{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:54:06Z","timestamp":1790744046842,"version":"4.1.0"},"reference-count":66,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JIR"],"DOI":"10.2147\/jir.s515002","type":"journal-article","created":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T13:30:14Z","timestamp":1755178214000},"page":"11109-11124","source":"Crossref","is-referenced-by-count":7,"title":["Rhoifolin Attenuates DSS-Induced Colitis in Mice by Modulating Gut Microbiota and Restoring Th17\/Treg Balance"],"prefix":"10.2147","volume":"Volume 18","author":[{"given":"Hao","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ze-Hui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng-Lan","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su-Zhi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song-Lin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Xuan","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Te","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2025,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1038\/s41572-020-0205-x","volume":"6","author":"Kobayashi","year":"2020","journal-title":"Nat Rev Dis Primers"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1756","DOI":"10.1016\/S0140-6736(16)32126-2","volume":"389","author":"Ungaro","year":"2017","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1016\/j.mayocp.2019.01.018","volume":"94","author":"Feuerstein","year":"2019","journal-title":"Mayo Clin Proc"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/S0140-6736(23)00966-2","volume":"402","author":"Le Berre","year":"2023","journal-title":"Lancet"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"2769","DOI":"10.1016\/S0140-6736(17)32448-0","volume":"390","author":"Ng","year":"2017","journal-title":"Lancet"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1053\/j.gastro.2016.10.020","volume":"152","author":"Kaplan","year":"2017","journal-title":"Gastroenterology"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"7247238","DOI":"10.1155\/2019\/7247238","volume":"2019","author":"Guan","year":"2019","journal-title":"J Immunol Res"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1038\/s41575-019-0121-2","volume":"16","author":"Richard","year":"2019","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"17004","DOI":"10.1038\/nmicrobiol.2017.4","volume":"2","author":"Halfvarson","year":"2017","journal-title":"Nat Microbiol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1111\/1751-2980.12849","volume":"21","author":"Guo","year":"2020","journal-title":"J Dig Dis"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1038\/nrmicro2403","volume":"8","author":"Nell","year":"2010","journal-title":"Nat Rev Microbiol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"4466","DOI":"10.3390\/nu15204466","volume":"15","author":"Shin","year":"2023","journal-title":"Nutrients"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"85838","DOI":"10.18632\/oncotarget.20689","volume":"8","author":"Diling","year":"2017","journal-title":"Oncotarget"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"10453","DOI":"10.2147\/JIR.S483958","volume":"17","author":"Subramanian","year":"2024","journal-title":"J Inflamm Res"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"3356","DOI":"10.3748\/wjg.v30.i27.3356","volume":"30","author":"Subramanian","year":"2024","journal-title":"World J Gastroenterol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"730","DOI":"10.3390\/ijms19030730","volume":"19","author":"Lee","year":"2018","journal-title":"Int J Mol Sci"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.immuni.2018.12.015","volume":"50","author":"Britton","year":"2019","journal-title":"Immunity"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1007\/s00281-019-00741-8","volume":"41","author":"Goschl","year":"2019","journal-title":"Semin Immunopathol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"5225","DOI":"10.7150\/thno.43716","volume":"10","author":"Liu","year":"2020","journal-title":"Theranostics"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1038\/ni1488","volume":"8","author":"Zhou","year":"2007","journal-title":"Nat Immunol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1038\/nature04753","volume":"441","author":"Bettelli","year":"2006","journal-title":"Nature"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"639","DOI":"10.3389\/fimmu.2015.00639","volume":"6","author":"Omenetti","year":"2015","journal-title":"Front Immunol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.chom.2008.09.009","volume":"4","author":"Ivanov","year":"2008","journal-title":"Cell Host Microbe"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"13942","DOI":"10.1073\/pnas.1323852111","volume":"111","author":"Shih","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref25","first-page":"288","volume":"9","author":"Barreca","year":"2020","journal-title":"Biological Functions Health Promoting Properties Plants"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"106112","DOI":"10.1016\/j.micpath.2023.106112","volume":"180","author":"Wen","year":"2023","journal-title":"Microb Pathog"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"5654","DOI":"10.1038\/s41598-022-09581-3","volume":"12","author":"Zheng","year":"2022","journal-title":"Sci Rep"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1016\/j.joca.2022.01.009","volume":"30","author":"Chen","year":"2022","journal-title":"Osteoarthritis Cartilage"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"2191","DOI":"10.1007\/s10753-020-01286-x","volume":"43","author":"Fang","year":"2020","journal-title":"Inflammation"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"154052","DOI":"10.1016\/j.phymed.2022.154052","volume":"100","author":"Li","year":"2022","journal-title":"Phytomedicine"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"e9489","DOI":"10.1590\/1414-431x20209489","volume":"53","author":"Peng","year":"2020","journal-title":"Braz J Med Biol Res"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1136\/gut.52.5.713","volume":"52","author":"Kihara","year":"2003","journal-title":"Gut"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1007\/s00253-015-7039-6","volume":"100","author":"Liu","year":"2016","journal-title":"Appl Microbiol Biotechnol"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"400","DOI":"10.3390\/jcm11020400","volume":"11","author":"Kaluzna","year":"2022","journal-title":"J Clin Med"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"154452","DOI":"10.1016\/j.phymed.2022.154452","volume":"107","author":"Cheng","year":"2022","journal-title":"Phytomedicine"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"733992","DOI":"10.3389\/fcimb.2022.733992","volume":"12","author":"Qiu","year":"2022","journal-title":"Front Cell Infect Microbiol"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.1053\/j.gastro.2017.07.047","volume":"153","author":"Hegazy","year":"2017","journal-title":"Gastroenterology"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"766126","DOI":"10.3389\/fmed.2021.766126","volume":"8","author":"Hu","year":"2021","journal-title":"Front Med"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"106610","DOI":"10.1016\/j.intimp.2020.106610","volume":"85","author":"Ibrahim","year":"2020","journal-title":"Int Immunopharmacol"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"117316","DOI":"10.1016\/j.jep.2023.117316","volume":"319","author":"Peng","year":"2024","journal-title":"J Ethnopharmacol"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"115613","DOI":"10.1016\/j.carbpol.2019.115613","volume":"230","author":"Chen","year":"2020","journal-title":"Carbohydr Polym"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1111\/jgh.12294","volume":"28 Suppl 4","author":"Ramakrishna","year":"2013","journal-title":"J Gastroenterol Hepatol"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"3328","DOI":"10.3389\/fmicb.2018.03328","volume":"9","author":"Iacob","year":"2018","journal-title":"Front Microbiol"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1038\/nature13828","volume":"517","author":"Buffie","year":"2015","journal-title":"Nature"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1136\/gutjnl-2021-326789","volume":"71","author":"de Vos","year":"2022","journal-title":"Gut"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"6025","DOI":"10.2147\/JIR.S300989","volume":"14","author":"Siddiqui","year":"2021","journal-title":"J Inflamm Res"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.ebiom.2018.03.030","volume":"30","author":"Chen","year":"2018","journal-title":"EBioMedicine"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"2145843","DOI":"10.1080\/19490976.2022.2145843","volume":"14","author":"Jia","year":"2022","journal-title":"Gut Microbes"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/s40168-022-01227-w","volume":"10","author":"Hu","year":"2022","journal-title":"Microbiome"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.aninu.2023.04.012","volume":"15","author":"Yuan","year":"2023","journal-title":"Anim Nutr"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"116662","DOI":"10.1016\/j.ecoenv.2024.116662","volume":"281","author":"Zhu","year":"2024","journal-title":"Ecotoxicol Environ Saf"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"111931","DOI":"10.1016\/j.biopha.2021.111931","volume":"141","author":"Chang","year":"2021","journal-title":"Biomed Pharmacother"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"154287","DOI":"10.1016\/j.phymed.2022.154287","volume":"104","author":"Zhong","year":"2022","journal-title":"Phytomedicine"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"116909","DOI":"10.1016\/j.jep.2023.116909","volume":"318","author":"Xiao","year":"2024","journal-title":"J Ethnopharmacol"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"43233","DOI":"10.1021\/acsomega.4c07915","volume":"9","author":"Zhao","year":"2024","journal-title":"ACS Omega"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1038\/s41591-022-01680-y","volume":"28","author":"Uzzan","year":"2022","journal-title":"Nat Med"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1002\/jgh3.12122","volume":"3","author":"Henriksson","year":"2019","journal-title":"JGH Open"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10787-011-0104-6","volume":"20","author":"Thomas","year":"2012","journal-title":"Inflammopharmacology"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1016\/j.mucimm.2024.06.008","volume":"17","author":"Sanchez-Garrido","year":"2024","journal-title":"Mucosal Immunol"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"129","DOI":"10.2147\/CEG.S368040","volume":"15","author":"Moraes Holst","year":"2022","journal-title":"Clin Exp Gastroenterol"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.it.2017.01.006","volume":"38","author":"Amatya","year":"2017","journal-title":"Trends Immunol"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1136\/annrheumdis-2020-217927","volume":"79","author":"Fauny","year":"2020","journal-title":"Ann Rheum Dis"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.cellimm.2008.12.002","volume":"256","author":"Mendez-Samperio","year":"2009","journal-title":"Cell Immunol"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1097\/01.MIB.0000178263.34099.89","volume":"11","author":"Hyun","year":"2005","journal-title":"Inflamm Bowel Dis"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1093\/jpp\/rgad013","volume":"75","author":"Mostafa","year":"2023","journal-title":"J Pharm Pharmacol"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"5504","DOI":"10.1039\/D2BM00309K","volume":"10","author":"Al-Shalabi","year":"2022","journal-title":"Biomater Sci"}],"container-title":["Journal of Inflammation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/105827","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/105827","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T13:30:15Z","timestamp":1755178215000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/rhoifolin-attenuates-dss-induced-colitis-in-mice-by-modulating-gut-mic-peer-reviewed-fulltext-article-JIR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":66,"URL":"https:\/\/doi.org\/10.2147\/jir.s515002","relation":{},"ISSN":["1178-7031"],"issn-type":[{"value":"1178-7031","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8]]}}}