{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T07:02:33Z","timestamp":1788850953436,"version":"build-2803163510"},"reference-count":60,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JIR"],"DOI":"10.2147\/jir.s581725","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T11:10:13Z","timestamp":1771499413000},"page":"1-22","source":"Crossref","is-referenced-by-count":2,"title":["Injury-Induced Epithelial Spp1 Engages Cd44 to Promote Neutrophil Recruitment and Exacerbate Acute Kidney Injury"],"prefix":"10.2147","volume":"Volume 19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5957-4840","authenticated-orcid":true,"given":"Jiayu","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6974-3951","authenticated-orcid":true,"given":"Zijian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runyi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaopeng","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2026,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1038\/s41572-021-00284-z","volume":"7","author":"Kellum","year":"2021","journal-title":"Nat Rev Dis Primers"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1038\/s41581-018-0052-0","volume":"14","author":"Hoste","year":"2018","journal-title":"Nat Rev Nephrol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/s0140-6736(13)60647-9","volume":"382","author":"Lameire","year":"2013","journal-title":"Lancet"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1038\/nrneph.2011.16","volume":"7","author":"Sharfuddin","year":"2011","journal-title":"Nat Rev Nephrol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1753","DOI":"10.1681\/asn.2016080925","volume":"28","author":"Nakazawa","year":"2017","journal-title":"J Am Soc Nephrol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1038\/nri.2017.105","volume":"18","author":"Papayannopoulos","year":"2018","journal-title":"Nat Rev Immunol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1038\/s41423-023-00974-6","volume":"20","author":"Cambier","year":"2023","journal-title":"Cell Mol Immunol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1093\/ndt\/gfad266","volume":"39","author":"Maier-Begandt","year":"2024","journal-title":"Nephrol Dial Transplant"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1038\/s41577-024-01027-3","volume":"24","author":"Huang","year":"2024","journal-title":"Nat Rev Immunol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1146\/annurev-pathmechdis-012419-032847","volume":"15","author":"Zindel","year":"2020","journal-title":"Annu Rev Pathol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1645","DOI":"10.1046\/j.1523-1755.2001.00032.x","volume":"60","author":"Xie","year":"2001","journal-title":"Kidney Int"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"2793","DOI":"10.1681\/asn.2020010052","volume":"31","author":"Rudman-Melnick","year":"2020","journal-title":"J Am Soc Nephrol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"eabm5900","DOI":"10.1126\/sciadv.abm5900","volume":"8","author":"Khamissi","year":"2022","journal-title":"Sci Adv"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"6743","DOI":"10.1182\/blood-2011-07-343566","volume":"118","author":"Zarbock","year":"2011","journal-title":"Blood"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/j.tem.2022.02.002","volume":"33","author":"Weng","year":"2022","journal-title":"Trends Endocrinol Metab"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1084\/jem.20071765","volume":"205","author":"McDonald","year":"2008","journal-title":"J Exp Med"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"7915","DOI":"10.1038\/s41467-023-43746-6","volume":"14","author":"Li","year":"2023","journal-title":"Nat Commun"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1016\/j.kint.2022.12.022","volume":"103","author":"Chang","year":"2023","journal-title":"Kidney Int"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1177\/154405910608500503","volume":"85","author":"Sodek","year":"2006","journal-title":"J Dent Res"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"109839","DOI":"10.1016\/j.isci.2024.109839","volume":"27","author":"Ding","year":"2024","journal-title":"IScience"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.ejpb.2021.07.014","volume":"167","author":"Veloso","year":"2021","journal-title":"Eur J Pharm Biopharm"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"114041","DOI":"10.1016\/j.jconrel.2025.114041","volume":"385","author":"Park","year":"2025","journal-title":"J Control Release"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"e1000412","DOI":"10.1371\/journal.pbio.1000412","volume":"8","author":"Kilkenny","year":"2010","journal-title":"PLoS Biol"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1949","DOI":"10.1016\/s0140-6736(19)32563-2","volume":"394","author":"Ronco","year":"2019","journal-title":"Lancet"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1038\/s41419-023-05830-z","volume":"14","author":"Chen","year":"2023","journal-title":"Cell Death Dis"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"113032","DOI":"10.1016\/j.celrep.2023.113032","volume":"42","author":"Marques","year":"2023","journal-title":"Cell Rep"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1016\/j.ymthe.2022.08.013","volume":"31","author":"Chen","year":"2023","journal-title":"Mol Ther"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"324","DOI":"10.7150\/thno.63735","volume":"12","author":"Jiang","year":"2022","journal-title":"Theranostics"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1681\/asn.2014101025","volume":"27","author":"Schlingmann","year":"2016","journal-title":"J Am Soc Nephrol"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1146\/annurev-pharmtox-010617-052713","volume":"58","author":"Nigam","year":"2018","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/nrneph.2016.170","volume":"13","author":"DeFronzo","year":"2017","journal-title":"Nat Rev Nephrol"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1111\/imr.13176","volume":"314","author":"Antuamwine","year":"2023","journal-title":"Immunol Rev"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aay6017","volume":"5","author":"Alshetaiwi","year":"2020","journal-title":"Sci Immunol"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1097\/hep.0000000000000773","volume":"81","author":"Zhang","year":"2025","journal-title":"Hepatology"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"1658987","DOI":"10.3389\/fimmu.2025.1658987","volume":"16","author":"Nguyen","year":"2025","journal-title":"Front Immunol"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"115072","DOI":"10.1016\/j.celrep.2024.115072","volume":"44","author":"Saqib","year":"2025","journal-title":"Cell Rep"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1007\/s10620-012-2556-y","volume":"58","author":"Chen","year":"2013","journal-title":"Dig Dis Sci"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.cbi.2018.05.002","volume":"289","author":"Ramadan","year":"2018","journal-title":"Chem Biol Interact"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"2778","DOI":"10.1084\/jem.20181468","volume":"215","author":"Casanova-Acebes","year":"2018","journal-title":"J Exp Med"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1016\/j.immuni.2021.06.006","volume":"54","author":"Burn","year":"2021","journal-title":"Immunity"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"2130","DOI":"10.1182\/blood.2021012295","volume":"139","author":"Margraf","year":"2022","journal-title":"Blood"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1016\/j.immuni.2024.03.002","volume":"57","author":"Ma","year":"2024","journal-title":"Immunity"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1038\/s41577-019-0215-7","volume":"20","author":"Gong","year":"2020","journal-title":"Nat Rev Immunol"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1016\/j.kint.2018.10.037","volume":"95","author":"Poluzzi","year":"2019","journal-title":"Kidney Int"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1016\/j.molmet.2014.03.004","volume":"3","author":"Kahles","year":"2014","journal-title":"Mol Metab"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"4049098","DOI":"10.1155\/2017\/4049098","volume":"2017","author":"Castello","year":"2017","journal-title":"Mediators Inflamm"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1111\/j.1365-2567.2007.02682.x","volume":"122","author":"Koh","year":"2007","journal-title":"Immunology"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1111\/j.1365-2567.2010.03335.x","volume":"132","author":"Atai","year":"2011","journal-title":"Immunology"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1186\/s13054-015-0782-3","volume":"19","author":"Hirano","year":"2015","journal-title":"Crit Care"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"e84479","DOI":"10.1371\/journal.pone.0084479","volume":"8","author":"Rampanelli","year":"2013","journal-title":"PLoS One"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1038\/s41419-018-0710-y","volume":"9","author":"Marwick","year":"2018","journal-title":"Cell Death Dis"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"2286","DOI":"10.1016\/j.jaci.2018.01.003","volume":"141","author":"Souwer","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.chom.2020.05.002","volume":"28","author":"Guo","year":"2020","journal-title":"Cell Host Microbe"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"3562","DOI":"10.1182\/bloodadvances.2019031609","volume":"3","author":"Aarts","year":"2019","journal-title":"Blood Adv"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1038\/ni.2194","volume":"13","author":"Puga","year":"2011","journal-title":"Nat Immunol"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12490","author":"Chapple","year":"2023","journal-title":"Periodontol 2000"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/s40001-022-00687-y","volume":"27","author":"Moss","year":"2022","journal-title":"Eur J Med Res"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1002\/ibd.20099","volume":"13","author":"Gisbert","year":"2007","journal-title":"Inflamm Bowel Dis"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"2954","DOI":"10.3390\/jcm11112954","volume":"11","author":"Achit","year":"2022","journal-title":"J Clin Med"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1053\/j.ackd.2019.09.002","volume":"27","author":"Adiga","year":"2020","journal-title":"Adv Chronic Kidney Dis"}],"container-title":["Journal of Inflammation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/112238","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/112238","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T11:10:13Z","timestamp":1771499413000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/injury-induced-epithelial-spp1-engages-cd44-to-promote-neutrophil-recr-peer-reviewed-fulltext-article-JIR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":60,"URL":"https:\/\/doi.org\/10.2147\/jir.s581725","relation":{},"ISSN":["1178-7031"],"issn-type":[{"value":"1178-7031","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]}}}