{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:40:59Z","timestamp":1787024459967,"version":"build-2736575974"},"reference-count":43,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JIR"],"DOI":"10.2147\/jir.s541871","type":"journal-article","created":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T09:20:22Z","timestamp":1766740822000},"page":"18151-18163","source":"Crossref","is-referenced-by-count":2,"title":["Plasma Bile Acid Profiling Reveals Novel Early Diagnostic Biomarkers for Pediatric Sepsis"],"prefix":"10.2147","volume":"Volume 18","author":[{"given":"Lipeng","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6427-3126","authenticated-orcid":true,"given":"Jing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanmei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuxiu","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2622-3574","authenticated-orcid":true,"given":"Danni","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongyuan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linying","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2025,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2023-062967","volume":"153","author":"Weiss","year":"2024","journal-title":"Pediatrics"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/S0140-6736(19)32989-7","volume":"395","author":"Rudd","year":"2020","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/s41390-021-01620-5","volume":"91","author":"Wong","year":"2022","journal-title":"Pediatr Res"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1186\/s13054-020-02993-5","volume":"24","author":"Pierrakos","year":"2020","journal-title":"Crit Care"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1007\/s00134-022-06956-y","volume":"49","author":"Povoa","year":"2023","journal-title":"Intensive Care Med"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1001\/jamapediatrics.2019.5669","volume":"174","author":"Brown","year":"2020","journal-title":"JAMA Pediatr"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.jpeds.2022.12.007","volume":"256","author":"Dhudasia","year":"2023","journal-title":"J Pediatr"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01851-19","volume":"58","author":"Downes","year":"2020","journal-title":"J Clin Microbiol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1186\/s12871-023-02317-4","volume":"23","author":"She","year":"2023","journal-title":"BMC Anesthesiol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"108841","DOI":"10.1016\/j.intimp.2022.108841","volume":"108","author":"Ding","year":"2022","journal-title":"Int Immunopharmacol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1186\/s12967-022-03320-y","volume":"20","author":"Chen","year":"2022","journal-title":"J Transl Med"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1186\/s13054-015-1026-2","volume":"19","author":"Mickiewicz","year":"2015","journal-title":"Crit Care"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1186\/s40168-021-01101-1","volume":"9","author":"Guzior","year":"2021","journal-title":"Microbiome"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1038\/s41564-018-0306-4","volume":"4","author":"Franzosa","year":"2019","journal-title":"Nat Microbiol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1007\/s11427-023-2353-0","volume":"67","author":"Jia","year":"2024","journal-title":"Sci China Life Sci"},{"key":"ref16","first-page":"1","volume":"2024","author":"Zhuang","year":"2024","journal-title":"J Adv Res"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1097\/CCM.0b013e31827e83af","volume":"41","author":"Dellinger","year":"2013","journal-title":"Crit Care Med"},{"key":"ref18","unstructured":"Emergency Medicine Group of the Chinese Medical Association Pediatric Branch CMAEMBPG, Chinese Medical Doctor Association Pediatric Intensivist Branch. Expert Consensus on the Diagnosis and Treatment of Septic Shock in Children (2015); 2015."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s12879-021-07014-6","volume":"22","author":"He","year":"2022","journal-title":"BMC Infect Dis"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"e932518","DOI":"10.12659\/MSM.932518","volume":"27","author":"He","year":"2021","journal-title":"Med Sci Monit"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"e002329","DOI":"10.1136\/bmjpo-2023-002329","volume":"8","author":"Liu","year":"2024","journal-title":"BMJ Paediatr Open"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1097\/MCC.0000000000000921","volume":"28","author":"Bauer","year":"2022","journal-title":"Curr Opin Crit Care"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1097\/SHK.0000000000002117","volume":"59","author":"Long","year":"2023","journal-title":"Shock"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1038\/s41390-018-0007-y","volume":"84","author":"Zohrer","year":"2018","journal-title":"Pediatr Res"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1984","DOI":"10.3389\/fimmu.2018.01984","volume":"9","author":"Chang","year":"2018","journal-title":"Front Immunol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1038\/s41390-024-03438-3","volume":"97","author":"Wang","year":"2025","journal-title":"Pediatr Res"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1124\/pr.113.008201","volume":"66","author":"Li","year":"2014","journal-title":"Pharmacol Rev"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1007\/s10620-020-06715-3","volume":"66","author":"Fiorucci","year":"2021","journal-title":"Dig Dis Sci"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nrgastro.2017.119","volume":"15","author":"Jia","year":"2018","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/nrd2619","volume":"7","author":"Thomas","year":"2008","journal-title":"Nat Rev Drug Discov"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"e5219","DOI":"10.1097\/MD.0000000000005219","volume":"95","author":"Zohrer","year":"2016","journal-title":"Medicine"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.autrev.2017.07.002","volume":"16","author":"Li","year":"2017","journal-title":"Autoimmun Rev"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1186\/s13054-020-02989-1","volume":"24","author":"Adelman","year":"2020","journal-title":"Crit Care"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s12882-025-03977-9","volume":"26","author":"Lou","year":"2025","journal-title":"BMC Nephrol"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"111161","DOI":"10.1016\/j.intimp.2023.111161","volume":"125","author":"He","year":"2023","journal-title":"Int Immunopharmacol"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1186\/s40168-022-01269-0","volume":"10","author":"He","year":"2022","journal-title":"Microbiome"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1177\/08971900211038363","volume":"36","author":"Al Sulaiman","year":"2023","journal-title":"J Pharm Pract"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.bbi.2021.09.021","volume":"99","author":"Huang","year":"2022","journal-title":"Brain Behav Immun"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1007\/s12072-023-10610-0","volume":"18","author":"Feng","year":"2024","journal-title":"Hepatol Int"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"308274","DOI":"10.1155\/2014\/308274","volume":"2014","author":"Yu","year":"2014","journal-title":"Int J Endocrinol"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1186\/s12931-022-02131-5","volume":"23","author":"Zhang","year":"2022","journal-title":"Respir Res"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.1016\/j.biopha.2017.11.083","volume":"96","author":"Xiong","year":"2017","journal-title":"Biomed Pharmacother"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/j.jtumed.2020.04.007","volume":"15","author":"Ainosah","year":"2020","journal-title":"J Taibah Univ Med Sci"}],"container-title":["Journal of Inflammation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/110418","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/110418","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T09:20:24Z","timestamp":1766740824000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/plasma-bile-acid-profiling-reveals-novel-early-diagnostic-biomarkers-f-peer-reviewed-fulltext-article-JIR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":43,"URL":"https:\/\/doi.org\/10.2147\/jir.s541871","relation":{},"ISSN":["1178-7031"],"issn-type":[{"value":"1178-7031","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]}}}