{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T22:47:35Z","timestamp":1787611655190,"version":"build-2736575974"},"reference-count":45,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JIR"],"DOI":"10.2147\/jir.s297166","type":"journal-article","created":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T15:57:32Z","timestamp":1615219052000},"page":"745-760","source":"Crossref","is-referenced-by-count":43,"title":["Engeletin Protects Against TNF-\u03b1-Induced Apoptosis and Reactive Oxygen Species Generation in Chondrocytes and Alleviates Osteoarthritis in vivo"],"prefix":"10.2147","volume":"Volume 14","author":[{"given":"Hao","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengxin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiying","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guobin","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingxuan","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuoqin","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengfeng","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2021,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/S0140-6736(18)32279-7","volume":"392","author":"James","year":"2018","journal-title":"Lancet"},{"key":"ref2","author":"Zhou","year":"2020","journal-title":"J Cell Mol Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.mad.2016.12.012","volume":"162","author":"Li","year":"2017","journal-title":"Mech Ageing Dev"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.clim.2012.12.011","volume":"146","author":"Haseeb","year":"2013","journal-title":"Clin immunol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1016\/S0140-6736(19)30417-9","volume":"393","author":"Hunter","year":"2019","journal-title":"Lancet"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.2106\/00004623-201310160-00010","volume":"95","author":"Jevsevar","year":"2013","journal-title":"J Bone Joint Surg Am"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.bbadis.2016.01.003","volume":"1862","author":"Lepetsos","year":"2016","journal-title":"Biochim Biophys Acta"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.freeradbiomed.2017.02.041","volume":"106","author":"Khan","year":"2017","journal-title":"Free Radic Biol Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1186\/s13075-019-2085-6","volume":"21","author":"Chen","year":"2019","journal-title":"Arthritis Res Ther"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"5873","DOI":"10.1039\/C9FO00742C","volume":"10","author":"Jiang","year":"2019","journal-title":"Food Funct"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"3427","DOI":"10.1038\/s41467-020-17242-0","volume":"11","author":"Arra","year":"2020","journal-title":"Nat Commun"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1023\/A:1009616228304","volume":"5","author":"Simon","year":"2000","journal-title":"Apoptosis"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/14786419.2019.1672062","author":"Pacheco","year":"2019","journal-title":"Nat Prod Res"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"11747","DOI":"10.1021\/acs.jafc.0c05102","volume":"68","author":"Wang","year":"2020","journal-title":"J Agric Food Chem"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"6171","DOI":"10.1021\/acs.jafc.6b02304","volume":"64","author":"Wu","year":"2016","journal-title":"J Agric Food Chem"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.jchromb.2017.06.018","volume":"1060","author":"Ye","year":"2017","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1759","DOI":"10.1007\/s10753-020-01250-9","volume":"43","author":"Huang","year":"2020","journal-title":"Inflammation"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"110221","DOI":"10.1016\/j.biopha.2020.110221","volume":"5","author":"Liu","year":"2000","journal-title":"Biomed Pharmacother"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1007\/s10753-018-0773-z","volume":"41","author":"Jiang","year":"2018","journal-title":"Inflammation"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.freeradbiomed.2018.01.013","volume":"116","author":"Khan","year":"2018","journal-title":"Free Radic Biol Med"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"4533","DOI":"10.2147\/DDDT.S258973","volume":"14","author":"Yang","year":"2020","journal-title":"Drug Des Devel Ther"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"8579","DOI":"10.1111\/jcmm.15484","volume":"24","author":"Xue","year":"2020","journal-title":"J Cell Mol Med"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.intimp.2018.08.013","volume":"63","author":"Xu","year":"2018","journal-title":"Int Immunopharmacol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"4443","DOI":"10.1039\/C8FO00732B","volume":"9","author":"Hu","year":"2018","journal-title":"Food Funct"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.jphs.2019.06.011","volume":"140","author":"Tian","year":"2019","journal-title":"J Pharmacol Sci"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"112785","DOI":"10.1016\/j.jep.2020.112785","volume":"256","author":"Feng","year":"2020","journal-title":"J Ethnopharmacol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.joca.2005.07.014","volume":"14","author":"Pritzker","year":"2006","journal-title":"Osteoarthritis Cartilage"},{"key":"ref29","author":"Tschaikowsky","year":"2020","journal-title":"Osteoarthritis Cartilage"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1002\/art.20020","volume":"50","author":"Sharif","year":"2004","journal-title":"Arthritis Rheum"},{"key":"ref31","first-page":"11","volume":"12","author":"Lin","year":"2020","journal-title":"Cancers"},{"key":"ref32","first-page":"11","volume":"10","author":"Lee","year":"2020","journal-title":"Biomolecules"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1038\/s41419-020-03144-y","volume":"11","author":"Kapoor","year":"2020","journal-title":"Cell Death Dis"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"112732","DOI":"10.1016\/j.jep.2020.112732","volume":"254","author":"Yapasert","year":"2020","journal-title":"J Ethnopharmacol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1152\/physrev.00026.2013","volume":"94","author":"Zorov","year":"2014","journal-title":"Physiol Rev"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"S37","DOI":"10.1097\/01.blo.0000144484.69656.e4","volume":"427 Suppl","author":"Goldring","year":"2004","journal-title":"Clin Orthop Relat Res"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"S265","DOI":"10.1016\/j.joca.2017.02.447","volume":"25","author":"Kavanaugh","year":"2017","journal-title":"Osteoarthritis Cartilage"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.freeradbiomed.2018.08.038","volume":"132","author":"Bolduc","year":"2019","journal-title":"Free Radic Biol Med"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1186\/s13075-015-0774-3","volume":"17","author":"Cai","year":"2015","journal-title":"Arthritis Res Ther"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/j.freeradbiomed.2020.01.185","volume":"152","author":"Yang","year":"2020","journal-title":"Free Radic Biol Med"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.1016\/j.biocel.2013.08.018","volume":"45","author":"Rigoglou","year":"2013","journal-title":"Int J Biochem Cell Biol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/s13075-017-1296-y","volume":"19","author":"Saito","year":"2017","journal-title":"Arthritis Res Ther"},{"key":"ref43","author":"Lu","year":"2020","journal-title":"J Cell Mol Med"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1016\/j.joca.2017.05.011","volume":"25","author":"Nazli","year":"2017","journal-title":"Osteoarthritis Cartilage"},{"key":"ref45","first-page":"(22):8513","volume":"21","author":"Sun","year":"2020","journal-title":"Int J Mol Sci"}],"container-title":["Journal of Inflammation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=67482","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=67482","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T15:57:58Z","timestamp":1615219078000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/engeletin-protects-against-tnf-alpha-induced-apoptosis-and-reactive-ox-peer-reviewed-article-JIR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":45,"URL":"https:\/\/doi.org\/10.2147\/jir.s297166","relation":{},"ISSN":["1178-7031"],"issn-type":[{"value":"1178-7031","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3]]}}}