{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:47:54Z","timestamp":1787838474652,"version":"build-2784847793"},"reference-count":57,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JHC"],"DOI":"10.2147\/jhc.s452152","type":"journal-article","created":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T08:10:11Z","timestamp":1715242211000},"page":"839-855","source":"Crossref","is-referenced-by-count":8,"title":["Mechanisms of Sorafenib Resistance in HCC Culture Relate to the Impaired Membrane Expression of Organic Cation Transporter 1 (OCT1)"],"prefix":"10.2147","volume":"Volume 11","author":[{"given":"Srinivas","family":"Chava","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nergiz","family":"Ekmen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Ferraris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yucel","family":"Aydin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"Moroz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swan","family":"Thung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srikanta","family":"Dash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2024,5]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.ajg.2010.04.001","volume":"11","author":"Ferenci","year":"2010","journal-title":"Arab J Gastroenterol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1002\/hep.27388","volume":"61","author":"Njei","year":"2014","journal-title":"Hepatology"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1038\/nrd2130","volume":"5","author":"Wilhelm","year":"2006","journal-title":"Nat Rev Drug Discov"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1056\/NEJMoa0708857","volume":"359","author":"Llovet","year":"2008","journal-title":"N Engl J Med"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1111\/j.1872-034X.2012.01113.x","volume":"43","author":"Gauthier","year":"2013","journal-title":"Hepatol Res"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1038\/nrc2442","volume":"8","author":"Bergers","year":"2008","journal-title":"Nat Rev Cancer"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.jhep.2012.02.019","volume":"57","author":"Eggelpo\u00ebl M-J","year":"2012","journal-title":"J Hepatol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"2961","DOI":"10.1002\/ijc.27604","volume":"131","author":"Ezzoukhry","year":"2012","journal-title":"Interna J Cancer"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1756-8722-4-30","volume":"4","author":"Wu","year":"2011","journal-title":"J Hematol Oncol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1038\/ncb2102","volume":"12","author":"Mazumdar","year":"2010","journal-title":"Nat Cell Biol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1972","DOI":"10.1053\/j.gastro.2008.08.008","volume":"135","author":"Villanueva","year":"2008","journal-title":"Gastroenterology"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1053\/j.gastro.2013.01.002","volume":"144","author":"Hernandez\u2013Gea","year":"2013","journal-title":"Gastroenterology"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1038\/nm.2713","volume":"18","author":"Ng","year":"2012","journal-title":"Nature Med"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"2235","DOI":"10.1002\/hep.26255","volume":"57","author":"Huang","year":"2013","journal-title":"Hepatology"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"6129","DOI":"10.1158\/0008-5472.CAN-06-0404","volume":"66","author":"Castillo","year":"2006","journal-title":"Cancer Res"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1038\/bjc.2012.559","volume":"108","author":"Shen","year":"2013","journal-title":"Br J Cancer"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1002\/ijc.26374","volume":"131","author":"Shimizu","year":"2012","journal-title":"Interna J Cancer"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"1847","DOI":"10.1002\/hep.26224","volume":"57","author":"Liang","year":"2013","journal-title":"Hepatology"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1777","DOI":"10.1136\/gutjnl-2012-303261","volume":"62","author":"Xin","year":"2013","journal-title":"Gut"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1159\/000343850","volume":"2","author":"Shen","year":"2013","journal-title":"Liver Cancer"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/S0169-409X(02)00173-4","volume":"55","author":"Faber","year":"2003","journal-title":"Adv Drug Delivery Rev"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1038\/nrd4626","volume":"14","author":"Lin","year":"2015","journal-title":"Nat Rev Drug Discov"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2013\/692071","volume":"2013","author":"Lozano","year":"2013","journal-title":"Biomed Res Int"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1002\/hep.26425","volume":"58","author":"Herraez","year":"2013","journal-title":"Hepatology"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1016\/j.ajpath.2015.11.027","volume":"186","author":"Ferraris","year":"2016","journal-title":"Am J Pathol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1159\/000334100","volume":"79","author":"Wilkens","year":"2012","journal-title":"Pathobiology"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1016\/j.ajpath.2010.10.029","volume":"178","author":"Bao","year":"2011","journal-title":"Am J Pathol"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1124\/dmd.112.048181","volume":"41","author":"Swift","year":"2013","journal-title":"Drug Metab Dispos"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1422","DOI":"10.1172\/JCI30558","volume":"117","author":"Shu","year":"2007","journal-title":"J Clin Invest"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1021\/mp400245g","volume":"11","author":"Zu Schwabedissen HE","year":"2014","journal-title":"Mol Pharmaceut"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"e65620","DOI":"10.1371\/journal.pone.0065620","volume":"8","author":"Savi\u0107","year":"2013","journal-title":"PLoS One"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"4293","DOI":"10.1200\/JCO.2005.01.3441","volume":"24","author":"Abou-Alfa","year":"2006","journal-title":"J clin oncol"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/j.mam.2012.05.007","volume":"34","author":"Young","year":"2013","journal-title":"Mol Aspect Med"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1016\/j.bbrc.2005.05.174","volume":"333","author":"Okabe","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"2033","DOI":"10.1124\/dmd.114.059832","volume":"42","author":"Namisaki","year":"2014","journal-title":"Drug Metab Dispos"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2407-12-109","volume":"12","author":"Heise","year":"2012","journal-title":"BMC Cancer"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1111\/eci.12441","volume":"45","author":"Delire","year":"2015","journal-title":"Eur J Clin Invest"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"11851","DOI":"10.1158\/0008-5472.CAN-06-1377","volume":"66","author":"Liu","year":"2006","journal-title":"Cancer Res"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1517\/13543781003767418","volume":"19","author":"W\u00f6rns","year":"2010","journal-title":"Expert Opin Invest Drugs"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"1344","DOI":"10.1002\/jcp.24291","volume":"228","author":"Carr","year":"2013","journal-title":"J Cell Physiol"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1124\/jpet.110.175786","volume":"337","author":"Chen","year":"2011","journal-title":"J Pharmacol Exp Ther"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.3390\/cancers12061663","volume":"12","author":"Marin","year":"2020","journal-title":"Cancers"},{"key":"ref43","doi-asserted-by":"crossref","unstructured":"Marin JJ, Romero MR, Herraez E, et al. Mechanisms of pharmacoresistance in hepatocellular carcinoma: new drugs but old problems. Paper presented at: Seminars in Liver Disease 2021.","DOI":"10.1055\/s-0041-1735631"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"2510","DOI":"10.1158\/0008-5472.CAN-14-3687","volume":"75","author":"Kuczynski","year":"2015","journal-title":"Cancer Res"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"2916","DOI":"10.1158\/1078-0432.CCR-14-1213","volume":"21","author":"Pribluda","year":"2015","journal-title":"Clin Cancer Res"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"8847","DOI":"10.1158\/0008-5472.CAN-06-0769","volume":"66","author":"Zhang","year":"2006","journal-title":"Cancer Res"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"190","DOI":"10.2133\/dmpk.25.190","volume":"25","author":"Ogasawara","year":"2010","journal-title":"Drug Metab. Pharmacokinet."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1007\/s10620-012-2424-9","volume":"58","author":"Lin","year":"2013","journal-title":"Dig Dis Sci"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"115812","DOI":"10.1016\/j.bcp.2023.115812","volume":"217","author":"Herraez","year":"2023","journal-title":"Biochem Pharmacol"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"1224","DOI":"10.2174\/0929867325666180105103637","volume":"26","author":"Ceballos","year":"2019","journal-title":"Curr Med Chem"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1002\/emmm.201101131","volume":"4","author":"Saunders","year":"2012","journal-title":"EMBO Mol Med"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1007\/s10038-006-0087-0","volume":"52","author":"Shikata","year":"2007","journal-title":"J Human Gene"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1016\/j.bcp.2013.06.019","volume":"86","author":"Tzvetkov","year":"2013","journal-title":"Biochem Pharmacol"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"3739","DOI":"10.1182\/blood-2003-12-4276","volume":"104","author":"Thomas","year":"2004","journal-title":"Blood"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1038\/s41392-020-0187-x","volume":"5","author":"Tang","year":"2020","journal-title":"Signal Trans Targe Thera"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"7207","DOI":"10.18632\/oncotarget.6889","volume":"7","author":"Tomonari","year":"2016","journal-title":"Oncotarget"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1002\/hep.30656","volume":"70","author":"Lozano","year":"2019","journal-title":"Hepatology"}],"container-title":["Journal of Hepatocellular Carcinoma"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=98939","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=98939","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T08:10:16Z","timestamp":1715242216000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/mechanisms-of-sorafenib-resistance-in-hcc-culture-relate-to-the-impair-peer-reviewed-fulltext-article-JHC"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":57,"URL":"https:\/\/doi.org\/10.2147\/jhc.s452152","relation":{},"ISSN":["2253-5969"],"issn-type":[{"value":"2253-5969","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5]]}}}