{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T09:13:40Z","timestamp":1774602820381,"version":"3.50.1"},"reference-count":70,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JIR"],"DOI":"10.2147\/jir.s589158","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T08:40:15Z","timestamp":1774600815000},"page":"1-21","source":"Crossref","is-referenced-by-count":0,"title":["Eburicoic Acid from Curculigo orchioides Gaertn Attenuates the Enzymatic and Pathological Activities of Vipera russelli Phospholipase A2"],"prefix":"10.2147","volume":"Volume 19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6161-2567","authenticated-orcid":true,"given":"Deepadarshan","family":"Urs","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giresha","family":"Shivanna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3898-3914","authenticated-orcid":true,"given":"Pratap","family":"G K","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Austin","family":"Surendranath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravindra","family":"Narayana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5672-5196","authenticated-orcid":true,"given":"Vishnu","family":"Senthilkumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8485-0894","authenticated-orcid":true,"given":"Dharmappa","family":"Krishnappa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2026,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"e20200059","DOI":"10.1590\/1678-9199-JVATITD-2020-0059","volume":"26","author":"Tchaou","year":"2020","journal-title":"J Venomous Anim Toxins Incl Trop Dis"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"150","DOI":"10.5527\/WJN.V6.I3.150","volume":"6","author":"Vikrant","year":"2017","journal-title":"World J Nephrol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/NRDP.2017.63","volume":"3","author":"Guti\u00e9rrez","year":"2017","journal-title":"Nat Rev Dis Primers"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/S41467-022-33627-9","volume":"13","author":"Roberts","year":"2022","journal-title":"Nat Commun"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PNTD.0000603","volume":"4","author":"Alirol","year":"2010","journal-title":"PLoS Negl Trop Dis"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.7554\/ELIFE.54076","volume":"9","author":"Suraweera","year":"2020","journal-title":"Elife"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1016\/0035-9203(89)90311-8","volume":"83","author":"Warrell","year":"1989","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/0041-0101(88)90216-4","volume":"26","author":"Jayanthi","year":"1988","journal-title":"Toxicon"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/0742-8413(88)90168-5","volume":"91","author":"Slater","year":"1988","journal-title":"Comparat Biochemi Physiol C"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038\/S41598-022-10950-1","volume":"12","author":"Giresha","year":"2022","journal-title":"Sci Rep"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1016\/j.toxicon.2003.11.006","volume":"42","author":"Teixeira","year":"2003","journal-title":"Toxicon"},{"key":"ref12","first-page":"217","volume":"2015","author":"Ga","year":"2015","journal-title":"Int J Pharm Pharm Sci"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/S10787-009-0018-8","volume":"18","author":"Dharmappa","year":"2010","journal-title":"Inflammopharmacology"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1055\/S-0028-1088374","volume":"75","author":"Dharmappa","year":"2009","journal-title":"Planta Med"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1007\/BF00914317","volume":"12","author":"Vishwanath","year":"1988","journal-title":"Inflammation"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/J.LFS.2006.08.032","volume":"80","author":"Jameel","year":"2006","journal-title":"Life Sci"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"48","DOI":"10.6026\/97320630008048","volume":"8","author":"Samy","year":"2012","journal-title":"Bioinformation"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"743","DOI":"10.2174\/156802607780487614","volume":"7","author":"Marcussi","year":"2007","journal-title":"Curr Top Med Chem"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"146832","DOI":"10.1155\/2014\/146832","volume":"2014","author":"F\u00fcrst","year":"2014","journal-title":"Mediators Inflamm"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1016\/J.JEP.2014.05.004","volume":"154","author":"Morvin Yabesh","year":"2014","journal-title":"J Ethnopharmacol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"48","DOI":"10.34894\/VQ1DJA","volume":"22","author":"Jena","year":"2021","journal-title":"Plant Cell Biotechnol Mol Biol"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.22377\/IJGP.V2I1.393","volume":"2","author":"Singh","year":"2008","journal-title":"Int J Green Pharmacy"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1007\/BF02867976","volume":"17","author":"Venukumar","year":"2002","journal-title":"Indian J Clin Biochem"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"S48","DOI":"10.1016\/S2222-1808(14)60414-X","volume":"4","author":"Singh","year":"2014","journal-title":"Asian Pac J Trop Dis"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"139","DOI":"10.13040\/IJPSR.0975-8232.1(8-S).139-43","volume":"1","author":"Kumar Agrahari","year":"2010","journal-title":"IJPSR"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/J.SAJB.2022.05.047","volume":"149","author":"Gk","year":"2022","journal-title":"S Afr J Bot"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1080\/22297928.2020.1837669","volume":"10","author":"Pratap","year":"2020","journal-title":"Anal Chem Lett"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1002\/JCC.21334","volume":"31","author":"Trott","year":"2010","journal-title":"J Comput Chem"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1016\/0041-0101(89)90098-6","volume":"27","author":"Bhat","year":"1989","journal-title":"Toxicon"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"1951","DOI":"10.1021\/CI500020M","volume":"54","author":"Kumari","year":"2014","journal-title":"J Chem Inf Model"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1007\/978-1-0716-0892-0_11","volume":"2199","author":"Micsonai","year":"2021","journal-title":"Methods Mol Biol"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1016\/0006-3002(57)90256-1","volume":"24","author":"Boman","year":"1957","journal-title":"Biochimica et Biophysica Acta"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1016\/0041-0101(87)90155-3","volume":"25","author":"Vishwanath","year":"1987","journal-title":"Toxicon"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"43","DOI":"10.7883\/YOKEN1952.13.43","volume":"13","author":"Kondo","year":"1960","journal-title":"Jpn J Med Sci Biol"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"4617","DOI":"10.1038\/1811199A0","volume":"181","author":"Blois","year":"1958","journal-title":"Nature"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/0968-0004(90)90206-Q","volume":"15","author":"Gutteridge","year":"1990","journal-title":"Trends Biochem Sci"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"307","DOI":"10.5264\/EIYOGAKUZASHI.44.307","volume":"44","author":"Oyaizu","year":"1986","journal-title":"Jpn J Nutr Diet"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1111\/1523-1747.EP12365541","volume":"101","author":"Bastian","year":"1993","journal-title":"J Invest Dermatol"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.3390\/ANTIOX11071251","volume":"11","author":"Giresha","year":"2022","journal-title":"Antioxidants"},{"key":"ref40","first-page":"865","volume":"48","author":"Gomes","year":"2010","journal-title":"GomesInd J Experimentv Biol"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.imr.2017.03.001","volume":"6","author":"Upasani","year":"2017","journal-title":"Integr Med Res"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1016\/j.toxrep.2014.08.012","volume":"1","author":"Gopi","year":"2014","journal-title":"Toxicol Rep"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"2625","DOI":"10.2174\/092986705774370655","volume":"12","author":"Soares","year":"2005","journal-title":"Curr Med Chem"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1016\/0041-0101(94)90314-X","volume":"32","author":"Alam","year":"1994","journal-title":"Toxicon"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/S0378-8741(03)00049-7","volume":"86","author":"Alam","year":"2003","journal-title":"J Ethnopharmacol"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1016\/j.fitote.2004.01.006","volume":"75","author":"Girish","year":"2004","journal-title":"Fitoterapia"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.jep.2005.11.031","volume":"106","author":"Chatterjee","year":"2006","journal-title":"J Ethnopharmacol"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.jep.2004.05.010","volume":"94","author":"Shirwaikar","year":"2004","journal-title":"J Ethnopharmacol"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"1082","DOI":"10.1002\/PTR.2735","volume":"23","author":"Chandrashekara","year":"2009","journal-title":"Phytother Res"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/0041-0101(94)00138-X","volume":"33","author":"Guti\u00e9rrez","year":"1995","journal-title":"Toxicon"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"213","DOI":"10.3109\/15569549809009250;REQUESTEDJOURNAL:JOURNAL:ITXR19;WGROUP:STRING:PUBLICATION","volume":"17","author":"Ownby","year":"1998","journal-title":"J Toxicol Toxin Rev"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1016\/S0022-3565(25)10471-0","volume":"263","author":"Miyake","year":"1992","journal-title":"J Pharmacol Exp Ther"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/j.toxicon.2005.04.023","volume":"46","author":"Ticli","year":"2005","journal-title":"Toxicon"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"1528","DOI":"10.1016\/J.BBAGEN.2016.03.031","volume":"1860","author":"Gopi","year":"2016","journal-title":"Biochim Biophys Acta Gen Subj"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1016\/j.toxicon.2009.09.021","volume":"55","author":"Melo","year":"2010","journal-title":"Toxicon"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"613","DOI":"10.5694\/J.1326-5377.1977.TB130959.X","volume":"1","author":"Sutherland","year":"1977","journal-title":"Med j Aust"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/J.FCT.2018.03.013","volume":"115","author":"Hejazi","year":"2018","journal-title":"Food and Chemical Toxicology"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/J.JAB.2017.03.003","volume":"15","author":"Navya","year":"2017","journal-title":"J Appl Biomed"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/j.jep.2013.03.066","volume":"147","author":"Nie","year":"2013","journal-title":"J Ethnopharmacol"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"10108","DOI":"10.3390\/MOLECULES170910108","volume":"17","author":"Wu","year":"2012","journal-title":"Molecules"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/B978-0-323-95698-7.00017-6","volume":"2023","author":"Maiti","year":"2023","journal-title":"Phospholipases Physiol Pathol"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-3-28","volume":"3","author":"Moses","year":"2006","journal-title":"J Neuroinflammation"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1016\/j.mcn.2012.02.006","volume":"49","author":"Villanueva","year":"2012","journal-title":"Mol Cell Neurosci"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"118869","DOI":"10.1016\/j.biopha.2025.118869","volume":"194","author":"Urs","year":"2026","journal-title":"Biomed Pharmacother"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1038\/S41598-018-28846-4","volume":"8","author":"Massimino","year":"2018","journal-title":"Sci Rep"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1016\/J.IJBIOMAC.2019.05.019","volume":"134","author":"de Andrade","year":"2019","journal-title":"Int J Biol Macromol"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"873","DOI":"10.7150\/IJBS.68093","volume":"18","author":"Ivanu\u0161ec","year":"2022","journal-title":"Int J Biol Sci"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/J.BRAINRES.2009.08.072","volume":"1298","author":"Levin","year":"2009","journal-title":"Brain Res"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1016\/j.bbamem.2019.02.002","volume":"1861","author":"Dutta","year":"2019","journal-title":"Biochim Biophys Acta Biomembr"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"15269","DOI":"10.1074\/jbc.M112.397893","volume":"288","author":"Lee","year":"2013","journal-title":"J Biol Chem"}],"container-title":["Journal of Inflammation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/113558","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/113558","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T08:40:19Z","timestamp":1774600819000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/eburicoic-acid-from-curculigo-orchioides-gaertn-attenuates-the-enzymat-peer-reviewed-fulltext-article-JIR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":70,"URL":"https:\/\/doi.org\/10.2147\/jir.s589158","relation":{},"ISSN":["1178-7031"],"issn-type":[{"value":"1178-7031","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]}}}