{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T22:11:47Z","timestamp":1788214307624,"version":"build-2803163510"},"reference-count":154,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JIR"],"DOI":"10.2147\/jir.s413565","type":"journal-article","created":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T04:10:10Z","timestamp":1700107810000},"page":"5339-5366","source":"Crossref","is-referenced-by-count":5,"title":["Anti-Inflammatory and Therapeutic Effects of a Novel Small-Molecule Inhibitor of Inflammation in a Male C57BL\/6J Mouse Model of Obesity-Induced NAFLD\/MAFLD"],"prefix":"10.2147","volume":"Volume 16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7307-5634","authenticated-orcid":true,"given":"Kelly","family":"McCall","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra","family":"Walter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Patton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean R","family":"Thuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria C","family":"Courreges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grzegorz","family":"Palczewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas J","family":"Goetz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Bergmeier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank L","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2023,11]]},"reference":[{"key":"ref1","first-page":"S5","volume":"40","author":"Clark","year":"2009","journal-title":"J Clin Gastroenterol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1111\/j.1478-3231.2006.01311.x","volume":"26","author":"Zelber-Sagi","year":"2006","journal-title":"Liver Int"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/nrgastro.2017.109","volume":"15","author":"Younossi","year":"2018","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1002\/hep.28431","volume":"64","author":"Younossi","year":"2016","journal-title":"Hepatology"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1767","DOI":"10.1002\/hep.27222","volume":"60","author":"El-Serag","year":"2014","journal-title":"Hepatology"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1053\/j.gastro.2007.11.038","volume":"134","author":"Fabbrini","year":"2008","journal-title":"Gastroenterology"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.jhep.2017.11.014","volume":"68","author":"Marra","year":"2018","journal-title":"J Hepatol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"3878","DOI":"10.1038\/ncomms4878","volume":"5","author":"Jia","year":"2014","journal-title":"Nat Commun"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"432","DOI":"10.3390\/nu10040432","volume":"10","author":"Rogero","year":"2018","journal-title":"Nutrients"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1016\/j.cmet.2018.03.014","volume":"27","author":"Lancaster","year":"2018","journal-title":"Cell Metab"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1530\/JOE-18-0078","volume":"237","author":"Patton","year":"2018","journal-title":"J Endocrinol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1172\/JCI113046","volume":"80","author":"Feingold","year":"1987","journal-title":"J Clin Invest"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1016\/S0022-2275(20)38435-2","volume":"29","author":"Grunfeld","year":"1988","journal-title":"J Lipid Res"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1016\/0026-0495(91)90062-2","volume":"40","author":"Grunfeld","year":"1991","journal-title":"Metabolism"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"E177","DOI":"10.1152\/ajpendo.1990.259.2.E177","volume":"259","author":"Feingold","year":"1990","journal-title":"Am J Physiol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1765","DOI":"10.1016\/S0022-2275(20)41334-3","volume":"33","author":"Feingold","year":"1992","journal-title":"J Lipid Res"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"5284","DOI":"10.3390\/ijms22105284","volume":"22","author":"Mass Sanchez","year":"2021","journal-title":"Int J Mol Sci"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"166656","DOI":"10.1016\/j.bbadis.2023.166656","volume":"1869","author":"Zhang","year":"2023","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1982","DOI":"10.1053\/j.gastro.2021.08.030","volume":"161","author":"Azzimato","year":"2021","journal-title":"Gastroenterology"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/j.tem.2013.05.009","volume":"24","author":"Moschen","year":"2013","journal-title":"Trends Endocrinol Metab"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1002\/cld.494","volume":"6","author":"Kirpich","year":"2015","journal-title":"Clin Liver Dis"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"133","DOI":"10.5152\/tjg.2014.7886","volume":"25","author":"Gangarapu","year":"2014","journal-title":"Turk J Gastroenterol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"e47713","DOI":"10.1371\/journal.pone.0047713","volume":"7","author":"Kim","year":"2012","journal-title":"PLoS One"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.jaci.2013.06.022","volume":"132","author":"Jin","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.2337\/db06-1491","volume":"56","author":"Cani","year":"2007","journal-title":"Diabetes"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.2337\/db07-1403","volume":"57","author":"Cani","year":"2008","journal-title":"Diabetes"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/1476-9255-7-15","volume":"7","author":"Harte","year":"2010","journal-title":"J Inflamm"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/j.numecd.2012.02.007","volume":"22","author":"Compare","year":"2012","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1111\/1469-0691.12140","volume":"19","author":"Aron-Wisnewsky","year":"2013","journal-title":"Clin Microbiol Infect"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1097\/01.shk.0000112346.38599.10","volume":"21","author":"Han","year":"2004","journal-title":"Shock"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1139\/y06-056","volume":"84","author":"Chin","year":"2006","journal-title":"Can J Physiol Pharmacol"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"2645465","DOI":"10.1155\/2018\/2645465","volume":"2018","author":"Lee","year":"2018","journal-title":"J Immunol Res"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s12276-018-0126-x","volume":"50","author":"Chelakkot","year":"2018","journal-title":"Exp Mol Med"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"G75","DOI":"10.1152\/ajpgi.00170.2018","volume":"316","author":"Liangpunsakul","year":"2019","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"1836","DOI":"10.1002\/hep.24001","volume":"52","author":"Tilg","year":"2010","journal-title":"Hepatology"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1038\/s41556-022-00853-8","volume":"24","author":"Chen","year":"2022","journal-title":"Nat Cell Biol"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1038\/nature25986","volume":"556","author":"Mills","year":"2018","journal-title":"Nature"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1038\/s41577-019-0128-5","volume":"19","author":"O\u2019Neill","year":"2019","journal-title":"Nat Rev Immunol"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"2893","DOI":"10.3389\/fimmu.2019.02893","volume":"10","author":"Oates","year":"2019","journal-title":"Front Immunol"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1186\/s12944-020-01271-1","volume":"19","author":"Berge","year":"2020","journal-title":"Lipids Health Dis"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1042\/CS20140392","volume":"129","author":"Yeung","year":"2015","journal-title":"Clin Sci"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1007\/s00535-017-1415-1","volume":"53","author":"Sumida","year":"2018","journal-title":"J Gastroenterol"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"533","DOI":"10.2147\/DMSO.S146339","volume":"11","author":"Sarwar","year":"2018","journal-title":"Diabetes Metab Syndr Obes"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/S2468-1253(16)30011-5","volume":"1","author":"Wong","year":"2016","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"40","DOI":"10.14218\/JCTH.2020.00055","volume":"9","author":"Sharma","year":"2021","journal-title":"J Clin Transl Hepatol"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1001\/jama.2011.520","volume":"305","author":"Lavine","year":"2011","journal-title":"JAMA"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1111\/j.1365-2036.2008.03869.x","volume":"29","author":"Loomba","year":"2009","journal-title":"Aliment Pharmacol Ther"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1111\/j.1365-2036.2004.02025.x","volume":"20","author":"Nair","year":"2004","journal-title":"Aliment Pharmacol Ther"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"305","DOI":"10.7326\/M15-1774","volume":"165","author":"Cusi","year":"2016","journal-title":"Ann Intern Med"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"2297","DOI":"10.1056\/NEJMoa060326","volume":"355","author":"Belfort","year":"2006","journal-title":"N Engl J Med"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1053\/j.gastro.2008.06.047","volume":"135","author":"Aithal","year":"2008","journal-title":"Gastroenterology"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1056\/NEJMoa2301972","volume":"389","author":"Jastreboff","year":"2023","journal-title":"N Engl J Med"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1016\/j.mayocp.2015.06.013","volume":"90","author":"Spengler","year":"2015","journal-title":"Mayo Clin Proc"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"2041","DOI":"10.4049\/jimmunol.173.3.2041","volume":"173","author":"Dagia","year":"2004","journal-title":"J Immunol"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"4226","DOI":"10.1210\/en.2007-0459","volume":"148","author":"McCall","year":"2007","journal-title":"Endocrinology"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1677\/JOE-09-0370","volume":"207","author":"McCall","year":"2010","journal-title":"J Endocrinol"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"3841","DOI":"10.3390\/molecules18043841","volume":"18","author":"McCall","year":"2013","journal-title":"Molecules"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"4114","DOI":"10.1158\/1078-0432.CCR-09-0005","volume":"15","author":"Schwartz","year":"2009","journal-title":"Clin Cancer Res"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1002\/ddr.21231","volume":"75","author":"Deosarkar","year":"2014","journal-title":"Drug Dev Res"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"12365","DOI":"10.3390\/molecules171012365","volume":"17","author":"Courreges","year":"2012","journal-title":"Molecules"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1210\/me.2004-0100","volume":"19","author":"Harii","year":"2005","journal-title":"Mol Endocrinol"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"113295","DOI":"10.18632\/oncotarget.10358","volume":"8","author":"Schwartz","year":"2017","journal-title":"Oncotarget"},{"key":"ref63","first-page":"973","volume":"6","author":"Gan","year":"2010","journal-title":"Synlett"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1038\/oby.2009.273","volume":"18","author":"Hwang","year":"2010","journal-title":"Obesity"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"e37794","DOI":"10.1371\/journal.pone.0037794","volume":"7","author":"Benz","year":"2012","journal-title":"PLoS One"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"2147","DOI":"10.1002\/oby.20811","volume":"22","author":"Yang","year":"2014","journal-title":"Obesity"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"e46057","DOI":"10.1371\/journal.pone.0046057","volume":"7","author":"Pettersson","year":"2012","journal-title":"PLoS One"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1111\/j.1463-1326.2011.01488.x","volume":"14","author":"Stubbins","year":"2012","journal-title":"Diabetes Obes Metab"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"2975","DOI":"10.1093\/hmg\/ddp236","volume":"18","author":"Hill-Baskin","year":"2009","journal-title":"Hum Mol Genet"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"355","DOI":"10.2353\/ajpath.2009.080703","volume":"175","author":"VanSaun","year":"2009","journal-title":"Am J Pathol"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"3382","DOI":"10.1007\/s00125-012-2703-1","volume":"55","author":"Nakamura","year":"2012","journal-title":"Diabetologia"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1007\/s12020-014-0384-x","volume":"48","author":"Pan","year":"2014","journal-title":"Endocrine"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"212","DOI":"10.3164\/jcbn.09-83","volume":"46","author":"Fraulob","year":"2010","journal-title":"J Clin Biochem Nutr"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.2337\/diab.37.9.1163","volume":"37","author":"Surwit","year":"1988","journal-title":"Diabetes"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/0026-0495(95)90123-X","volume":"44","author":"Surwit","year":"1995","journal-title":"Metabolism"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1074\/mcp.M500016-MCP200","volume":"4","author":"Qiu","year":"2005","journal-title":"Mol Cell Proteomics"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1002\/pmic.200600641","volume":"7","author":"List","year":"2007","journal-title":"Proteomics"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/s12876-019-0958-4","volume":"19","author":"Sun","year":"2019","journal-title":"BMC Gastroenterol"},{"key":"ref79","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1007\/s00394-011-0266-4","volume":"51","author":"Stubbins","year":"2012","journal-title":"Eur J Nutr"},{"key":"ref80","doi-asserted-by":"publisher","first-page":"425","DOI":"10.3892\/mmr.2016.5236","volume":"14","author":"Fu","year":"2016","journal-title":"Mol Med Rep"},{"key":"ref81","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1177\/1535370215570189","volume":"240","author":"Xin","year":"2015","journal-title":"Exp Biol Med"},{"key":"ref82","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1210\/me.2006-0012","volume":"20","author":"Gao","year":"2006","journal-title":"Mol Endocrinol"},{"key":"ref83","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1530\/JOE-10-0462","volume":"210","author":"Chow","year":"2011","journal-title":"J Endocrinol"},{"key":"ref84","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1097\/gme.0b013e31817b8159","volume":"15","author":"Paquette","year":"2008","journal-title":"Menopause"},{"key":"ref85","doi-asserted-by":"publisher","first-page":"4751","DOI":"10.1210\/endo.142.11.8504","volume":"142","author":"Geary","year":"2001","journal-title":"Endocrinology"},{"key":"ref86","doi-asserted-by":"publisher","first-page":"12735","DOI":"10.1073\/pnas.97.23.12735","volume":"97","author":"Jones","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref87","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1177\/153537020422901107","volume":"229","author":"Cooke","year":"2004","journal-title":"Exp Biol Med"},{"key":"ref88","doi-asserted-by":"publisher","first-page":"615917","DOI":"10.1155\/2014\/615917","volume":"2014","author":"Monteiro","year":"2014","journal-title":"Mediators Inflamm"},{"key":"ref89","doi-asserted-by":"publisher","first-page":"7873","DOI":"10.1021\/acs.jafc.5b02830","volume":"63","author":"Lai","year":"2015","journal-title":"J Agric Food Chem"},{"key":"ref90","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1002\/ptr.7615","volume":"37","author":"Gopal","year":"2023","journal-title":"Phytother Res"},{"key":"ref91","doi-asserted-by":"publisher","first-page":"1647","DOI":"10.1007\/s00125-009-1402-z","volume":"52","author":"List","year":"2009","journal-title":"Diabetologia"},{"key":"ref92","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1002\/2211-5463.12240","volume":"7","author":"Mukai","year":"2017","journal-title":"FEBS Open Bio"},{"key":"ref93","first-page":"1073","volume":"8","author":"Ni","year":"2016","journal-title":"Am J Transl Res"},{"key":"ref94","first-page":"443","volume":"9","author":"Salmon","year":"1985","journal-title":"Int J Obes"},{"key":"ref95","doi-asserted-by":"publisher","first-page":"e10459","DOI":"10.15252\/msb.202110459","volume":"17","author":"Zeybel","year":"2021","journal-title":"Mol Syst Biol"},{"key":"ref96","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"ref97","doi-asserted-by":"publisher","first-page":"708978","DOI":"10.3389\/fimmu.2021.708978","volume":"12","author":"Xu","year":"2021","journal-title":"Front Immunol"},{"key":"ref98","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1111\/j.1872-034X.2007.00008.x","volume":"37","author":"Ito","year":"2007","journal-title":"Hepatol Res"},{"key":"ref99","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.2337\/diacare.27.5.1047","volume":"27","author":"Wild","year":"2004","journal-title":"Diabetes Care"},{"key":"ref100","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1007\/s40471-014-0012-6","volume":"1","author":"Imes","year":"2014","journal-title":"Curr Epidemiol Rep"},{"key":"ref101","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1080\/00365520902845268","volume":"44","author":"Haukeland","year":"2009","journal-title":"Scand J Gastroenterol"},{"key":"ref102","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1053\/j.gastro.2008.03.078","volume":"135","author":"Ratziu","year":"2008","journal-title":"Gastroenterology"},{"key":"ref103","first-page":"CD008623","volume":"12","author":"Eslami","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"ref104","doi-asserted-by":"publisher","first-page":"1821","DOI":"10.1172\/JCI200319451","volume":"112","author":"Xu","year":"2003","journal-title":"J Clin Invest"},{"key":"ref105","doi-asserted-by":"publisher","first-page":"1796","DOI":"10.1172\/JCI200319246","volume":"112","author":"Weisberg","year":"2003","journal-title":"J Clin Invest"},{"key":"ref106","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/j.cmet.2012.04.001","volume":"15","author":"Glass","year":"2012","journal-title":"Cell Metab"},{"key":"ref107","doi-asserted-by":"publisher","first-page":"2008","DOI":"10.1001\/jama.288.16.2008","volume":"288","author":"Davi","year":"2002","journal-title":"JAMA"},{"key":"ref108","doi-asserted-by":"publisher","first-page":"2033","DOI":"10.2337\/diacare.27.8.2033","volume":"27","author":"Kriketos","year":"2004","journal-title":"Diabetes Care"},{"key":"ref109","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1161\/01.ATV.21.6.961","volume":"21","author":"Lemieux","year":"2001","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref110","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1038\/oby.2006.40","volume":"14","author":"Poitou","year":"2006","journal-title":"Obesity"},{"key":"ref111","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1172\/JCI25102","volume":"115","author":"Wellen","year":"2005","journal-title":"J Clin Invest"},{"key":"ref112","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.atherosclerosis.2006.08.021","volume":"191","author":"Targher","year":"2007","journal-title":"Atherosclerosis"},{"key":"ref113","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1038\/oby.2008.210","volume":"16","author":"Davis","year":"2008","journal-title":"Obesity"},{"key":"ref114","doi-asserted-by":"publisher","first-page":"e65061","DOI":"10.1371\/journal.pone.0065061","volume":"8","author":"Pierre","year":"2013","journal-title":"PLoS One"},{"key":"ref115","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1111\/hepr.12199","volume":"44","author":"Sawada","year":"2014","journal-title":"Hepatol Res"},{"key":"ref116","doi-asserted-by":"publisher","first-page":"R698","DOI":"10.1152\/ajpregu.00039.2002","volume":"283","author":"Frost","year":"2002","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"ref117","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1002\/hep.21138","volume":"43","author":"Gustot","year":"2006","journal-title":"Hepatology"},{"key":"ref118","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1016\/j.bbrc.2006.05.170","volume":"346","author":"Song","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"ref119","doi-asserted-by":"publisher","first-page":"R773","DOI":"10.1152\/ajpregu.00490.2005","volume":"290","author":"Frost","year":"2006","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"ref120","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1097\/01.shk.0000055237.25446.80","volume":"19","author":"Lang","year":"2003","journal-title":"Shock"},{"key":"ref121","doi-asserted-by":"publisher","first-page":"2595","DOI":"10.2337\/db08-0038","volume":"57","author":"Reyna","year":"2008","journal-title":"Diabetes"},{"key":"ref122","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1007\/s00125-007-0861-3","volume":"51","author":"Radin","year":"2008","journal-title":"Diabetologia"},{"key":"ref123","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1038\/s41575-019-0261-4","volume":"17","author":"Burgueno","year":"2020","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref124","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1210\/jc.2013-3092","volume":"99","author":"Jialal","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"ref125","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1002\/hep.26081","volume":"57","author":"Miura","year":"2013","journal-title":"Hepatology"},{"key":"ref126","doi-asserted-by":"publisher","first-page":"3015","DOI":"10.1172\/JCI28898","volume":"116","author":"Shi","year":"2006","journal-title":"J Clin Invest"},{"key":"ref127","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1093\/ajcn\/86.5.1286","volume":"86","author":"Erridge","year":"2007","journal-title":"Am J Clin Nutr"},{"key":"ref128","doi-asserted-by":"publisher","first-page":"E740","DOI":"10.1152\/ajpendo.00302.2006","volume":"292","author":"Creely","year":"2007","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref129","doi-asserted-by":"publisher","first-page":"172","DOI":"10.2337\/db09-0367","volume":"59","author":"Mehta","year":"2009","journal-title":"Diabetes"},{"key":"ref130","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1038\/4441022a","volume":"444","author":"Ley","year":"2006","journal-title":"Nature"},{"key":"ref131","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1038\/4441009a","volume":"444","author":"Bajzer","year":"2006","journal-title":"Nature"},{"key":"ref132","doi-asserted-by":"publisher","first-page":"G440","DOI":"10.1152\/ajpgi.00098.2010","volume":"299","author":"de La Serre","year":"2010","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"ref133","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1038\/nature05414","volume":"444","author":"Turnbaugh","year":"2006","journal-title":"Nature"},{"key":"ref134","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1038\/oby.2008.607","volume":"17","author":"Kopp","year":"2009","journal-title":"Obesity"},{"key":"ref135","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1055\/s-0029-1202852","volume":"41","author":"Davis","year":"2009","journal-title":"Horm Metab Res"},{"key":"ref136","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1111\/j.1365-2362.2009.02185.x","volume":"39","author":"Kopp","year":"2009","journal-title":"Eur J Clin Invest"},{"key":"ref137","doi-asserted-by":"publisher","first-page":"823486","DOI":"10.1155\/2010\/823486","volume":"2010","author":"Poulain-Godefroy","year":"2010","journal-title":"Mediators Inflamm"},{"key":"ref138","doi-asserted-by":"publisher","first-page":"16971","DOI":"10.1074\/jbc.M312990200","volume":"279","author":"Lee","year":"2004","journal-title":"J Biol Chem"},{"key":"ref139","doi-asserted-by":"publisher","first-page":"1858","DOI":"10.1172\/JCI43378","volume":"121","author":"Holland","year":"2011","journal-title":"J Clin Invest"},{"key":"ref140","doi-asserted-by":"publisher","first-page":"3428","DOI":"10.1038\/ncomms4428","volume":"5","author":"Uchimura","year":"2014","journal-title":"Nat Commun"},{"key":"ref141","doi-asserted-by":"publisher","first-page":"1767","DOI":"10.1002\/eji.200324037","volume":"33","author":"Underhill","year":"2003","journal-title":"Eur J Immunol"},{"key":"ref142","doi-asserted-by":"publisher","first-page":"24255","DOI":"10.1074\/jbc.M002137200","volume":"275","author":"Lin","year":"2000","journal-title":"J Biol Chem"},{"key":"ref143","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1161\/CIRCRESAHA.106.142851","volume":"100","author":"Kim","year":"2007","journal-title":"Circ Res"},{"key":"ref144","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1007\/s00125-007-0654-8","volume":"50","author":"Poggi","year":"2007","journal-title":"Diabetologia"},{"key":"ref145","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.bbrc.2006.12.190","volume":"354","author":"Suganami","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"ref146","doi-asserted-by":"publisher","first-page":"1986","DOI":"10.2337\/db06-1595","volume":"56","author":"Tsukumo","year":"2007","journal-title":"Diabetes"},{"key":"ref147","doi-asserted-by":"publisher","first-page":"1620","DOI":"10.1002\/hep.24552","volume":"54","author":"Li","year":"2011","journal-title":"Hepatology"},{"key":"ref148","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.2337\/dc10-2197","volume":"34","author":"Lassenius","year":"2011","journal-title":"Diabetes Care"},{"key":"ref149","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1007\/s11010-013-1911-4","volume":"388","author":"Jayashree","year":"2014","journal-title":"Mol Cell Biochem"},{"key":"ref150","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1210\/er.2014-1100","volume":"36","author":"Velloso","year":"2015","journal-title":"Endocr Rev"},{"key":"ref151","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/s00441-018-2845-7","volume":"374","author":"Hashani","year":"2018","journal-title":"Cell Tissue Res"},{"key":"ref152","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1097\/MOL.0000000000000057","volume":"25","author":"Kimmel","year":"2014","journal-title":"Curr Opin Lipidol"},{"key":"ref153","doi-asserted-by":"publisher","first-page":"599","DOI":"10.2337\/dbi21-0020","volume":"71","author":"Kahn","year":"2022","journal-title":"Diabetes"},{"key":"ref154","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1210\/jc.2014-2404","volume":"100","author":"Jin","year":"2015","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Journal of Inflammation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=94397","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=94397","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T04:10:25Z","timestamp":1700107825000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/anti-inflammatory-and-therapeutic-effects-of-a-novel-small-molecule-in-peer-reviewed-fulltext-article-JIR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":154,"URL":"https:\/\/doi.org\/10.2147\/jir.s413565","relation":{},"ISSN":["1178-7031"],"issn-type":[{"value":"1178-7031","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11]]}}}