{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T06:06:46Z","timestamp":1785564406942,"version":"3.56.0"},"reference-count":74,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JIR"],"DOI":"10.2147\/jir.s383441","type":"journal-article","created":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T12:05:07Z","timestamp":1672401907000},"page":"6905-6921","source":"Crossref","is-referenced-by-count":15,"title":["Corosolic Acid Inhibits Secretory Phospholipase A2IIa as an Anti-Inflammatory Function and Exhibits Anti-Tumor Activity in Ehrlich Ascites Carcinoma Bearing Mice"],"prefix":"10.2147","volume":"Volume 15","author":[{"given":"Sophiya","family":"Pundalik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishna Ram","family":"Hanumappa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aladahalli S","family":"Giresha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6161-2567","authenticated-orcid":true,"given":"Deepadarshan","family":"Urs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6126-9578","authenticated-orcid":true,"given":"Sharath","family":"Rajashekarappa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narayanappa","family":"Muniyappa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manjunatha","family":"Jamballi G","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devaraju","family":"Kuaramkote Shivanna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajkumar","family":"S Meti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sathisha","family":"Anekere Dasappa Setty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prabhakar Bettadathunga\u200b","family":"Thippegowda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dharmappa Kattepura","family":"Krishnappa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2022,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"121","DOI":"10.4103\/aam.aam_56_18","volume":"18","author":"Singh","year":"2019","journal-title":"Ann Afr Med"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1158\/1078-0432.CCR-08-0149","volume":"15","author":"Aggarwal","year":"2009","journal-title":"Clin Cancer Res"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/S0952-7915(02)00315-1","volume":"2","author":"Dranoff","year":"2002","journal-title":"Curr Opin Immunol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1038\/nri774","volume":"2","author":"Pardoll","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1002\/jso.2930240119","volume":"24","author":"Waddell","year":"1983","journal-title":"J Surg Oncol"},{"key":"ref6","first-page":"559","volume":"13","author":"Harris","year":"2005","journal-title":"Oncol Rep"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"29","DOI":"10.4255\/mcpharmacol.09.05","volume":"1","author":"Rayburn","year":"2009","journal-title":"Mol Cell Pharmacol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1158\/1940-6207.CAPR-16-0209","volume":"9","author":"Todoric","year":"2016","journal-title":"Cancer Prev Res"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"17381","DOI":"10.1016\/S0021-9258(18)38167-5","volume":"265","author":"Prescott","year":"1990","journal-title":"J Biol Chem"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1164\/ajrccm.155.2.9032172","volume":"155","author":"Bowton","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.prostaglandins.2005.10.005","volume":"79","author":"Menschikowski","year":"2006","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/j.biochi.2010.03.019","volume":"92","author":"Scott","year":"2010","journal-title":"Biochimie"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1517","DOI":"10.1093\/carcin\/bgh150","volume":"25","author":"Meyer","year":"2004","journal-title":"Carcinogenesis"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1038\/nrc2809","volume":"10","author":"Wang","year":"2010","journal-title":"Nat Rev Cancer"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1948","DOI":"10.1093\/carcin\/bgq188","volume":"31","author":"Dong","year":"2010","journal-title":"Carcinogenesis"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/S0398-0499(06)76511-8","volume":"31","author":"Hatmi","year":"2006","journal-title":"J Mal Vasc"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"734","DOI":"10.3390\/molecules27030734","volume":"27","author":"Nasir","year":"2022","journal-title":"Molecules"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"114147","DOI":"10.1016\/j.bcp.2020.114147","volume":"1","author":"Bindu","year":"2020","journal-title":"Biochem Pharmacol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.1172\/JCI13271","volume":"107","author":"Smith","year":"2001","journal-title":"J Clin Invest"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1146\/annurev.biochem.76.062405.154007","volume":"77","author":"Lambeau","year":"2008","journal-title":"Annu Rev Biochem"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s10557-008-6132-9","volume":"23","author":"Burke","year":"2009","journal-title":"Cardiovasc Drugs Ther"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1001\/jama.2013.282836","volume":"311","author":"Nicholls","year":"2014","journal-title":"JAMA"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.1097\/01.CCM.0000171540.54520.69","volume":"33","author":"Zeiher","year":"2005","journal-title":"Crit Care Med"},{"key":"ref24","first-page":"166","volume":"289","author":"Garcia-Pastor","year":"1999","journal-title":"J Pharmacol Exp Ther"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"546","DOI":"10.4103\/0250-474X.78519","volume":"72","author":"Gohil","year":"2010","journal-title":"Indian J Pharm Sci"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1248\/bpb.29.585","volume":"29","author":"Miura","year":"2006","journal-title":"Biol Pharm Bull"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1271\/bbb.68.85","volume":"68","author":"Banno","year":"2004","journal-title":"Biosci Biotechnol Biochem"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"2474","DOI":"10.1016\/j.lfs.2006.08.007","volume":"79","author":"Yamaguchi","year":"2006","journal-title":"Life Sci"},{"key":"ref29","first-page":"346","volume":"16","author":"Zong","year":"2007","journal-title":"Asia Pac J Clin Nutr"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13046-018-0889-x","volume":"37","author":"Ma","year":"2018","journal-title":"J Exp Clin Cancer Res"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1055\/s-0028-1088374","volume":"75","author":"Dharmappa","year":"2009","journal-title":"Planta Med"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"583","DOI":"10.2174\/1871520617666171020124916","volume":"18","author":"Niu","year":"2018","journal-title":"Anticancer Agents Med Chem"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/0041-0101(89)90136-0","volume":"27","author":"Kasturi","year":"1989","journal-title":"Toxicon"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1038\/227680a0","volume":"227","author":"Laemmli","year":"1970","journal-title":"nature"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"W363","DOI":"10.1093\/nar\/gky473","volume":"46","author":"Tian","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1126\/science.1948070","volume":"254","author":"Scott","year":"1991","journal-title":"Science"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"2785","DOI":"10.1002\/jcc.21256","volume":"30","author":"Morris","year":"2009","journal-title":"J Comput Chem"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1002\/jcc.21334","volume":"31","author":"Trott","year":"2010","journal-title":"J Comput Chem"},{"key":"ref39","first-page":"331","volume":"4","author":"Shastri","year":"2016","journal-title":"World J Pharm Res"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"239","DOI":"10.15171\/bi.2019.29","volume":"9","author":"Jinadatta","year":"2019","journal-title":"BioImpacts"},{"key":"ref41","first-page":"000118","volume":"1","author":"Shastri","year":"2017","journal-title":"Bioinform Proteom Opn Acc J"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/0005-2760(72)90211-1","volume":"280","author":"Patriarca","year":"1972","journal-title":"Biochim Biophys Acta"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"1906","DOI":"10.3390\/ijms23031906","volume":"23","author":"Pastwi\u0144ska","year":"2022","journal-title":"Int J Mol Sci"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"7734","DOI":"10.1016\/S0021-9258(19)43892-1","volume":"255","author":"Prigent-Dachary","year":"1980","journal-title":"J Biol Chem"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1016\/0006-3002(57)90256-1","volume":"Jan","author":"Boman","year":"1957","journal-title":"Biochim Biophys Acta"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/978-1-4684-0886-7_10","volume":"1","author":"Yamakawa","year":"1976","journal-title":"Animal Plant Microbial Toxins"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1016\/0041-0101(87)90155-3","volume":"25","author":"Vishwanath","year":"1987","journal-title":"Toxicon"},{"key":"ref48","first-page":"589","volume":"48","author":"Alley","year":"1988","journal-title":"Cancer Res"},{"key":"ref49","unstructured":"BD Biosciences . Product datasheet - FITC rabbit anti- active caspase-3 IgG Antibody - BD biosciences, catalogue no. 559341. Available from: https:\/\/www.bdbiosciences.com\/content\/dam\/bdb\/products\/global\/reagents\/flow-cytometry-reagents\/research-reagents\/single-color-antibodies-ruo\/559341_base\/pdf\/559341.pdf"},{"key":"ref50","first-page":"3309","volume":"93","author":"Dai","year":"1999","journal-title":"J Am Soc Hematol"},{"key":"ref51","first-page":"38","volume":"6","author":"Amidzadeh","year":"2014","journal-title":"Avicenna J Med Biotechnol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"143","DOI":"10.5099\/aj120200143","volume":"4","author":"Raihan","year":"2012","journal-title":"Am J Biomed Sci"},{"key":"ref53","unstructured":"BD Biosciences. BD Biosciences PE mouse anti-human IL-6 (Technical Data Sheet, Cat No: 340527). Available from: https:\/\/www.bdbiosciences.com\/content\/dam\/bdb\/products\/global\/reagents\/flow-cytometry-reagents\/clinical-discovery-research\/single-color-antibodies-ruo-gmp\/340527_base\/pdf\/23-3468.pdf"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/s11010-010-0561-z","volume":"345","author":"Mohamed","year":"2010","journal-title":"Mol Cell Biochem"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"2531","DOI":"10.2174\/156802611797633429","volume":"11","author":"Mohamed","year":"2011","journal-title":"Curr Top Med Chem"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"1973","DOI":"10.1039\/C5MB00073D","volume":"11","author":"Dileep","year":"2015","journal-title":"Mol Biosyst"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"2834","DOI":"10.3390\/molecules27092834","volume":"27","author":"Gnanaraj","year":"2022","journal-title":"Molecules"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2014\/726585","volume":"2014","author":"Toyama","year":"2014","journal-title":"Biomed Res Int"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"3904","DOI":"10.4049\/jimmunol.146.11.3904","volume":"146","author":"Bomalaski","year":"1991","journal-title":"J Immunol"},{"key":"ref60","first-page":"129","volume":"11","author":"Weichman","year":"1989","journal-title":"Int J Tissue React"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1007\/BF01965048","volume":"25","author":"Fawzy","year":"1988","journal-title":"Mech Action Agents Action"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"1472","DOI":"10.3390\/cells10061472","volume":"10","author":"Vecchi","year":"2021","journal-title":"Cells"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12935-021-02091-8","volume":"21","author":"Javed","year":"2021","journal-title":"Cancer Cell Int"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/S2225-4110(16)30082-7","volume":"2","author":"Lee","year":"2012","journal-title":"J Tradit Complement Med"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.fct.2014.02.019","volume":"1","author":"Kim","year":"2014","journal-title":"Food Chem"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1002\/mnfr.201200610","volume":"57","author":"Horlad","year":"2013","journal-title":"Mol Nutr Food Res"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1002\/ptr.5306","volume":"29","author":"Yoo","year":"2015","journal-title":"Phytotherapy Res"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"153696","DOI":"10.1016\/j.phymed.2021.153696","volume":"1","author":"Qian","year":"2021","journal-title":"Phytomedicine"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2011\/738301","volume":"2011","author":"Lu","year":"2011","journal-title":"Int J Cell Biol"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1756-9966-30-87","volume":"30","author":"Wong","year":"2011","journal-title":"J Exp Clin"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1007\/s00383-003-1003-8","volume":"19","author":"Tazuke","year":"2003","journal-title":"Pediatr Surg Int"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1177\/000456329603300615","volume":"33","author":"Bertsch","year":"1996","journal-title":"Ann Clin Biochem"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"S60","DOI":"10.1016\/0090-1229(92)90042-M","volume":"62","author":"Hirano","year":"1992","journal-title":"Clin Immunol Immunopathol"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"29820","DOI":"10.18632\/oncotarget.25661","volume":"9","author":"Vainer","year":"2018","journal-title":"Oncotarget"}],"container-title":["Journal of Inflammation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=86552","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=86552","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,19]],"date-time":"2023-03-19T13:00:51Z","timestamp":1679230851000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/corosolic-acid-inhibits-secretory-phospholipase-a2iia-as-an-anti-infla-peer-reviewed-fulltext-article-JIR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":74,"URL":"https:\/\/doi.org\/10.2147\/jir.s383441","relation":{},"ISSN":["1178-7031"],"issn-type":[{"value":"1178-7031","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12]]}}}