{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T14:27:04Z","timestamp":1788964024406,"version":"build-2803163510"},"reference-count":169,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JIR"],"DOI":"10.2147\/jir.s513367","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T11:15:13Z","timestamp":1747134913000},"page":"6245-6261","source":"Crossref","is-referenced-by-count":18,"title":["PANoptosis in Sepsis: A Central Role and Emerging Therapeutic Target"],"prefix":"10.2147","volume":"Volume 18","author":[{"given":"Qiqi","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1582-2324","authenticated-orcid":true,"given":"Siyuan","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaofeng","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangjun","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5058-6052","authenticated-orcid":true,"given":"Zhanfei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xijie","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2025,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1001\/jama.2016.0287","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1038\/s41392-021-00816-9","volume":"6","author":"Zhang","year":"2021","journal-title":"Signal Transduct Target Ther"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/S0140-6736(18)30696-2","volume":"392","author":"Cecconi","year":"2018","journal-title":"Lancet"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1038\/s41569-020-00492-2","volume":"18","author":"Hollenberg","year":"2021","journal-title":"Nat Rev Cardiol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2023.13114","volume":"28","author":"Song","year":"2023","journal-title":"Mol Med Rep"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/s11658-024-00536-2","volume":"29","author":"Li","year":"2024","journal-title":"Cell Mol Biol Lett"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1521","DOI":"10.1038\/s41401-023-01068-9","volume":"44","author":"Sheng","year":"2023","journal-title":"Acta Pharmacol Sin"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"112103","DOI":"10.1016\/j.intimp.2024.112103","volume":"133","author":"Meng","year":"2024","journal-title":"Int Immunopharmacol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"e219","DOI":"10.1097\/CCM.0000000000006172","volume":"52","author":"Chaudhuri","year":"2024","journal-title":"Crit Care Med"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1186\/s13054-023-04552-0","volume":"27","author":"Chang","year":"2023","journal-title":"Crit Care"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"k4891","DOI":"10.1136\/bmj.k4891","volume":"364","author":"Poston","year":"2019","journal-title":"BMJ"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.ccc.2020.11.010","volume":"37","author":"Manrique-Caballero","year":"2021","journal-title":"Crit Care Clin"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/s13054-020-03424-1","volume":"25","author":"van der Slikke","year":"2021","journal-title":"Crit Care"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.jare.2022.01.014","volume":"41","author":"Zou","year":"2022","journal-title":"J Adv Res"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1097\/MCC.0000000000001022","volume":"29","author":"Piva","year":"2023","journal-title":"Curr Opin Crit Care"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"4583","DOI":"10.1038\/s41467-022-32325-w","volume":"13","author":"Bao","year":"2022","journal-title":"Nat Commun"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1080\/22221751.2022.2045876","volume":"11","author":"Liang","year":"2022","journal-title":"Emerg Microbes Infect"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1038\/cdd.2014.137","volume":"22","author":"Galluzzi","year":"2015","journal-title":"Cell Death Differ"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"245\u2013249;quiz249","DOI":"10.1016\/S1081-1206(10)63176-6","volume":"78","author":"Fleisher","year":"1997","journal-title":"Ann Allergy Asthma Immunol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/j.tcb.2017.05.005","volume":"27","author":"Kovacs","year":"2017","journal-title":"Trends Cell Biol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1038\/s41423-020-00630-3","volume":"18","author":"Bertheloot","year":"2021","journal-title":"Cell Mol Immunol"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.2147\/JIR.S403819","volume":"16","author":"Shi","year":"2023","journal-title":"J Inflamm Res"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1186\/s13054-021-03481-0","volume":"25","author":"Qi","year":"2021","journal-title":"Crit Care"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1038\/s41419-019-2015-1","volume":"10","author":"Cao","year":"2019","journal-title":"Cell Death Dis"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1038\/nrneph.2017.165","volume":"14","author":"Venet","year":"2018","journal-title":"Nat Rev Nephrol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1007\/s10495-016-1325-3","volume":"22","author":"Girardot","year":"2017","journal-title":"Apoptosis"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1038\/s41418-017-0012-4","volume":"25","author":"Galluzzi","year":"2018","journal-title":"Cell Death Differ"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"963955","DOI":"10.3389\/fimmu.2022.963955","volume":"13","author":"Zhu","year":"2022","journal-title":"Front Immunol"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12111942","volume":"12","author":"Briassoulis","year":"2023","journal-title":"Antioxidants"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"711939","DOI":"10.3389\/fimmu.2021.711939","volume":"12","author":"Zheng","year":"2021","journal-title":"Front Immunol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1186\/s13054-021-03775-3","volume":"25","author":"Jiao","year":"2021","journal-title":"Crit Care"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"101781","DOI":"10.1016\/j.smim.2023.101781","volume":"69","author":"Vasudevan","year":"2023","journal-title":"Semin Immunol"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"3337","DOI":"10.7150\/ijbs.69141","volume":"18","author":"Zhang","year":"2022","journal-title":"Int J Biol Sci"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"453","DOI":"10.23736\/S2724-5683.23.06476-1","volume":"72","author":"Pang","year":"2024","journal-title":"Minerva Cardiol Angiol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"149245","DOI":"10.1016\/j.bbrc.2023.149245","volume":"690","author":"Yan","year":"2024","journal-title":"Biochem Biophys Res Commun"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1097\/SHK.0000000000002370","volume":"62","author":"Yang","year":"2024","journal-title":"Shock"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"e0315219","DOI":"10.1371\/journal.pone.0315219","volume":"19","author":"Zhao","year":"2024","journal-title":"PLoS One"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20210518","volume":"218","author":"Chen","year":"2021","journal-title":"J Exp Med"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.freeradbiomed.2020.08.009","volume":"160","author":"Li","year":"2020","journal-title":"Free Radic Biol Med"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s11658-020-00205-0","volume":"25","author":"Liu","year":"2020","journal-title":"Cell Mol Biol Lett"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"956361","DOI":"10.3389\/fimmu.2022.956361","volume":"13","author":"Xl","year":"2022","journal-title":"Front Immunol"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1007\/s10753-018-0890-8","volume":"42","author":"Qiu","year":"2019","journal-title":"Inflammation"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/nature07383","volume":"456","author":"Saitoh","year":"2008","journal-title":"Nature"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1038\/nri3532","volume":"13","author":"Deretic","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"1520","DOI":"10.1080\/15548627.2015.1063765","volume":"11","author":"Unuma","year":"2015","journal-title":"Autophagy"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.cell.2014.02.049","volume":"157","author":"Green","year":"2014","journal-title":"Cell"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1242\/bio.201410322","volume":"4","author":"Chen","year":"2015","journal-title":"Biol Open"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"406","DOI":"10.3389\/fcimb.2019.00406","volume":"9","author":"Malireddi","year":"2019","journal-title":"Front Cell Infect Microbiol"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1111\/imr.13279","volume":"321","author":"Sun","year":"2024","journal-title":"Immunol Rev"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"eabo6294","DOI":"10.1126\/sciimmunol.abo6294","volume":"7","author":"Karki","year":"2022","journal-title":"Science Immunol"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"847345","DOI":"10.3389\/fimmu.2022.847345","volume":"13","author":"Liu","year":"2022","journal-title":"Front Immunol"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"1120034","DOI":"10.3389\/fimmu.2023.1120034","volume":"14","author":"Zhu","year":"2023","journal-title":"Front Immunol"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"e14226","DOI":"10.1111\/eci.14226","volume":"54","author":"Zhou","year":"2024","journal-title":"Eur J Clin Invest"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.cell.2020.11.025","volume":"184","author":"Karki","year":"2021","journal-title":"Cell"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"4641","DOI":"10.1016\/j.csbj.2021.07.038","volume":"19","author":"Wang","year":"2021","journal-title":"Comput Struct Biotechnol J"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.mib.2020.07.012","volume":"59","author":"Place","year":"2021","journal-title":"Curr Opin Microbiol"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"640","DOI":"10.7150\/thno.91814","volume":"14","author":"Ocansey","year":"2024","journal-title":"Theranostics"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"238","DOI":"10.3389\/fcimb.2020.00238","volume":"10","author":"Samir","year":"2020","journal-title":"Front Cell Infect Microbiol"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1038\/s41401-024-01376-8","volume":"42","author":"You","year":"2024","journal-title":"Acta Pharmacol Sin"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"102348","DOI":"10.1016\/j.coi.2023.102348","volume":"83","author":"Karki","year":"2023","journal-title":"Curr Opin Immunol"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1186\/s12915-024-01901-5","volume":"22","author":"Bynigeri","year":"2024","journal-title":"BMC Biol"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"2783","DOI":"10.1016\/j.cell.2023.05.005","volume":"186","author":"Sundaram","year":"2023","journal-title":"Cell"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"122158","DOI":"10.1016\/j.lfs.2023.122158","volume":"333","author":"Qi","year":"2023","journal-title":"Life Sci"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/s41586-021-03875-8","volume":"597","author":"Lee","year":"2021","journal-title":"Nature"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"1148727","DOI":"10.3389\/fimmu.2023.1148727","volume":"14","author":"Oh","year":"2023","journal-title":"Front Immunol"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abl4348","volume":"6","author":"Asano","year":"2021","journal-title":"Science Immunol"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"3625","DOI":"10.1172\/JCI126363","volume":"129","author":"Channappanavar","year":"2019","journal-title":"J Clin Invest"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.micinf.2020.04.009","volume":"22","author":"Moreno-Eutimio","year":"2020","journal-title":"Microbes Infect"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"2689","DOI":"10.1128\/JVI.79.5.2689-2699.2005","volume":"79","author":"Sumpter","year":"2005","journal-title":"J Virol"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.cell.2010.01.020","volume":"140","author":"Rehwinkel","year":"2010","journal-title":"Cell"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1038\/s41419-022-04664-5","volume":"13","author":"Messaoud-Nacer","year":"2022","journal-title":"Cell Death Dis"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1084\/jem.20171922","volume":"215","author":"Malireddi","year":"2018","journal-title":"J Exp Med"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1126\/science.aau2818","volume":"362","author":"Orning","year":"2018","journal-title":"Science"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"2871","DOI":"10.1074\/jbc.M608083200","volume":"282","author":"Cruz","year":"2007","journal-title":"J Biol Chem"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"106013","DOI":"10.1016\/j.biocel.2021.106013","volume":"136","author":"Mishra","year":"2021","journal-title":"Int J Biochem Cell Biol"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1111\/imr.12909","volume":"297","author":"Zheng","year":"2020","journal-title":"Immunol Rev"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"1632","DOI":"10.1038\/s12276-023-01069-y","volume":"55","author":"Lee","year":"2023","journal-title":"Exp Mol Med"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.cell.2011.11.031","volume":"148","author":"Sun","year":"2012","journal-title":"Cell"},{"key":"ref79","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/s12929-021-00724-8","volume":"28","author":"Faria","year":"2021","journal-title":"J Biomed Sci"},{"key":"ref80","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1038\/nature15514","volume":"526","author":"Shi","year":"2015","journal-title":"Nature"},{"key":"ref81","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1038\/s41419-023-06370-2","volume":"14","author":"Wang","year":"2023","journal-title":"Cell Death Dis"},{"key":"ref82","doi-asserted-by":"publisher","first-page":"1247131","DOI":"10.3389\/fimmu.2023.1247131","volume":"14","author":"Dai","year":"2023","journal-title":"Front Immunol"},{"key":"ref83","doi-asserted-by":"publisher","first-page":"4765","DOI":"10.2147\/JIR.S461809","volume":"17","author":"Xu","year":"2024","journal-title":"J Inflamm Res"},{"key":"ref84","volume":"10","author":"Wang","year":"2024","journal-title":"Heliyon"},{"key":"ref85","doi-asserted-by":"publisher","first-page":"e70136","DOI":"10.1002\/iid3.70136","volume":"13","author":"Lu","year":"2025","journal-title":"Immun Inflamm Dis"},{"key":"ref86","doi-asserted-by":"publisher","first-page":"1941","DOI":"10.2147\/JIR.S452608","volume":"17","author":"Yang","year":"2024","journal-title":"J Inflamm Res"},{"key":"ref87","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1038\/s41419-024-06849-6","volume":"15","author":"Wang","year":"2024","journal-title":"Cell Death Dis"},{"key":"ref88","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1186\/s40779-024-00574-z","volume":"11","author":"Gong","year":"2024","journal-title":"Mil Med Res"},{"key":"ref89","doi-asserted-by":"publisher","first-page":"177438","DOI":"10.1016\/j.ejphar.2025.177438","volume":"996","author":"Zhang","year":"2025","journal-title":"Eur J Pharmacol"},{"key":"ref90","doi-asserted-by":"publisher","first-page":"349","DOI":"10.2147\/DDDT.S495225","volume":"19","author":"Yang","year":"2025","journal-title":"Drug Des Devel Ther"},{"key":"ref91","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1007\/s12026-024-09491-8","volume":"72","author":"Liu","year":"2024","journal-title":"Immunol Res"},{"key":"ref92","volume":"24","author":"Zhou","year":"2023","journal-title":"Int J Mol Sci"},{"key":"ref93","doi-asserted-by":"publisher","first-page":"150140","DOI":"10.1016\/j.bbrc.2024.150140","volume":"724","author":"Zhou","year":"2024","journal-title":"Biochem Biophys Res Commun"},{"key":"ref94","doi-asserted-by":"publisher","first-page":"115914","DOI":"10.1016\/j.biopha.2023.115914","volume":"169","author":"Jiang","year":"2023","journal-title":"Biomed Pharmacother"},{"key":"ref95","doi-asserted-by":"publisher","first-page":"899","DOI":"10.14336\/AD.2021.1023","volume":"13","author":"Cui","year":"2022","journal-title":"Aging Dis"},{"key":"ref96","doi-asserted-by":"publisher","first-page":"118699","DOI":"10.1016\/j.jep.2024.118699","volume":"336","author":"Zhang","year":"2025","journal-title":"J Ethnopharmacol"},{"key":"ref97","doi-asserted-by":"publisher","first-page":"1474","DOI":"10.1097\/CM9.0000000000002010","volume":"135","author":"Zhou","year":"2022","journal-title":"Chin Med J"},{"key":"ref98","doi-asserted-by":"publisher","first-page":"2403649","DOI":"10.1080\/0886022X.2024.2403649","volume":"46","author":"Wei","year":"2024","journal-title":"Renal Failure"},{"key":"ref99","doi-asserted-by":"publisher","first-page":"7289","DOI":"10.1021\/acs.jafc.2c08382","volume":"71","author":"Guo","year":"2023","journal-title":"J Agric Food Chem"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"111161","DOI":"10.1016\/j.intimp.2023.111161","volume":"125","author":"He","year":"2023","journal-title":"Int Immunopharmacol"},{"key":"ref101","doi-asserted-by":"publisher","first-page":"118740","DOI":"10.1016\/j.jep.2024.118740","volume":"336","author":"Wang","year":"2025","journal-title":"J Ethnopharmacol"},{"key":"ref102","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1038\/s41423-023-01107-9","volume":"20","author":"Oh","year":"2023","journal-title":"Cell Mol Immunol"},{"key":"ref103","doi-asserted-by":"publisher","first-page":"R568","DOI":"10.1016\/j.cub.2016.02.019","volume":"26","author":"Vande Walle","year":"2016","journal-title":"Curr Biol"},{"key":"ref104","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1038\/nrm.2016.149","volume":"18","author":"Weinlich","year":"2017","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref105","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1038\/s41586-019-1770-6","volume":"575","author":"Fritsch","year":"2019","journal-title":"Nature"},{"key":"ref106","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/s40779-022-00422-y","volume":"9","author":"Liu","year":"2022","journal-title":"Mil Med Res"},{"key":"ref107","doi-asserted-by":"publisher","first-page":"2255","DOI":"10.1056\/NEJMra2026131","volume":"383","author":"Fajgenbaum","year":"2020","journal-title":"New Engl J Med"},{"key":"ref108","doi-asserted-by":"publisher","first-page":"2241","DOI":"10.1016\/j.febslet.2013.05.053","volume":"587","author":"Joshi","year":"2013","journal-title":"FEBS Lett"},{"key":"ref109","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1038\/nri.2017.105","volume":"18","author":"Papayannopoulos","year":"2018","journal-title":"Nat Rev Immunol"},{"key":"ref110","doi-asserted-by":"publisher","first-page":"e2113872119","DOI":"10.1073\/pnas.2113872119","volume":"119","author":"Muendlein","year":"2022","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref111","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1038\/s41401-023-01182-8","volume":"45","author":"Shi","year":"2024","journal-title":"Acta Pharmacol Sin"},{"key":"ref112","doi-asserted-by":"publisher","first-page":"109019","DOI":"10.1016\/j.clim.2022.109019","volume":"238","author":"Pan","year":"2022","journal-title":"Clin Immunol"},{"key":"ref113","doi-asserted-by":"publisher","first-page":"102870","DOI":"10.1016\/j.jaut.2022.102870","volume":"132","author":"Li","year":"2022","journal-title":"J Autoimmun"},{"key":"ref114","doi-asserted-by":"publisher","first-page":"109660","DOI":"10.1016\/j.clim.2023.109660","volume":"253","author":"Sun","year":"2023","journal-title":"Clin Immunol"},{"key":"ref115","doi-asserted-by":"publisher","first-page":"113083","DOI":"10.1016\/j.intimp.2024.113083","volume":"142","author":"Yang","year":"2024","journal-title":"Int Immunopharmacol"},{"key":"ref116","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1186\/s12943-024-02130-8","volume":"23","author":"Zhang","year":"2024","journal-title":"Mol Cancer"},{"key":"ref117","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1186\/s11658-024-00602-9","volume":"29","author":"Zheng","year":"2024","journal-title":"Cell Mol Biol Lett"},{"key":"ref118","doi-asserted-by":"publisher","first-page":"2450","DOI":"10.1016\/j.immuni.2021.10.012","volume":"54","author":"van der Poll","year":"2021","journal-title":"Immunity"},{"key":"ref119","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1097\/SHK.0000000000002174","volume":"60","author":"Dong","year":"2023","journal-title":"Shock"},{"key":"ref120","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1186\/s11658-024-00646-x","volume":"29","author":"Zhang","year":"2024","journal-title":"Cell Mol Biol Lett"},{"key":"ref121","doi-asserted-by":"publisher","first-page":"1007705","DOI":"10.3389\/fimmu.2022.1007705","volume":"13","author":"Moltrasio","year":"2022","journal-title":"Front Immunol"},{"key":"ref122","doi-asserted-by":"publisher","first-page":"112710","DOI":"10.1016\/j.intimp.2024.112710","volume":"139","author":"Yuan","year":"2024","journal-title":"Int Immunopharmacol"},{"key":"ref123","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1186\/s12943-024-01977-1","volume":"23","author":"Yang","year":"2024","journal-title":"Mol Cancer"},{"key":"ref124","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/s13045-023-01453-1","volume":"16","author":"Yang","year":"2023","journal-title":"J Hematol Oncol"},{"key":"ref125","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1016\/j.it.2021.06.001","volume":"42","author":"Karki","year":"2021","journal-title":"Trends Immunol"},{"key":"ref126","doi-asserted-by":"publisher","first-page":"357","DOI":"10.4103\/1673-5374.346545","volume":"18","author":"Yan","year":"2023","journal-title":"Neural Regen Res"},{"key":"ref127","doi-asserted-by":"publisher","first-page":"14971","DOI":"10.1021\/acs.jmedchem.2c01518","volume":"65","author":"Shi","year":"2022","journal-title":"J Med Chem"},{"key":"ref128","doi-asserted-by":"publisher","first-page":"5685","DOI":"10.1016\/j.bmcl.2012.06.098","volume":"22","author":"Choi","year":"2012","journal-title":"Bioorg Med Chem Lett"},{"key":"ref129","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1159\/000510864","volume":"106","author":"Qiao","year":"2021","journal-title":"Pharmacology"},{"key":"ref130","doi-asserted-by":"publisher","first-page":"4903","DOI":"10.1016\/j.bmcl.2013.06.073","volume":"23","author":"Wu","year":"2013","journal-title":"Bioorg Med Chem Lett"},{"key":"ref131","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1038\/s41420-020-0240-0","volume":"6","author":"Brito","year":"2020","journal-title":"Cell Death Discov"},{"key":"ref132","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1038\/s41419-017-0245-7","volume":"9","author":"Martens","year":"2018","journal-title":"Cell Death Dis"},{"key":"ref133","doi-asserted-by":"publisher","first-page":"114542","DOI":"10.1016\/j.bcp.2021.114542","volume":"188","author":"Rui","year":"2021","journal-title":"Biochem Pharmacol"},{"key":"ref134","doi-asserted-by":"publisher","first-page":"113484","DOI":"10.1016\/j.ejmech.2021.113484","volume":"220","author":"Xia","year":"2021","journal-title":"Eur J Med Chem"},{"key":"ref135","doi-asserted-by":"publisher","first-page":"107979","DOI":"10.1016\/j.pharmthera.2021.107979","volume":"231","author":"Li","year":"2022","journal-title":"Pharmacol Ther"},{"key":"ref136","doi-asserted-by":"publisher","first-page":"2163","DOI":"10.1021\/acs.jmedchem.5b01898","volume":"59","author":"Harris","year":"2016","journal-title":"J Med Chem"},{"key":"ref137","doi-asserted-by":"publisher","first-page":"113947","DOI":"10.1016\/j.bcp.2020.113947","volume":"177","author":"Qin","year":"2020","journal-title":"Biochem Pharmacol"},{"key":"ref138","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1186\/s13287-021-02532-1","volume":"12","author":"Zhang","year":"2021","journal-title":"Stem Cell Res Ther"},{"key":"ref139","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1167\/iovs.64.14.42","volume":"64","author":"Feng","year":"2023","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref140","doi-asserted-by":"publisher","first-page":"109262","DOI":"10.1016\/j.intimp.2022.109262","volume":"112","author":"Xu","year":"2022","journal-title":"Int Immunopharmacol"},{"key":"ref141","doi-asserted-by":"publisher","first-page":"2702","DOI":"10.1182\/blood.2021011525","volume":"138","author":"Silva","year":"2021","journal-title":"Blood"},{"key":"ref142","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aat2738","volume":"3","author":"Rathkey","year":"2018","journal-title":"Science Immunol"},{"key":"ref143","doi-asserted-by":"publisher","first-page":"1633","DOI":"10.1126\/science.abb9818","volume":"369","author":"Humphries","year":"2020","journal-title":"Science"},{"key":"ref144","doi-asserted-by":"publisher","first-page":"5411","DOI":"10.1021\/jacs.1c12924","volume":"144","author":"Ngai","year":"2022","journal-title":"J Am Chem Soc"},{"key":"ref145","doi-asserted-by":"publisher","first-page":"17485","DOI":"10.1074\/jbc.M115.641191","volume":"290","author":"Lopez-Pastrana","year":"2015","journal-title":"J Biol Chem"},{"key":"ref146","doi-asserted-by":"publisher","first-page":"108405","DOI":"10.1016\/j.intimp.2021.108405","volume":"102","author":"Wang","year":"2022","journal-title":"Int Immunopharmacol"},{"key":"ref147","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.bbrc.2022.05.001","volume":"617","author":"Xu","year":"2022","journal-title":"Biochem Biophys Res Commun"},{"key":"ref148","doi-asserted-by":"publisher","first-page":"e12828","DOI":"10.1111\/jpi.12828","volume":"73","author":"Ye","year":"2022","journal-title":"J Pineal Res"},{"key":"ref149","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1186\/s12967-022-03641-y","volume":"20","author":"Ren","year":"2022","journal-title":"J Transl Med"},{"key":"ref150","doi-asserted-by":"publisher","first-page":"112373","DOI":"10.1016\/j.intimp.2024.112373","volume":"137","author":"Cui","year":"2024","journal-title":"Int Immunopharmacol"},{"key":"ref151","doi-asserted-by":"publisher","first-page":"E1530","DOI":"10.1073\/pnas.1716095115","volume":"115","author":"Marchetti","year":"2018","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref152","doi-asserted-by":"publisher","first-page":"108595","DOI":"10.1016\/j.intimp.2022.108595","volume":"106","author":"Bakhshi","year":"2022","journal-title":"Int Immunopharmacol"},{"key":"ref153","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1038\/nm.3806","volume":"21","author":"Coll","year":"2015","journal-title":"Nat Med"},{"key":"ref154","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1038\/nm.3804","volume":"21","author":"Youm","year":"2015","journal-title":"Nat Med"},{"key":"ref155","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201708689","volume":"10","author":"Huang","year":"2018","journal-title":"EMBO Mol Med"},{"key":"ref156","doi-asserted-by":"publisher","first-page":"1824","DOI":"10.1080\/08941939.2022.2128117","volume":"35","author":"Uysal","year":"2022","journal-title":"J Invest Surg"},{"key":"ref157","doi-asserted-by":"publisher","first-page":"114194","DOI":"10.1016\/j.ejmech.2022.114194","volume":"232","author":"Jiao","year":"2022","journal-title":"Eur J Med Chem"},{"key":"ref158","doi-asserted-by":"publisher","first-page":"153019","DOI":"10.1016\/j.phymed.2019.153019","volume":"63","author":"Kim","year":"2019","journal-title":"Phytomedicine"},{"key":"ref159","doi-asserted-by":"publisher","first-page":"109858","DOI":"10.1016\/j.celrep.2021.109858","volume":"37","author":"Karki","year":"2021","journal-title":"Cell Rep"},{"key":"ref160","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1007\/s00109-018-1642-9","volume":"96","author":"Eguchi","year":"2018","journal-title":"J Mol Med"},{"key":"ref161","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1007\/s12328-021-01585-2","volume":"15","author":"Lekakis","year":"2022","journal-title":"Clin J Gastroenterol"},{"key":"ref162","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1056\/NEJMoa2031994","volume":"384","author":"Kalil","year":"2021","journal-title":"New Engl J Med"},{"key":"ref163","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1186\/s12967-022-03767-z","volume":"20","author":"Karki","year":"2022","journal-title":"J Transl Med"},{"key":"ref164","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1007\/s12013-024-01488-2","volume":"83","author":"Zhu","year":"2024","journal-title":"Cell Biochem Biophys"},{"key":"ref165","doi-asserted-by":"publisher","first-page":"112564","DOI":"10.1016\/j.jep.2020.112564","volume":"251","author":"Jiang","year":"2020","journal-title":"J Ethnopharmacol"},{"key":"ref166","doi-asserted-by":"publisher","first-page":"110844","DOI":"10.1016\/j.intimp.2023.110844","volume":"124","author":"Guo","year":"2023","journal-title":"Int Immunopharmacol"},{"key":"ref167","doi-asserted-by":"publisher","first-page":"118153","DOI":"10.1016\/j.jep.2024.118153","volume":"329","author":"Liang","year":"2024","journal-title":"J Ethnopharmacol"},{"key":"ref168","doi-asserted-by":"publisher","first-page":"117097","DOI":"10.1016\/j.jep.2023.117097","volume":"319","author":"Lin","year":"2024","journal-title":"J Ethnopharmacol"},{"key":"ref169","doi-asserted-by":"publisher","first-page":"11697","DOI":"10.1039\/D4FO03468F","volume":"15","author":"Cui","year":"2024","journal-title":"Food Funct"}],"container-title":["Journal of Inflammation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/102920","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/102920","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T11:15:15Z","timestamp":1747134915000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/panoptosis-in-sepsis-a-central-role-and-emerging-therapeutic-target-peer-reviewed-fulltext-article-JIR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":169,"URL":"https:\/\/doi.org\/10.2147\/jir.s513367","relation":{},"ISSN":["1178-7031"],"issn-type":[{"value":"1178-7031","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5]]}}}