Mohan","year":"2019","journal-title":"Pharmacogn Mag"},{"key":"ref35","first-page":"421","volume":"7","author":"Nigatu","year":"2019","journal-title":"J Pharm Pharmacol"},{"key":"ref36","first-page":"1195","volume":"23","author":"Alkadi","year":"2002","journal-title":"Saudi Med J"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.sjbs.2011.01.002","volume":"19","author":"Al-Hashem","year":"2012","journal-title":"Saudi J Biol Sci"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.jep.2011.04.042","volume":"136","author":"Admassie","year":"2011","journal-title":"J Ethnopharmacol"},{"key":"ref39","first-page":"1","volume":"33","author":"Revikumar","year":"2021","journal-title":"J Pharm Res Int"},{"key":"ref40","unstructured":"Ali AE, Mohamed SAH, Ali SA, Elmahdi SA. The effect of atorvastatin therapy on skeletal muscle function in hyperlipidemia patients in Khartoum. 2022."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1515\/cclm-2018-0656","volume":"57","author":"Lippi","year":"2018","journal-title":"Clin Chem Laboratory Med"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1007\/s13273-022-00287-1","volume":"18","author":"Kim","year":"2022","journal-title":"Mol Cellular Toxicol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"359","DOI":"10.4103\/pm.pm_142_19","volume":"15","author":"Mohan","year":"2019","journal-title":"Pharmacogn Mag"},{"key":"ref44","volume-title":"Serum Myoglobin","year":"2023"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1001\/jama.2017.0148","volume":"317","author":"Malachowski","year":"2017","journal-title":"JAMA"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1002\/jcsm.12654","volume":"12","author":"Mollazadeh","year":"2021","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"14","DOI":"10.53590\/japt.02.1018","volume":"12","author":"Pappa","year":"2021","journal-title":"J Atheroscler Prev Treat"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12931-019-1261-1","volume":"21","author":"M-y","year":"2020","journal-title":"Respir Res"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"1","DOI":"10.59846\/abhathjournalofbasicandappliedsciences.v1i2.437","volume":"1","author":"Al-Kamarany","year":"2022","journal-title":"Abhath J Basic Appl Sci"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"440","DOI":"10.4103\/1735-5362.236837","volume":"13","author":"Hamzeh","year":"2018","journal-title":"Res Pharm Sci"},{"key":"ref51","doi-asserted-by":"crossref","unstructured":"Hussain HK, Ahmad A, Adam MA, Kiruthiga T, Gupta K, editors. Prediction of Blood Lactate Levels in Children after Cardiac Surgery using Machine Learning Algorithms. 2023 Third International Conference on Artificial Intelligence and Smart Energy (ICAIS); 2023: IEEE.","DOI":"10.1109\/ICAIS56108.2023.10073941"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2012\/829401","volume":"2012","author":"Alsalahi","year":"2012","journal-title":"Evid Based Complement Alternat Med"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"061","DOI":"10.15580\/GJEPH.2016.3.102116188","volume":"4","author":"Muema","year":"2016","journal-title":"Greener J Epidemiol Public Health"},{"key":"ref54","first-page":"9","volume":"3","author":"Alam","year":"2014","journal-title":"Inter J Applied Natural Sci"},{"key":"ref55","first-page":"535","volume":"66","author":"Chang","year":"2011","journal-title":"Die Pharmazie"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2017\/3204504","volume":"2017","author":"Chojnacki","year":"2017","journal-title":"Biomed Res Int"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1472-6882-14-66","volume":"14","author":"Shewamene","year":"2014","journal-title":"BMC Complement Alter Med"},{"key":"ref58","volume-title":"Renal Function Tests and Lipid Profiles Among Apparently Healthy Adult Male Khat-Chewers and Non-Khat Chewers in Dilla Town","year":"2024"},{"key":"ref59","doi-asserted-by":"crossref","unstructured":"Othman MA, Awash S, ALtholi A, et al. Effect of khat chewing and smoking on liver function according to blood group among students at amran university. 2024.","DOI":"10.21203\/rs.3.rs-5206375\/v1"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1080\/0886022X.2021.1915799","volume":"43","author":"Zhao","year":"2021","journal-title":"Ren Fail"},{"key":"ref61","first-page":"32","volume":"33","author":"Al-Hashem","year":"2011","journal-title":"Bahrain Med Bull"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"27","DOI":"10.31254\/phyto.2017.6104","volume":"6","author":"Gitonga","year":"2017","journal-title":"J Pharmacol"},{"key":"ref63","first-page":"145","volume":"8","author":"Ageely","year":"2015","journal-title":"Int J Adv Life Sci"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"4","DOI":"10.25156\/ptj.v9n1y2019.pp13-16","volume":"9","author":"Mustafa","year":"2019","journal-title":"Polytechnic J"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1136\/practneurol-2017-001738","volume":"18","author":"Hilton-Jones","year":"2018","journal-title":"Practical Neurol"}],"container-title":["Journal of Experimental Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/108272","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/108272","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T06:45:15Z","timestamp":1761547515000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/effects-of-catha-edulis-extract-on-atorvastatin-induced-myotoxicity-in-peer-reviewed-fulltext-article-JEP"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":65,"URL":"https:\/\/doi.org\/10.2147\/jep.s555519","relation":{},"ISSN":["1179-1454"],"issn-type":[{"value":"1179-1454","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]}}}