{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T07:31:52Z","timestamp":1786865512258,"version":"build-2736575974"},"reference-count":55,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JIR"],"DOI":"10.2147\/jir.s511645","type":"journal-article","created":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T07:50:14Z","timestamp":1750492214000},"page":"8173-8197","source":"Crossref","is-referenced-by-count":4,"title":["Exploring Potential Causal Links: How Parkinson\u2019s Disease Brain Damage Impacts Liver Health\u2013A Mendelian Randomization and Transcriptomic Study"],"prefix":"10.2147","volume":"Volume 18","author":[{"given":"Tingting","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haojie","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiyan","family":"Xian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keke","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoyang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianshe","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2025,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1146\/annurev-pathmechdis-031521-034145","volume":"18","author":"Ye","year":"2023","journal-title":"Annu Rev Pathol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.3233\/JPD-181474","volume":"8","author":"Dorsey","year":"2018","journal-title":"J Parkinson's Dis"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"394","DOI":"10.4103\/1673-5374.266045","volume":"15","author":"Popa-Wagner","year":"2020","journal-title":"Neural Regen Res"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1111\/ene.14108","volume":"27","author":"Balestrino","year":"2020","journal-title":"Eur J Neurol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1111\/jnc.14308","volume":"144","author":"Zhang","year":"2018","journal-title":"J Neurochem"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1002\/hep.22478","volume":"48","author":"Beraza","year":"2008","journal-title":"Hepatology"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"864263","DOI":"10.3389\/fphys.2022.864263","volume":"13","author":"Vegas-Su\u00e1rez","year":"2022","journal-title":"Front Physiol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1218","DOI":"10.1021\/acs.jproteome.8b00847","volume":"18","author":"Zheng","year":"2019","journal-title":"J Proteome Res"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1941","DOI":"10.2174\/138161210791208875","volume":"16","author":"Bugianesi","year":"2010","journal-title":"Curr Pharm Des"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/978-1-4939-8916-4_3","volume":"1894","author":"Kermanizadeh","year":"2019","journal-title":"Methods Mol Biol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1038\/nrendo.2017.80","volume":"13","author":"Petersen","year":"2017","journal-title":"Nat Rev Endocrinol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"71","DOI":"10.3389\/fnbeh.2013.00071","volume":"7","author":"Vaglini","year":"2013","journal-title":"Front Behav Neurosci"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1080\/17425255.2021.1872543","volume":"17","author":"Bromek","year":"2021","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1055\/s-2007-1007167","volume":"18","author":"Ookhtens","year":"1998","journal-title":"Semin Liver Dis"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.mam.2008.05.005","volume":"30","author":"Lu","year":"2009","journal-title":"Mol Aspects Med"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1002\/ana.410180411","volume":"18","author":"Perry","year":"1985","journal-title":"Ann Neurol"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1007\/s00702-009-0283-0","volume":"116","author":"Squitti","year":"2009","journal-title":"J Neural Transm"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"463","DOI":"10.7916\/D8TB1K44","volume":"7","author":"Shin","year":"2017","journal-title":"Tremor Other Hyperkinet Mov"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1518","DOI":"10.1042\/BST20130237","volume":"41","author":"Rose","year":"2013","journal-title":"Biochem Soc Trans"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1038\/s43586-021-00092-5","volume":"2","author":"Sanderson","year":"2022","journal-title":"Nat Rev Meth Primers"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"6490","DOI":"10.1038\/s41467-022-34164-1","volume":"13","author":"Cheng","year":"2022","journal-title":"Nat Commun"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"46,543","DOI":"10.1038\/ng.2982","author":"Shin","year":"2014","journal-title":"Nat Genet"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.jeconom.2015.06.004","volume":"190","author":"Sanderson","year":"2016","journal-title":"J Econom"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"5434","DOI":"10.1002\/sim.9133","volume":"40","author":"Sanderson","year":"2021","journal-title":"Stat Med"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1002\/gepi.21758","volume":"37","author":"Burgess","year":"2013","journal-title":"Genet Epidemiol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1002\/gepi.21965","volume":"40","author":"Bowden","year":"2016","journal-title":"Genet Epidemiol"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1093\/ije\/dyv080","volume":"44","author":"Bowden","year":"2015","journal-title":"Int J Epidemiol"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1089\/omi.2011.0118","volume":"16","author":"Yu","year":"2012","journal-title":"OMICS"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1471-2105-14-7","volume":"14","author":"H\u00e4nzelmann","year":"2013","journal-title":"BMC Bioinf"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1016\/j.immuni.2013.10.003","volume":"39","author":"Bindea","year":"2013","journal-title":"Immunity"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/s12967-020-02698-x","volume":"19","author":"Zhao","year":"2021","journal-title":"J Transl Med"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1002\/0471250953.bi0814s24","volume":"24","author":"Morris","year":"2008","journal-title":"Curr Protoc Bioinformatics"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"D955","DOI":"10.1093\/nar\/gkw1118","volume":"45","author":"Wang","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/BF03033338","volume":"1","author":"Schwarting","year":"1999","journal-title":"Neurotox Res"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"115619","DOI":"10.1016\/j.bcp.2023.115619","volume":"213","author":"Huang","year":"2023","journal-title":"Biochem Pharmacol"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"661505","DOI":"10.3389\/fnagi.2021.661505","volume":"13","author":"Samidurai","year":"2021","journal-title":"Front Aging Neurosci"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1210\/er.2017-00211","volume":"39","author":"Smith","year":"2018","journal-title":"Endocr Rev"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1038\/s41573-020-0072-x","volume":"19","author":"Cunnane","year":"2020","journal-title":"Nat Rev Drug Discov"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"822","DOI":"10.5604\/01.3001.0012.3143","volume":"17","author":"Heiser","year":"2018","journal-title":"Ann Hepatol"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1111\/hepr.12760","volume":"47","author":"Mizuno","year":"2017","journal-title":"Hepatol Res"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"2097","DOI":"10.1053\/j.gastro.2018.02.016","volume":"154","author":"Denson","year":"2018","journal-title":"Gastroenterology"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"3769","DOI":"10.1016\/j.bbadis.2018.09.009","volume":"1864","author":"G\u00e1mez-Belmonte","year":"2018","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"988332","DOI":"10.3389\/fonc.2022.988332","volume":"12","author":"Li","year":"2022","journal-title":"Front Oncol"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1038\/s41588-021-00803-4","volume":"53","author":"Wang","year":"2021","journal-title":"Nat Genet"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"2316","DOI":"10.4103\/1673-5374.310700","volume":"16","author":"Cao","year":"2021","journal-title":"Neural Regen Res"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"1687","DOI":"10.3390\/cells9071687","volume":"9","author":"Pajares","year":"2020","journal-title":"Cells"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"436813","DOI":"10.4061\/2011\/436813","volume":"2011","author":"Ferrari","year":"2011","journal-title":"Parkinson's Dis"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"105940","DOI":"10.1016\/j.nbd.2022.105940","volume":"176","author":"Gopinath","year":"2023","journal-title":"Neurobiol Dis"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"743","DOI":"10.2165\/00002018-200326110-00001","volume":"26","author":"Borges","year":"2003","journal-title":"Drug Saf"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"154911","DOI":"10.1016\/j.phymed.2023.154911","volume":"117","author":"Wang","year":"2023","journal-title":"Phytomedicine"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.intimp.2017.02.022","volume":"46","author":"Lv","year":"2017","journal-title":"Int Immunopharmacol"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"974","DOI":"10.4158\/EP161222.OR","volume":"22","author":"Niculescu","year":"2016","journal-title":"Endocr Pract"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.3390\/antiox9101007","volume":"9","author":"Prasad","year":"2020","journal-title":"Antioxidants"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/0024-3205(88)90291-3","volume":"43","author":"Thakar","year":"1988","journal-title":"Life Sci"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1007\/s00210-019-01715-1","volume":"393","author":"Datta","year":"2020","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"}],"container-title":["Journal of Inflammation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/104086","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/104086","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T07:50:15Z","timestamp":1750492215000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/exploring-potential-causal-links-how-parkinsons-disease-brain-damage-i-peer-reviewed-fulltext-article-JIR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":55,"URL":"https:\/\/doi.org\/10.2147\/jir.s511645","relation":{},"ISSN":["1178-7031"],"issn-type":[{"value":"1178-7031","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6]]}}}