{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T15:07:54Z","timestamp":1779462474051,"version":"3.53.1"},"reference-count":119,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JIR"],"DOI":"10.2147\/jir.s560084","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T14:55:14Z","timestamp":1779461714000},"page":"1-19","source":"Crossref","is-referenced-by-count":0,"title":["The Role of Alpha-1 Antitrypsin in the Pathophysiology and Treatment of Inflammatory Lung Diseases"],"prefix":"10.2147","volume":"Volume 19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4054-0314","authenticated-orcid":true,"given":"Daniella","family":"Spittle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5947-3254","authenticated-orcid":true,"given":"Alice","family":"Turner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2026,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"240139","DOI":"10.1183\/16000617.0139-2024","volume":"33","author":"Crowley","year":"2024","journal-title":"Eur Respir Rev"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.3390\/biom11081065","volume":"11","author":"Voynow","year":"2021","journal-title":"Biomolecules"},{"key":"ref3","unstructured":"World Health Organization. Chronic obstructive pulmonary disease. 2024."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1186\/s12890-025-03816-5","volume":"25","author":"Hu","year":"2025","journal-title":"BMC Pulm Med"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"7534666251390073","DOI":"10.1177\/17534666251390073","volume":"19","author":"Laska","year":"2025","journal-title":"Ther Adv Respir Dis"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1513\/AnnalsATS.202408-800FR","volume":"23","author":"Fajac","year":"2026","journal-title":"Ann Am Thoracic Soc"},{"key":"ref7","first-page":"1","volume":"16","author":"Moldoveanu","year":"2008","journal-title":"J Inflamm Res"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1111\/crj.13718","volume":"17","author":"Huang","year":"2023","journal-title":"Clin Respir J"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"5226","DOI":"10.4049\/jimmunol.1302584","volume":"192","author":"Lugade","year":"2014","journal-title":"J Immunol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"557","DOI":"10.12688\/f1000research.18411.1","volume":"8","author":"Jasper","year":"2019","journal-title":"F1000Research"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1941","DOI":"10.1056\/NEJMra1813799","volume":"380","author":"Boucher Richard","year":"2019","journal-title":"N Engl J Med"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"5996","DOI":"10.3390\/ijms22115996","volume":"22","author":"Oriano","year":"2021","journal-title":"Int J Mol Sci"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1056\/NEJMra1910234","volume":"382","author":"Strnad","year":"2020","journal-title":"N Engl J Med"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1183\/09031936.00046114","volume":"45","author":"Van\u2019t Wout","year":"2015","journal-title":"Eur Respir J"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"419","DOI":"10.2147\/COPD.S149429","volume":"13","author":"Chapman","year":"2018","journal-title":"Int J Chronic Obstr"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"5259","DOI":"10.1021\/bi00391a008","volume":"26","author":"Nukiwa","year":"1987","journal-title":"Biochemistry"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1016\/j.rmed.2011.02.002","volume":"105","author":"Janciauskiene","year":"2011","journal-title":"Respir Med"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"e00046","DOI":"10.1042\/BSR20130038","volume":"33","author":"Haq","year":"2013","journal-title":"Biosci Rep"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1164\/rccm.201308-1458OC","volume":"189","author":"Alam","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"e45043","DOI":"10.1097\/MD.0000000000045043","volume":"104","author":"Gegin","year":"2025","journal-title":"Medicine"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"450","DOI":"10.3325\/cmj.2024.65.450","volume":"65","author":"Ozdemir","year":"2024","journal-title":"Croat Med J"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1186\/s13023-024-03069-1","volume":"19","author":"Ferrarotti","year":"2024","journal-title":"Orphanet J Rare Dis"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1038\/357605a0","volume":"357","author":"Lomas","year":"1992","journal-title":"Nature"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"7251","DOI":"10.1073\/pnas.84.20.7251","volume":"84","author":"Gauldie","year":"1987","journal-title":"Proc Natl Acad Sci"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1007\/s12072-019-10007-y","volume":"14","author":"G\u00f3mez-Mariano","year":"2020","journal-title":"Hepatol Internat"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1042\/bst0300093","volume":"30","author":"Kalsheker","year":"2002","journal-title":"Biochem Soc Trans"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1042\/bj20011312","volume":"365","author":"Morgan","year":"2002","journal-title":"Biochem J"},{"key":"ref28","first-page":"15","volume":"1","author":"Celine","year":"2022","journal-title":"Rare Dis Orphan Drugs J"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1165\/ajrcmb.20.4.3371","volume":"20","author":"Witko-Sarsat","year":"1999","journal-title":"Am J Respir Cell Mol Biol"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"L179","DOI":"10.1152\/ajplung.00179.2014","volume":"308","author":"Sinden","year":"2014","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1183\/09031936.00089712","volume":"41","author":"Sinden","year":"2013","journal-title":"Eur Respir J"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"23437","DOI":"10.1074\/jbc.270.40.23437","volume":"270","author":"Lomas","year":"1995","journal-title":"J Biol Chemist"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1900","DOI":"10.1128\/iai.61.5.1900-1908.1993","volume":"61","author":"Shafer","year":"1993","journal-title":"Infect Immun"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.720742","volume":"11","author":"Weeks","year":"2021","journal-title":"Front Cell Infect Microbiol"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.3389\/fimmu.2019.01417","volume":"10","author":"Bai","year":"2019","journal-title":"Front Immunol"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1189\/jlb.0208145","volume":"85","author":"Pott","year":"2009","journal-title":"J Leukoc Biol"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.2353\/ajpath.2006.060058","volume":"169","author":"Petrache","year":"2006","journal-title":"Am J Pathol"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"146","DOI":"10.4049\/jimmunol.1101340","volume":"189","author":"Ozeri","year":"2012","journal-title":"J Immunol"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1073\/pnas.1117665109","volume":"109","author":"Tawara","year":"2012","journal-title":"Proc Natl Acad Sci"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1007\/s11011-011-9239-9","volume":"26","author":"Subramanian","year":"2011","journal-title":"Metab Brain Dis"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"445","DOI":"10.2119\/molmed.2011.00207","volume":"18","author":"Lockett","year":"2012","journal-title":"Mol Med"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"1421598","DOI":"10.3389\/fphar.2024.1421598","volume":"15","author":"Chen","year":"2024","journal-title":"Front Pharmacol"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1080\/15412555.2018.1476475","volume":"15","author":"Butler","year":"2018","journal-title":"COPD"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1186\/s12931-019-1145-4","volume":"20","author":"Thulborn","year":"2019","journal-title":"Respir Res"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.cell.2018.12.002","volume":"176","author":"Genschmer","year":"2019","journal-title":"Cell"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"27258","DOI":"10.1016\/S0021-9258(19)61505-X","volume":"275","author":"Taggart","year":"2000","journal-title":"J Biol Chem"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1080\/15412555.2018.1541448","volume":"15","author":"Topic","year":"2018","journal-title":"COPD"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/j.chest.2018.04.039","volume":"154","author":"Bazzan","year":"2018","journal-title":"Chest"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1136\/thx.2008.102079","volume":"64","author":"Engstr\u00f6m","year":"2009","journal-title":"Thorax"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.4081\/mrm.2011.442","volume":"6","author":"Serapinas","year":"2019","journal-title":"Multidiscip Respir Med"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/1465-9921-9-35","volume":"9","author":"Senn","year":"2008","journal-title":"Respir Res"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"240091","DOI":"10.1183\/16000617.0091-2024","volume":"33","author":"Nigro","year":"2024","journal-title":"Eur Respir Rev"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"642503","DOI":"10.1155\/2015\/642503","volume":"2015","author":"Dente","year":"2015","journal-title":"Med Inflamm"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"240179","DOI":"10.1183\/16000617.0179-2024","volume":"34","author":"Chalmers","year":"2025","journal-title":"Eur Respir Rev"},{"key":"ref55","first-page":"6","volume":"147","author":"Cole","year":"1986","journal-title":"Eur J Respir Dis"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"1384","DOI":"10.1164\/rccm.201605-1027OC","volume":"195","author":"Chalmers","year":"2016","journal-title":"Am J Respir Crit Care Med"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"e14474","DOI":"10.1111\/acel.14474","volume":"24","author":"Xu","year":"2025","journal-title":"Aging Cell"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"507","DOI":"10.15326\/jcopdf.2024.0526","volume":"11","author":"De Soyza","year":"2024","journal-title":"Chronic Obstr Pulm Dis"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1186\/s13023-023-02830-2","volume":"18","author":"Stockley","year":"2023","journal-title":"Orphanet J Rare Dis"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"e47298","DOI":"10.1097\/MD.0000000000047298","volume":"105","author":"\u00d6zdemir","year":"2026","journal-title":"Medicine"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1016\/S0002-9440(10)62040-8","volume":"167","author":"Park","year":"2005","journal-title":"Am J Pathol"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1056\/NEJMoa2411664","volume":"392","author":"Chalmers James","year":"2025","journal-title":"N Engl J Med"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"101740","DOI":"10.1016\/j.rmcr.2022.101740","volume":"39","author":"Buck","year":"2022","journal-title":"Respir Med Case Rep"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"S191","DOI":"10.1513\/AnnalsATS.201504-245KV","volume":"13","author":"McElvaney","year":"2016","journal-title":"Ann Am Thoracic Soc"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"43430","DOI":"10.1038\/s41598-025-26263-y","volume":"15","author":"Cammarata-Mouchtouris","year":"2025","journal-title":"Sci Rep"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"101856","DOI":"10.1016\/j.pupt.2019.101856","volume":"59","author":"Oriano","year":"2019","journal-title":"Pulm Pharmacol Ther"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"1701910","DOI":"10.1183\/13993003.01910-2017","volume":"51","author":"Dittrich","year":"2018","journal-title":"Eur Respir J"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.jcf.2014.09.003","volume":"14","author":"Hentschel","year":"2015","journal-title":"J Cyst Fibros"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.jcf.2015.07.009","volume":"15","author":"Gaggar","year":"2016","journal-title":"J Cyst Fibros"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"S16","DOI":"10.1513\/AnnalsATS.201410-448MG","volume":"12","author":"Chambers","year":"2015","journal-title":"Ann Am Thoracic Soc"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"00424","DOI":"10.1183\/23120541.00424-2025","volume":"11","author":"Chong","year":"2025","journal-title":"ERJ Open Res"},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2025.114125","volume":"29","author":"Matson","year":"2026","journal-title":"iScience"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1183\/09031936.98.11010120","volume":"11","author":"Yamanouchi","year":"1998","journal-title":"Eur Respir J"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"e0162186","DOI":"10.1371\/journal.pone.0162186","volume":"11","author":"Cho","year":"2016","journal-title":"PLoS One"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1164\/rccm.200512-1842OC","volume":"173","author":"Petrache","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1111\/ajt.14756","volume":"18","author":"Berger","year":"2018","journal-title":"Am J Transplant"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1002\/1097-4652(200101)186:1<73::AID-JCP1002>3.0.CO;2-Q","volume":"186","author":"Dabbagh","year":"2001","journal-title":"J Cell Physiol"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1164\/rccm.201902-0333ED","volume":"200","author":"Summers","year":"2019","journal-title":"Am J Respir Crit Care Med"},{"key":"ref79","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1038\/s41591-020-01202-8","volume":"27","author":"Brodin","year":"2021","journal-title":"Nature Med"},{"key":"ref80","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1165\/rcmb.2011-0230OC","volume":"46","author":"Rzepka","year":"2012","journal-title":"Am J Respir Cell Mol Biol"},{"key":"ref81","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1136\/thorax-2024-222596","volume":"80","author":"Flower","year":"2025","journal-title":"Thorax"},{"key":"ref82","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1164\/arrd.1985.132.5.1098","volume":"132","author":"Idell","year":"1985","journal-title":"Amer Rev Respir Dis"},{"key":"ref83","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.2147\/COPD.S105717","volume":"11","author":"Berman","year":"2016","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"ref84","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1164\/rccm.202005-1583OC","volume":"202","author":"McElvaney","year":"2020","journal-title":"Am J Respir Crit Care Med"},{"key":"ref85","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1164\/rccm.202201-0046ED","volume":"205","author":"Shaver","year":"2022","journal-title":"Am J Respir Crit Care Med"},{"key":"ref86","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/S2213-2600(21)00018-7","volume":"9","author":"Yang","year":"2021","journal-title":"Lancet Respir Med"},{"key":"ref87","doi-asserted-by":"publisher","first-page":"1726","DOI":"10.1038\/s41467-021-21972-0","volume":"12","author":"Wettstein","year":"2021","journal-title":"Nat Commun"},{"key":"ref88","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/s12931-025-03100-4","volume":"26","author":"Li","year":"2025","journal-title":"Respir Res"},{"key":"ref89","doi-asserted-by":"publisher","first-page":"e54268","DOI":"10.7759\/cureus.54268","volume":"16","author":"Man","year":"2024","journal-title":"Cureus"},{"key":"ref90","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1164\/rccm.200406-761OC","volume":"170","author":"Parr","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"key":"ref91","first-page":"100","volume":"6","author":"Brantly","year":"2019","journal-title":"Chronic Obstr Pulm Dis"},{"key":"ref92","doi-asserted-by":"publisher","first-page":"00537","DOI":"10.1183\/23120541.00537-2024","volume":"11","author":"Brantly","year":"2025","journal-title":"ERJ Open Res"},{"key":"ref93","doi-asserted-by":"publisher","first-page":"17534666251318841","DOI":"10.1177\/17534666251318841","volume":"19","author":"Turner","year":"2025","journal-title":"Ther Adv Respir Dis"},{"key":"ref94","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1016\/S0140-6736(15)60860-1","volume":"386","author":"Chapman","year":"2015","journal-title":"Lancet"},{"key":"ref95","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/S2213-2600(16)30430-1","volume":"5","author":"McElvaney","year":"2017","journal-title":"Lancet Respir Med"},{"key":"ref96","doi-asserted-by":"publisher","first-page":"00194","DOI":"10.1183\/23120541.00194-2021","volume":"7","author":"Schouten","year":"2021","journal-title":"ERJ Open Res"},{"key":"ref97","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1164\/rccm.202305-0863OC","volume":"208","author":"Fraughen","year":"2023","journal-title":"Am J Respir Crit Care Med"},{"key":"ref98","doi-asserted-by":"publisher","first-page":"282","DOI":"10.15326\/jcopdf.2023.0469","volume":"11","author":"Brantly","year":"2024","journal-title":"Chronic Obstr Pulm Dis"},{"key":"ref99","doi-asserted-by":"publisher","first-page":"2653","DOI":"10.1007\/s13346-023-01346-3","volume":"13","author":"Bianchera","year":"2023","journal-title":"Drug Delivery Transl Res"},{"key":"ref100","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1183\/09031936.00047306","volume":"29","author":"Griese","year":"2007","journal-title":"Eur Respir J"},{"key":"ref101","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1038\/s41573-023-00704-7","volume":"22","author":"Khorkova","year":"2023","journal-title":"Nat Rev Drug Discov"},{"key":"ref102","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.135348","volume":"5","author":"Wooddell","year":"2020","journal-title":"JCI Insight"},{"key":"ref103","first-page":"1","author":"Kim","year":"2025","journal-title":"Nature Biotechnol"},{"key":"ref104","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1089\/hum.2025.040","volume":"36","author":"Philippidis","year":"2025","journal-title":"Hum Gene Ther"},{"key":"ref105","doi-asserted-by":"publisher","first-page":"109001","DOI":"10.1016\/j.intimp.2022.109001","volume":"110","author":"Sun","year":"2022","journal-title":"Int Immunopharmacol"},{"key":"ref106","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1443297","volume":"15","author":"Mazzuca","year":"2024","journal-title":"Front Immunol"},{"key":"ref107","doi-asserted-by":"publisher","first-page":"40673","DOI":"10.1038\/s41598-025-13851-1","volume":"15","author":"Farber","year":"2025","journal-title":"Sci Rep"},{"key":"ref108","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1038\/labinvest.3780324","volume":"81","author":"Churg","year":"2001","journal-title":"Lab Invest"},{"key":"ref109","first-page":"2022","author":"Bai","year":"2022","journal-title":"bioRxiv"},{"key":"ref110","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00877","volume":"9","author":"Siebers","year":"2018","journal-title":"Front Immunol"},{"key":"ref111","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.3390\/biom5031266","volume":"5","author":"Schuliga","year":"2015","journal-title":"Biomolecules"},{"key":"ref112","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1038\/s41392-024-01757-9","volume":"9","author":"Guo","year":"2024","journal-title":"Signal Transd Targeted Ther"},{"key":"ref113","doi-asserted-by":"publisher","first-page":"4236","DOI":"10.1172\/JCI41196","volume":"120","author":"Bergin","year":"2010","journal-title":"J Clin Invest"},{"key":"ref114","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1016\/j.bbrc.2004.06.123","volume":"321","author":"Janciauskiene","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"ref115","doi-asserted-by":"publisher","first-page":"397","DOI":"10.3390\/medicina57040397","volume":"57","author":"Park","year":"2021","journal-title":"Medicina"},{"key":"ref116","doi-asserted-by":"publisher","first-page":"e0177450","DOI":"10.1371\/journal.pone.0177450","volume":"12","author":"Sarabhai","year":"2017","journal-title":"PLoS One"},{"key":"ref117","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.medj.2022.03.001","volume":"3","author":"McElvaney","year":"2022","journal-title":"Med"},{"key":"ref118","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1164\/rccm.202104-0833LE","volume":"204","author":"Ritzmann","year":"2021","journal-title":"Am J Respir Crit Care Med"},{"key":"ref119","doi-asserted-by":"publisher","first-page":"1346","DOI":"10.1164\/rccm.201709-1954LE","volume":"197","author":"McCarthy","year":"2017","journal-title":"Am J Respir Crit Care Med"}],"container-title":["Journal of Inflammation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/115540","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/115540","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T14:55:17Z","timestamp":1779461717000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/the-role-of-alpha-1-antitrypsin-in-the-pathophysiology-and-treatment-o-peer-reviewed-fulltext-article-JIR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":119,"URL":"https:\/\/doi.org\/10.2147\/jir.s560084","relation":{},"ISSN":["1178-7031"],"issn-type":[{"value":"1178-7031","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]}}}