{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:45:29Z","timestamp":1785422729180,"version":"3.56.0"},"reference-count":79,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JHC"],"DOI":"10.2147\/jhc.s452924","type":"journal-article","created":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T06:20:13Z","timestamp":1710829213000},"page":"565-580","source":"Crossref","is-referenced-by-count":12,"title":["Plumbagin Regulates Snail to Inhibit Hepatocellular Carcinoma Epithelial-Mesenchymal Transition in vivo and in vitro"],"prefix":"10.2147","volume":"Volume 11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5474-4246","authenticated-orcid":true,"given":"Yuan-Qin","family":"Du","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1796-2244","authenticated-orcid":true,"given":"Yi-Xian","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng-ling","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Jing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Fei","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2024,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"European Association for Study of Liver; European Organisation for Research and Treatment of Cancer. EASL-EORTC clinical practice guidelines: management of hepatocellular carcinoma [published correction appears in Eur J Cancer. 2012 May;48(8):1255-6]. Eur J Cancer. 2012;48(5):599\u2013641. doi:10.1016\/j.ejca.2011.12.021","DOI":"10.1016\/j.ejca.2011.12.021"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1002\/hep.31288","volume":"73","author":"McGlynn","year":"2021","journal-title":"Hepatology"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1016\/S0140-6736(22)01200-4","volume":"400","author":"Vogel","year":"2022","journal-title":"Lancet"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"5006","DOI":"10.1002\/cam4.1772","volume":"7","author":"Wang","year":"2018","journal-title":"Cancer Med"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1016\/j.cell.2009.11.007","volume":"139","author":"Thiery","year":"2009","journal-title":"Cell"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1158\/0008-5472.CAN-18-3539","volume":"80","author":"Navas","year":"2020","journal-title":"Cancer Res"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1038\/nrc.2017.118","volume":"18","author":"Brabletz","year":"2018","journal-title":"Nat Rev Cancer"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"e108647","DOI":"10.15252\/embj.2021108647","volume":"40","author":"Brabletz","year":"2021","journal-title":"EMBO J"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.dld.2020.09.008","volume":"53","author":"Song","year":"2021","journal-title":"Dig Liver Dis"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.2174\/1386207324666210303093629","volume":"25","author":"Xiao","year":"2022","journal-title":"Comb Chem High Throughput Screen"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/s41556-018-0195-z","volume":"21","author":"Pei","year":"2019","journal-title":"Nat Cell Biol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1038\/s41419-021-03973-5","volume":"12","author":"Xia","year":"2021","journal-title":"Cell Death Dis"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1038\/nature15748","volume":"527","author":"Fischer","year":"2015","journal-title":"Nature"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1038\/nature16064","volume":"527","author":"Zheng","year":"2015","journal-title":"Nature"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/s13148-020-0821-z","volume":"12","author":"Galle","year":"2020","journal-title":"Clin Epigenet"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"2083","DOI":"10.2147\/JHC.S436962","volume":"10","author":"Li","year":"2023","journal-title":"J Hepatocell Carcinoma"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1142\/S0192415X12500188","volume":"40","author":"Xutian","year":"2012","journal-title":"Am J Chin Med"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1038\/labinvest.2015.107","volume":"95","author":"Kong","year":"2015","journal-title":"Lab Invest"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.ejphar.2018.03.007","volume":"827","author":"Iqbal","year":"2018","journal-title":"Eur J Pharmacol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1643","DOI":"10.1016\/j.biopha.2018.04.113","volume":"103","author":"Ijaz","year":"2018","journal-title":"Biomed Pharmacother"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1016\/j.fct.2019.01.018","volume":"125","author":"Tripathi","year":"2019","journal-title":"Food Chem Toxicol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/j.intimp.2017.12.021","volume":"55","author":"Yu","year":"2018","journal-title":"Int Immunopharmacol"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"153133","DOI":"10.1016\/j.phymed.2019.153133","volume":"66","author":"Pradubyat","year":"2020","journal-title":"Phytomedicine"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"2586","DOI":"10.1093\/carcin\/bgs291","volume":"33","author":"Hafeez","year":"2012","journal-title":"Carcinogenesis"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"104517","DOI":"10.1016\/j.phrs.2019.104517","volume":"150","author":"Sakunrangsit","year":"2019","journal-title":"Pharmacol Res"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"9820","DOI":"10.1002\/jcb.28262","volume":"120","author":"Lin","year":"2019","journal-title":"J Cell Biochem"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"2343","DOI":"10.2147\/DDDT.S204787","volume":"13","author":"Wei","year":"2019","journal-title":"Drug Des Devel Ther"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"15230","DOI":"10.18632\/oncotarget.14774","volume":"8","author":"Wei","year":"2017","journal-title":"Oncotarget"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"6110","DOI":"10.12659\/MSM.915782","volume":"25","author":"Zhong","year":"2019","journal-title":"Med Sci Monit"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"6279","DOI":"10.3390\/ijms24076279","volume":"24","author":"Liu","year":"2023","journal-title":"Int J Mol Sci"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"103200","DOI":"10.1016\/j.etap.2019.103200","volume":"70","author":"Zhou","year":"2019","journal-title":"Environ Toxicol Pharmacol"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1138348","DOI":"10.3389\/fonc.2023.1138348","volume":"13","author":"Li","year":"2023","journal-title":"Front Oncol"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"8951","DOI":"10.2147\/CMAR.S252679","volume":"12","author":"Zhang","year":"2020","journal-title":"Cancer Manag Res"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.canlet.2019.11.001","volume":"469","author":"Ye","year":"2020","journal-title":"Cancer Lett"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s12964-022-00870-y","volume":"20","author":"Kong","year":"2022","journal-title":"Cell Commun Signal"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.mrrev.2011.05.002","volume":"728","author":"van Zijl","year":"2011","journal-title":"Mutat Res"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1136\/gutjnl-2013-306627","volume":"63","author":"Bruix","year":"2014","journal-title":"Gut"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"a021535","DOI":"10.1101\/cshperspect.a021535","volume":"5","author":"Liu","year":"2015","journal-title":"Cold Spring Harb Perspect Med"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"1010428317719272","DOI":"10.1177\/1010428317719272","volume":"39","author":"Zou","year":"2017","journal-title":"Tumour Biol"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1016\/j.jhep.2016.05.007","volume":"65","author":"Giannelli","year":"2016","journal-title":"J Hepatol"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1007\/s00432-017-2556-6","volume":"144","author":"Trevisani","year":"2018","journal-title":"J Cancer Res Clin Oncol"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"437","DOI":"10.3390\/ijms24010437","volume":"24","author":"Khanam","year":"2022","journal-title":"Int J Mol Sci"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1080\/14737140.2023.2181162","volume":"23","author":"Stefanini","year":"2023","journal-title":"Expert Rev Anticancer Ther"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"152930","DOI":"10.1016\/j.phymed.2019.152930","volume":"62","author":"Liu","year":"2019","journal-title":"Phytomedicine"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"527","DOI":"10.3390\/antiox10040527","volume":"10","author":"Park","year":"2021","journal-title":"Antioxidants"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/j.joim.2021.08.004","volume":"19","author":"Li","year":"2021","journal-title":"J Integr Med"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1038\/nrm3758","volume":"15","author":"Lamouille","year":"2014","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"1234850","DOI":"10.1126\/science.1234850","volume":"342","author":"Nieto","year":"2013","journal-title":"Science"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/j.jhep.2011.02.001","volume":"55","author":"Pinzani","year":"2011","journal-title":"J Hepatol"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1172\/JCI42615","volume":"120","author":"Jou","year":"2010","journal-title":"J Clin Invest"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"2555","DOI":"10.3390\/ijms24032555","volume":"24","author":"Liang","year":"2023","journal-title":"Int J Mol Sci"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"1801","DOI":"10.3390\/antiox10111801","volume":"10","author":"Seebacher","year":"2021","journal-title":"Antioxidants"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"E161","DOI":"10.1002\/ijc.29097","volume":"136","author":"Fernando","year":"2015","journal-title":"Int, J, Cancer"},{"key":"ref55","first-page":"1789","volume":"33","author":"Yanfei","year":"2022","journal-title":"Chin Modern Appl Pharm"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"6205","DOI":"10.1158\/0008-5472.CAN-16-0176","volume":"76","author":"Alba-Castell\u00f3n","year":"2016","journal-title":"Cancer Res"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"8289","DOI":"10.1002\/cam4.5527","volume":"12","author":"Long","year":"2023","journal-title":"Cancer Med"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"883444","DOI":"10.3389\/fonc.2022.883444","volume":"12","author":"Hu","year":"2022","journal-title":"Front Oncol"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"433","DOI":"10.4161\/cam.21687","volume":"6","author":"Smith","year":"2012","journal-title":"Cell Adh Migr"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.semcancer.2022.11.002","volume":"87","author":"Wang","year":"2022","journal-title":"Semin Cancer Biol"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"22","DOI":"10.3389\/fmolb.2020.00022","volume":"7","author":"Tian","year":"2020","journal-title":"Front Mol Biosci"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"2061","DOI":"10.3390\/jcm9072061","volume":"9","author":"Steinbichler","year":"2020","journal-title":"J Clin Med"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"105267","DOI":"10.1016\/j.archoralbio.2021.105267","volume":"131","author":"Maria de Fran\u00e7a","year":"2021","journal-title":"Arch Oral Biol"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"109085","DOI":"10.1016\/j.exer.2022.109085","volume":"220","author":"Wei","year":"2022","journal-title":"Exp Eye Res"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1895\/wormbook.1.50.1","author":"Pettitt","year":"2005","journal-title":"WormBook"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"e0178581","DOI":"10.1371\/journal.pone.0178581","volume":"12","author":"Liu","year":"2017","journal-title":"PLoS One"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"15966","DOI":"10.18632\/oncotarget.3862","volume":"6","author":"Liu","year":"2015","journal-title":"Oncotarget"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s12964-021-00714-1","volume":"19","author":"You","year":"2021","journal-title":"Cell Commun Signal"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1165\/rcmb.2013-0314TR","volume":"50","author":"Kidd","year":"2014","journal-title":"Am J Respir Cell Mol Biol"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s13046-016-0487-8","volume":"36","author":"Xu","year":"2017","journal-title":"J Exp Clin Cancer Res"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"2811","DOI":"10.3390\/molecules28062811","volume":"28","author":"Singh","year":"2023","journal-title":"Molecules"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"114180","DOI":"10.1016\/j.addr.2022.114180","volume":"184","author":"Nong","year":"2022","journal-title":"Adv Drug Deliv Rev"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"93","DOI":"10.15406\/jabb.2021.08.00259","volume":"8","author":"Mathi Maran","year":"2021","journal-title":"JABB"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1007\/s10517-022-05629-6","volume":"173","author":"Zhu","year":"2022","journal-title":"Bull Exp Biol Med"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"2918","DOI":"10.3390\/ijms20122918","volume":"20","author":"Kong","year":"2019","journal-title":"Int J Mol Sci"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"109711","DOI":"10.1016\/j.cbi.2021.109711","volume":"351","author":"Wang","year":"2022","journal-title":"Chem Biol Interact"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1186\/s12951-022-01554-y","volume":"20","author":"Zheng","year":"2022","journal-title":"J Nanobiotechnology"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.jconrel.2014.05.025","volume":"187","author":"Markovsky","year":"2014","journal-title":"J Control Release"},{"key":"ref79","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.jpha.2020.05.002","volume":"10","author":"Wang","year":"2020","journal-title":"J Pharm Anal"}],"container-title":["Journal of Hepatocellular Carcinoma"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=97707","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=97707","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T06:20:21Z","timestamp":1710829221000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/plumbagin-regulates-snail-to-inhibit-hepatocellular-carcinoma-epitheli-peer-reviewed-fulltext-article-JHC"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":79,"URL":"https:\/\/doi.org\/10.2147\/jhc.s452924","relation":{},"ISSN":["2253-5969"],"issn-type":[{"value":"2253-5969","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3]]}}}