{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T03:48:18Z","timestamp":1775706498539,"version":"3.50.1"},"reference-count":47,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JIR"],"DOI":"10.2147\/jir.s562027","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T02:40:14Z","timestamp":1775702414000},"page":"1-15","source":"Crossref","is-referenced-by-count":0,"title":["S100A12 as a Shared Inflammatory Driver of Intervertebral Disc Degeneration and Osteoporosis: A Mendelian Randomization and Experimental Study"],"prefix":"10.2147","volume":"Volume 19","author":[{"given":"Zexin","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2629-2692","authenticated-orcid":true,"given":"Bin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenchuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanqiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leixiang","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2026,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1378\/chest.117.4.1162","volume":"117","author":"Opal","year":"2000","journal-title":"Chest"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"e2004433","DOI":"10.1002\/advs.202004433","volume":"8","author":"Liu","year":"2021","journal-title":"Adv Sci"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"561459","DOI":"10.1155\/2014\/561459","volume":"2014","author":"Wojdasiewicz","year":"2014","journal-title":"Mediators Inflamm"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"e253455","DOI":"10.1001\/jamanetworkopen.2025.3455","volume":"8","author":"Long","year":"2025","journal-title":"JAMA Network Open"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"7573165","DOI":"10.1155\/2023\/7573165","volume":"2023","author":"Liu","year":"2023","journal-title":"Anal Cell Pathol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1038\/s41392-025-02178-y","volume":"10","author":"Nie","year":"2025","journal-title":"Signal Transduct Target Ther"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.bone.2016.02.020","volume":"86","author":"Loi","year":"2016","journal-title":"Bone"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1111\/os.13254","volume":"14","author":"Xin","year":"2022","journal-title":"Orthop Surg"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.bioactmat.2024.03.020","volume":"37","author":"Zhou","year":"2024","journal-title":"Bioact Mater"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"e1349","DOI":"10.1002\/jsp2.1349","volume":"7","author":"Xu","year":"2024","journal-title":"JOR Spine"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"110660","DOI":"10.1016\/j.biopha.2020.110660","volume":"131","author":"Wang","year":"2020","journal-title":"Biomed Pharmacother"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1016\/j.mcna.2021.05.016","volume":"105","author":"Anam","year":"2021","journal-title":"Med Clin North Am"},{"key":"ref13","first-page":"2237","volume":"28","author":"Yi","year":"2024","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1163258","DOI":"10.3389\/fimmu.2023.1163258","volume":"14","author":"Mei","year":"2023","journal-title":"Front Immunol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1298531","DOI":"10.3389\/fendo.2024.1298531","volume":"15","author":"Liu","year":"2024","journal-title":"Front Endocrinol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1007\/s00223-023-01165-1","volume":"114","author":"Zhao","year":"2024","journal-title":"Calcif Tissue Int"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1161\/CIRCULATIONAHA.119.040180","volume":"140","author":"Chong","year":"2019","journal-title":"Circulation"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"1925","DOI":"10.1001\/jama.2017.17219","volume":"318","author":"Emdin","year":"2017","journal-title":"JAMA"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1038\/s41586-022-05473-8","volume":"613","author":"Kurki","year":"2023","journal-title":"Nature"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.34408","volume":"7","author":"Hemani","year":"2018","journal-title":"Elife"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1007\/s10654-017-0255-x","volume":"32","author":"Burgess","year":"2017","journal-title":"Eur J Epidemiol"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1093\/ije\/dyv080","volume":"44","author":"Bowden","year":"2015","journal-title":"Int J Epidemiol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1002\/gepi.21965","volume":"40","author":"Bowden","year":"2016","journal-title":"Genet Epidemiol"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"884298","DOI":"10.3389\/fcimb.2022.884298","volume":"12","author":"Tan","year":"2022","journal-title":"Front Cell Infect Microbiol"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/s41588-018-0099-7","volume":"50","author":"Verbanck","year":"2018","journal-title":"Nat Genet"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1186\/s13102-025-01271-7","volume":"17","author":"Kuzu","year":"2025","journal-title":"BMC Sports Sci Med Rehabil"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/s40779-024-00544-5","volume":"11","author":"Li","year":"2024","journal-title":"Mil Med Res"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.jare.2024.06.010","volume":"71","author":"Li","year":"2025","journal-title":"J Adv Res"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"2409","DOI":"10.1080\/15548627.2023.2186112","volume":"19","author":"Wang","year":"2023","journal-title":"Autophagy"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"5561","DOI":"10.2147\/IJN.S424731","volume":"18","author":"Jia","year":"2023","journal-title":"Int J Nanomed"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"e12152","DOI":"10.1002\/jev2.12152","volume":"10","author":"Lee","year":"2021","journal-title":"J Extracell Vesicles"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"13441","DOI":"10.1021\/acsnano.3c01713","volume":"17","author":"Liu","year":"2023","journal-title":"ACS Nano"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11914-014-0195-2","volume":"12","author":"Charles","year":"2014","journal-title":"Curr Osteoporos Rep"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/j.ecl.2012.04.006","volume":"41","author":"Armas","year":"2012","journal-title":"Endocrinol Metab Clin North Am"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.2147\/JIR.S505296","volume":"18","author":"Jiang","year":"2025","journal-title":"J Inflamm Res"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1007\/s10787-022-01098-5","volume":"31","author":"Gong","year":"2023","journal-title":"Inflammopharmacology"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"1386556","DOI":"10.3389\/fendo.2024.1386556","volume":"15","author":"Zheng","year":"2024","journal-title":"Front Endocrinol"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"1148107","DOI":"10.3389\/fimmu.2023.1148107","volume":"14","author":"Xu","year":"2023","journal-title":"Front Immunol"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1186\/s12916-020-01778-5","volume":"18","author":"Wu","year":"2020","journal-title":"BMC Med"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"1724","DOI":"10.1038\/s41598-020-58534-1","volume":"10","author":"Wang","year":"2020","journal-title":"Sci Rep"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.biopha.2015.10.029","volume":"76","author":"Gunaldi","year":"2015","journal-title":"Biomed Pharmacother"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/19336918.2024.2434209","volume":"19","author":"Liu","year":"2025","journal-title":"Cell Adh Migr"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.lfs.2017.10.036","volume":"191","author":"Nazari","year":"2017","journal-title":"Life Sci"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1111\/imm.13722","volume":"171","author":"Xia","year":"2024","journal-title":"Immunology"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1111\/1751-2980.12012","volume":"14","author":"van de Logt","year":"2013","journal-title":"J Dig Dis"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1080\/03008207.2024.2310852","volume":"65","author":"Zhang","year":"2024","journal-title":"Connect Tissue Res"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.7754\/Clin.Lab.2024.241041","volume":"71","author":"Sharma","year":"2025","journal-title":"Clin Lab"}],"container-title":["Journal of Inflammation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/113895","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/113895","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T02:40:18Z","timestamp":1775702418000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/s100a12-as-a-shared-inflammatory-driver-of-intervertebral-disc-degener-peer-reviewed-fulltext-article-JIR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":47,"URL":"https:\/\/doi.org\/10.2147\/jir.s562027","relation":{},"ISSN":["1178-7031"],"issn-type":[{"value":"1178-7031","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]}}}