{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:43:24Z","timestamp":1791477804309,"version":"4.3.4"},"reference-count":23,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JHC"],"DOI":"10.2147\/jhc.s459983","type":"journal-article","created":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T08:10:13Z","timestamp":1738915813000},"page":"231-246","source":"Crossref","is-referenced-by-count":4,"title":["Tolerability and Effectiveness of Regorafenib Treatment in Patients with Unresectable Hepatocellular Carcinoma: Real-World Data from the United States"],"prefix":"10.2147","volume":"Volume 12","author":[{"given":"Richard","family":"Finn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renuka","family":"Iyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Kalman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neehar","family":"Parikh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roniel","family":"Cabrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana","family":"Babajanyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Kaseb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2025,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1038\/s41572-020-00240-3","volume":"7","author":"Llovet","year":"2021","journal-title":"Nat Rev Dis Primers"},{"key":"ref2","unstructured":"Centers for Disease Control and Prevention. Liver cancer. November 15, 2022. Available from: https:\/\/www.cdc.gov\/cancer\/liver\/index.htm. Accessed December 4, 2023."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"732","DOI":"10.3889\/oamjms.2015.111","volume":"3","author":"Janevska","year":"2015","journal-title":"Open Access Maced J Med Sci"},{"key":"ref4","unstructured":"Asafo-Agyei KO, Samant H. Hepatocellular carcinoma. (Updated Jun 12, 2023.) In: statPearls [Internet]. Treasure island (FL): Statpearls publishing. 2024. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK559177\/. Accessed December 4, 2023."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"16630","DOI":"10.3748\/wjg.v20.i44.16630","volume":"20","author":"Chen","year":"2014","journal-title":"World J Gastroenterol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/bs.acr.2020.12.001","volume":"149","author":"Demir","year":"2021","journal-title":"Adv Cancer Res"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1056\/NEJMoa0708857","volume":"359","author":"Llovet","year":"2008","journal-title":"N Engl J Med"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/S1470-2045(08)70285-7","volume":"10","author":"Cheng","year":"2009","journal-title":"Lancet Oncol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/S0140-6736(16)32453-9","volume":"389","author":"Bruix","year":"2017","journal-title":"Lancet"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/S0140-6736(12)61900-X","volume":"381","author":"Grothey","year":"2013","journal-title":"Lancet"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/S0140-6736(12)61857-1","volume":"381","author":"Demetri","year":"2013","journal-title":"Lancet"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1016\/S1470-2045(15)70156-7","volume":"16","author":"Li","year":"2015","journal-title":"Lancet Oncol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"e16114","DOI":"10.1200\/JCO.2023.41.16_suppl.e16114","volume":"41","author":"Kaseb","year":"2023","journal-title":"J Clin Oncol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"3061","DOI":"10.1200\/jco.2011.29.15_suppl.3061","volume":"29","author":"Ball","year":"2011","journal-title":"J Clin Oncol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"2471","DOI":"10.1002\/ijc.31280","volume":"142","author":"Maucort-Boulch","year":"2018","journal-title":"Int, J, Cancer"},{"key":"ref16","first-page":"00049","volume":"S0923-7534","author":"Sangro","year":"2024","journal-title":"Ann Oncol"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1894","DOI":"10.1056\/NEJMoa1915745","volume":"382","author":"Finn","year":"2020","journal-title":"N Engl J Med"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"e000714","DOI":"10.1136\/esmoopen-2020-000714","volume":"5","author":"Kelley","year":"2020","journal-title":"ESMO Open"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1159\/000529636","volume":"12","author":"Merle","year":"2023","journal-title":"Liver Cancer"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/S1470-2045(18)30937-9","volume":"20","author":"Zhu","year":"2019","journal-title":"Lancet Oncol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"e204564","DOI":"10.1001\/jamaoncol.2020.4564","volume":"6","author":"Yau","year":"2020","journal-title":"JAMA Oncol"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1200\/JCO.2022.40.4_suppl.379","volume":"40","author":"Abou-Alfa","year":"2022","journal-title":"J Clin Oncol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1016\/j.jhep.2021.11.030","volume":"76","author":"Cheng","year":"2022","journal-title":"J Hepatol"}],"container-title":["Journal of Hepatocellular Carcinoma"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/99994","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/99994","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T08:10:17Z","timestamp":1738915817000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/tolerability-and-effectiveness-of-regorafenib-treatment-in-patients-wi-peer-reviewed-fulltext-article-JHC"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":23,"URL":"https:\/\/doi.org\/10.2147\/jhc.s459983","relation":{},"ISSN":["2253-5969"],"issn-type":[{"value":"2253-5969","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2]]}}}