{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T23:28:39Z","timestamp":1787614119556,"version":"build-2736575974"},"reference-count":67,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JIR"],"DOI":"10.2147\/jir.s335502","type":"journal-article","created":{"date-parts":[[2021,12,29]],"date-time":"2021-12-29T10:10:19Z","timestamp":1640772619000},"page":"7487-7497","source":"Crossref","is-referenced-by-count":14,"title":["Protease-Activated Receptors \u2013 Key Regulators of Inflammatory Bowel Diseases Progression"],"prefix":"10.2147","volume":"Volume 14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4563-2303","authenticated-orcid":true,"given":"Damian","family":"Jacenik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakub","family":"Fichna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Ma\u0142ecka-Wojciesko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Mokrowiecka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2021,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1111\/jgh.13723","volume":"32","author":"Lu","year":"2017","journal-title":"J Gastroenterol Hepatol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"32592","DOI":"10.18632\/oncotarget.8693","volume":"7","author":"Xie","year":"2016","journal-title":"Oncotarget"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"233","DOI":"10.2147\/jir.s234710","volume":"13","author":"Curciarello","year":"2020","journal-title":"J Inflamm Res"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1111\/j.1365-2249.2008.03836.x","volume":"155","author":"Pedersen","year":"2009","journal-title":"Clin Exp Immunol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1016\/j.dld.2007.05.010","volume":"39","author":"Meijer","year":"2007","journal-title":"Dig Liver Dis"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1097\/01.mib.0000234133.97594.04","volume":"12","author":"Rath","year":"2006","journal-title":"Inflamm Bowel Dis"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1756284819881590","DOI":"10.1177\/1756284819881590","volume":"12","author":"Yablecovitch","year":"2019","journal-title":"Therap Adv Gastroenterol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1564","DOI":"10.1053\/j.gastro.2015.07.002","volume":"149","author":"Biancheri","year":"2015","journal-title":"Gastroenterology"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"2253","DOI":"10.2165\/00003495-200565160-00002","volume":"65","author":"Ardizzone","year":"2005","journal-title":"Drugs"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1038\/nrgastro.2013.253","volume":"11","author":"Ben-Horin","year":"2014","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"359","DOI":"10.2147\/ceg.s45297","volume":"7","author":"Guerra","year":"2014","journal-title":"Clin Exp Gastroenterol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"21","DOI":"10.3389\/fcimb.2020.00021","volume":"10","author":"Jablaoui","year":"2020","journal-title":"Front Cell Infect Microbiol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1038\/s41385-021-00375-w","volume":"14","author":"Motta","year":"2021","journal-title":"Mucosal Immunol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1093\/ecco-jcc\/jjaa229","volume":"15","author":"Motta","year":"2021","journal-title":"J Crohns Colitis"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"7834","DOI":"10.1038\/s41598-018-26282-y","volume":"8","author":"Denadai-Souza","year":"2018","journal-title":"Sci Rep"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"e144","DOI":"10.1093\/ibd\/izab144","volume":"12","author":"Galipeau","year":"2021","journal-title":"Inflamm Bowel Dis"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1053\/j.gastro.2020.12.004","volume":"160","author":"Galipeau","year":"2021","journal-title":"Gastroenterology"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1016\/0092-8674(91)90261-v","volume":"64","author":"Vu","year":"1991","journal-title":"Cell"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1038\/368648a0","volume":"368","author":"Gerszten","year":"1994","journal-title":"Nature"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"16466","DOI":"10.1074\/jbc.271.28.16466","volume":"271","author":"Blackhart","year":"1996","journal-title":"J Biol Chem"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"13502","DOI":"10.1074\/jbc.275.18.13502","volume":"275","author":"O\u2019Brien","year":"2000","journal-title":"J Biol Chem"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.1074\/jbc.M109160200","volume":"277","author":"Paing","year":"2002","journal-title":"J Biol Chem"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"9374","DOI":"10.1021\/bi0602617","volume":"45","author":"Wang","year":"2006","journal-title":"Biochemistry"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1038\/ni1525","volume":"8","author":"Kaneider","year":"2007","journal-title":"Nat Immunol"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"11285","DOI":"10.1074\/jbc.M115.710681","volume":"291","author":"Jensen","year":"2016","journal-title":"J Biol Chem"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1136\/gut.2003.021899","volume":"53","author":"Mul\u00e8","year":"2004","journal-title":"Gut"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"5702","DOI":"10.4049\/jimmunol.181.8.5702","volume":"181","author":"Chin","year":"2008","journal-title":"J Immunol"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"207","DOI":"10.2353\/ajpath.2009.080986","volume":"175","author":"Dabek","year":"2009","journal-title":"Am J Pathol"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1097\/mib.0000000000001045","volume":"23","author":"Saeed","year":"2017","journal-title":"Inflamm Bowel Dis"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"1903","DOI":"10.1016\/s0002-9440(10)64466-5","volume":"161","author":"Cenac","year":"2002","journal-title":"Am J Pathol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1292\/jvms.14-0060","volume":"76","author":"Maeda","year":"2014","journal-title":"J Vet Med Sci"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1097\/00054725-200307000-00002","volume":"9","author":"Kim","year":"2003","journal-title":"Inflamm Bowel Dis"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/j.canlet.2019.11.015","volume":"469","author":"Ke","year":"2020","journal-title":"Cancer Lett"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1007\/s10238-008-0025-x","volume":"9","author":"Tahara","year":"2009","journal-title":"Clin Exp Med"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"667","DOI":"10.2217\/epi-2016-0006","volume":"8","author":"Gould","year":"2016","journal-title":"Epigenomics"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"13936","DOI":"10.1073\/pnas.241377298","volume":"98","author":"Fiorucci","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1097\/01.mib.0000177506.71784.bd","volume":"11","author":"Cenac","year":"2005","journal-title":"Inflamm Bowel Dis"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.crohns.2008.11.003","volume":"3","author":"Christerson","year":"2009","journal-title":"J Crohns Colitis"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"54","DOI":"10.4103\/0975-1483.62214","volume":"2","author":"Patel","year":"2010","journal-title":"J Young Pharm"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.abb.2018.09.003","volume":"657","author":"Feng","year":"2018","journal-title":"Arch Biochem Biophys"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1093\/ibd\/izaa125","volume":"27","author":"Liu","year":"2021","journal-title":"Inflamm Bowel Dis"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1172\/jci21404","volume":"116","author":"Yen","year":"2006","journal-title":"J Clin Invest"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1096\/fasebj.10.2.8641564","volume":"10","author":"Mari","year":"1996","journal-title":"FASEB j"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.crohns.2008.10.002","volume":"3","author":"Christerson","year":"2009","journal-title":"J Crohns Colitis"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/s0002-9440(10)62264-x","volume":"166","author":"Wang","year":"2005","journal-title":"Am J Pathol"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"26205","DOI":"10.1074\/jbc.M602164200","volume":"281","author":"Graham","year":"2006","journal-title":"J Biol Chem"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1038\/labinvest.3700373","volume":"86","author":"Blair","year":"2006","journal-title":"Lab Invest"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1136\/gut.2007.140210","volume":"57","author":"Gecse","year":"2008","journal-title":"Gut"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1016\/j.cgh.2006.12.004","volume":"5","author":"R\u00f3ka","year":"2007","journal-title":"Clin Gastroenterol Hepatol"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.1002\/ibd.21454","volume":"17","author":"Dabek","year":"2011","journal-title":"Inflamm Bowel Dis"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"3656","DOI":"10.1111\/bph.14430","volume":"175","author":"S\u00e9bert","year":"2018","journal-title":"Br J Pharmacol"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1136\/gut.2003.036632","volume":"53","author":"Zeissig","year":"2004","journal-title":"Gut"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1053\/j.gastro.2011.05.032","volume":"141","author":"Dirisina","year":"2011","journal-title":"Gastroenterology"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"1420","DOI":"10.1038\/cdd.2010.19","volume":"17","author":"Kim","year":"2010","journal-title":"Cell Death Differ"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"34366","DOI":"10.1074\/jbc.M114.610485","volume":"289","author":"Iablokov","year":"2014","journal-title":"J Biol Chem"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"G30","DOI":"10.1152\/ajpgi.00203.2020","volume":"320","author":"Her","year":"2021","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1016\/j.crohns.2013.11.001","volume":"8","author":"Schmid","year":"2014","journal-title":"J Crohns Colitis"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1016\/s0140-6736(09)61963-2","volume":"375","author":"Grainge","year":"2010","journal-title":"Lancet"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1007\/bf01536380","volume":"34","author":"Conlan","year":"1989","journal-title":"Dig Dis Sci"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1097\/00001721-199212000-00011","volume":"3","author":"Hudson","year":"1992","journal-title":"Blood Coagul Fibrinolysis"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1016\/0016-5085(94)90741-2","volume":"106","author":"Collins","year":"1994","journal-title":"Gastroenterology"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.1136\/gut.52.10.1435","volume":"52","author":"Danese","year":"2003","journal-title":"Gut"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"6819","DOI":"10.1074\/jbc.275.10.6819","volume":"275","author":"Sambrano","year":"2000","journal-title":"J Biol Chem"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1136\/gut.48.4.526","volume":"48","author":"Eaden","year":"2001","journal-title":"Gut"},{"key":"ref65","first-page":"148","volume":"8","author":"Fala","year":"2015","journal-title":"Am Health Drug Benefits"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"1843","DOI":"10.1161\/circulationaha.110.000786","volume":"123","author":"O\u2019Donoghue","year":"2011","journal-title":"Circulation"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"2601","DOI":"10.1093\/eurheartj\/ehq320","volume":"31","author":"Goto","year":"2010","journal-title":"Eur Heart J"}],"container-title":["Journal of Inflammation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=77180","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=77180","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,29]],"date-time":"2021-12-29T10:10:24Z","timestamp":1640772624000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/protease-activated-receptors--key-regulators-of-inflammatory-bowel-dis-peer-reviewed-fulltext-article-JIR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":67,"URL":"https:\/\/doi.org\/10.2147\/jir.s335502","relation":{},"ISSN":["1178-7031"],"issn-type":[{"value":"1178-7031","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12]]}}}