{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:04:49Z","timestamp":1792087489253,"version":"4.4.0"},"reference-count":96,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JIR"],"DOI":"10.2147\/jir.s520726","type":"journal-article","created":{"date-parts":[[2025,5,24]],"date-time":"2025-05-24T07:25:12Z","timestamp":1748071512000},"page":"6719-6733","source":"Crossref","is-referenced-by-count":12,"title":["Advances in Research on the Release of von Willebrand Factor from Endothelial Cells through the Membrane Attack Complex C5b-9 in Sepsis"],"prefix":"10.2147","volume":"Volume 18","author":[{"given":"Yi","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weili","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linjun","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongfang","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bangting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8493-7625","authenticated-orcid":true,"given":"Haoling","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2025,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1001\/jama.2016.0287","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"838","DOI":"10.3389\/fimmu.2018.00838","volume":"9","author":"Leligdowicz","year":"2018","journal-title":"Front Immunol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"S26","DOI":"10.1097\/CCM.0b013e3181c98d21","volume":"38","author":"Levi","year":"2010","journal-title":"Crit Care Med"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"863846","DOI":"10.3389\/fcvm.2022.863846","volume":"9","author":"Zaid","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"2475","DOI":"10.1111\/jth.15852","volume":"20","author":"Iba","year":"2022","journal-title":"J Thromb Haemost"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1055\/s-0042-1756300","volume":"48","author":"Iba","year":"2022","journal-title":"Semin Thromb Hemost"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1007\/s11239-020-02297-z","volume":"51","author":"Wang","year":"2021","journal-title":"J Thromb Thrombolysis"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"25","DOI":"10.3390\/ijms25147770","volume":"26","author":"Srdi\u0107","year":"2024","journal-title":"Int J Mol Sci"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.ccc.2017.08.003","volume":"34","author":"Pool","year":"2018","journal-title":"Crit Care Clin"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s12959-019-0198-4","volume":"17","author":"Chang","year":"2019","journal-title":"Thromb J"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/s12959-020-00231-0","volume":"18","author":"Chang","year":"2020","journal-title":"Thromb J"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.15761\/vdt.1000132","volume":"2","author":"Chang","year":"2017","journal-title":"Vasc Dis Therap"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1038\/nrmicro1824","volume":"6","author":"Lambris","year":"2008","journal-title":"Nat Rev Microbiol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"715","DOI":"10.2353\/ajpath.2007.070166","volume":"171","author":"Markiewski","year":"2007","journal-title":"Am J Pathol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1146\/annurev.immunol.23.021704.115835","volume":"23","author":"Guo","year":"2005","journal-title":"Annu Rev Immunol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"2245","DOI":"10.1111\/j.1582-4934.2008.00504.x","volume":"12","author":"Markiewski","year":"2008","journal-title":"J Cell Mol Med"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1056\/nejm200104053441406","volume":"344","author":"Walport","year":"2001","journal-title":"N Engl J Med"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.4049\/jimmunol.176.3.1305","volume":"176","author":"Thurman","year":"2006","journal-title":"J Immunol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.celrep.2016.03.002","volume":"15","author":"Sharp","year":"2016","journal-title":"Cell Rep"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1007\/s00281-005-0004-1","volume":"27","author":"Pilzer","year":"2005","journal-title":"Springer Sem Immunopathol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1912","DOI":"10.1073\/pnas.85.6.1912","volume":"85","author":"Bhakdi","year":"1988","journal-title":"Proc Natl Acad Sci"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"3173","DOI":"10.4049\/jimmunol.176.5.3173","volume":"176","author":"Cudrici","year":"2006","journal-title":"J Immunol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1955","DOI":"10.1111\/cmi.12170","volume":"15","author":"Berends","year":"2013","journal-title":"Cell Microbiol"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"877988","DOI":"10.3389\/fphar.2022.877988","volume":"13","author":"Wang","year":"2022","journal-title":"Front Pharmacol"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1172\/jci90962","volume":"127","author":"Afshar-Kharghan","year":"2017","journal-title":"J Clin Invest"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.kint.2019.01.009","volume":"96","author":"Ueda","year":"2019","journal-title":"Kidney Int"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"2166","DOI":"10.3389\/fimmu.2019.02166","volume":"10","author":"Zipfel","year":"2019","journal-title":"Front Immunol"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.imbio.2011.07.028","volume":"217","author":"Kerr","year":"2012","journal-title":"Immunobiology"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"3733","DOI":"10.1182\/blood-2013-12-547067","volume":"123","author":"Cataland","year":"2014","journal-title":"Blood"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"3048","DOI":"10.1038\/s41598-021-82733-z","volume":"11","author":"Youssef","year":"2021","journal-title":"Sci Rep"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1093\/ckj\/sfaa195","volume":"14","author":"Blasco","year":"2021","journal-title":"Clin Kidney J"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1182\/blood.V68.4.875.875","volume":"68","author":"Wiedmer","year":"1986","journal-title":"Blood"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1111\/j.1600-065X.2007.00579.x","volume":"220","author":"Lotze","year":"2007","journal-title":"Immunol Rev"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"C589","DOI":"10.1152\/ajpcell.00235.2017","volume":"314","author":"Alsaffar","year":"2018","journal-title":"Am J Physiol Cell Physiol"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"1530","DOI":"10.4049\/jimmunol.138.5.1530","volume":"138","author":"Kim","year":"1987","journal-title":"J Immunol"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1189\/jlb.0904554","volume":"77","author":"Cook-Mills","year":"2005","journal-title":"J Leukocyte Biol"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"2462","DOI":"10.2174\/1381612823666170222122822","volume":"23","author":"Karimian","year":"2017","journal-title":"Curr Pharm Des"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"26478","DOI":"10.1074\/jbc.M112.359489","volume":"287","author":"Wilhelmsen","year":"2012","journal-title":"J Biol Chem"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1172\/JCI15645","volume":"111","author":"Pippin","year":"2003","journal-title":"J Clin Invest"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1097\/mbc.0000000000000727","volume":"29","author":"Chang","year":"2018","journal-title":"Blood Coagul Fibrinolysis"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1016\/j.semnephrol.2013.08.009","volume":"33","author":"Takano","year":"2013","journal-title":"Semin Nephrol"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1113\/jphysiol.2001.013381","volume":"539","author":"Farkas","year":"2002","journal-title":"J Physiol"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.biocel.2017.01.001","volume":"84","author":"Yin","year":"2017","journal-title":"Int J Biochem Cell Biol"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"102560","DOI":"10.1016\/j.jaut.2020.102560","volume":"116","author":"Cugno","year":"2021","journal-title":"J Autoimmun"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1097\/shk.0000000000001823","volume":"57","author":"Fern\u00e1ndez","year":"2022","journal-title":"Shock"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.jaci.2020.05.006","volume":"146","author":"Cugno","year":"2020","journal-title":"J Allergy Clin Immunol"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"6740827","DOI":"10.1155\/2016\/6740827","volume":"2016","author":"Segura-Cervantes","year":"2016","journal-title":"Mediators Inflamm"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1089\/ars.2021.0027","volume":"35","author":"Joffre","year":"2021","journal-title":"Antioxid Redox Signal"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"22","DOI":"10.3390\/ijms22168882","volume":"23","author":"Moriyama","year":"2021","journal-title":"Int J Mol Sci"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"781","DOI":"10.3390\/biomedicines9070781","volume":"9","author":"Theofilis","year":"2021","journal-title":"Biomedicines"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"2045894019883607","DOI":"10.1177\/2045894019883607","volume":"9","author":"Tielemans","year":"2019","journal-title":"Pulm Circ"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"1426526","DOI":"10.3389\/fimmu.2024.1426526","volume":"15","author":"Vahldieck","year":"2024","journal-title":"Front Immunol"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"25","DOI":"10.3390\/ijms251910673","volume":"26","author":"Mrozewski","year":"2024","journal-title":"Int J Mol Sci"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"e38317","DOI":"10.1371\/journal.pone.0038317","volume":"7","author":"Hao","year":"2012","journal-title":"PLoS One"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1002\/jlb.4mir1118-425r","volume":"106","author":"Ward","year":"2019","journal-title":"J Leukoc Biol"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"3702","DOI":"10.1182\/blood-2003-03-0703","volume":"102","author":"Sprong","year":"2003","journal-title":"Blood"},{"key":"ref57","first-page":"183","author":"Hansen","year":"2021","journal-title":"Ugeskr Laeger"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1111\/j.1538-7836.2009.03375.x","volume":"7","author":"Sadler","year":"2009","journal-title":"J Thromb Haemost"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"2019","DOI":"10.1182\/blood-2014-06-528406","volume":"125","author":"Lenting","year":"2015","journal-title":"Blood"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"2171","DOI":"10.1182\/blood.V83.8.2171.2171","volume":"83","author":"Tsai","year":"1994","journal-title":"Blood"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"2939","DOI":"10.1182\/blood.V88.8.2939.bloodjournal8882939","volume":"88","author":"Siedlecki","year":"1996","journal-title":"Blood"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"18578","DOI":"10.1073\/pnas.1411979112","volume":"111","author":"South","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1182\/blood-2017-04-636431","volume":"130","author":"Sadler","year":"2017","journal-title":"Blood"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1111\/ijlh.13785","volume":"44","author":"Jang","year":"2022","journal-title":"Int J Lab Hematol"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"5102","DOI":"10.1182\/blood-2009-07-231597","volume":"114","author":"Turner","year":"2009","journal-title":"Blood"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1182\/blood-2013-04-495853","volume":"123","author":"Rayes","year":"2014","journal-title":"Blood"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1111\/jth.13956","volume":"16","author":"Kremer Hovinga","year":"2018","journal-title":"J Thromb Haemost"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1002\/ajh.22091","volume":"86","author":"Booth","year":"2011","journal-title":"Am J Hematol"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1111\/j.1368-5031.2004.0080.x","volume":"58","author":"Naqvi","year":"2004","journal-title":"Int J Clin Pract"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1002\/(sici)1096-8652(199609)53:1<11::Aid-ajh3>3.0.Co;2-8","volume":"53","author":"Chang","year":"1996","journal-title":"Am J Hematol"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"9053","DOI":"10.1016\/S0021-9258(18)81901-9","volume":"264","author":"Hattori","year":"1989","journal-title":"J Biol Chem"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.kint.2016.03.023","volume":"90","author":"Noone","year":"2016","journal-title":"Kidney Int"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1161\/01.atv.17.1.164","volume":"17","author":"Christiansen","year":"1997","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"3809","DOI":"10.1016\/S0021-9258(19)39666-8","volume":"265","author":"Hamilton","year":"1990","journal-title":"J Biol Chem"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"1484","DOI":"10.1111\/jth.14767","volume":"18","author":"Riedl Khursigara","year":"2020","journal-title":"J Thromb Haemost"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"5664","DOI":"10.3390\/ijms24065664","volume":"24","author":"Guo","year":"2023","journal-title":"Int J Mol Sci"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/s12959-018-0174-4","volume":"16","author":"Chang","year":"2018","journal-title":"Thromb J"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"58","DOI":"10.3390\/medicina58091311","volume":"59","author":"Chang","year":"2022","journal-title":"Medicina"},{"key":"ref79","doi-asserted-by":"publisher","first-page":"273","DOI":"10.2147\/vhrm.S299357","volume":"17","author":"Chang","year":"2021","journal-title":"Vasc Health Risk Manag"},{"key":"ref80","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3390\/life12020220","volume":"13","author":"Chang","year":"2022","journal-title":"Life"},{"key":"ref81","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.37","volume":"2","author":"Gando","year":"2016","journal-title":"Nature Reviews Disease Primers"},{"key":"ref82","doi-asserted-by":"publisher","first-page":"6128","DOI":"10.1182\/blood-2011-09-380535","volume":"119","author":"Schiviz","year":"2012","journal-title":"Blood"},{"key":"ref83","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1111\/jth.14686","volume":"18","author":"Peetermans","year":"2020","journal-title":"J Thromb Haemost"},{"key":"ref84","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1172\/jci41062","volume":"121","author":"Chen","year":"2011","journal-title":"J Clin Invest"},{"key":"ref85","doi-asserted-by":"publisher","first-page":"e1277","DOI":"10.1097\/mjt.0000000000000386","volume":"23","author":"Cabanillas","year":"2016","journal-title":"Am J Ther"},{"key":"ref86","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1182\/blood-2016-09-738856","volume":"129","author":"Tersteeg","year":"2017","journal-title":"Blood"},{"key":"ref87","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1007\/s11239-015-1259-6","volume":"41","author":"Rottenstreich","year":"2016","journal-title":"J Thromb Thrombolysis"},{"key":"ref88","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1056\/NEJMoa1806311","volume":"380","author":"Scully","year":"2019","journal-title":"N Engl J Med"},{"key":"ref89","doi-asserted-by":"publisher","first-page":"e0244853","DOI":"10.1371\/journal.pone.0244853","volume":"16","author":"Kamran","year":"2021","journal-title":"PLoS One"},{"key":"ref90","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.ijid.2020.06.064","volume":"99","author":"Khamis","year":"2020","journal-title":"Int J Infect Dis"},{"key":"ref91","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1186\/s13063-020-04454-4","volume":"21","author":"Faqihi","year":"2020","journal-title":"Trials"},{"key":"ref92","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1007\/s40620-021-00981-8","volume":"35","author":"Aigner","year":"2022","journal-title":"J Nephrol"},{"key":"ref93","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1007\/s00467-014-2975-4","volume":"30","author":"Ohta","year":"2015","journal-title":"Pediatr Nephrol"},{"key":"ref94","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1007\/s10157-015-1142-y","volume":"20","author":"Ito","year":"2016","journal-title":"Clin Exp Nephrol"},{"key":"ref95","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1007\/s11255-016-1234-y","volume":"48","author":"Okumi","year":"2016","journal-title":"Int Urol Nephrol"},{"key":"ref96","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1159\/000485194","volume":"138","author":"Nakamura","year":"2018","journal-title":"Nephron"}],"container-title":["Journal of Inflammation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/103268","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/103268","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,24]],"date-time":"2025-05-24T07:25:13Z","timestamp":1748071513000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/advances-in-research-on-the-release-of-von-willebrand-factor-from-endo-peer-reviewed-fulltext-article-JIR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":96,"URL":"https:\/\/doi.org\/10.2147\/jir.s520726","relation":{},"ISSN":["1178-7031"],"issn-type":[{"value":"1178-7031","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5]]}}}