{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T18:52:24Z","timestamp":1789671144157,"version":"4.0.1"},"reference-count":64,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JIR"],"DOI":"10.2147\/jir.s488553","type":"journal-article","created":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T07:50:14Z","timestamp":1730793014000},"page":"8241-8259","source":"Crossref","is-referenced-by-count":8,"title":["GSDMD Mediates Ang II-Induced Hypertensive Nephropathy by Regulating the GATA2\/AQP4 Signaling Pathway"],"prefix":"10.2147","volume":"Volume 17","author":[{"given":"Xiaoxi","family":"Fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenli","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruihan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yucong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianhui","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jibo","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zimin","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingjiang","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijian","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bozhi","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5124-5882","authenticated-orcid":true,"given":"Shanshan","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2024,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1038\/s41581-019-0244-2","volume":"16","author":"Mills","year":"2020","journal-title":"Nat Rev Nephrol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/nrneph.2010.154","volume":"7","author":"Udani","year":"2011","journal-title":"Nat Rev Nephrol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1146\/annurev-physiol-022516-034227","volume":"80","author":"Humphreys","year":"2018","journal-title":"Annu Rev Physiol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.coph.2011.01.009","volume":"11","author":"Navar","year":"2011","journal-title":"Curr Opin Pharmacol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1152\/physrev.00038.2017","volume":"98","author":"Forrester","year":"2018","journal-title":"Physiol Rev"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1016\/s1357-2725(02)00271-6","volume":"35","author":"Suzuki","year":"2003","journal-title":"Int J Biochem Cell Biol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"F938","DOI":"10.1152\/ajprenal.00146.2007","volume":"293","author":"Kobori","year":"2007","journal-title":"Am J Physiol Renal Physiol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1681\/ASN.2010060624","volume":"22","author":"Gonzalez-Villalobos","year":"2011","journal-title":"J Am Soc Nephrol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.tibs.2016.10.004","volume":"42","author":"Shi","year":"2017","journal-title":"Trends Biochem Sci"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1038\/nature15514","volume":"526","author":"Shi","year":"2015","journal-title":"Nature"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"2768","DOI":"10.1016\/j.apsb.2021.02.006","volume":"11","author":"Burdette","year":"2021","journal-title":"Acta Pharm Sin B"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1038\/nature18629","volume":"535","author":"Liu","year":"2016","journal-title":"Nature"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"2453","DOI":"10.1084\/jem.20190545","volume":"216","author":"Orning","year":"2019","journal-title":"J Exp Med"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-05138-4","volume":"13","author":"Wang","year":"2022","journal-title":"Cell Death Dis"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"e23","DOI":"10.1017\/erm.2021.27","volume":"23","author":"Zuo","year":"2021","journal-title":"Expert Rev Mol Med"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1038\/s41401-020-00525-z","volume":"42","author":"Cheng","year":"2021","journal-title":"Acta Pharmacol Sin"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1002\/biof.1959","volume":"49","author":"Ali","year":"2023","journal-title":"Biofactors"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.770863","volume":"12","author":"Long","year":"2021","journal-title":"Front Pharmacol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"111104","DOI":"10.1016\/j.intimp.2023.111104","volume":"125","author":"Tang","year":"2023","journal-title":"Int Immunopharmacol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1038\/nm.3901","volume":"21","author":"Grande","year":"2015","journal-title":"Nat Med"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"eabb5460","DOI":"10.1126\/sciadv.abb5460","volume":"6","author":"Ettou","year":"2020","journal-title":"Sci Adv"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1111\/j.1523-1755.2004.00379.x","volume":"65","author":"Suzuki","year":"2004","journal-title":"Kidney Int"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"115303","DOI":"10.1016\/j.addr.2024.115303","volume":"209","author":"Bonadio","year":"2024","journal-title":"Adv Drug Deliv Rev"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.addr.2017.07.014","volume":"121","author":"Karsdal","year":"2017","journal-title":"Adv Drug Deliv Rev"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-024-01736-5","volume":"16","author":"Tan","year":"2024","journal-title":"Clin Clin Epigenet"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1002\/path.5680","volume":"254","author":"Budi","year":"2021","journal-title":"J Pathol"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.3390\/cells11091386","volume":"11","author":"Venugopal","year":"2022","journal-title":"Cells"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1038\/s41392-023-01379-7","volume":"8","author":"Huang","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1161\/atvbaha.123.320612","volume":"44","author":"Fan","year":"2024","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-023-01010-4","volume":"118","author":"Zhong","year":"2023","journal-title":"Basic Res Cardiol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1016\/j.kint.2017.09.033","volume":"93","author":"Liu","year":"2018","journal-title":"Kidney Int"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1038\/nrneph.2014.114","volume":"10","author":"Meng","year":"2014","journal-title":"Nat Rev Nephrol"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1766","DOI":"10.15252\/embj.201694696","volume":"35","author":"Sborgi","year":"2016","journal-title":"EMBO J"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/bs.ai.2017.02.002","volume":"135","author":"Liu","year":"2017","journal-title":"Adv Immunol"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"3899","DOI":"10.1096\/fj.15-271734","volume":"29","author":"Kadoya","year":"2015","journal-title":"FASEB J"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"4281","DOI":"10.1210\/en.2015-1408","volume":"156","author":"Shirasuna","year":"2015","journal-title":"Endocrinology"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1111\/bph.13230","volume":"173","author":"Krishnan","year":"2016","journal-title":"Br J Pharmacol"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1093\/cvr\/cvy252","volume":"115","author":"Krishnan","year":"2019","journal-title":"Cardiovasc Res"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1038\/nrneph.2009.231","volume":"6","author":"Noda","year":"2010","journal-title":"Nat Rev Nephrol"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"366","DOI":"10.3390\/ijms20020366","volume":"20","author":"He","year":"2019","journal-title":"Int J Mol Sci"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.jcpa.2011.08.005","volume":"146","author":"Ampawong","year":"2012","journal-title":"J Comp Pathol"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"1707","DOI":"10.1242\/jeb.024125","volume":"212","author":"Verkman","year":"2009","journal-title":"J Exp Biol"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"1845","DOI":"10.3390\/ijms22041845","volume":"22","author":"da Silva","year":"2021","journal-title":"Int J Mol Sci"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-018-0211-9","volume":"8","author":"Rump","year":"2018","journal-title":"Cell Biosci"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"e2205862","DOI":"10.1002\/advs.202205862","volume":"10","author":"Zhu","year":"2023","journal-title":"Adv Sci (Weinh)"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-024-03135-2","volume":"21","author":"Zhao","year":"2024","journal-title":"J Neuroinflammation"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"2196","DOI":"10.1007\/s10753-018-0862-z","volume":"41","author":"Li","year":"2018","journal-title":"Inflammation"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/j.biopha.2018.03.093","volume":"102","author":"Liu","year":"2018","journal-title":"Biomed Pharmacother"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"3133","DOI":"10.1111\/jcmm.17176","volume":"26","author":"Li","year":"2022","journal-title":"J Cell Mol Med"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"2312","DOI":"10.1128\/MCB.06699-11","volume":"32","author":"Ainoya","year":"2012","journal-title":"Mol Cell Biol"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"1929","DOI":"10.1128\/MCB.01659-13","volume":"34","author":"Yu","year":"2014","journal-title":"Mol Cell Biol"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/j.kint.2022.10.007","volume":"103","author":"Zhang","year":"2023","journal-title":"Kidney Int"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"3033","DOI":"10.1016\/j.cell.2023.05.027","volume":"186","author":"He","year":"2023","journal-title":"Cell"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1038\/nrm3434","volume":"13","author":"Massague","year":"2012","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"113357","DOI":"10.1016\/j.biopha.2022.113357","volume":"153","author":"Chu","year":"2022","journal-title":"Biomed Pharmacother"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"C994","DOI":"10.1152\/ajpcell.00367.2024","volume":"327","author":"Lei","year":"2024","journal-title":"Am J Physiol Cell Physiol"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"C661","DOI":"10.1152\/ajpcell.00177.2023","volume":"325","author":"Chen","year":"2023","journal-title":"Am J Physiol Cell Physiol"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"C951","DOI":"10.1152\/ajpcell.00528.2022","volume":"324","author":"Chen","year":"2023","journal-title":"Am J Physiol Cell Physiol"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"113947","DOI":"10.1016\/j.biopha.2022.113947","volume":"156","author":"Lu","year":"2022","journal-title":"Biomed Pharmacother"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1038\/s41590-020-0669-6","volume":"21","author":"Hu","year":"2020","journal-title":"Nat Immunol"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"2505","DOI":"10.1161\/hypertensionaha.122.20004","volume":"79","author":"Han","year":"2022","journal-title":"Hypertension"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1038\/nature15541","volume":"526","author":"Kayagaki","year":"2015","journal-title":"Nature"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"2462","DOI":"10.1038\/s41401-022-00887-6","volume":"43","author":"Yang","year":"2022","journal-title":"Acta Pharmacol Sin"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1016\/j.immuni.2020.04.002","volume":"52","author":"Schwarzer","year":"2020","journal-title":"Immunity"}],"container-title":["Journal of Inflammation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/97008","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/97008","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T07:50:17Z","timestamp":1730793017000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/gsdmd-mediates-ang-ii-induced-hypertensive-nephropathy-by-regulating-t-peer-reviewed-fulltext-article-JIR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":64,"URL":"https:\/\/doi.org\/10.2147\/jir.s488553","relation":{},"ISSN":["1178-7031"],"issn-type":[{"value":"1178-7031","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11]]}}}