{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:18:17Z","timestamp":1792113497284,"version":"4.4.0"},"reference-count":97,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JIR"],"DOI":"10.2147\/jir.s592917","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T07:30:14Z","timestamp":1776411014000},"page":"1-22","source":"Crossref","is-referenced-by-count":1,"title":["Acupuncture Activates PI3K\/Akt Pathway to Promote Spinal Microglial M2 Polarization and Alleviate Spastic Hemiplegia Following Ischemic Stroke"],"prefix":"10.2147","volume":"Volume 19","author":[{"given":"Ling-Hui","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9851-0225","authenticated-orcid":true,"given":"Liang-Xiao","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8291-8728","authenticated-orcid":true,"given":"Xu","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Yun","family":"Xiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Yu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Ling","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2026,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1038\/s43856-025-00939-y","volume":"5","author":"Liu","year":"2025","journal-title":"Commun Med"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"2452","DOI":"10.1097\/CM9.0000000000003725","volume":"138","author":"Wang","year":"2025","journal-title":"Chin Med J"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"e240","DOI":"10.1161\/STROKEAHA.125.051589","volume":"56","author":"Xu","year":"2025","journal-title":"Stroke"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1080\/10749357.2020.1843845","volume":"28","author":"Glaess-Leistner","year":"2021","journal-title":"Top Stroke Rehabil"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"S13","DOI":"10.1212\/WNL.0b013e3182762448","volume":"80","author":"Wissel","year":"2013","journal-title":"Neurology"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"2277","DOI":"10.1007\/s40120-025-00825-8","volume":"14","author":"Chan","year":"2025","journal-title":"Neurol Ther"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1038\/nrneurol.2014.207","volume":"11","author":"Hu","year":"2015","journal-title":"Nat Rev Neurol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1047550","DOI":"10.3389\/fimmu.2022.1047550","volume":"13","author":"Zeng","year":"2023","journal-title":"Front Immunol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"306","DOI":"10.3390\/biom11020306","volume":"11","author":"Petralla","year":"2021","journal-title":"Biomolecules"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"831977","DOI":"10.3389\/fncel.2022.831977","volume":"16","author":"Zhao","year":"2022","journal-title":"Front Cell Neurosci"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"571","DOI":"10.3390\/biom13030571","volume":"13","author":"Qiao","year":"2023","journal-title":"Biomolecules"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1182621","DOI":"10.3389\/fncel.2023.1182621","volume":"17","author":"Wang","year":"2023","journal-title":"Front Cell Neurosci"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"114464","DOI":"10.1016\/j.bcp.2021.114464","volume":"186","author":"Lu","year":"2021","journal-title":"Biochem Pharmacol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"8329","DOI":"10.1523\/JNEUROSCI.3410-17.2018","volume":"38","author":"Jiang","year":"2018","journal-title":"J Neurosci"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"e114328","DOI":"10.1371\/journal.pone.0114328","volume":"9","author":"Toda","year":"2014","journal-title":"PLoS One"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"113605","DOI":"10.1016\/j.expneurol.2021.113605","volume":"338","author":"Bilchak","year":"2021","journal-title":"Exp Neurol"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"12896","DOI":"10.1523\/JNEUROSCI.6451-11.2012","volume":"32","author":"Tan","year":"2012","journal-title":"J Neurosci"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"113015","DOI":"10.1016\/j.expneurol.2019.113015","volume":"321","author":"Jiang","year":"2019","journal-title":"Exp Neurol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"22655","DOI":"10.1038\/srep22655","volume":"6","author":"Dang","year":"2016","journal-title":"Sci Rep"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1007\/s002210050277","volume":"118","author":"Wu","year":"1998","journal-title":"Exp Brain Res"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"46980","DOI":"10.31083\/JIN46980","volume":"24","author":"He","year":"2025","journal-title":"J Integr Neurosci"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"575","DOI":"10.3109\/00207454.2013.783578","volume":"123","author":"Shi","year":"2013","journal-title":"Int J Neurosci"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"2758","DOI":"10.4103\/NRR.NRR-D-24-00568","volume":"20","author":"Liu","year":"2025","journal-title":"Neural Regener Res"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"7930","DOI":"10.1007\/s12035-024-04039-1","volume":"61","author":"Zheng","year":"2024","journal-title":"Mol Neurobiol"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"112915","DOI":"10.1016\/j.intimp.2024.112915","volume":"141","author":"Jia","year":"2024","journal-title":"Int Immunopharmacol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"e12023","DOI":"10.1002\/ccs3.12023","volume":"18","author":"Duan","year":"2024","journal-title":"J Cell Commun Signal"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1097\/WNR.0000000000002115","volume":"36","author":"Rao","year":"2025","journal-title":"Neuroreport"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"3225","DOI":"10.1016\/j.bbrc.2018.08.130","volume":"503","author":"Xu","year":"2018","journal-title":"Biochem Biophys Res Commun"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"387","DOI":"10.3233\/CH-190659","volume":"75","author":"Wei","year":"2020","journal-title":"Clin Hemorheol Microcirc"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.neulet.2013.10.029","volume":"558","author":"Xue","year":"2014","journal-title":"Neurosci Lett"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"154297","DOI":"10.1016\/j.phymed.2022.154297","volume":"104","author":"Birch","year":"2022","journal-title":"Phytomedicine"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"e125","DOI":"10.1097\/MJT.0000000000001892","volume":"32","author":"Wang","year":"2025","journal-title":"Am J Ther"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2021\/8841720","volume":"2021","author":"Lv","year":"2021","journal-title":"Neural Plast"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"942597","DOI":"10.3389\/fneur.2022.942597","volume":"13","author":"Xue","year":"2022","journal-title":"Front Neurol"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"15","DOI":"10.3389\/fneur.2024.1415792","author":"Liu","year":"2024","journal-title":"Front Neurol"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"514","DOI":"10.19852\/j.cnki.jtcm.20230328.001","volume":"43","author":"Zhang","year":"2023","journal-title":"J Tradit Chin Med"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.brainres.2015.01.011","volume":"1601","author":"Chen","year":"2015","journal-title":"Brain Res"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"178","DOI":"10.3389\/fnhum.2017.00178","volume":"11","author":"Ning","year":"2017","journal-title":"Front Hum Neurosci"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"114027","DOI":"10.1016\/j.expneurol.2022.114027","volume":"354","author":"Mu","year":"2022","journal-title":"Exp Neurol"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1186\/s13020-025-01213-y","volume":"20","author":"He","year":"2025","journal-title":"Chin Med"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"7191","DOI":"10.2147\/JIR.S341581","volume":"14","author":"Li","year":"2021","journal-title":"J Inflammation Res"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"900520","DOI":"10.3389\/fneur.2022.900520","volume":"13","author":"Wang","year":"2022","journal-title":"Front Neurol"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s12929-016-0249-0","volume":"23","author":"Jung","year":"2016","journal-title":"J Biomed Sci"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"8163052","DOI":"10.1155\/2020\/8163052","volume":"2020","author":"Liu","year":"2020","journal-title":"Evid-Based Complement Altern Med"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"2061","DOI":"10.2147\/JIR.S307841","volume":"14","author":"Lin","year":"2021","journal-title":"J Inflammation Res"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.18146","volume":"5","author":"Kathe","year":"2016","journal-title":"eLife"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"829753","DOI":"10.1155\/2013\/829753","volume":"2013","author":"Brumovsky","year":"2013","journal-title":"ISRN Neurol"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"834","DOI":"10.3390\/ijms23020834","volume":"23","author":"Shimizu-Okabe","year":"2022","journal-title":"Int J Mol Sci"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"3769","DOI":"10.1007\/s12035-021-02370-5","volume":"58","author":"Mazzone","year":"2021","journal-title":"Mol Neurobiol"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.bbi.2022.10.013","volume":"107","author":"McDonough","year":"2023","journal-title":"Brain Behav Immun"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"429815","DOI":"10.1155\/2013\/429815","volume":"2013","author":"Ferrini","year":"2013","journal-title":"Neural Plast"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"e525","DOI":"10.1038\/cddis.2013.54","volume":"4","author":"Kobayashi","year":"2013","journal-title":"Cell Death Dis"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"773","DOI":"10.4103\/1673-5374.268898","volume":"15","author":"Naderi","year":"2020","journal-title":"Neural Regener Res"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1080\/13880209.2022.2102656","volume":"60","author":"Wang","year":"2022","journal-title":"Pharm Biol"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.3233\/JAD-191032","volume":"76","author":"Sun","year":"2020","journal-title":"J Alzheimers Dis"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"15333175221141531","DOI":"10.1177\/15333175221141531","volume":"37","author":"Chen","year":"2022","journal-title":"Am J Alzheimers Dis Other Demen"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1007\/s12975-017-0554-2","volume":"8","author":"McBride","year":"2017","journal-title":"Transl Stroke Res"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1007\/s00401-017-1667-0","volume":"133","author":"Sommer","year":"2017","journal-title":"Acta Neuropathol"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"115059","DOI":"10.1016\/j.physbeh.2025.115059","volume":"301","author":"Zhang","year":"2025","journal-title":"Physiol Behav"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1186\/1472-6882-14-338","volume":"14","author":"Lee","year":"2014","journal-title":"BMC Complement Altern Med"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"4351723","DOI":"10.1155\/2017\/4351723","volume":"2017","author":"Zhao","year":"2017","journal-title":"Evid-Based Complement Altern Med: eCAM"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"2682","DOI":"10.1161\/hs1101.098367","volume":"32","author":"Chen","year":"2001","journal-title":"Stroke"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1093\/ptj\/67.2.206","volume":"67","author":"Bohannon","year":"1987","journal-title":"Phys Ther"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"e0171937","DOI":"10.1371\/journal.pone.0171937","volume":"12","author":"Ryu","year":"2017","journal-title":"PLoS One"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2019\/3017678","volume":"2019","author":"Chang","year":"2019","journal-title":"Neural Plast"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/s12974-019-1693-z","volume":"17","author":"Ye","year":"2020","journal-title":"J Neuroinflammation"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"115803","DOI":"10.1016\/j.biopha.2023.115803","volume":"168","author":"Zvejniece","year":"2023","journal-title":"Biomed Pharmacother"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"2316","DOI":"10.4103\/1673-5374.337055","volume":"17","author":"Cui","year":"2022","journal-title":"Neural Regener Res"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"2410889","DOI":"10.1002\/advs.202410889","volume":"12","author":"Wang","year":"2025","journal-title":"Adv Sci"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.1152\/jn.1992.68.5.1473","volume":"68","author":"Thompson","year":"1992","journal-title":"J Neurophysiol"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1002\/glia.24501","volume":"72","author":"Planas","year":"2024","journal-title":"Glia"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"886909","DOI":"10.3389\/fnins.2022.886909","volume":"16","author":"Sheng","year":"2022","journal-title":"Front Neurosci"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"636","DOI":"10.4103\/1673-5374.380903","volume":"19","author":"Mu","year":"2024","journal-title":"Neural Regener Res"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"13101","DOI":"10.3390\/ijms222313101","volume":"22","author":"Stuckey","year":"2021","journal-title":"Int J Mol Sci"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"103024","DOI":"10.1016\/j.ctim.2024.103024","volume":"80","author":"Yi","year":"2024","journal-title":"Complement Ther Med"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"2378","DOI":"10.1097\/CM9.0000000000001960","volume":"135","author":"Lyu","year":"2022","journal-title":"Chin Med J (Engl)"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.neuropharm.2016.03.027","volume":"107","author":"Suryanarayanan","year":"2016","journal-title":"Neuropharmacology"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"1430080","DOI":"10.3389\/fnmol.2024.1430080","volume":"17","author":"Gilio","year":"2024","journal-title":"Front Mol Neurosci"},{"key":"ref79","doi-asserted-by":"publisher","first-page":"8928","DOI":"10.1038\/s41467-025-62631-y","volume":"16","author":"Schmidt-Pogoda","year":"2025","journal-title":"Nat Commun"},{"key":"ref80","doi-asserted-by":"publisher","first-page":"115804","DOI":"10.1016\/j.jep.2022.115804","volume":"301","author":"Xu","year":"2023","journal-title":"J Ethnopharmacol"},{"key":"ref81","doi-asserted-by":"publisher","first-page":"115653","DOI":"10.1016\/j.biopha.2023.115653","volume":"168","author":"Li","year":"2023","journal-title":"Biomed Pharmacother"},{"key":"ref82","doi-asserted-by":"publisher","first-page":"7777","DOI":"10.1007\/s12035-016-0255-y","volume":"54","author":"Shi","year":"2017","journal-title":"Mol Neurobiol"},{"key":"ref83","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.4049\/jimmunol.1601515","volume":"198","author":"Vergadi","year":"2017","journal-title":"J Immunol"},{"key":"ref84","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.lfs.2016.01.045","volume":"151","author":"Liu","year":"2016","journal-title":"Life Sci"},{"key":"ref85","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s10020-021-00297-0","volume":"27","author":"Xu","year":"2021","journal-title":"Mol Med"},{"key":"ref86","doi-asserted-by":"publisher","first-page":"363","DOI":"10.3389\/fnmol.2017.00363","volume":"10","author":"Jiang","year":"2017","journal-title":"Front Mol Neurosci"},{"key":"ref87","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1523\/JNEUROSCI.3441-15.2016","volume":"36","author":"Jiang","year":"2016","journal-title":"J Neurosci"},{"key":"ref88","doi-asserted-by":"publisher","volume-title":"Progress in Brain Research","year":"2010","DOI":"10.1016\/B978-0-444-53613-6.00006-X"},{"key":"ref89","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.neuropharm.2013.10.003","volume":"82","author":"Ram\u00edrez-Jarqu\u00edn","year":"2014","journal-title":"Neuropharmacology"},{"key":"ref90","doi-asserted-by":"publisher","first-page":"58","DOI":"10.12703\/r\/10-58","volume":"10","author":"Grigoras","year":"2021","journal-title":"Fac Rev"},{"key":"ref91","doi-asserted-by":"publisher","first-page":"149201","DOI":"10.1016\/j.brainres.2024.149201","volume":"1845","author":"Chen","year":"2024","journal-title":"Brain Res"},{"key":"ref92","doi-asserted-by":"publisher","first-page":"1358323","DOI":"10.3389\/fphar.2024.1358323","volume":"15","author":"Llansola","year":"2024","journal-title":"Front Pharmacol"},{"key":"ref93","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1111\/jnc.12263","volume":"125","author":"Ye","year":"2013","journal-title":"J Neurochem"},{"key":"ref94","doi-asserted-by":"publisher","first-page":"31631","DOI":"10.1038\/s41598-024-80196-6","volume":"14","author":"Rocha","year":"2024","journal-title":"Sci Rep"},{"key":"ref95","doi-asserted-by":"publisher","first-page":"102793","DOI":"10.1016\/j.autneu.2021.102793","volume":"232","author":"Pan","year":"2021","journal-title":"Auton Neurosci"},{"key":"ref96","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1002\/jnr.23962","volume":"95","author":"Spychala","year":"2017","journal-title":"J Neurosci Res"},{"key":"ref97","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.1111\/cns.13267","volume":"25","author":"Kerr","year":"2019","journal-title":"CNS Neurosci Ther"}],"container-title":["Journal of Inflammation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/114192","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/114192","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T07:30:23Z","timestamp":1776411023000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/acupuncture-activates-pi3kakt-pathway-to-promote-spinal-microglial-m2--peer-reviewed-fulltext-article-JIR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":97,"URL":"https:\/\/doi.org\/10.2147\/jir.s592917","relation":{},"ISSN":["1178-7031"],"issn-type":[{"value":"1178-7031","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]}}}