{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T09:03:14Z","timestamp":1781082194096,"version":"3.54.1"},"reference-count":51,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JIR"],"DOI":"10.2147\/jir.s583575","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T08:40:11Z","timestamp":1781080811000},"page":"1-24","source":"Crossref","is-referenced-by-count":0,"title":["Multi-Cohort Transcriptomics Combined with Mendelian Randomization Identifies PPARGC1A, NAAA and GIPC2 as NLRP3 Inflammasome-Related Key Genes in Ulcerative Colitis"],"prefix":"10.2147","volume":"Volume 19","author":[{"given":"Jian","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6813-1731","authenticated-orcid":true,"given":"Yangfeng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2026,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1016\/j.gtc.2020.07.001","volume":"49","author":"Kaenkumchorn","year":"2020","journal-title":"Gastroenterol Clin North Am"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1016\/j.gtc.2020.07.005","volume":"49","author":"Du","year":"2020","journal-title":"Gastroenterol Clin North Am"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.12659\/msm.933537","volume":"28","author":"Jia","year":"2021","journal-title":"Med Sci Monit"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1128\/mmbr.00015-18","volume":"82","author":"Hayward","year":"2018","journal-title":"Microbiol Mol Biol Rev"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/08916934.2021.1995860","volume":"55","author":"Kong","year":"2021","journal-title":"Autoimmunity"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00276","volume":"10","author":"Zhen","year":"2019","journal-title":"Front Immunol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/j.jcmgh.2016.03.006","volume":"2","author":"Nadatani","year":"2016","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/j.intimp.2017.11.036","volume":"54","author":"Pashenkov","year":"2018","journal-title":"Int Immunopharmacol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1038\/cmi.2016.35","volume":"14","author":"Ratsimandresy","year":"2016","journal-title":"Cell Mol Immunol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1093\/ecco-jcc\/jjx139","volume":"12","author":"Taman","year":"2018","journal-title":"J Crohns Colitis"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"k601","DOI":"10.1136\/bmj.k601","author":"Davies","year":"2018","journal-title":"Br Med J"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1001\/jamadermatol.2022.3682","volume":"158","author":"Freuer","year":"2022","journal-title":"JAMA Dermatol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"3245","DOI":"10.1039\/d4tb02868f","volume":"13","author":"Wan","year":"2025","journal-title":"J Mat Chem B"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"126000","DOI":"10.1016\/j.ijbiomac.2023.126000","volume":"249","author":"Lei","year":"2023","journal-title":"Int J Biol Macromol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.1001\/jama.2021.18236","volume":"326","author":"Skrivankova","year":"2021","journal-title":"JAMA"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbaa345","volume":"22","author":"Ju","year":"2021","journal-title":"Brief Bioinform"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1093\/nar\/gkv007","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"3844","DOI":"10.1093\/bioinformatics\/btac409","volume":"38","author":"Gustavsson","year":"2022","journal-title":"Bioinformatics"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"2847","DOI":"10.1093\/bioinformatics\/btw313","volume":"32","author":"Gu","year":"2016","journal-title":"Bioinformatics"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-14-7","volume":"14","author":"H\u00e4nzelmann","year":"2013","journal-title":"BMC Bioinf"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-9-559","volume":"9","author":"Langfelder","year":"2008","journal-title":"BMC Bioinf"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"100141","DOI":"10.1016\/j.xinn.2021.100141","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1101\/gr.1239303","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.34408","volume":"7","author":"Hemani","year":"2018","journal-title":"eLife"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1093\/ije\/dyv080","volume":"44","author":"Bowden","year":"2015","journal-title":"Int J Epidemiol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1002\/gepi.21965","volume":"40","author":"Bowden","year":"2016","journal-title":"Genet Epidemiol"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1007\/s10654-015-0011-z","volume":"30","author":"Burgess","year":"2015","journal-title":"Eur J Epidemiol"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"1985","DOI":"10.1093\/ije\/dyx102","volume":"46","author":"Hartwig","year":"2017","journal-title":"Int J Epidemiol"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1125415","volume":"14","author":"Qin","year":"2023","journal-title":"Front Immunol"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"R89","DOI":"10.1093\/hmg\/ddu328","volume":"23","author":"Davey Smith","year":"2014","journal-title":"Hum Mol Genet"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-022-03691-2","volume":"20","author":"Xiao","year":"2022","journal-title":"J Transl Med"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"e627","DOI":"10.1002\/cpz1.627","volume":"2","author":"Rasooly","year":"2022","journal-title":"Current Protocols"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-12-77","volume":"12","author":"Robin","year":"2011","journal-title":"BMC Bioinf"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/978-1-0716-0301-7_11","author":"Yu","year":"2020","journal-title":"Methods Mol Biol"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"60","DOI":"10.3390\/ani12010060","volume":"12","author":"Robles-Jimenez","year":"2021","journal-title":"Animals"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2022\/9129984","volume":"2022","author":"Han","year":"2022","journal-title":"Mediat in Flamm"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"3083","DOI":"10.2147\/jir.S350109","volume":"Volume 15","author":"Wang","year":"2022","journal-title":"J Inflamm Res"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1080\/15548627.2020.1741332","volume":"17","author":"Wu","year":"2020","journal-title":"Autophagy"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1016\/s2468-1253(23)00011-0","volume":"8","author":"Massironi","year":"2023","journal-title":"Lancet Microbe"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"115119","DOI":"10.1016\/j.bcp.2022.115119","volume":"202","author":"Liu","year":"2022","journal-title":"Biochem Pharmacol"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-03731-7","volume":"12","author":"Dong","year":"2021","journal-title":"Cell Death Dis"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.722797","volume":"11","author":"Yao","year":"2021","journal-title":"Front Oncol"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1111\/imr.12909","volume":"297","author":"Zheng","year":"2020","journal-title":"Immunol Rev"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"108405","DOI":"10.1016\/j.celrep.2020.108405","volume":"33","author":"Duan","year":"2020","journal-title":"Cell Rep"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"1687","DOI":"10.1038\/s41401-023-01054-1","volume":"44","author":"H-y","year":"2023","journal-title":"Acta Pharmacol Sin"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.intimp.2018.09.007","volume":"64","author":"Liu","year":"2018","journal-title":"Int Immunopharmacol"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"117503","DOI":"10.1016\/j.jep.2023.117503","volume":"322","author":"Zhang","year":"2024","journal-title":"J Ethnopharmacol"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.781003","volume":"13","author":"Shi","year":"2022","journal-title":"Front Immunol"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"111953","DOI":"10.1016\/j.ejmech.2019.111953","volume":"188","author":"Tripathi","year":"2020","journal-title":"Eur J Med Chem"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.783254","volume":"13","author":"Zhang","year":"2022","journal-title":"Front Immunol"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"3493","DOI":"10.1016\/j.celrep.2018.02.071","volume":"22","author":"Kang","year":"2018","journal-title":"Cell Rep"}],"container-title":["Journal of Inflammation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/116201","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/116201","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T08:40:12Z","timestamp":1781080812000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/multi-cohort-transcriptomics-combined-with-mendelian-randomization-ide-peer-reviewed-fulltext-article-JIR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":51,"URL":"https:\/\/doi.org\/10.2147\/jir.s583575","relation":{},"ISSN":["1178-7031"],"issn-type":[{"value":"1178-7031","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]}}}