{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T10:55:18Z","timestamp":1791888918069,"version":"4.3.4"},"reference-count":66,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JIR"],"DOI":"10.2147\/jir.s302117","type":"journal-article","created":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T20:46:55Z","timestamp":1624999615000},"page":"2883-2896","source":"Crossref","is-referenced-by-count":14,"title":["Increased Sphingosine-1-Phosphate Serum Concentrations in Subjects with Periodontitis: A Matter of Inflammation"],"prefix":"10.2147","volume":"Volume 14","author":[{"given":"Eileen","family":"Moritz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Jedlitschky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josefine","family":"Negnal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mladen V","family":"Tzvetkov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcnter","family":"Daum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7471-475X","authenticated-orcid":true,"given":"Marcus","family":"D\u00f6rr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan B","family":"Felix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"V\u00f6lzke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Nauck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3597-6276","authenticated-orcid":true,"given":"Edzard","family":"Schwedhelm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Meisel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Kocher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6003-4662","authenticated-orcid":true,"given":"Bernhard H","family":"Rauch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birte","family":"Holtfreter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2021,6]]},"reference":[{"key":"ref1","volume-title":"Robbins & Cotran Pathologic Basis of Disease","year":"2021"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1177\/0022034514552491","volume":"93","author":"Kassebaum","year":"2014","journal-title":"J Dent Res"},{"key":"ref3","volume-title":"F\u00fcnfte Deutsche Mundgesundheitsstudie (DMS V)"},{"key":"ref4","volume-title":"F\u00fcnfte Deutsche Mundgesundheitsstudie (DMS V)"},{"key":"ref5","first-page":"501","volume":"15","author":"Kocher","year":"2017","journal-title":"Oral Health Prev Dent"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1111\/jcpe.12352","volume":"42","author":"Sch\u00fctzhold","year":"2015","journal-title":"J Clin Periodontol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/nri3785","volume":"15","author":"Hajishengallis","year":"2015","journal-title":"Nat Rev Immunol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"S51","DOI":"10.1111\/jcpe.12060","volume":"40","author":"Schenkein","year":"2013","journal-title":"J Clin Periodontol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.yexmp.2016.01.006","volume":"100","author":"Chistiakov","year":"2016","journal-title":"Exp Mol Pathol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"e84603","DOI":"10.1371\/journal.pone.0084603","volume":"8","author":"Holtfreter","year":"2013","journal-title":"PLoS One"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1111\/jcpe.12335","volume":"42","author":"Yu","year":"2015","journal-title":"J Clin Periodontol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1016\/j.hlc.2018.05.102","volume":"27","author":"Carrizales-Sep\u00falveda","year":"2018","journal-title":"Heart Lung Circ"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1111\/j.1600-051X.2011.01784.x","volume":"39","author":"Tom\u00e1s","year":"2012","journal-title":"J Clin Periodontol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1093\/intimm\/dxz037","volume":"31","author":"Obinata","year":"2019","journal-title":"Int Immunol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"104170","DOI":"10.1016\/j.phrs.2019.02.009","volume":"154","author":"Stepanovska","year":"2020","journal-title":"Pharmaco Res"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1038\/nrm1103","volume":"4","author":"Spiegel","year":"2003","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1596","DOI":"10.1194\/jlr.R046300","volume":"55","author":"Blaho","year":"2014","journal-title":"J Lipid Res"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1146\/annurev-biochem-062411-130916","volume":"82","author":"Rosen","year":"2013","journal-title":"Annu Rev Biochem"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.1002\/jcb.22507","volume":"109","author":"Bode","year":"2010","journal-title":"J Cell Biochem"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.bbalip.2012.06.007","volume":"1831","author":"Olivera","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1111\/j.1538-7836.2011.04194.x","volume":"9","author":"Ulrych","year":"2011","journal-title":"J Thromb Haemost"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"e0168302","DOI":"10.1371\/journal.pone.0168302","volume":"11","author":"Soltau","year":"2016","journal-title":"PLoS One"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1186\/s13054-015-1089-0","volume":"19","author":"Winkler","year":"2015","journal-title":"Critical Care"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.cca.2017.01.029","volume":"468","author":"Moritz","year":"2017","journal-title":"Clin Chim Acta"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.dib.2017.03.019","volume":"12","author":"Moritz","year":"2017","journal-title":"Data Brief"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.bbalip.2012.06.002","volume":"1831","author":"Ishii","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1038\/s41591-018-0005-y","volume":"24","author":"Weske","year":"2018","journal-title":"Nat Med"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1093\/ije\/dyp394","volume":"40","author":"V\u00f6lzke","year":"2011","journal-title":"Int J Epidemiol"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"185","DOI":"10.3238\/arztebl.2015.0185","volume":"112","author":"V\u00f6lzke","year":"2015","journal-title":"Dtsch Arztebl Int"},{"key":"ref30","unstructured":"Poul Erik Petersen, Ramon J Baez, World Health Organization. Citation: Petersen PE, Ramon RJ & World Health Organization. Oral health surveys: basic methods, 5th ed. Geneva:World Health Organisation;2013"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1111\/j.1600-0528.2008.00435.x","volume":"36","author":"Demmer","year":"2008","journal-title":"Community Dent Oral Epidemiol"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1111\/jcpe.12392","volume":"42","author":"Holtfreter","year":"2015","journal-title":"J Clin Periodontol"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1902\/jop.2007.060264","volume":"78","author":"Page","year":"2007","journal-title":"J Periodontol"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1177\/154405910208100512","volume":"81","author":"Meisel","year":"2002","journal-title":"J Dent Res"},{"key":"ref35","author":"Meisel","year":"2020","journal-title":"Clin Oral Investig"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1111\/jcpe.12473","volume":"42","author":"Pink","year":"2015","journal-title":"J Clin Periodontol"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.atherosclerosis.2014.05.926","volume":"235","author":"Gocke","year":"2014","journal-title":"Atherosclerosis"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"7348","DOI":"10.1074\/jbc.M110.171819","volume":"286","author":"Allende","year":"2011","journal-title":"J Biol Chem"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1038\/ni1534","volume":"9","author":"Ledgerwood","year":"2008","journal-title":"Nat Immunol"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.3389\/fimmu.2019.01409","volume":"10","author":"Xiao","year":"2019","journal-title":"Front Immunol"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"831059","DOI":"10.1155\/2015\/831059","volume":"2015","author":"Mahajan-Thakur","year":"2015","journal-title":"Mediators Inflamm"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"3583","DOI":"10.1038\/onc.2013.319","volume":"33","author":"Kim","year":"2014","journal-title":"Oncogene"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.bone.2017.07.002","volume":"103","author":"Bougault","year":"2017","journal-title":"Bone"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"e39","DOI":"10.4110\/in.2018.18.e39","volume":"18","author":"Choi","year":"2018","journal-title":"Immune Netw"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1093\/cvr\/cvt112","volume":"99","author":"B\u00f6hm","year":"2013","journal-title":"Cardiovasc Res"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"1314","DOI":"10.1182\/blood-2004-09-3687","volume":"106","author":"Halin","year":"2005","journal-title":"Blood"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1038\/nature13475","volume":"510","author":"Maceyka","year":"2014","journal-title":"Nature"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1038\/ni1545","volume":"8","author":"Schwab","year":"2007","journal-title":"Nat Immunol"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.neulet.2010.04.052","volume":"477","author":"Ku\u0142akowska","year":"2010","journal-title":"Neurosci Lett"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1096\/fj.08-118109","volume":"23","author":"Snider","year":"2009","journal-title":"FASEB J"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.ccr.2012.11.013","volume":"23","author":"Liang","year":"2013","journal-title":"Cancer Cell"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"469","DOI":"10.3978\/j.issn.2218-676X.2015.10.06","volume":"4","author":"Suh","year":"2015","journal-title":"Transl Cancer Res"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"8010","DOI":"10.4049\/jimmunol.181.11.8010","volume":"181","author":"Lai","year":"2008","journal-title":"J Immunol"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1002\/art.21668","volume":"54","author":"Kitano","year":"2006","journal-title":"Arthritis Rheum"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"1818","DOI":"10.4049\/jimmunol.180.3.1818","volume":"180","author":"Eskan","year":"2008","journal-title":"J Immunol"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1002\/eji.200737898","volume":"38","author":"Eskan","year":"2008","journal-title":"Eur J Immunol"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1111\/jre.12276","volume":"51","author":"Yu","year":"2016","journal-title":"J Periodontal Res"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1186\/s12944-015-0057-7","volume":"14","author":"Yu","year":"2015","journal-title":"Lipids Health Dis"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1111\/jre.12366","volume":"52","author":"Lee","year":"2017","journal-title":"J Periodontal Res"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"1515","DOI":"10.3390\/cells9061515","volume":"9","author":"Lucaciu","year":"2020","journal-title":"Cells"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"117542","DOI":"10.1016\/j.lfs.2020.117542","volume":"249","author":"Han","year":"2020","journal-title":"Life Sci"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"4389","DOI":"10.1111\/jcmm.15155","volume":"24","author":"Zhang","year":"2020","journal-title":"J Cell Mol Med"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"87","DOI":"10.11005\/jbm.2018.25.2.87","volume":"25","author":"Ardawi","year":"2018","journal-title":"J Bone Metab"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"8651","DOI":"10.1158\/0008-5472.CAN-10-1388","volume":"70","author":"Pchejetski","year":"2010","journal-title":"Cancer Res"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"1536","DOI":"10.1016\/j.cellsig.2010.05.022","volume":"22","author":"Tonelli","year":"2010","journal-title":"Cell Signal"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1002\/jbt.20193","volume":"21","author":"Vessey","year":"2007","journal-title":"J Biochem Mol Toxicol"}],"container-title":["Journal of Inflammation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=71180","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=71180","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T20:47:06Z","timestamp":1624999626000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/increased-sphingosine-1-phosphate-serum-concentrations-in-subjects-wit-peer-reviewed-fulltext-article-JIR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":66,"URL":"https:\/\/doi.org\/10.2147\/jir.s302117","relation":{},"ISSN":["1178-7031"],"issn-type":[{"value":"1178-7031","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6]]}}}