{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:43:52Z","timestamp":1791607432022,"version":"4.3.4"},"reference-count":48,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JIR"],"DOI":"10.2147\/jir.s356551","type":"journal-article","created":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T09:51:16Z","timestamp":1648720276000},"page":"2141-2156","source":"Crossref","is-referenced-by-count":40,"title":["Multi-Transcriptomic Analysis and Experimental Validation Implicate a Central Role of STAT3 in Skin Barrier Dysfunction Induced Aggravation of Rosacea"],"prefix":"10.2147","volume":"Volume 15","author":[{"given":"Yaling","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingxue","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangfan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sha","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongfu","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3644-3500","authenticated-orcid":true,"given":"Yiya","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2022,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.jaad.2017.06.150","volume":"78","author":"Gallo","year":"2018","journal-title":"J Am Acad Dermatol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1111\/1346-8138.15301","volume":"47","author":"Li","year":"2020","journal-title":"J Dermatol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.jaad.2017.08.037","volume":"78","author":"Gallo","year":"2018","journal-title":"J Am Acad Dermatol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1056\/NEJMcp1506630","volume":"377","author":"van Zuuren","year":"2017","journal-title":"N Engl J Med"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"adv00081","DOI":"10.2340\/00015555-3442","volume":"100","author":"Zuo","year":"2020","journal-title":"Acta Derm Venereol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1242\/jcs.033969","volume":"122","author":"Sandilands","year":"2009","journal-title":"J Cell Sci"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1517","DOI":"10.1016\/j.jaci.2020.04.024","volume":"145","author":"Celebi S\u00f6zener","year":"2020","journal-title":"J Allergy Clin Immunol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1111\/j.1365-2133.2004.05985.x","volume":"150","author":"Dirschka","year":"2004","journal-title":"Br J Dermatol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1111\/j.1365-2133.2011.10662.x","volume":"166","author":"Ni Raghallaigh","year":"2012","journal-title":"Br J Dermatol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1111\/1346-8138.14792","volume":"46","author":"Deng","year":"2019","journal-title":"J Dermatol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1938","DOI":"10.1016\/j.jid.2020.02.025","volume":"140","author":"Medgyesi","year":"2020","journal-title":"J Invest Dermatol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2021.09.012","author":"Ravipati","year":"2021","journal-title":"J Invest Dermatol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"2646","DOI":"10.1016\/j.jid.2021.05.033","volume":"141","author":"Dai","year":"2021","journal-title":"J Invest Dermatol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1016\/j.jid.2019.09.021","volume":"140","author":"Shih","year":"2020","journal-title":"J Invest Dermatol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"674871","DOI":"10.3389\/fimmu.2021.674871","volume":"12","author":"Deng","year":"2021","journal-title":"Front Immunol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1572","DOI":"10.1093\/bioinformatics\/btq170","volume":"26","author":"Wilkerson","year":"2010","journal-title":"Bioinformatics"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1038\/s41596-018-0103-9","volume":"14","author":"Reimand","year":"2019","journal-title":"Nat Protoc"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2020.102990","volume":"60","author":"Sun","year":"2020","journal-title":"E Bio Med"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1186\/s13059-017-1349-1","volume":"18","author":"Aran","year":"2017","journal-title":"Genome Biol"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbaa224","author":"Long","year":"2020","journal-title":"Brief Bioinform"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1016\/j.cell.2017.10.049","volume":"171","author":"Subramanian","year":"2017","journal-title":"Cell"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1038\/nm1616","volume":"13","author":"Yamasaki","year":"2007","journal-title":"Nat Med"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"e96801","DOI":"10.1371\/journal.pone.0096801","volume":"9","author":"Varghese","year":"2014","journal-title":"PLoS One"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"2198","DOI":"10.1038\/jid.2015.141","volume":"135","author":"Buhl","year":"2015","journal-title":"J Invest Dermatol"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1046\/j.1468-3083.2001.00331.x","volume":"15","author":"Georgala","year":"2001","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"S170","DOI":"10.1016\/j.jid.2019.09.021","volume":"139","author":"Shih","year":"2019","journal-title":"J Invest Dermatol"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1080\/14656566.2018.1447562","volume":"19","author":"Sahni","year":"2018","journal-title":"Expert Opin Pharmacother"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.1038\/s41564-021-00968-y","volume":"6","author":"Ojha","year":"2021","journal-title":"Nat Microbiol"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1007\/s12011-021-02722-1","volume":"200","author":"Oyagbemi","year":"2022","journal-title":"Biol Trace Elem Res"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"958","DOI":"10.3390\/biology10100958","volume":"10","author":"Saeed","year":"2021","journal-title":"Biology"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1111\/exd.12251","volume":"22","author":"Darlenski","year":"2013","journal-title":"Exp Dermatol"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1111\/j.1365-2133.2011.10590.x","volume":"165","author":"Powell","year":"2011","journal-title":"Br J Dermatol"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1038\/jid.2010.351","volume":"131","author":"Yamasaki","year":"2011","journal-title":"J Invest Dermatol"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1111\/j.1600-0560.2006.00695.x","volume":"34","author":"Gomaa","year":"2007","journal-title":"J Cutan Pathol"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1016\/j.jid.2016.12.025","volume":"137","author":"Dajnoki","year":"2017","journal-title":"J Invest Dermatol"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1885","DOI":"10.12688\/f1000research.16537.1","volume":"7","author":"Buddenkotte","year":"2018","journal-title":"F1000Res"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1111\/j.1346-8138.2002.tb00250.x","volume":"29","author":"Abul","year":"2002","journal-title":"J Dermatol"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.clim.2017.04.001","volume":"180","author":"Diani","year":"2017","journal-title":"Clin Immunol"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1111\/imr.12546","volume":"278","author":"Han","year":"2017","journal-title":"Immunol Rev"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1016\/j.jaci.2010.08.041","volume":"126","author":"Oyoshi","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1038\/s41419-019-1510-8","volume":"10","author":"Sun","year":"2019","journal-title":"Cell Death Dis"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"1838","DOI":"10.1038\/jid.2011.140","volume":"131","author":"Fridman","year":"2011","journal-title":"J Invest Dermatol"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1038\/nrd.2017.201","volume":"16","author":"Schwartz","year":"2017","journal-title":"Nat Rev Drug Discov"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"e2931","DOI":"10.1038\/cddis.2017.322","volume":"8","author":"Tsuji","year":"2017","journal-title":"Cell Death Dis"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19061654","volume":"19","author":"Hashimoto-Hachiya","year":"2018","journal-title":"Int J Mol Sci"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.jdermsci.2018.02.005","volume":"90","author":"Tsuji","year":"2018","journal-title":"J Dermatol Sci"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.jdermsci.2018.02.017","volume":"90","author":"Ryu","year":"2018","journal-title":"J Dermatol Sci"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/s13555-020-00461-0","volume":"11","author":"Zhang","year":"2021","journal-title":"Dermatol Ther"}],"container-title":["Journal of Inflammation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=79544","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=79544","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T09:51:19Z","timestamp":1648720279000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/multi-transcriptomic-analysis-and-experimental-validation-implicate-a--peer-reviewed-fulltext-article-JIR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":48,"URL":"https:\/\/doi.org\/10.2147\/jir.s356551","relation":{},"ISSN":["1178-7031"],"issn-type":[{"value":"1178-7031","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3]]}}}