{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T13:18:11Z","timestamp":1788268691698,"version":"build-2803163510"},"reference-count":50,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JIR"],"DOI":"10.2147\/jir.s338815","type":"journal-article","created":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T17:00:20Z","timestamp":1639414820000},"page":"6857-6869","source":"Crossref","is-referenced-by-count":20,"title":["Modulation of Sirt1-mTORC1 Pathway in Microglia Attenuates Retinal Ganglion Cell Loss After Optic Nerve Injury"],"prefix":"10.2147","volume":"Volume 14","author":[{"given":"Qianxue","family":"Mou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4338-0341","authenticated-orcid":true,"given":"Ke","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bowen","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotong","family":"Lou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huixia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1470-7184","authenticated-orcid":true,"given":"Yin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2021,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"16067","DOI":"10.1038\/nrdp.2016.67","volume":"2","author":"Weinreb","year":"2016","journal-title":"Nature Reviews. Disease Primers"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1016\/j.mayocp.2020.03.018","volume":"95","author":"Shah","year":"2020","journal-title":"Mayo Clin proc"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1146\/annurev-vision-022720-094953","volume":"6","author":"Williams","year":"2020","journal-title":"Ann Rev Vision Sci"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/0166-2236(96)10045-X","volume":"19","author":"Ransom","year":"1996","journal-title":"Trends Neurosci"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/S1350-9462(99)00010-5","volume":"19","author":"Dezawa","year":"2000","journal-title":"Prog Retin Eye Res"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"100886","DOI":"10.1016\/j.preteyeres.2020.100886","volume":"81","author":"Yazdankhah","year":"2021","journal-title":"Prog Retin Eye Res"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1016\/j.neuron.2012.03.026","volume":"74","author":"Schafer","year":"2012","journal-title":"Neuron"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1975","DOI":"10.3389\/fimmu.2019.01975","volume":"10","author":"Rashid","year":"2019","journal-title":"Front Immunol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1038\/nn1997","volume":"10","author":"Hanisch","year":"2007","journal-title":"Nat Neurosci"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1038\/cdd.2017.141","volume":"25","author":"Huang","year":"2018","journal-title":"Cell Death Differ"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1007\/s11064-020-02984-6","volume":"45","author":"Cai","year":"2020","journal-title":"Neurochem Res"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"610788","DOI":"10.3389\/fnins.2021.610788","volume":"15","author":"Zhao","year":"2021","journal-title":"Front Neurosci"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/j.neuron.2020.08.002","volume":"108","author":"Cheadle","year":"2020","journal-title":"Neuron"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1126\/sciadv.abc4898","volume":"7","author":"Zarb","year":"2021","journal-title":"Sci Adv"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1016\/j.tins.2021.06.007","volume":"44","author":"Guerrero","year":"2021","journal-title":"Trends Neurosci"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1038\/s41582-020-00435-y","volume":"17","author":"Leng","year":"2021","journal-title":"Nature Reviews. Neurology"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"693051","DOI":"10.3389\/fcimb.2021.693051","volume":"11","author":"Wan","year":"2021","journal-title":"Front Cell Infect Microbiol"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"8152373","DOI":"10.1155\/2018\/8152373","volume":"2018","author":"Gomes","year":"2018","journal-title":"Oxidative Medicine and Cellular Longevity"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"40364","DOI":"10.1074\/jbc.M509329200","volume":"280","author":"Chen","year":"2005","journal-title":"J Biol Chem"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1523\/JNEUROSCI.2939-14.2015","volume":"35","author":"Cho","year":"2015","journal-title":"The Journal of Neuroscience: The Official Journal of the Society for Neuroscience"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.semcancer.2019.07.003","volume":"59","author":"Murugan","year":"2019","journal-title":"Semin Cancer Biol"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1016\/j.cellsig.2009.01.012","volume":"21","author":"Dunlop","year":"2009","journal-title":"Cell Signal"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"13132","DOI":"10.1074\/jbc.M113.520734","volume":"289","author":"Hong","year":"2014","journal-title":"J Biol Chem"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1053\/j.gastro.2013.11.008","volume":"146","author":"Yin","year":"2014","journal-title":"Gastroenterology"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"3001","DOI":"10.1210\/en.2019-00427","volume":"160","author":"Jin","year":"2019","journal-title":"Endocrinology"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"3979","DOI":"10.1038\/s41598-018-22361-2","volume":"8","author":"Giacci","year":"2018","journal-title":"Scientific Reports"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.exer.2011.02.008","volume":"92","author":"Galindo-Romero","year":"2011","journal-title":"Exp Eye Res"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"3860","DOI":"10.1167\/iovs.08-3267","volume":"50","author":"Nadal-Nicol\u00e1s","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"6095","DOI":"10.1167\/iovs.15-17195","volume":"56","author":"Nadal-Nicol\u00e1s","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1186\/s12974-017-0982-7","volume":"14","author":"Nadal-Nicol\u00e1s","year":"2017","journal-title":"J Neuroinflammation"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.1002\/cne.23521","volume":"522","author":"Rodriguez","year":"2014","journal-title":"J Comp Neurol"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"2871","DOI":"10.1016\/j.devcel.2021.08.004","volume":"56","author":"Jecrois","year":"2021","journal-title":"Dev Cell"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"4487","DOI":"10.1167\/iovs.15-17145","volume":"56","author":"Rovere","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"2573","DOI":"10.1016\/j.neuron.2021.06.012","volume":"109","author":"Cao","year":"2021","journal-title":"Neuron"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.tins.2020.03.012","volume":"43","author":"Yu","year":"2020","journal-title":"Trends Neurosci"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1186\/s40478-018-0571-8","volume":"6","author":"Heuss","year":"2018","journal-title":"Acta Neuropathologica Communications"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.2147\/JIR.S299927","volume":"14","author":"Jing","year":"2021","journal-title":"J Inflamm Res"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1186\/s12974-015-0366-9","volume":"12","author":"Dagher","year":"2015","journal-title":"J Neuroinflammation"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1186\/s12974-018-1304-4","volume":"15","author":"Unger","year":"2018","journal-title":"J Neuroinflammation"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"3758","DOI":"10.1038\/s41467-019-11674-z","volume":"10","author":"Spangenberg","year":"2019","journal-title":"Nature Communications"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"104956","DOI":"10.1016\/j.nbd.2020.104956","volume":"142","author":"Casali","year":"2020","journal-title":"Neurobiol Dis"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"2960","DOI":"10.1523\/JNEUROSCI.2402-19.2020","volume":"40","author":"Henry","year":"2020","journal-title":"The Journal of Neuroscience: The Official Journal of the Society for Neuroscience"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1523\/JNEUROSCI.2469-20.2020","volume":"41","author":"Dziabis","year":"2021","journal-title":"J Neurosci"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"6113","DOI":"10.1523\/JNEUROSCI.0584-17.2017","volume":"37","author":"Hilla","year":"2017","journal-title":"The Journal of Neuroscience: The Official Journal of the Society for Neuroscience"},{"key":"ref45","doi-asserted-by":"crossref","unstructured":"Vessey KA, Waugh M, Jobling AI, et al. Assessment of Retinal Function and Morphology in Aging Ccl2 Knockout Mice. Invest Ophthalmol Vis Sci. 2015;56(2):1238\u20131252. doi:10.1167\/iovs.14-15334","DOI":"10.1167\/iovs.14-15334"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"eaap8492","DOI":"10.1126\/sciadv.aap8492","volume":"4","author":"Zhang","year":"2018","journal-title":"Science Advances"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"2366","DOI":"10.1002\/glia.23475","volume":"66","author":"Takeda","year":"2018","journal-title":"Glia"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1186\/s12974-018-1151-3","volume":"15","author":"Chen","year":"2018","journal-title":"J Neuroinflammation"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"2953","DOI":"10.3389\/fimmu.2019.02953","volume":"10","author":"Li","year":"2019","journal-title":"Front Immunol"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"e9199","DOI":"10.1371\/journal.pone.0009199","volume":"5","author":"Ghosh","year":"2010","journal-title":"PLoS One"}],"container-title":["Journal of Inflammation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=76728","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=76728","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T17:00:24Z","timestamp":1639414824000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/modulation-of-sirt1-mtorc1-pathway-in-microglia-attenuates-retinal-gan-peer-reviewed-fulltext-article-JIR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":50,"URL":"https:\/\/doi.org\/10.2147\/jir.s338815","relation":{},"ISSN":["1178-7031"],"issn-type":[{"value":"1178-7031","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12]]}}}