{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T17:05:16Z","timestamp":1781715916847,"version":"3.54.5"},"reference-count":60,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JIR"],"DOI":"10.2147\/jir.s595375","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T16:10:14Z","timestamp":1781712614000},"page":"1-23","source":"Crossref","is-referenced-by-count":0,"title":["Guilu Erxian Glue Restores Immune Homeostasis in Aplastic Anemia Mice by Regulating Treg Lineage Stability via the miRNA-17\/10a and FasL\/Fas Signaling Pathways"],"prefix":"10.2147","volume":"Volume 19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8308-1181","authenticated-orcid":true,"given":"Song","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boyang","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghao","family":"Sang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingkai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4894-1435","authenticated-orcid":true,"given":"Deze","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongyang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingxin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingmin","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limin","family":"Chai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2026,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"110036","DOI":"10.1016\/j.intimp.2023.110036","volume":"117","author":"Pan","year":"2023","journal-title":"Int Immunopharmacol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"2778","DOI":"10.3324\/haematol.2023.284312","volume":"109","author":"Wang","year":"2024","journal-title":"Haematologica"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1038\/s41375-023-01892-2","volume":"37","author":"Gale","year":"2023","journal-title":"Leukemia"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"489","DOI":"10.3324\/haematol.12855","volume":"93","author":"Young","year":"2008","journal-title":"Haematologica"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1182\/blood.2024024173","volume":"144","author":"Montoro","year":"2024","journal-title":"Blood"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1378432","DOI":"10.3389\/fimmu.2024.1378432","volume":"15","author":"Piekarska","year":"2024","journal-title":"Front Immunol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"101284","DOI":"10.1016\/j.beha.2021.101284","volume":"34","author":"Bacigalupo","year":"2021","journal-title":"Best Pract Res Clin Haematol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1730","DOI":"10.2174\/1381612828666220418132432","volume":"28","author":"Ding","year":"2022","journal-title":"Curr Pharmaceu Design"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1056\/NEJMoa1103975","volume":"365","author":"Scheinberg","year":"2011","journal-title":"New England J Med"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"126","DOI":"10.3324\/haematol.2021.278413","volume":"107","author":"Zaimoku","year":"2021","journal-title":"Haematologica"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"3925","DOI":"10.2174\/0929867327666201006153202","volume":"28","author":"Patocka","year":"2021","journal-title":"Curr Med Chem"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1016\/j.fct.2018.06.054","volume":"118","author":"Wu","year":"2018","journal-title":"Food Chem Toxicol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/5584_2015_148","volume":"866","author":"Pawelec","year":"2015","journal-title":"Adv Experim Med Biol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1182\/blood.2020008966","volume":"138","author":"Zhu","year":"2021","journal-title":"Blood"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1798795","DOI":"10.1155\/2020\/1798795","volume":"2020","author":"Ding","year":"2020","journal-title":"J Immunol Res"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/s00277-025-06210-7","volume":"104","author":"Chen","year":"2025","journal-title":"Ann Hematol"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"973813","DOI":"10.3389\/fimmu.2022.973813","volume":"13","author":"Schl\u00f6der","year":"2022","journal-title":"Front Immunol"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.intimp.2016.03.009","volume":"34","author":"Chen","year":"2016","journal-title":"Int Immunopharmacol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1146\/annurev-immunol-042718-041717","volume":"38","author":"Sakaguchi","year":"2020","journal-title":"Ann Rev Immunol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"1603","DOI":"10.1182\/blood-2007-01-066258","volume":"110","author":"Solomou","year":"2007","journal-title":"Blood"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1006\/cimm.1995.1130","volume":"163","author":"Shinohara","year":"1995","journal-title":"Cellular Immunol"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1016\/j.cell.2010.08.012","volume":"142","author":"Lu","year":"2010","journal-title":"Cell"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1038\/ni.2286","volume":"13","author":"Takahashi","year":"2012","journal-title":"Nat Immunol"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.immuni.2016.06.022","volume":"45","author":"Yang","year":"2016","journal-title":"Immunity"},{"key":"ref25","first-page":"947","volume":"34","author":"Wang","year":"2014","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi Zhongguo Zhongxiyi Jiehe"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"118575","DOI":"10.1016\/j.jep.2024.118575","volume":"335","author":"Sun","year":"2024","journal-title":"J Ethnopharmacol"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"2003","DOI":"10.2147\/DDDT.S107909","volume":"10","author":"Chen","year":"2016","journal-title":"Drug Design Develop Therapy"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"6198067","DOI":"10.1155\/2019\/6198067","volume":"2019","author":"Lin","year":"2019","journal-title":"BioMed Res Int"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","volume":"22","author":"Reagan-Shaw","year":"2008","journal-title":"Faseb J"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1007\/s11655-020-3098-3","volume":"26","author":"Wang","year":"2020","journal-title":"Chinese J Integrative Med"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1053\/j.seminhematol.2021.12.002","volume":"59","author":"Giudice","year":"2022","journal-title":"Seminars Hematol"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1038\/s41422-020-0324-7","volume":"30","author":"Ohkura","year":"2020","journal-title":"Cell Res"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1007\/s00281-019-00741-8","volume":"41","author":"G\u00f6schl","year":"2019","journal-title":"Seminars Immunopathol"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"4269","DOI":"10.1007\/s00018-020-03534-7","volume":"77","author":"Wang","year":"2020","journal-title":"Cellular Molecular Life Sci"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"2225868","DOI":"10.1080\/13510002.2023.2225868","volume":"28","author":"Liu","year":"2023","journal-title":"Redox Report"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1002\/JLB.MR1217-481R","volume":"104","author":"Hsu","year":"2018","journal-title":"J Leukocyte Biol"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1126\/science.1176077","volume":"325","author":"Pan","year":"2009","journal-title":"Science"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/978-3-030-34461-0_18","volume":"1232","author":"Multhoff","year":"2020","journal-title":"Adv Experim Med Biol"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1038\/nri1685","volume":"5","author":"Sitkovsky","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1186\/s13020-025-01266-z","volume":"20","author":"Liu","year":"2025","journal-title":"Chinese Med"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1111\/imm.12393","volume":"145","author":"Sawant","year":"2015","journal-title":"Immunology"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"8011","DOI":"10.3390\/ijms21218011","volume":"21","author":"Zhu","year":"2020","journal-title":"Int J Mole Sci"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1111\/imr.12888","volume":"296","author":"Wing","year":"2020","journal-title":"Immunol Rev"},{"key":"ref44","first-page":"142","volume":"1","author":"Li","year":"2004","journal-title":"Cellular Mole Immunol"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1182\/blood.2019001347","volume":"136","author":"Lim","year":"2020","journal-title":"Blood"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"2479","DOI":"10.1182\/blood-2014-04-568451","volume":"124","author":"De Bruin","year":"2014","journal-title":"Blood"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"2621","DOI":"10.1182\/blood-2015-06-652453","volume":"126","author":"Chen","year":"2015","journal-title":"Blood"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"1387975","DOI":"10.3389\/fimmu.2024.1387975","volume":"15","author":"Zong","year":"2024","journal-title":"Front Immunol"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1126\/science.aac5560","volume":"351","author":"Kim","year":"2016","journal-title":"Science"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.4049\/jimmunol.173.2.1444","volume":"173","author":"Viguier","year":"2004","journal-title":"J Immunol"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"2597","DOI":"10.1007\/s00262-023-03442-2","volume":"72","author":"Berger","year":"2023","journal-title":"Cancer Immunol Immunotherapy"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.yexcr.2014.09.016","volume":"329","author":"Libregts","year":"2014","journal-title":"Experim Cell Res"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1038\/nri.2016.31","volume":"16","author":"Di Rosa","year":"2016","journal-title":"Nat Rev Immunol"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.ejphar.2015.09.044","volume":"766","author":"Nasr Bouzaiene","year":"2015","journal-title":"Euro J Pharmacol"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"9786972","DOI":"10.1155\/2017\/9786972","volume":"2017","author":"Zhou","year":"2017","journal-title":"J Immunol Res"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"101142","DOI":"10.1016\/j.jpha.2024.101142","volume":"15","author":"Zhong","year":"2025","journal-title":"J Pharmaceu Analys"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"115689","DOI":"10.1016\/j.ecoenv.2023.115689","volume":"268","author":"Iqbal","year":"2023","journal-title":"Ecotoxicol Environ Safety"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"2013","DOI":"10.1016\/j.fct.2011.05.012","volume":"49","author":"Arjumand","year":"2011","journal-title":"Food Chem Toxicol"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1142\/S0192415X23500118","volume":"51","author":"Cai","year":"2023","journal-title":"Ame J Chinese Med"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"12446","DOI":"10.1074\/jbc.M114.550723","volume":"289","author":"Liu","year":"2014","journal-title":"J Biolog Chem"}],"container-title":["Journal of Inflammation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/116484","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/116484","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T16:10:15Z","timestamp":1781712615000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/guilu-erxian-glue-restores-immune-homeostasis-in-aplastic-anemia-mice--peer-reviewed-fulltext-article-JIR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":60,"URL":"https:\/\/doi.org\/10.2147\/jir.s595375","relation":{},"ISSN":["1178-7031"],"issn-type":[{"value":"1178-7031","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]}}}