{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T17:06:09Z","timestamp":1756573569954,"version":"3.40.5"},"reference-count":133,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JIR"],"DOI":"10.2147\/jir.s359887","type":"journal-article","created":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T10:22:24Z","timestamp":1650536544000},"page":"2583-2599","source":"Crossref","is-referenced-by-count":14,"title":["The Application of Extracellular Vesicles Mediated miRNAs in Osteoarthritis: Current Knowledge and Perspective"],"prefix":"10.2147","volume":"Volume 15","author":[{"given":"Xiaobin","family":"Shang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0231-6474","authenticated-orcid":true,"given":"Wenqiang","family":"Xin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongbo","family":"You","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2022,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.joca.2020.10.006","volume":"29","author":"van den Bosch","year":"2021","journal-title":"Osteoarthritis Cartilage"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1056\/NEJMcp1903768","volume":"384","author":"Sharma","year":"2021","journal-title":"N Engl J Med"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.maturitas.2016.04.006","volume":"89","author":"Kulkarni","year":"2016","journal-title":"Maturitas"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"463","DOI":"10.2174\/138161210790232167","volume":"16","author":"Fazio","year":"2010","journal-title":"Curr Pharm Des"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1038\/oby.2009.376","volume":"18","author":"Kushner","year":"2010","journal-title":"Obes Silver Spring Md"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.1016\/S0140-6736(19)30417-9","volume":"393","author":"Hunter","year":"2019","journal-title":"Lancet Lond Engl"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ijms22189887","volume":"22","author":"Shang","year":"2021","journal-title":"Int J Mol Sci"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1038\/s41584-020-00523-9","volume":"17","author":"Arden","year":"2021","journal-title":"Nat Rev Rheumatol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1503\/cmaj.121584","volume":"186","author":"Gandhi","year":"2014","journal-title":"CMAJ Can Med Assoc J"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1016\/j.jaci.2017.08.034","volume":"141","author":"Lu","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.gpb.2012.07.005","volume":"10","author":"Li","year":"2012","journal-title":"Genomics Proteomics Bioinformatics"},{"key":"ref12","first-page":"40","volume":"37","author":"Swingler","year":"2019","journal-title":"Clin Exp Rheumatol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"121","DOI":"10.11005\/jbm.2016.23.3.121","volume":"23","author":"Asahara","year":"2016","journal-title":"J Bone Metab"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1038\/ncb1596","volume":"9","author":"Valadi","year":"2007","journal-title":"Nat Cell Biol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"120467","DOI":"10.1016\/j.biomaterials.2020.120467","volume":"269","author":"Wu","year":"2021","journal-title":"Biomaterials"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1007\/s00223-021-00864-x","volume":"1","author":"Taheri","year":"2021","journal-title":"Calcif Tissue Int"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/jev2.12024","volume":"10","author":"Kuang","year":"2020","journal-title":"J Extracell Vesicles"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/j.jconrel.2011.11.021","volume":"161","author":"van Dommelen","year":"2012","journal-title":"J Control Release Off J Control Release Soc"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.2217\/nnm-2021-0047","volume":"16","author":"Zhang","year":"2021","journal-title":"Nanomed"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"4883","DOI":"10.1111\/jcmm.16290","volume":"25","author":"Song","year":"2021","journal-title":"J Cell Mol Med"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/cells10061287","volume":"10","author":"Mohd Noor","year":"2021","journal-title":"Cells"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1097\/BOR.0000000000000471","volume":"30","author":"Hammaker","year":"2018","journal-title":"Curr Opin Rheumatol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"255","DOI":"10.2174\/1566523219666190716092203","volume":"19","author":"Wu","year":"2019","journal-title":"Curr Gene Ther"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1836","DOI":"10.1093\/bib\/bby054","volume":"20","author":"Chen","year":"2019","journal-title":"Brief Bioinform"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"6749","DOI":"10.2147\/IJN.S327059","volume":"16","author":"Ng","year":"2021","journal-title":"Int J Nanomed"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1146\/annurev-cellbio-101512-122326","volume":"30","author":"Colombo","year":"2014","journal-title":"Annu Rev Cell Dev Biol"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/s41556-018-0250-9","volume":"21","author":"Mathieu","year":"2019","journal-title":"Nat Cell Biol"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"E307","DOI":"10.3390\/cells8040307","volume":"8","author":"Gurunathan","year":"2019","journal-title":"Cells"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"26913","DOI":"10.3402\/jev.v3.26913","volume":"3","author":"L\u00f6tvall","year":"2014","journal-title":"J Extracell Vesicles"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"1535750","DOI":"10.1080\/20013078.2018.1535750","volume":"7","author":"Th\u00e9ry","year":"2018","journal-title":"J Extracell Vesicles"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1186\/s13287-018-1069-9","volume":"9","author":"Qiu","year":"2018","journal-title":"Stem Cell Res. Ther"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"7309","DOI":"10.4049\/jimmunol.166.12.7309","volume":"166","author":"Th\u00e9ry","year":"2001","journal-title":"J Immunol"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.semcdb.2015.02.010","volume":"40","author":"Minciacchi","year":"2015","journal-title":"Semin Cell Dev Biol"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"575057","DOI":"10.3389\/fbioe.2020.575057","volume":"8","author":"Zhao","year":"2020","journal-title":"Front Bioeng Biotechnol"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1089\/ten.TEB.2019.0326","volume":"27","author":"Tan","year":"2021","journal-title":"Tissue Eng Part B Rev"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1136\/annrheumdis-2018-213882","volume":"78","author":"de Almeida","year":"2019","journal-title":"Ann Rheum Dis"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"R163","DOI":"10.1186\/ar4679","volume":"16","author":"Kato","year":"2014","journal-title":"Arthritis Res Ther"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1080\/14397595.2019.1651445","volume":"30","author":"Gao","year":"2020","journal-title":"Mod Rheumatol"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1007\/5584_2021_625","volume":"12","author":"Taghiyar","year":"2021","journal-title":"Adv Exp Med Biol"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1038\/s41419-019-1739-2","volume":"10","author":"Ni","year":"2019","journal-title":"Cell Death Dis"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1136\/annrheumdis-2020-218089","volume":"413","author":"Hu","year":"2020","journal-title":"Ann Rheum Dis"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.2174\/0929867327666201118161232","author":"Duan","year":"2020","journal-title":"Curr Med Chem"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"9195","DOI":"10.1093\/nar\/gku594","volume":"42","author":"Goldie","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1038\/s41598-018-19581-x","volume":"8","author":"Ferguson","year":"2018","journal-title":"Sci Rep"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"C155","DOI":"10.1152\/ajpcell.00017.2019","volume":"317","author":"Borgovan","year":"2019","journal-title":"Am J Physiol Cell Physiol"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"5109","DOI":"10.1039\/c7tb01020f","volume":"5","author":"Li","year":"2017","journal-title":"J Mater Chem B"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.actbio.2020.12.034","volume":"122","author":"Rong","year":"2021","journal-title":"Acta Biomater"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"E1926","DOI":"10.3390\/ijms19071926","volume":"19","author":"Damia","year":"2018","journal-title":"Int J Mol Sci"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.3390\/cells10051072","volume":"10","author":"Ragni","year":"2021","journal-title":"Cells"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.actbio.2021.04.003","volume":"128","author":"Yang","year":"2021","journal-title":"Acta Biomater"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"119682","DOI":"10.1016\/j.biomaterials.2019.119682","volume":"231","author":"Jing","year":"2020","journal-title":"Biomaterials"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.biomaterials.2017.11.028","volume":"156","author":"Zhang","year":"2018","journal-title":"Biomaterials"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1002\/sctm.20-0390","volume":"10","author":"Ragni","year":"2021","journal-title":"Stem Cells Transl Med"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1016\/j.omtn.2020.09.014","volume":"22","author":"Wang","year":"2020","journal-title":"Mol Ther Nucleic Acids"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.biomaterials.2019.03.022","volume":"206","author":"Wu","year":"2019","journal-title":"Biomaterials"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"5475","DOI":"10.1111\/jcmm.14430","volume":"23","author":"Wang","year":"2019","journal-title":"J Cell Mol Med"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1186\/s13578-020-00427-x","volume":"10","author":"Cai","year":"2020","journal-title":"Cell Biosci"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1186\/s13287-021-02317-6","volume":"12","author":"Li","year":"2021","journal-title":"Stem Cell Res Ther"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"4455","DOI":"10.1016\/j.bioactmat.2021.04.031","volume":"6","author":"Tao","year":"2021","journal-title":"Bioact Mater"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"118987","DOI":"10.1016\/j.lfs.2020.118987","volume":"269","author":"Qiu","year":"2021","journal-title":"Life Sci"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1186\/s13075-020-02325-6","volume":"22","author":"Chen","year":"2020","journal-title":"Arthritis Res Ther"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"10855","DOI":"10.1111\/jcmm.15714","volume":"24","author":"Qiu","year":"2020","journal-title":"J Cell Mol Med"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1186\/s13287-020-01677-9","volume":"11","author":"Ragni","year":"2020","journal-title":"Stem Cell Res Ther"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"1881","DOI":"10.3892\/mmr.2020.10982","volume":"21","author":"Zhao","year":"2020","journal-title":"Mol Med Rep"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"105946","DOI":"10.1016\/j.intimp.2019.105946","volume":"78","author":"Jin","year":"2020","journal-title":"Int Immunopharmacol"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1186\/s13287-019-1341-7","volume":"10","author":"Luo","year":"2019","journal-title":"Stem Cell Res Ther"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1002\/jcb.27289","volume":"120","author":"Sun","year":"2019","journal-title":"J Cell Biochem"},{"key":"ref68","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2018.1556063","volume":"17","author":"Wang","year":"2018","journal-title":"Cell Cycle Georget Tex"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"180","DOI":"10.7150\/thno.17133","volume":"7","author":"Tao","year":"2017","journal-title":"Theranostics"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.jot.2019.10.012","volume":"21","author":"Wu","year":"2020","journal-title":"J Orthop Transl"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"13282","DOI":"10.3390\/ijms222413282","volume":"22","author":"Shang","year":"2021","journal-title":"Int J Mol Sci"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1111\/nyas.14590","volume":"1503","author":"Peng","year":"2021","journal-title":"Ann N Y Acad Sci"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41420-021-00418-y","volume":"7","author":"Zhou","year":"2021","journal-title":"Cell Death Discov"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"251","DOI":"10.3390\/cells10020251","volume":"10","author":"Wu","year":"2021","journal-title":"Cells"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"C21","DOI":"10.1152\/ajpcell.00039.2020","volume":"319","author":"Dai","year":"2020","journal-title":"Am J Physiol Cell Physiol"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1016\/j.bbrc.2019.12.065","volume":"523","author":"Li","year":"2020","journal-title":"Biochem Biophys Res Commun"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"5354","DOI":"10.1111\/jcmm.13808","volume":"22","author":"Mao","year":"2018","journal-title":"J Cell Mol Med"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1016\/j.joca.2019.04.010","volume":"27","author":"Hecht","year":"2019","journal-title":"Osteoarthritis Cartilage"},{"key":"ref79","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1113\/JP279810","volume":"599","author":"Stadnik","year":"2021","journal-title":"J Physiol"},{"key":"ref80","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s13075-017-1229-9","volume":"19","author":"Mathiessen","year":"2017","journal-title":"Arthritis Res Ther"},{"key":"ref81","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1016\/j.joca.2014.05.023","volume":"22","author":"Yuan","year":"2014","journal-title":"Osteoarthritis Cartilage"},{"key":"ref82","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1002\/jor.20883","volume":"27","author":"Pan","year":"2009","journal-title":"J Orthop Res"},{"key":"ref83","doi-asserted-by":"publisher","first-page":"16214","DOI":"10.1038\/s41598-017-15376-8","volume":"7","author":"Cosenza","year":"2017","journal-title":"Sci Rep"},{"key":"ref84","doi-asserted-by":"publisher","first-page":"2271","DOI":"10.3390\/cells9102271","volume":"9","author":"Munir","year":"2020","journal-title":"Cells"},{"key":"ref85","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.coph.2018.03.009","volume":"40","author":"De Bari","year":"2018","journal-title":"Curr Opin Pharmacol"},{"key":"ref86","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1002\/sctm.17-0260","volume":"7","author":"Hawkins","year":"2018","journal-title":"Stem Cells Transl Med"},{"key":"ref87","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1002\/stem.2557","volume":"35","author":"Ragni","year":"2017","journal-title":"STEM CELLS"},{"key":"ref88","doi-asserted-by":"publisher","first-page":"4150705","DOI":"10.1155\/2017\/4150705","volume":"2017","author":"Shao","year":"2017","journal-title":"Bio Med Res Int"},{"key":"ref89","doi-asserted-by":"publisher","first-page":"6917","DOI":"10.2147\/IJN.S264498","volume":"15","author":"Zhang","year":"2020","journal-title":"Int J Nanomedicine"},{"key":"ref90","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1038\/s41598-020-57497-7","volume":"10","author":"Brennan","year":"2020","journal-title":"Sci Rep"},{"key":"ref91","doi-asserted-by":"publisher","first-page":"29975","DOI":"10.3402\/jev.v5.29975","volume":"5","author":"Koliha","year":"2016","journal-title":"J Extracell Vesicles"},{"key":"ref92","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1039\/b916199f","volume":"10","author":"Chen","year":"2010","journal-title":"Lab Chip"},{"key":"ref93","doi-asserted-by":"publisher","first-page":"32945","DOI":"10.3402\/jev.v5.32945","volume":"5","author":"Gardiner","year":"2016","journal-title":"J Extracell Vesicles"},{"key":"ref94","doi-asserted-by":"publisher","first-page":"E1955","DOI":"10.3390\/cells9091955","volume":"9","author":"Royo","year":"2020","journal-title":"Cells"},{"key":"ref95","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1007\/s00018-020-03585-w","volume":"78","author":"Esmaeili","year":"2021","journal-title":"Cell Mol Life Sci CMLS"},{"key":"ref96","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1186\/1471-2164-15-303","volume":"15","author":"Hu","year":"2014","journal-title":"BMC Genomics"},{"key":"ref97","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1126\/science.1215157","volume":"336","author":"Johnson","year":"2012","journal-title":"Science"},{"key":"ref98","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1534\/genetics.111.136689","volume":"190","author":"Szuplewski","year":"2012","journal-title":"Genetics"},{"key":"ref99","doi-asserted-by":"publisher","first-page":"340","DOI":"10.3389\/fgene.2015.00340","volume":"6","author":"Jin","year":"2015","journal-title":"Front Genet"},{"key":"ref100","doi-asserted-by":"publisher","first-page":"e55214","DOI":"10.1371\/journal.pone.0055214","volume":"8","author":"Thomson","year":"2013","journal-title":"PLoS One"},{"key":"ref101","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1038\/ni1575","volume":"9","author":"Xiao","year":"2008","journal-title":"Nat Immunol"},{"key":"ref102","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1038\/ni.2648","volume":"14","author":"Kang","year":"2013","journal-title":"Nat Immunol"},{"key":"ref103","doi-asserted-by":"publisher","first-page":"2377","DOI":"10.1038\/emboj.2013.178","volume":"32","author":"Jin","year":"2013","journal-title":"EMBO J"},{"key":"ref104","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1186\/s13287-020-01594-x","volume":"11","author":"Wang","year":"2020","journal-title":"Stem Cell Res Ther"},{"key":"ref105","doi-asserted-by":"publisher","first-page":"19861","DOI":"10.3402\/jev.v2i0.19861","volume":"2","author":"Webber","year":"2013","journal-title":"J Extracell Vesicles"},{"key":"ref106","doi-asserted-by":"publisher","first-page":"383","DOI":"10.2217\/bmm-2017-0458","volume":"12","author":"Paolini","year":"2018","journal-title":"Biomark Med"},{"key":"ref107","doi-asserted-by":"publisher","first-page":"120539","DOI":"10.1016\/j.biomaterials.2020.120539","volume":"269","author":"Xu","year":"2021","journal-title":"Biomaterials"},{"key":"ref108","doi-asserted-by":"publisher","first-page":"237","DOI":"10.7150\/thno.21945","volume":"8","author":"He","year":"2018","journal-title":"Theranostics"},{"key":"ref109","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1038\/mt.2012.180","volume":"21","author":"Ohno","year":"2013","journal-title":"Mol Ther J Am Soc Gene Ther"},{"key":"ref110","doi-asserted-by":"publisher","first-page":"e0194288","DOI":"10.1371\/journal.pone.0194288","volume":"13","author":"Kim","year":"2018","journal-title":"PLoS One"},{"key":"ref111","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1186\/s13287-020-01781-w","volume":"11","author":"He","year":"2020","journal-title":"Stem Cell Res Ther"},{"key":"ref112","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.biomaterials.2019.02.006","volume":"200","author":"Zhang","year":"2019","journal-title":"Biomaterials"},{"key":"ref113","doi-asserted-by":"publisher","first-page":"119544","DOI":"10.1016\/j.biomaterials.2019.119544","volume":"226","author":"Ruiz","year":"2020","journal-title":"Biomaterials"},{"key":"ref114","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1177\/0300985815588611","volume":"52","author":"McCoy","year":"2015","journal-title":"Vet Pathol"},{"key":"ref115","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1208\/s12248-013-9454-x","volume":"15","author":"Teeple","year":"2013","journal-title":"AAPS J"},{"key":"ref116","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.joca.2012.01.017","volume":"20","author":"Little","year":"2012","journal-title":"Osteoarthritis Cartilage"},{"key":"ref117","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/j.knee.2011.07.005","volume":"19","author":"Proffen","year":"2012","journal-title":"Knee"},{"key":"ref118","doi-asserted-by":"publisher","first-page":"13","DOI":"10.2147\/ORR.S38400","volume":"2013","author":"Pedersen","year":"2013","journal-title":"Orthop Res Rev"},{"key":"ref119","doi-asserted-by":"publisher","first-page":"621","DOI":"10.2217\/thy.10.75","volume":"7","author":"Pelletier","year":"2010","journal-title":"Therapy"},{"key":"ref120","doi-asserted-by":"publisher","first-page":"1735249","DOI":"10.1080\/20013078.2020.1735249","volume":"9","author":"Woo","year":"2020","journal-title":"J Extracell Vesicles"},{"key":"ref121","doi-asserted-by":"publisher","first-page":"E6466","DOI":"10.3390\/ijms21186466","volume":"21","author":"Sidhom","year":"2020","journal-title":"Int J Mol Sci"},{"key":"ref122","doi-asserted-by":"publisher","first-page":"14888","DOI":"10.1073\/pnas.1408301111","volume":"111","author":"Chevillet","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref123","doi-asserted-by":"publisher","first-page":"1703244","DOI":"10.1080\/20013078.2019.1703244","volume":"9","author":"Catalano","year":"2020","journal-title":"J Extracell Vesicles"},{"key":"ref124","doi-asserted-by":"publisher","first-page":"e0221679","DOI":"10.1371\/journal.pone.0221679","volume":"14","author":"Zeh","year":"2019","journal-title":"PLoS One"},{"key":"ref125","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1038\/s41598-018-19211-6","volume":"8","author":"Cha","year":"2018","journal-title":"Sci Rep"},{"key":"ref126","doi-asserted-by":"publisher","first-page":"1528109","DOI":"10.1080\/20013078.2018.1528109","volume":"7","author":"Ludwig","year":"2018","journal-title":"J Extracell Vesicles"},{"key":"ref127","doi-asserted-by":"publisher","first-page":"23743","DOI":"10.3402\/jev.v3.23743","volume":"3","author":"Cheng","year":"2014","journal-title":"J Extracell Vesicles"},{"key":"ref128","doi-asserted-by":"publisher","first-page":"2666","DOI":"10.3390\/ijms22052666","volume":"22","author":"Maehara","year":"2021","journal-title":"Int J Mol Sci"},{"key":"ref129","doi-asserted-by":"publisher","first-page":"2029","DOI":"10.1038\/s41598-017-01905-y","volume":"7","author":"Kolhe","year":"2017","journal-title":"Sci Rep"},{"key":"ref130","doi-asserted-by":"publisher","first-page":"273","DOI":"10.2217\/nnm-2019-0208","volume":"15","author":"Liu","year":"2020","journal-title":"Nanomed"},{"key":"ref131","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/s10616-018-0264-y","volume":"71","author":"Xu","year":"2019","journal-title":"Cytotechnology"},{"key":"ref132","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1038\/s41419-020-02945-5","volume":"11","author":"Bai","year":"2020","journal-title":"Cell Death Dis"},{"key":"ref133","doi-asserted-by":"publisher","first-page":"1498","DOI":"10.1007\/s10753-020-01227-8","volume":"43","author":"Tan","year":"2020","journal-title":"Inflammation"}],"container-title":["Journal of Inflammation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=80179","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=80179","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T10:22:27Z","timestamp":1650536547000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/the-application-of-extracellular-vesicles-mediated-mirnas-in-osteoarth-peer-reviewed-fulltext-article-JIR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":133,"URL":"https:\/\/doi.org\/10.2147\/jir.s359887","relation":{},"ISSN":["1178-7031"],"issn-type":[{"type":"electronic","value":"1178-7031"}],"subject":[],"published":{"date-parts":[[2022,4]]}}}