{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T22:43:50Z","timestamp":1777416230673,"version":"3.51.4"},"reference-count":52,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JIR"],"DOI":"10.2147\/jir.s337559","type":"journal-article","created":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T11:05:08Z","timestamp":1641207908000},"page":"1-15","source":"Crossref","is-referenced-by-count":12,"title":["Associations Among Disseminated Intravascular Coagulation, Thrombocytopenia Cytokines\/Chemokines and Genetic Polymorphisms of Toll-Like Receptor 2\/4 in Chinese Patients with Sepsis"],"prefix":"10.2147","volume":"Volume 15","author":[{"given":"Shaowei","family":"Jiang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Connor","family":"Meaney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy Evan","family":"Moore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuming","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6867-8024","authenticated-orcid":true,"given":"Chengjin","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2022,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1001\/jama.2016.0287","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"5376","DOI":"10.3390\/ijms20215376","volume":"20","author":"Huang","year":"2019","journal-title":"Int J Mol Sci"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"2204","DOI":"10.3389\/fimmu.2019.02204","volume":"10","author":"Guo","year":"2019","journal-title":"Front Immunol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"3062","DOI":"10.1182\/blood-2015-11-680744","volume":"127","author":"Claushuis","year":"2016","journal-title":"Blood"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1182\/blood.2020007214","volume":"136","author":"Manne","year":"2020","journal-title":"Blood"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1111\/jth.14848","volume":"18","author":"Yang","year":"2020","journal-title":"J Thromb Haemost"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1093\/gerona\/glu082","volume":"70","author":"Rondina","year":"2015","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"e75","DOI":"10.1097\/CCM.0000000000000853","volume":"43","author":"van den Boogaard","year":"2015","journal-title":"Crit Care Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"3781","DOI":"10.1182\/blood-2014-05-573915","volume":"124","author":"de Stoppelaar","year":"2014","journal-title":"Blood"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"121","DOI":"10.3389\/fmed.2018.00121","volume":"5","author":"Hottz","year":"2018","journal-title":"Front Med"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"271","DOI":"10.3389\/fimmu.2016.00271","volume":"7","author":"Carestia","year":"2016","journal-title":"Front Immunol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1055\/s-0033-1343894","volume":"39","author":"Levi","year":"2013","journal-title":"Semin Thromb Hemost"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"9605894","DOI":"10.1155\/2017\/9605894","volume":"2017","author":"Vallance","year":"2017","journal-title":"Mediators Inflamm"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"e1006385","DOI":"10.1371\/journal.ppat.1006385","volume":"13","author":"Trugilho","year":"2017","journal-title":"PLoS Pathog"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1161\/CIRCGENETICS.113.000398","volume":"7","author":"Ding","year":"2014","journal-title":"Circ Cardiovasc Genet"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"S2","DOI":"10.1053\/j.seminhematol.2016.04.002","volume":"53","author":"Kapur","year":"2016","journal-title":"Semin Hematol"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"83","DOI":"10.3389\/fimmu.2015.00083","volume":"6","author":"Cognasse","year":"2015","journal-title":"Front Immunol"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1182\/blood-2005-06-2202","volume":"107","author":"Aslam","year":"2006","journal-title":"Blood"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1518","DOI":"10.1016\/j.intimp.2009.09.006","volume":"9","author":"Funayama","year":"2009","journal-title":"Int Immunopharmacol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"e12771","DOI":"10.1111\/sji.12771","volume":"90","author":"Mukherjee","year":"2019","journal-title":"Scand J Immunol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1038\/nrrheum.2016.61","volume":"12","author":"Joosten","year":"2016","journal-title":"Nat Rev Rheumatol"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"1661","DOI":"10.1093\/clinchem\/48.10.1661","volume":"48","author":"Schmitt","year":"2002","journal-title":"Clin Chem"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"3495","DOI":"10.4049\/jimmunol.181.5.3495","volume":"181","author":"Shashkin","year":"2008","journal-title":"J Immunol"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"3572","DOI":"10.1182\/blood-2005-12-4811","volume":"107","author":"Patrignani","year":"2006","journal-title":"Blood"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1097\/01.CCM.0000202209.42491.38","volume":"34","author":"Gando","year":"2006","journal-title":"Crit Care Med"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1055\/s-0037-1616068","volume":"86","author":"Taylor","year":"2001","journal-title":"Thromb Haemost"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1097\/00003246-199811000-00016","volume":"26","author":"Vincent","year":"1998","journal-title":"Crit Care Med"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1097\/00003246-198510000-00009","volume":"13","author":"Knaus","year":"1985","journal-title":"Crit Care Med"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1016\/j.ajem.2019.10.023","volume":"38","author":"Huang","year":"2020","journal-title":"Am J Emerg Med"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1038\/nri3345","volume":"13","author":"Engelmann","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.thromres.2016.11.007","volume":"149","author":"Levi","year":"2017","journal-title":"Thromb Res"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/j.it.2004.07.003","volume":"25","author":"Weyrich","year":"2004","journal-title":"Trends Immunol"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.it.2004.02.006","volume":"25","author":"Romagnani","year":"2004","journal-title":"Trends Immunol"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1097\/00062752-200303000-00009","volume":"10","author":"McIntyre","year":"2003","journal-title":"Curr Opin Hematol"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1161\/01.CIR.0000028590.02477.6F","volume":"106","author":"Schober","year":"2002","journal-title":"Circulation"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1046\/j.1365-3148.2001.00340.x","volume":"11","author":"Boehlen","year":"2001","journal-title":"Transfus Med"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1111\/j.1365-2141.2010.08292.x","volume":"151","author":"Berthet","year":"2010","journal-title":"Br J Haematol"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1152\/japplphysiol.01576.2005","volume":"102","author":"Jayachandran","year":"2007","journal-title":"J Appl Physiol"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"2417","DOI":"10.1182\/blood-2005-03-0916","volume":"106","author":"Andonegui","year":"2005","journal-title":"Blood"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1038\/nm1565","volume":"13","author":"Clark","year":"2007","journal-title":"Nat Med"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1038\/ni.1863","volume":"11","author":"Kawai","year":"2010","journal-title":"Nat Immunol"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.intimp.2018.03.002","volume":"59","author":"Vijay","year":"2018","journal-title":"Int Immunopharmacol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1161\/CIRCRESAHA.108.185785","volume":"104","author":"Blair","year":"2009","journal-title":"Circ Res"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"5963","DOI":"10.1182\/blood-2010-09-304949","volume":"117","author":"Beaulieu","year":"2011","journal-title":"Blood"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"866","DOI":"10.3390\/ijms21030866","volume":"21","author":"Szil\u00e1gyi","year":"2020","journal-title":"Int J Mol Sci"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1182\/blood.2019000067","volume":"134","author":"Middleton","year":"2019","journal-title":"Blood"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1186\/s13054-015-1130-3","volume":"19","author":"Gao","year":"2015","journal-title":"Crit Care"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1111\/apm.12734","volume":"125","author":"Smeland","year":"2017","journal-title":"APMIS"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.imlet.2013.07.002","volume":"153","author":"Rodriguez-Osorio","year":"2013","journal-title":"Immunol Lett"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"322","DOI":"10.4049\/jimmunol.177.1.322","volume":"177","author":"Rallabhandi","year":"2006","journal-title":"J Immunol"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"25163","DOI":"10.1074\/jbc.M111.338426","volume":"287","author":"Sato","year":"2012","journal-title":"J Biol Chem"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1186\/1479-5876-12-177","volume":"12","author":"Mansur","year":"2014","journal-title":"J Transl Med"}],"container-title":["Journal of Inflammation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=77298","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=77298","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T11:05:13Z","timestamp":1641207913000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/associations-among-disseminated-intravascular-coagulation-thrombocytop-peer-reviewed-fulltext-article-JIR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":52,"URL":"https:\/\/doi.org\/10.2147\/jir.s337559","relation":{},"ISSN":["1178-7031"],"issn-type":[{"value":"1178-7031","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]}}}