{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T11:34:00Z","timestamp":1774438440829,"version":"3.50.1"},"reference-count":41,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JIR"],"DOI":"10.2147\/jir.s587712","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T08:25:13Z","timestamp":1774427113000},"page":"1-18","source":"Crossref","is-referenced-by-count":0,"title":["APOE and CCR2: Potential Macrophage-Specific Biomarkers in the Rheumatoid Arthritis Synovial Microenvironment Identified by Bioinformatics and Experimental Verification in Murine Models"],"prefix":"10.2147","volume":"Volume 19","author":[{"given":"Dongyi","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Le","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Shang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2026,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1016\/s0140-6736(01)06075-5","volume":"358","author":"Lee","year":"2001","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"2338","DOI":"10.1016\/s0140-6736(17)31491-5","volume":"389","author":"Burmester","year":"2017","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s11926-021-00993-0","volume":"23","author":"Kronzer","year":"2021","journal-title":"Curr Rheumatol Rep"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"2019","DOI":"10.1016\/s0140-6736(23)01525-8","volume":"402","author":"Di Matteo","year":"2023","journal-title":"Lancet"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1038\/s41586-023-06002-x","volume":"618","author":"Lazarov","year":"2023","journal-title":"Nature"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1038\/s41586-019-1471-1","volume":"572","author":"Culemann","year":"2019","journal-title":"Nature"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1016\/j.it.2023.10.004","volume":"44","author":"Rodr\u00edguez-Morales","year":"2023","journal-title":"Trends Immunol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1016\/j.it.2023.10.006","volume":"44","author":"Katkar","year":"2023","journal-title":"Trends Immunol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1042\/bst20210962","volume":"50","author":"Rasmussen","year":"2022","journal-title":"Biochem Soc Trans"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1097\/shk.0000000000001601","volume":"55","author":"Mu","year":"2021","journal-title":"Shock"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"708186","DOI":"10.3389\/fimmu.2021.708186","volume":"12","author":"Ross","year":"2021","journal-title":"Front Immunol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2023\/8821610","volume":"2023","author":"Peng","year":"2023","journal-title":"Mediators Inflamm"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"867260","DOI":"10.3389\/fimmu.2022.867260","volume":"13","author":"Cutolo","year":"2022","journal-title":"Front Immunol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1038\/s41584-022-00790-8","volume":"18","author":"Kurowska-Stolarska","year":"2022","journal-title":"Nat Rev Rheumatol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"102397","DOI":"10.1016\/j.autrev.2019.102397","volume":"18","author":"Tardito","year":"2019","journal-title":"Autoimmun Rev"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"102112","DOI":"10.1016\/j.tice.2023.102112","volume":"82","author":"Song","year":"2023","journal-title":"Tissue Cell"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1538","DOI":"10.1136\/ard-2023-224068","volume":"82","author":"Triaille","year":"2023","journal-title":"Ann Rheum Dis"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"2407","DOI":"10.3390\/ijms25042407","volume":"25","author":"Fuchs","year":"2024","journal-title":"Int J Mol Sci"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"3479","DOI":"10.3390\/ijms19113479","volume":"19","author":"Getz","year":"2018","journal-title":"Int J Mol Sci"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1161\/ATVBAHA.123.318977","volume":"43","author":"Bea","year":"2023","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"12947","DOI":"10.3390\/ijms232112947","volume":"23","author":"Civeira-Marin","year":"2022","journal-title":"Int J Mol Sci"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1161\/circresaha.123.323921","volume":"134","author":"Toribio-Fern\u00e1ndez","year":"2024","journal-title":"Circ Res"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"4138","DOI":"10.1172\/JCI57559","volume":"121","author":"Murphy","year":"2011","journal-title":"J Clin Invest"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1657","DOI":"10.1016\/j.neuron.2021.03.024","volume":"109","author":"Wang","year":"2021","journal-title":"Neuron"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"e12345","DOI":"10.1002\/jev2.12345","volume":"12","author":"Phu","year":"2023","journal-title":"J Extracell Vesicles"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1097\/MOL.0b013e328356f967","volume":"23","author":"Raffai","year":"2012","journal-title":"Curr Opin Lipidol"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"e79908","DOI":"10.1371\/journal.pone.0079908","volume":"8","author":"Braesch-Andersen","year":"2013","journal-title":"PLoS One"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1161\/circresaha.121.319737","volume":"129","author":"Revelo","year":"2021","journal-title":"Circ Res"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"e2202964","DOI":"10.1002\/advs.202202964","volume":"10","author":"Li","year":"2023","journal-title":"Adv Sci (Weinh)"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"e2305659","DOI":"10.1002\/smll.202305659","volume":"20","author":"Gu","year":"2024","journal-title":"Small"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"3033","DOI":"10.1093\/rheumatology\/keab825","volume":"61","author":"Zoshima","year":"2022","journal-title":"Rheumatology (Oxford)"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1002\/eji.201747400","volume":"48","author":"Boniakowski","year":"2018","journal-title":"Eur J Immunol"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"3866","DOI":"10.1002\/art.20615","volume":"50","author":"Garc\u00eda-Vicu\u00f1a","year":"2004","journal-title":"Arthritis Rheum"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aau8587","volume":"11","author":"Kuo","year":"2019","journal-title":"Sci Transl Med"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1016\/j.celrep.2014.09.032","volume":"9","author":"Misharin","year":"2014","journal-title":"Cell Rep"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1002\/art.30232","volume":"63","author":"Pickens","year":"2011","journal-title":"Arthritis Rheum"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1002\/art.27287","volume":"62","author":"Kennedy","year":"2010","journal-title":"Arthritis Rheum"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"e22607","DOI":"10.1096\/fj.202201162R","volume":"36","author":"Muscat","year":"2022","journal-title":"THE FASEB Journal"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"120963","DOI":"10.1016\/j.biomaterials.2021.120963","volume":"275","author":"Kuang","year":"2021","journal-title":"Biomaterials"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.molimm.2019.10.008","volume":"117","author":"Espericueta","year":"2020","journal-title":"Mol Immunol"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1038\/s41598-023-28554-8","volume":"13","author":"Guillaume","year":"2023","journal-title":"Sci Rep"}],"container-title":["Journal of Inflammation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/113465","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/113465","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T08:25:15Z","timestamp":1774427115000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/apoe-and-ccr2-potential-macrophage-specific-biomarkers-in-the-rheumato-peer-reviewed-fulltext-article-JIR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":41,"URL":"https:\/\/doi.org\/10.2147\/jir.s587712","relation":{},"ISSN":["1178-7031"],"issn-type":[{"value":"1178-7031","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]}}}