{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T16:07:54Z","timestamp":1772122074687,"version":"3.50.1"},"reference-count":35,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JIR"],"DOI":"10.2147\/jir.s516556","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T06:40:14Z","timestamp":1747204814000},"page":"6263-6280","source":"Crossref","is-referenced-by-count":2,"title":["Si-Ni Decoction as a Potential Treatment for Ulcerative Colitis: Modulation of Gut Microbiota and AKT1 Inhibition Through Network Pharmacology and in vivo Validation"],"prefix":"10.2147","volume":"Volume 18","author":[{"given":"Lihao","family":"Shi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leilei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guiyuan","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yonghong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengqin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7803-605X","authenticated-orcid":true,"given":"Guangxi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2025,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1606","DOI":"10.1016\/s0140-6736(12)60150-0","volume":"380","author":"Ord\u00e1s","year":"2012","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"733992","DOI":"10.3389\/fcimb.2022.733992","volume":"12","author":"Qiu","year":"2022","journal-title":"Front Cell Infect Microbiol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1038\/nature10209","volume":"474","author":"Khor","year":"2011","journal-title":"Nature"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1889","DOI":"10.1016\/j.cgh.2024.03.049","volume":"22","author":"Xue","year":"2024","journal-title":"Clin Gastroenterol Hepatol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1001\/jama.2023.23814","volume":"331","author":"Voelker","year":"2024","journal-title":"JAMA"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1016\/j.tips.2024.08.003","volume":"45","author":"Wangchuk","year":"2024","journal-title":"Trends Pharmacol Sci"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1007\/s11739-023-03329-1","volume":"18","author":"Di Sabatino","year":"2023","journal-title":"Int Emerg Med"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1038\/nri2653","volume":"9","author":"Turner","year":"2009","journal-title":"Nat Rev Immunol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"94","DOI":"10.3390\/jcm9010094","volume":"9","author":"Kayal","year":"2019","journal-title":"J Clin Med"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1038\/s41598-018-19689-0","volume":"8","author":"Duggal","year":"2018","journal-title":"Sci Rep"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.3390\/ph16091216","volume":"16","author":"Gao","year":"2023","journal-title":"Pharmaceuticals"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1108289","DOI":"10.3389\/fimmu.2023.1108289","volume":"14","author":"Lechuga","year":"2023","journal-title":"Front Immunol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"155212","DOI":"10.1016\/j.phymed.2023.155212","volume":"123","author":"Gu","year":"2024","journal-title":"Phytomedicine"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"510","DOI":"10.7150\/thno.80066","volume":"13","author":"Ding","year":"2023","journal-title":"Theranostics"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1186\/s12906-022-03575-4","volume":"22","author":"Zhao","year":"2022","journal-title":"BMC Complement Med Therap"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"108971","DOI":"10.1016\/j.biopha.2019.108971","volume":"115","author":"Chen","year":"2019","journal-title":"Biomed Pharmacother"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"105187","DOI":"10.1016\/j.bioorg.2021.105187","volume":"115","author":"Liang","year":"2021","journal-title":"Bioorg Chem"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"D605","DOI":"10.1093\/nar\/gkaa1074","volume":"49","author":"Szklarczyk","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"D833","DOI":"10.1093\/nar\/gkw943","volume":"45","author":"Pi\u00f1ero","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"39","DOI":"10.2147\/dddt.S385208","volume":"17","author":"Di","year":"2023","journal-title":"Drug Des Devel Ther"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1038\/s41467-019-09234-6","volume":"10","author":"Zhou","year":"2019","journal-title":"Nat Commun"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1021\/acs.jproteome.2c00651","volume":"22","author":"Doncheva","year":"2023","journal-title":"J Prot Res"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1859","DOI":"10.1002\/jcc.20945","volume":"29","author":"Jo","year":"2008","journal-title":"J Comput Chem"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"9954","DOI":"10.1021\/jp003020w","volume":"105","author":"Mark","year":"2001","journal-title":"J Phys Chem A"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"745","DOI":"10.3389\/fimmu.2018.00745","volume":"9","author":"Vall\u00e9e","year":"2018","journal-title":"Front Immunol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1038\/s41392-023-01553-x","volume":"8","author":"Fu","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.jare.2023.08.008","volume":"52","author":"An","year":"2023","journal-title":"J Adv Res"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s40168-023-01722-8","volume":"12","author":"Xie","year":"2024","journal-title":"Microbiome"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.1053\/j.gastro.2022.07.004","volume":"163","author":"Leibovitzh","year":"2022","journal-title":"Gastroenterology"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"O161","DOI":"10.1111\/codi.12503","volume":"16","author":"Lennon","year":"2014","journal-title":"Colorectal Dis"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1016\/j.chom.2019.04.002","volume":"25","author":"Brown","year":"2019","journal-title":"Cell Host Microbe"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"3294","DOI":"10.1038\/s41467-018-05470-4","volume":"9","author":"Roager","year":"2018","journal-title":"Nat Commun"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1016\/j.chom.2018.05.003","volume":"23","author":"Agus","year":"2018","journal-title":"Cell Host Microbe"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"1285982","DOI":"10.3389\/fmicb.2023.1285982","volume":"14","author":"Cao","year":"2023","journal-title":"Front Microbiol"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"757508","DOI":"10.3389\/fphar.2021.757508","volume":"12","author":"Zhang","year":"2021","journal-title":"Front Pharmacol"}],"container-title":["Journal of Inflammation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/102926","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/102926","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T06:40:15Z","timestamp":1747204815000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/si-ni-decoction-as-a-potential-treatment-for-ulcerative-colitis-modula-peer-reviewed-fulltext-article-JIR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":35,"URL":"https:\/\/doi.org\/10.2147\/jir.s516556","relation":{},"ISSN":["1178-7031"],"issn-type":[{"value":"1178-7031","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5]]}}}