{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T09:06:17Z","timestamp":1779959177629,"version":"3.53.1"},"reference-count":53,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JHC"],"DOI":"10.2147\/jhc.s598850","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T08:35:14Z","timestamp":1779957314000},"page":"1-13","source":"Crossref","is-referenced-by-count":0,"title":["Rare Long-Term Transformation from Solitary Hepatocellular Carcinoma to Synchronous Double Primary Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma: A Case Report and Literature Review"],"prefix":"10.2147","volume":"Volume 13","author":[{"given":"Liyi","family":"Qiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengcheng","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Lo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0231-0383","authenticated-orcid":true,"given":"Yongjing","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuoliang","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiye","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2026,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1053\/j.gastro.2023.01.033","volume":"164","author":"Toh","year":"2023","journal-title":"Gastroenterology"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"13","DOI":"10.20517\/2574-1225.2022.112","volume":"7","author":"Elena","year":"2023","journal-title":"Mini-Invasive Surg"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"S228","DOI":"10.3350\/cmh.2024.0824","volume":"31","author":"Hwang","year":"2025","journal-title":"Clin Mol Hepatol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"18","DOI":"10.20517\/2574-1225.2023.12","volume":"7","author":"Alexandra","year":"2023","journal-title":"Mini-Invasive Surg"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"198","DOI":"10.3322\/caac.21759","volume":"73","author":"Moris","year":"2023","journal-title":"CA Cancer J Clin"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"e27349","DOI":"10.1097\/MD.0000000000027349","volume":"100","author":"Qu","year":"2021","journal-title":"Medicine"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1007\/s00268-016-3787-4","volume":"41","author":"Jung","year":"2017","journal-title":"World J Surg"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"109599","DOI":"10.1016\/j.ijscr.2024.109599","volume":"118","author":"Fukuda","year":"2024","journal-title":"Int J Surg Case Rep"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"991","DOI":"10.14218\/JCTH.2022.00382","volume":"11","author":"Sakata","year":"2023","journal-title":"J Clin Transl Hepatol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1007\/s005340050144","volume":"6","author":"Itamoto","year":"1999","journal-title":"J Hepatobiliary Pancreat Surg"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1111\/j.1440-1746.2005.03806.x","volume":"20","author":"Fuji","year":"2005","journal-title":"J Gastroenterol Hepatol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1007\/s00534-006-1118-0","volume":"13","author":"Matsuda","year":"2006","journal-title":"J Hepatobiliary Pancreat Surg"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1007\/s00534-006-1134-0","volume":"14","author":"Inaba","year":"2007","journal-title":"J Hepatobiliary Pancreat Surg"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"103","DOI":"10.4254\/wjh.v1.i1.103","volume":"1","author":"Watanabe","year":"2009","journal-title":"World J Hepatol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1007\/s00595-012-0346-y","volume":"43","author":"Shimizu","year":"2013","journal-title":"Surg Today"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1186\/1756-0500-6-520","volume":"6","author":"Jung","year":"2013","journal-title":"BMC Res Notes"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"135","DOI":"10.4166\/kjg.2013.62.2.135","volume":"62","author":"Kim","year":"2013","journal-title":"Korean J Gastroenterol"},{"key":"ref18","first-page":"125","volume":"5","author":"Geramizadeh","year":"2014","journal-title":"Int J Organ Transplant Med"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"209","DOI":"10.5152\/tjg.2014.6188","volume":"25","author":"Topaloglu","year":"2014","journal-title":"Turk J Gastroenterol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1186\/1477-7819-12-337","volume":"12","author":"Wu","year":"2014","journal-title":"World J Surg Oncol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"273","DOI":"10.3892\/ol.2015.3896","volume":"11","author":"Zhou","year":"2016","journal-title":"Oncol Lett"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1186\/s12957-016-0974-6","volume":"14","author":"Hu","year":"2016","journal-title":"World J Surg Oncol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1186\/s13256-018-1762-4","volume":"12","author":"Yamamoto","year":"2018","journal-title":"J Med Case Rep"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"3615","DOI":"10.12998\/wjcc.v10.i11.3615","volume":"10","author":"Gao","year":"2022","journal-title":"World J Clin Cases"},{"key":"ref25","first-page":"486","volume":"49","author":"Tsukamoto","year":"2022","journal-title":"Gan To Kagaku Ryoho"},{"key":"ref26","first-page":"667","volume":"8","author":"Ma","year":"2023","journal-title":"J Clin Med Pract"},{"key":"ref27","first-page":"200","volume":"32","author":"Gao","year":"2023","journal-title":"Chin J Gen Surg"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"109140","DOI":"10.1016\/j.ijscr.2023.109140","volume":"114","author":"Khessairi","year":"2024","journal-title":"Int J Surg Case Rep"},{"key":"ref29","first-page":"e70085","volume":"8","author":"Szodorai","year":"2025","journal-title":"Cancer Rep"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1053\/j.gastro.2016.11.048","volume":"152","author":"Sia","year":"2016","journal-title":"Gastroenterology"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1002\/hep.29913","volume":"68","author":"Marrero","year":"2018","journal-title":"Hepatology"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1002\/hep.29086","volume":"67","author":"Heimbach","year":"2018","journal-title":"Hepatology"},{"key":"ref33","doi-asserted-by":"crossref","unstructured":"European Association for the Study of the Liver. EASL clinical practice guidelines: management of hepatocellular carcinoma. J Hepatol. 2018;69(1):182\u2013236. doi:10.1016\/j.jhep.2018.03.019","DOI":"10.1016\/j.jhep.2018.03.019"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"3818","DOI":"10.1038\/sj.onc.1209558","volume":"25","author":"Roskams","year":"2006","journal-title":"Oncogene"},{"key":"ref35","first-page":"111","volume":"55","author":"Heim","year":"2009","journal-title":"Minerva Gastroenterol Dietol"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1631","DOI":"10.1016\/j.jhep.2022.07.029","volume":"77","author":"Rosenberg","year":"2022","journal-title":"J Hepatol"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.joim.2020.02.002","volume":"18","author":"Tang","year":"2020","journal-title":"J Integr Med"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1038\/ng.3252","volume":"47","author":"Schulze","year":"2015","journal-title":"Nat Genet"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1158\/2159-8290.CD-17-0368","volume":"7","author":"Jusakul","year":"2017","journal-title":"Cancer Discov"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"e18761429358008","DOI":"10.2174\/0118761429358008250305070518","volume":"17","author":"Xu","year":"2024","journal-title":"Curr Mol Pharmacol"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"48","DOI":"10.2174\/0113892029308243240709073945","volume":"26","author":"Gudivada","year":"2025","journal-title":"Curr Genomics"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"706","DOI":"10.2174\/0109298665330781240830042601","volume":"31","author":"Ye","year":"2024","journal-title":"Protein Pept Lett"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"2","DOI":"10.2174\/0113892029273682240111052317","volume":"25","author":"Mu","year":"2024","journal-title":"Curr Genomics"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"1771","DOI":"10.1158\/2159-8290.CD-23-0225","volume":"13","author":"Davies","year":"2023","journal-title":"Cancer Discov"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1016\/j.stem.2020.08.016","volume":"27","author":"Gadd","year":"2020","journal-title":"Cell Stem Cell"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.3748\/wjg.v25.i9.1037","volume":"25","author":"Tsuchiya","year":"2019","journal-title":"World J Gastroenterol"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"26772","DOI":"10.1038\/srep26772","volume":"6","author":"Li","year":"2016","journal-title":"Sci Rep"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1007\/s00261-017-1261-x","volume":"43","author":"Horvat","year":"2018","journal-title":"Abdom Radiol"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1002\/hep.29789","volume":"68","author":"Brunt","year":"2018","journal-title":"Hepatology"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1016\/j.surg.2006.12.014","volume":"141","author":"Itamoto","year":"2007","journal-title":"Surgery"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"3878","DOI":"10.3390\/cancers16223878","volume":"16","author":"Lin","year":"2024","journal-title":"Cancers"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"3007","DOI":"10.21037\/tcr-23-1278","volume":"12","author":"Yang","year":"2023","journal-title":"Transl Cancer Res"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1007\/s44178-025-00157-5","volume":"4","author":"Zhang","year":"2025","journal-title":"Holist Integr Oncol"}],"container-title":["Journal of Hepatocellular Carcinoma"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/115758","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/115758","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T08:35:22Z","timestamp":1779957322000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/rare-long-term-transformation-from-solitary-hepatocellular-carcinoma-t-peer-reviewed-fulltext-article-JHC"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":53,"URL":"https:\/\/doi.org\/10.2147\/jhc.s598850","relation":{},"ISSN":["2253-5969"],"issn-type":[{"value":"2253-5969","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]}}}