{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:42:28Z","timestamp":1787024548886,"version":"build-2736575974"},"reference-count":61,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JIR"],"DOI":"10.2147\/jir.s503428","type":"journal-article","created":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T08:55:27Z","timestamp":1739436927000},"page":"2229-2245","source":"Crossref","is-referenced-by-count":6,"title":["Fingolimod Suppresses NLRP3 Inflammasome Activation and Alleviates Oxidative Stress in Traumatic Brain Injury-Induced Acute Lung Injury"],"prefix":"10.2147","volume":"Volume 18","author":[{"given":"Qi","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixia","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayuanyuan","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yehong","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijia","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoli","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoguang","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2025,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1016\/S1474-4422(19)30237-6","volume":"18","author":"Han","year":"2019","journal-title":"Lancet Neurol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.3171\/2017.10.JNS17352","volume":"130","author":"Dewan","year":"2019","journal-title":"J Neurosurg"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1016\/S1474-4422(17)30371-X","volume":"16","author":"Maas","year":"2017","journal-title":"Lancet Neurol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1186\/1742-2094-9-236","volume":"9","author":"Das","year":"2012","journal-title":"J Neuroinflammation"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1007\/s10571-022-01238-z","volume":"43","author":"Li","year":"2023","journal-title":"Cell mol Neurobiol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1007\/s12028-009-9242-8","volume":"11","author":"Mascia","year":"2009","journal-title":"Neurocrit Care"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1089\/neu.2020.7257","volume":"38","author":"Kerr","year":"2021","journal-title":"J Neurotrauma"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1227\/NEU.0b013e3182672ae5","volume":"71","author":"Rincon","year":"2012","journal-title":"Neurosurgery"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1186\/s13578-024-01252-2","volume":"14","author":"Kim","year":"2024","journal-title":"Cell Biosci"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1710","DOI":"10.1097\/CCM.0000000000001101","volume":"43","author":"Busl","year":"2015","journal-title":"Crit Care Med"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.1016\/j.bbadis.2018.02.011","volume":"1864","author":"Xu","year":"2018","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1742","DOI":"10.1038\/s41401-020-00603-2","volume":"42","author":"Chen","year":"2021","journal-title":"Acta Pharmacol Sin"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"7699","DOI":"10.4049\/jimmunol.1001099","volume":"185","author":"Hu","year":"2010","journal-title":"J Immunol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"984","DOI":"10.5114\/aoms\/174264","volume":"20","author":"Li","year":"2024","journal-title":"Arch Med Sci"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"174664","DOI":"10.1016\/j.ejphar.2021.174664","volume":"914","author":"Li","year":"2022","journal-title":"Eur J Pharmacol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"2067","DOI":"10.1089\/neu.2017.5430","volume":"35","author":"Kerr","year":"2018","journal-title":"J Neurotrauma"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"106175","DOI":"10.1016\/j.intimp.2019.106175","volume":"79","author":"Shao","year":"2020","journal-title":"Int Immunopharmacol"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"112133","DOI":"10.1016\/j.biopha.2021.112133","volume":"143","author":"Zhang","year":"2021","journal-title":"Biomed Pharmacother"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1021\/acs.jmedchem.0c01307","volume":"64","author":"Schwaid","year":"2021","journal-title":"J Med Chem"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1146\/annurev-pharmtox-010818-021358","volume":"59","author":"Chun","year":"2019","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.expneurol.2012.12.009","volume":"241","author":"Rolland","year":"2013","journal-title":"Exp Neurol"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1002\/ana.22186","volume":"69","author":"Wei","year":"2011","journal-title":"Ann Neurol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"2251","DOI":"10.1093\/hmg\/ddt615","volume":"23","author":"Di Pardo","year":"2014","journal-title":"Hum Mol Genet"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/j.bbr.2013.06.016","volume":"252","author":"Hemmati","year":"2013","journal-title":"Behav Brain Res"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.pbb.2012.08.025","volume":"103","author":"Gao","year":"2012","journal-title":"Pharmacol Biochem Behav"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.1016\/j.ajpath.2011.12.012","volume":"180","author":"Norimatsu","year":"2012","journal-title":"Am J Pathol"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"8348","DOI":"10.1007\/s12035-016-0318-0","volume":"54","author":"Gao","year":"2017","journal-title":"mol Neurobiol"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"e189","DOI":"10.1097\/CCM.0000000000000097","volume":"42","author":"Wang","year":"2014","journal-title":"Crit Care Med"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"L149","DOI":"10.1152\/ajplung.00100.2021","volume":"322","author":"Wang","year":"2022","journal-title":"Am J Physiol Lung Cell mol Physiol"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"3000605211032806","DOI":"10.1177\/03000605211032806","volume":"49","author":"Shi","year":"2021","journal-title":"J Int Med Res"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000200100","volume":"10","author":"Malhotra","year":"2023","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1111\/jnc.14575","volume":"147","author":"Komnig","year":"2018","journal-title":"J Neurochem"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"118582","DOI":"10.1016\/j.lfs.2020.118582","volume":"263","author":"Guo","year":"2020","journal-title":"Life Sci"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"7455","DOI":"10.18632\/aging.204290","volume":"14","author":"Huang","year":"2022","journal-title":"Aging"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1165\/rcmb.2009-0210ST","volume":"44","author":"Matute-Bello","year":"2011","journal-title":"Am J Respir Cell mol Biol"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"2131","DOI":"10.1089\/neu.2019.6951","volume":"37","author":"Qian","year":"2020","journal-title":"J Neurotrauma"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"e14669","DOI":"10.1111\/cns.14669","volume":"30","author":"Feng","year":"2024","journal-title":"CNS Neurosci Ther"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1111\/j.1365-2990.2007.00893.x","volume":"34","author":"Zhang","year":"2008","journal-title":"Neuropathol Appl Neurobiol"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1111\/j.1582-4934.2007.00019.x","volume":"11","author":"Zhang","year":"2007","journal-title":"J Cell Mol Med"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"807639","DOI":"10.3389\/fphar.2022.807639","volume":"13","author":"Pournajaf","year":"2022","journal-title":"Front Pharmacol"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"18315","DOI":"10.1073\/pnas.1416166111","volume":"111","author":"Fu","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1001\/jamaneurol.2014.1065","volume":"71","author":"Fu","year":"2014","journal-title":"JAMA Neurol"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"105768","DOI":"10.1016\/j.neuint.2024.105768","volume":"178","author":"Li","year":"2024","journal-title":"Neurochem Int"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1186\/s13054-021-03778-0","volume":"25","author":"Ziaka","year":"2021","journal-title":"Crit Care"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1097\/00003246-199007000-00019","volume":"18","author":"Demling","year":"1990","journal-title":"Crit Care Med"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1164\/rccm.202303-0558WS","volume":"209","author":"Matthay","year":"2024","journal-title":"Am J Respir Crit Care Med"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1111\/nyas.14442","volume":"1480","author":"Businaro","year":"2020","journal-title":"Ann N Y Acad Sci"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1002\/path.4361","volume":"233","author":"Hommes","year":"2014","journal-title":"J Pathol"},{"key":"ref49","first-page":"1327","volume":"152","author":"Lentsch","year":"1998","journal-title":"Am J Pathol"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1016\/j.intimp.2014.05.025","volume":"21","author":"Qian","year":"2014","journal-title":"Int Immunopharmacol"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"L1245","DOI":"10.1152\/ajplung.00302.2014","volume":"308","author":"Stone","year":"2015","journal-title":"Am J Physiol Lung Cell mol Physiol"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1111\/j.1600-6143.2006.01710.x","volume":"7","author":"Okazaki","year":"2007","journal-title":"Am J Transplant"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1038\/nri2725","volume":"10","author":"Tschopp","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"3328","DOI":"10.3390\/ijms20133328","volume":"20","author":"Kelley","year":"2019","journal-title":"Int J mol Sci"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1084\/jem.20122196","volume":"210","author":"Dai","year":"2013","journal-title":"J Exp Med"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1152\/physrev.00026.2013","volume":"94","author":"Zorov","year":"2014","journal-title":"Physiol Rev"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"12515","DOI":"10.1096\/fj.201802805RR","volume":"33","author":"An","year":"2019","journal-title":"FASEB J"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"13000","DOI":"10.3390\/ijms232113000","volume":"23","author":"Fesharaki-Zadeh","year":"2022","journal-title":"Int J mol Sci"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1111\/jnc.13217","volume":"136 Suppl 1","author":"Freeman","year":"2016","journal-title":"J Neurochem"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1038\/nature09663","volume":"469","author":"Zhou","year":"2011","journal-title":"Nature"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1007\/s40268-020-00316-1","volume":"20","author":"Bascunana","year":"2020","journal-title":"Drugs R D"}],"container-title":["Journal of Inflammation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/100165","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/100165","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T08:55:30Z","timestamp":1739436930000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/fingolimod-suppresses-nlrp3-inflammasome-activation-and-alleviates-oxi-peer-reviewed-fulltext-article-JIR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":61,"URL":"https:\/\/doi.org\/10.2147\/jir.s503428","relation":{},"ISSN":["1178-7031"],"issn-type":[{"value":"1178-7031","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2]]}}}