{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T14:11:06Z","timestamp":1772547066950,"version":"3.50.1"},"reference-count":53,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JIR"],"DOI":"10.2147\/jir.s551466","type":"journal-article","created":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T09:46:07Z","timestamp":1772531167000},"page":"1-21","source":"Crossref","is-referenced-by-count":0,"title":["Obacunone Inhibits Microglia-Mediated Neuroinflammation and Ischemic Injury by Targeting Mitogen-Activated Protein Kinase 1"],"prefix":"10.2147","volume":"Volume 19","author":[{"given":"Jing","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuobin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ran","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengnan","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiyan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyu","family":"Bao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4696-9696","authenticated-orcid":true,"given":"Xiaolei","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiali","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2026,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"GBD 2021 Stroke Risk Factor Collaborators. Global, regional, and national burden of stroke and its risk factors, 1990\u20132021: a systematic analysis for the Global Burden of Disease Study 2021. Lancet Neurol. 2024;23(10):973\u201321. doi:10.1016\/s1474-4422(24)00369-7","DOI":"10.1016\/S1474-4422(24)00369-7"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"GBD 2021 Diseases and Injuries Collaborators. Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 countries and territories and 811 subnational locations, 1990\u20132021: a systematic analysis for the Global Burden of Disease Study 2021. Lancet. 2024;403(10440):2133\u20132161. doi:10.1016\/s0140-6736(24)00757-8","DOI":"10.1016\/S0140-6736(24)00757-8"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.3390\/biom14091130","volume":"14","author":"Pawluk","year":"2024","journal-title":"Biomolecules"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"2823","DOI":"10.3390\/cells11182823","volume":"11","author":"Sato","year":"2022","journal-title":"Cells"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1007\/s12264-019-00388-3","volume":"35","author":"Qin","year":"2019","journal-title":"Neurosci Bull"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"113217","DOI":"10.1016\/j.intimp.2024.113217","volume":"143","author":"Wang","year":"2024","journal-title":"Int Immunopharmacol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1186\/s12974-024-03206-4","volume":"21","author":"Ma","year":"2024","journal-title":"J Neuroinflammation"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1186\/s13073-023-01257-5","volume":"15","author":"Li","year":"2023","journal-title":"Genome Med"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"e14696","DOI":"10.1111\/cns.14696","volume":"30","author":"Lan","year":"2024","journal-title":"CNS Neurosci Ther"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1111\/cns.13748","volume":"28","author":"Ge","year":"2022","journal-title":"CNS Neurosci Ther"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1021\/np070588o","volume":"71","author":"Yoon","year":"2008","journal-title":"J Nat Prod"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1007\/s12272-010-0818-9","volume":"33","author":"Jeong","year":"2010","journal-title":"Arch Pharm Res"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1080\/13880209.2020.1812673","volume":"58","author":"Luo","year":"2020","journal-title":"Pharm Biol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.ibror.2019.12.004","volume":"8","author":"Calvo","year":"2020","journal-title":"IBRO Rep"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/s41401-020-0411-9","volume":"42","author":"Fu","year":"2021","journal-title":"Acta Pharmacol Sin"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"165260","DOI":"10.1016\/j.bbadis.2018.09.012","volume":"1866","author":"Barthels","year":"2020","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"133","DOI":"10.2147\/jir.S487482","volume":"18","author":"Chen","year":"2025","journal-title":"J Inflamm Res"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"111648","DOI":"10.1016\/j.intimp.2024.111648","volume":"129","author":"Liang","year":"2024","journal-title":"Int Immunopharmacol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"2875","DOI":"10.1161\/strokeaha.119.026652","volume":"50","author":"Bieber","year":"2019","journal-title":"Stroke"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"105676","DOI":"10.1016\/j.neuint.2024.105676","volume":"175","author":"Sun","year":"2024","journal-title":"Neurochem Int"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1097\/js9.0000000000002081","volume":"111","author":"Yao","year":"2025","journal-title":"Int J Surg"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"e2303711","DOI":"10.1002\/advs.202303711","volume":"10","author":"Yao","year":"2023","journal-title":"Adv Sci"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"56","DOI":"10.36922\/an025100020","volume":"5","author":"He","year":"2025","journal-title":"Adv Neurol"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1004215","DOI":"10.3389\/fphar.2022.1004215","volume":"13","author":"Zou","year":"2022","journal-title":"Front Pharmacol"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"156047","DOI":"10.1016\/j.phymed.2024.156047","volume":"135","author":"Zhang","year":"2024","journal-title":"Phytomedicine"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"118721","DOI":"10.1016\/j.jep.2024.118721","volume":"336","author":"Shang","year":"2025","journal-title":"J Ethnopharmacol"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"2100","DOI":"10.1038\/nprot.2014.138","volume":"9","author":"Jafari","year":"2014","journal-title":"Nat Protoc"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"154862","DOI":"10.1016\/j.phymed.2023.154862","volume":"116","author":"Tu","year":"2023","journal-title":"Phytomedicine"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"101069","DOI":"10.1016\/j.jpha.2024.101069","volume":"15","author":"Chen","year":"2025","journal-title":"J Pharm Anal"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1186\/s12974-019-1516-2","volume":"16","author":"Jayaraj","year":"2019","journal-title":"J Neuroinflammation"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"155599","DOI":"10.1016\/j.phymed.2024.155599","volume":"129","author":"Wang","year":"2024","journal-title":"Phytomedicine"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"15347354241285435","DOI":"10.1177\/15347354241285435","volume":"23","author":"Zhang","year":"2024","journal-title":"Integr Cancer Ther"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1578","DOI":"10.21037\/atm-21-5125","volume":"9","author":"Yuan","year":"2021","journal-title":"Ann Transl Med"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/j.bbi.2024.10.007","volume":"123","author":"Satyanarayanan","year":"2025","journal-title":"Brain Behav Immun"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1111\/cns.13620","volume":"27","author":"Lyu","year":"2021","journal-title":"CNS Neurosci Ther"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"3555","DOI":"10.3390\/cells10123555","volume":"10","author":"Var","year":"2021","journal-title":"Cells"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"1791","DOI":"10.3390\/molecules29081791","volume":"29","author":"Zhou","year":"2024","journal-title":"Molecules"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s11658-022-00318-8","volume":"27","author":"Li","year":"2022","journal-title":"Cell Mol Biol Lett"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"154469","DOI":"10.1016\/j.phymed.2022.154469","volume":"107","author":"Chen","year":"2022","journal-title":"Phytomedicine"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"497","DOI":"10.3389\/fmicb.2020.00497","volume":"11","author":"Luo","year":"2020","journal-title":"Front Microbiol"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1161\/str.0000000000000513","author":"Prabhakaran","year":"2026","journal-title":"Stroke"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"8204","DOI":"10.3390\/ijms25158204","volume":"25","author":"Bernis","year":"2024","journal-title":"Int J Mol Sci"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"14303","DOI":"10.3390\/ijms241814303","volume":"24","author":"Burguete","year":"2023","journal-title":"Int J Mol Sci"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"706","DOI":"10.3390\/ijms23020706","volume":"23","author":"Schanbacher","year":"2022","journal-title":"Int J Mol Sci"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.jep.2017.10.009","volume":"213","author":"Costa","year":"2018","journal-title":"J Ethnopharmacol"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1186\/s12974-016-0690-8","volume":"13","author":"Okazaki","year":"2016","journal-title":"J Neuroinflammation"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1007\/s12264-007-0046-6","volume":"23","author":"Yang","year":"2007","journal-title":"Neurosci Bull"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1186\/s12974-020-01754-z","volume":"17","author":"Wang","year":"2020","journal-title":"J Neuroinflammation"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1186\/s12967-023-04648-9","volume":"21","author":"Jiang","year":"2023","journal-title":"J Transl Med"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"1671","DOI":"10.1007\/s12264-021-00765-x","volume":"37","author":"Peng","year":"2021","journal-title":"Neurosci Bull"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.freeradbiomed.2021.03.037","volume":"168","author":"Liu","year":"2021","journal-title":"Free Radic Biol Med"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"156482","DOI":"10.1016\/j.cyto.2023.156482","volume":"175","author":"Kumar","year":"2024","journal-title":"Cytokine"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"567238","DOI":"10.3389\/fphar.2020.567238","volume":"11","author":"Lu","year":"2020","journal-title":"Front Pharmacol"}],"container-title":["Journal of Inflammation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/112627","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/112627","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T09:46:14Z","timestamp":1772531174000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/obacunone-inhibits-microglia-mediated-neuroinflammation-and-ischemic-i-peer-reviewed-fulltext-article-JIR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":53,"URL":"https:\/\/doi.org\/10.2147\/jir.s551466","relation":{},"ISSN":["1178-7031"],"issn-type":[{"value":"1178-7031","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]}}}