{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T12:46:17Z","timestamp":1788266777499,"version":"build-2803163510"},"reference-count":46,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JIR"],"DOI":"10.2147\/jir.s505306","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T03:15:13Z","timestamp":1751858113000},"page":"8899-8913","source":"Crossref","is-referenced-by-count":1,"title":["Metabolomic Profiling Reveals Serum Tryptophan as a Potential Therapeutic Target for Systemic Lupus Erythematosus"],"prefix":"10.2147","volume":"Volume 18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0511-8038","authenticated-orcid":true,"given":"Kai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rujie","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kexin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deqian","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2025,7]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1136\/annrheumdis-2017-211206","volume":"76","author":"Gergianaki","year":"2017","journal-title":"Ann Rheum Dis"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1038\/s41467-021-21049-y","volume":"12","author":"Wang","year":"2021","journal-title":"Nat Commun"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1136\/annrheumdis-2019-215361","volume":"78","author":"Jog","year":"2019","journal-title":"Ann Rheum Dis"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1177\/0961203317693096","volume":"26","author":"Taraborelli","year":"2017","journal-title":"Lupus"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1038\/s41572-019-0141-9","volume":"6","author":"Anders","year":"2020","journal-title":"Nat Rev Dis Primers"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"e55","DOI":"10.1097\/PEC.0000000000001527","volume":"37","author":"Lee","year":"2021","journal-title":"Pediatr Emerg Care"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"858","DOI":"10.3109\/14397595.2013.874743","volume":"24","author":"Anyfantakis","year":"2014","journal-title":"Mod Rheumatol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"140","DOI":"10.3390\/cells8020140","volume":"8","author":"Nagafuchi","year":"2019","journal-title":"Cells"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"3220","DOI":"10.1021\/acs.jproteome.0c00179","volume":"19","author":"Fern\u00e1ndez-Ochoa","year":"2020","journal-title":"J Proteome Res"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.3390\/jcm8091291","volume":"8","author":"Bellocchi","year":"2019","journal-title":"J Clin Med"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1093\/rheumatology\/keaa126","volume":"60","author":"Zhang","year":"2021","journal-title":"Rheumatology"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"3322","DOI":"10.1021\/acs.jproteome.5b00354","volume":"14","author":"Th\u00e9venot","year":"2015","journal-title":"J Proteome Res"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"D478","DOI":"10.1093\/nar\/gkt1067","volume":"42","author":"Jewison","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"186","DOI":"10.3390\/metabo10050186","volume":"10","author":"Pang","year":"2020","journal-title":"Metabolites"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"976","DOI":"10.3389\/fimmu.2019.00976","volume":"10","author":"Zhang","year":"2019","journal-title":"Front Immunol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"2138","DOI":"10.3389\/fimmu.2020.02138","volume":"11","author":"Yan","year":"2020","journal-title":"Front Immunol"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.22038\/ijbms.2019.38713.9178","volume":"22","author":"Kalantari","year":"2019","journal-title":"Iran J Basic Med Sci"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1002\/pst.1893","volume":"17","author":"Sondag","year":"2018","journal-title":"Pharm Stat"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"5617","DOI":"10.1002\/mp.12556","volume":"44","author":"Sheng","year":"2017","journal-title":"Med Phys"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1186\/s12859-020-03608-0","volume":"21","author":"Chen","year":"2020","journal-title":"BMC Bioinf"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.gaceta.2017.07.012","volume":"33","author":"Cabrera Torres","year":"2019","journal-title":"Gac Sanit"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.amjsurg.2017.07.026","volume":"216","author":"Lawson","year":"2018","journal-title":"Am J Surg"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1777","DOI":"10.1158\/1078-0432.CCR-15-1250","volume":"22","author":"Zhao","year":"2016","journal-title":"Clin Cancer Res"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1111\/j.1600-065X.2012.01149.x","volume":"249","author":"McGaha","year":"2012","journal-title":"Immunol Rev"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.2741\/4363","volume":"20","author":"Wang","year":"2015","journal-title":"Front Biosci"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"2526174","DOI":"10.1155\/2016\/2526174","volume":"2016","author":"Yang","year":"2016","journal-title":"Oxid Med Cell Longev"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"274ra218","DOI":"10.1126\/scitranslmed.aaa0835","volume":"7","author":"Yin","year":"2015","journal-title":"Sci Transl Med"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1038\/nrrheum.2017.43","volume":"13","author":"Morel","year":"2017","journal-title":"Nat Rev Rheumatol"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1038\/ni.2833","volume":"15","author":"Everts","year":"2014","journal-title":"Nat Immunol"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1093\/advances\/nmy115","volume":"10","author":"Dolan","year":"2019","journal-title":"Adv Nutr"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/s00394-018-1881-0","volume":"59","author":"Saunders","year":"2020","journal-title":"Eur J Nutr"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1016\/S0171-2985(00)80079-0","volume":"201","author":"Widner","year":"2000","journal-title":"Immunobiology"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1729","DOI":"10.4049\/jimmunol.2000260","volume":"206","author":"Cho","year":"2021","journal-title":"J Immunol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1042\/CS20160153","volume":"130","author":"Badawy","year":"2016","journal-title":"Clin Sci"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1158\/2326-6066.CIR-19-0041","volume":"8","author":"Schramme","year":"2020","journal-title":"Cancer Immunol Res"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"636081","DOI":"10.3389\/fimmu.2021.636081","volume":"12","author":"Kim","year":"2021","journal-title":"Front Immunol"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"158","DOI":"10.3389\/fendo.2019.00158","volume":"10","author":"H\u00f6glund","year":"2019","journal-title":"Front Endocrinol"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"7509","DOI":"10.4049\/jimmunol.0804328","volume":"182","author":"Scott","year":"2009","journal-title":"J Immunol"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"2374","DOI":"10.4049\/jimmunol.1402854","volume":"195","author":"Shinde","year":"2015","journal-title":"J Immunol"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"9555","DOI":"10.1038\/s41598-024-60217-0","volume":"14","author":"Rojo-S\u00e1nchez","year":"2024","journal-title":"Sci Rep"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"1937","DOI":"10.1007\/s00726-023-03353-7","volume":"55","author":"Eryavuz Onmaz","year":"2023","journal-title":"Amino Acids"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"1861","DOI":"10.3389\/fimmu.2020.01861","volume":"11","author":"Merlo","year":"2020","journal-title":"Front Immunol"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1038\/nri1457","volume":"4","author":"Mellor","year":"2004","journal-title":"Nat Rev Immunol"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20150197","volume":"35","author":"Badawy","year":"2015","journal-title":"Biosci Rep"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"2259","DOI":"10.1002\/art.40223","volume":"69","author":"Perl","year":"2017","journal-title":"Arthritis Rheumatol"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"5381","DOI":"10.2174\/092986712803833353","volume":"19","author":"Filippini","year":"2012","journal-title":"Curr Med Chem"}],"container-title":["Journal of Inflammation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/104556","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/104556","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T03:15:15Z","timestamp":1751858115000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/metabolomic-profiling-reveals-serum-tryptophan-as-a-potential-therapeu-peer-reviewed-fulltext-article-JIR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":46,"URL":"https:\/\/doi.org\/10.2147\/jir.s505306","relation":{},"ISSN":["1178-7031"],"issn-type":[{"value":"1178-7031","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]}}}