{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T03:00:40Z","timestamp":1790996440575,"version":"4.1.0"},"reference-count":89,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JIR"],"DOI":"10.2147\/jir.s483350","type":"journal-article","created":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T07:05:11Z","timestamp":1732172711000},"page":"9307-9317","source":"Crossref","is-referenced-by-count":15,"title":["The Role of the TRPV4 Channel in Intestinal Physiology and Pathology"],"prefix":"10.2147","volume":"Volume 17","author":[{"given":"Dandan","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingli","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolin","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyu","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2024,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1038\/35036318","volume":"2","author":"Strotmann","year":"2000","journal-title":"Nat Cell Biol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/S0092-8674(00)00143-4","volume":"103","author":"Liedtke","year":"2000","journal-title":"Cell"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/S0014-5793(00)02212-2","volume":"485","author":"Wissenbach","year":"2000","journal-title":"FEBS Lett"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1152\/physiolgenomics.2001.4.3.165","volume":"4","author":"Delany","year":"2001","journal-title":"Physiol Genom"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1038\/nature01807","volume":"424","author":"Watanabe","year":"2003","journal-title":"Nature"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1073\/pnas.0303329101","volume":"101","author":"Vriens","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"22664","DOI":"10.1074\/jbc.M302561200","volume":"278","author":"Suzuki","year":"2003","journal-title":"J Biol Chem"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"5317","DOI":"10.1113\/JP280309","volume":"598","author":"Kollmann","year":"2020","journal-title":"J Physiol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1007\/s00395-020-0775-5","volume":"115","author":"Adapala","year":"2020","journal-title":"Basic Res Cardiol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"4181","DOI":"10.1111\/bph.15161","volume":"177","author":"Yang","year":"2020","journal-title":"Br J Pharmacol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1007\/s10571-020-00909-z","volume":"41","author":"Aghazadeh","year":"2021","journal-title":"Cell Mol Neurobiol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"5512","DOI":"10.3748\/wjg.v22.i24.5512","volume":"22","author":"Mihara","year":"2016","journal-title":"WJG"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"G556","DOI":"10.1152\/ajpgi.00433.2009","volume":"299","author":"Ceppa","year":"2010","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"101847","DOI":"10.1016\/j.jbc.2022.101847","volume":"298","author":"Wan","year":"2022","journal-title":"J Biol Chem"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1053\/j.gastro.2015.04.011","volume":"149","author":"Cenac","year":"2015","journal-title":"Gastroenterology"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2022\/7294775","volume":"2022","author":"Cheng","year":"2022","journal-title":"Gastroenterol Res Pract"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2020\/2906845","volume":"2020","author":"Toledo Mauri\u00f1o","year":"2020","journal-title":"J Immunol Res"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1111\/bph.14072","volume":"175","author":"Matsumoto","year":"2018","journal-title":"Br J Pharmacol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.neuroscience.2015.10.028","volume":"311","author":"Zhang","year":"2015","journal-title":"Neuroscience"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1053\/j.gastro.2010.09.045","volume":"140","author":"D\u2019Aldebert","year":"2011","journal-title":"Gastroenterology"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"61","DOI":"10.3390\/cells7060061","volume":"7","author":"Rizopoulos","year":"2018","journal-title":"Cells"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"G33","DOI":"10.1152\/ajpgi.00105.2013","volume":"307","author":"Yamawaki","year":"2014","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.immuni.2018.04.021","volume":"49","author":"Luo","year":"2018","journal-title":"Immunity"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1007\/s00109-015-1336-5","volume":"93","author":"Fichna","year":"2015","journal-title":"J Mol Med"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"2059","DOI":"10.1053\/j.gastro.2008.01.074","volume":"134","author":"Brierley","year":"2008","journal-title":"Gastroenterology"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1016\/j.jcmgh.2020.10.001","volume":"11","author":"Sarnelli","year":"2021","journal-title":"CMGH"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"3635","DOI":"10.1007\/s00018-011-0822-3","volume":"68","author":"Johansson","year":"2011","journal-title":"Cell Mol Life Sci"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.immuni.2014.12.028","volume":"42","author":"Mukherjee","year":"2015","journal-title":"Immunity"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"2394","DOI":"10.1097\/MIB.0000000000000204","volume":"20","author":"S\u00e1nchez De Medina","year":"2014","journal-title":"Inflamm Bowel Dis"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"a029314","DOI":"10.1101\/cshperspect.a029314","volume":"10","author":"Buckley","year":"2018","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1038\/nri2653","volume":"9","author":"Turner","year":"2009","journal-title":"Nat Rev Immunol"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"871713","DOI":"10.3389\/fimmu.2022.871713","volume":"13","author":"An","year":"2022","journal-title":"Front Immunol"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"109697","DOI":"10.1016\/j.biopha.2019.109697","volume":"122","author":"Huang","year":"2020","journal-title":"Biomed Pharmacother"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"7476","DOI":"10.1021\/acs.jafc.3c09290","volume":"72","author":"Xie","year":"2024","journal-title":"J Agric Food Chem"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"15064","DOI":"10.1073\/pnas.0803124105","volume":"105","author":"Johansson","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1146\/annurev-immunol-070119-115104","volume":"38","author":"Kayama","year":"2020","journal-title":"Annu Rev Immunol"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"113375","DOI":"10.1016\/j.envpol.2019.113375","volume":"256","author":"Duan","year":"2020","journal-title":"Environ Pollut"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"G277","DOI":"10.1152\/ajpgi.00176.2019","volume":"318","author":"Li","year":"2020","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.micres.2013.02.008","volume":"168","author":"Yan","year":"2013","journal-title":"Microbiol Res"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.jaci.2009.05.038","volume":"124","author":"Groschwitz","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"100544","DOI":"10.1016\/j.jaim.2022.100544","volume":"14","author":"Prakash","year":"2023","journal-title":"J Ayurveda Integr Med"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1248\/bpb.31.426","volume":"31","author":"Ma","year":"2008","journal-title":"Pharm Bull"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"e14082","DOI":"10.1111\/nmo.14082","volume":"33","author":"Lu","year":"2021","journal-title":"Neurogastroenterology Motil"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"e63893","DOI":"10.1371\/journal.pone.0063893","volume":"8","author":"Distrutti","year":"2013","journal-title":"PLoS One"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1007\/s00248-013-0241-0","volume":"66","author":"Aguilera","year":"2013","journal-title":"Microb Ecol"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1146\/annurev.physiol.61.1.117","volume":"61","author":"Kunze","year":"1999","journal-title":"Annu Rev Physiol"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1038\/nrgastro.2012.168","volume":"9","author":"Sanders","year":"2012","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1113\/jphysiol.2006.121111","volume":"578","author":"Grant","year":"2007","journal-title":"J Physiol"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1038\/s41575-020-0271-2","volume":"17","author":"Spencer","year":"2020","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1053\/j.gastro.2008.05.024","volume":"135","author":"Cenac","year":"2008","journal-title":"Gastroenterology"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1136\/gut.2009.192567","volume":"59","author":"Cenac","year":"2010","journal-title":"Gut"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"5790","DOI":"10.1074\/jbc.M112.438184","volume":"288","author":"Poole","year":"2013","journal-title":"J Biol Chem"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"13875","DOI":"10.1074\/jbc.M115.642736","volume":"290","author":"Zhao","year":"2015","journal-title":"J Biol Chem"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"27215","DOI":"10.1074\/jbc.M114.599712","volume":"289","author":"Zhao","year":"2014","journal-title":"J Biol Chem"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"G338","DOI":"10.1152\/ajpgi.00116.2018","volume":"316","author":"Balemans","year":"2019","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"3881","DOI":"10.1111\/bph.12750","volume":"171","author":"Grace","year":"2014","journal-title":"Br J Pharmacol"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1139\/cjpp-2020-0306","volume":"99","author":"Park","year":"2021","journal-title":"Can J Physiol Pharmacol"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1016\/j.ceca.2014.02.002","volume":"55","author":"Jung","year":"2014","journal-title":"Cell Calcium"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"3727","DOI":"10.18632\/oncotarget.23197","volume":"9","author":"Yang","year":"2018","journal-title":"Oncotarget"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"684538","DOI":"10.3389\/fphar.2021.684538","volume":"12","author":"Cui","year":"2021","journal-title":"Front Pharmacol"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"1739","DOI":"10.1172\/JCI0215695","volume":"110","author":"Musch","year":"2002","journal-title":"J Clin Invest"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1038\/nature06005","volume":"448","author":"Xavier","year":"2007","journal-title":"Nature"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"2643","DOI":"10.3390\/jcm9082643","volume":"9","author":"Morita","year":"2020","journal-title":"JCM"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2012.01999.x","volume":"24","author":"Fichna","year":"2012","journal-title":"Neurogastroenterology Motil"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"e21238","DOI":"10.1096\/fj.201903207RRR","volume":"35","author":"Kobayashi","year":"2021","journal-title":"FASEB J"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"33841","DOI":"10.1038\/srep33841","volume":"6","author":"Dalsgaard","year":"2016","journal-title":"Sci Rep"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1038\/s41374-020-0430-7","volume":"100","author":"Peng","year":"2020","journal-title":"Lab Invest"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1053\/j.gastro.2006.11.039","volume":"132","author":"Barbara","year":"2007","journal-title":"Gastroenterology"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1038\/nrgastro.2010.4","volume":"7","author":"\u00d6hman","year":"2010","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"4852","DOI":"10.3748\/wjg.v21.i16.4852","volume":"21","author":"Shi","year":"2015","journal-title":"WJG"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"109648","DOI":"10.1016\/j.intimp.2022.109648","volume":"116","author":"Chen","year":"2023","journal-title":"Int Immunopharmacol"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"26894","DOI":"10.1038\/srep26894","volume":"6","author":"Kanju","year":"2016","journal-title":"Sci Rep"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1053\/j.gastro.2007.04.005","volume":"133","author":"Kassinen","year":"2007","journal-title":"Gastroenterology"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"1651","DOI":"10.1053\/j.gastro.2003.09.028","volume":"125","author":"Dunlop","year":"2003","journal-title":"Gastroenterology"},{"key":"ref75","doi-asserted-by":"publisher","DOI":"10.1101\/2024.01.09.574831","author":"Rajasekhar","year":"2024","journal-title":"bioRxiv"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"e338","DOI":"10.1038\/oncsis.2017.39","volume":"6","author":"Lee","year":"2017","journal-title":"Oncogenesis"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"14257","DOI":"10.1038\/srep14257","volume":"5","author":"Thoppil","year":"2015","journal-title":"Sci Rep"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"6490","DOI":"10.1038\/onc.2017.234","volume":"36","author":"Peters","year":"2017","journal-title":"Oncogene"},{"key":"ref79","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/s12931-015-0224-4","volume":"16","author":"Nayak","year":"2015","journal-title":"Respir Res"},{"key":"ref80","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1038\/onc.2011.231","volume":"31","author":"Fiorio Pla","year":"2012","journal-title":"Oncogene"},{"key":"ref81","doi-asserted-by":"publisher","first-page":"172853","DOI":"10.1016\/j.ejphar.2019.172853","volume":"867","author":"Matsumoto","year":"2020","journal-title":"Eur J Pharmacol"},{"key":"ref82","doi-asserted-by":"publisher","first-page":"208","DOI":"10.31768\/2312-8852.2015.37(3):208-212","volume":"37","author":"Sozucan","year":"2015","journal-title":"Exp Oncol"},{"key":"ref83","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1038\/s41419-019-1700-4","volume":"10","author":"Liu","year":"2019","journal-title":"Cell Death Dis"},{"key":"ref84","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1136\/gutjnl-2019-318536","volume":"69","author":"Wauters","year":"2020","journal-title":"Gut"},{"key":"ref85","doi-asserted-by":"publisher","first-page":"1521","DOI":"10.1053\/j.gastro.2020.12.016","volume":"160","author":"Wauters","year":"2021","journal-title":"Gastroenterology"},{"key":"ref86","doi-asserted-by":"publisher","first-page":"e12361","DOI":"10.1111\/hel.12361","volume":"22","author":"Mihara","year":"2017","journal-title":"Helicobacter"},{"key":"ref87","doi-asserted-by":"publisher","first-page":"2777882","DOI":"10.1155\/2022\/2777882","volume":"2022","author":"Li","year":"2022","journal-title":"Biomed Res Int"},{"key":"ref88","doi-asserted-by":"publisher","first-page":"513","DOI":"10.3390\/life11060513","volume":"11","author":"Zheng","year":"2021","journal-title":"Life"},{"key":"ref89","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1007\/s40256-018-00320-6","volume":"19","author":"Goyal","year":"2019","journal-title":"Am J Cardiovasc Drugs"}],"container-title":["Journal of Inflammation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/97536","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/97536","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T07:05:15Z","timestamp":1732172715000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/the-role-of-the-trpv4-channel-in-intestinal-physiology-and-pathology-peer-reviewed-fulltext-article-JIR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":89,"URL":"https:\/\/doi.org\/10.2147\/jir.s483350","relation":{},"ISSN":["1178-7031"],"issn-type":[{"value":"1178-7031","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11]]}}}