{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T21:40:01Z","timestamp":1768254001617,"version":"3.49.0"},"reference-count":24,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPR"],"DOI":"10.2147\/jpr.s366460","type":"journal-article","created":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T12:15:11Z","timestamp":1675944911000},"page":"395-406","source":"Crossref","is-referenced-by-count":2,"title":["Subcutaneous Methylnaltrexone as Treatment for Opioid-Induced Constipation in Patients with Advanced Cancer and Noncancer Illnesses: A Post Hoc Analysis of Two Clinical Trials"],"prefix":"10.2147","volume":"Volume 16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3611-8628","authenticated-orcid":true,"given":"Eric D","family":"Shah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce H","family":"Chamberlain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Rhiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4389-7343","authenticated-orcid":true,"given":"Neal E","family":"Slatkin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Stambler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J","family":"Israel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2023,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1016\/j.jpainsymman.2015.12.340","volume":"51","author":"van den Beuken-van Everdingen","year":"2016","journal-title":"J Pain Symptom Manage"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.jpainsymman.2006.10.015","volume":"34","author":"Teunissen","year":"2007","journal-title":"J Pain Symptom Manage"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.jpainsymman.2005.06.007","volume":"31","author":"Solano","year":"2006","journal-title":"J Pain Symptom Manage"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1177\/1049909106289068","volume":"23","author":"Glare","year":"2006","journal-title":"Am J Hosp Palliat Care"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1224","DOI":"10.1111\/j.1365-2036.2008.03689.x","volume":"27","author":"Cook","year":"2008","journal-title":"Aliment Pharmacol Ther"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1111\/papr.12445","volume":"17","author":"Rauck","year":"2017","journal-title":"Pain Pract"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"11S","DOI":"10.1016\/S0002-9610(01)00782-6","volume":"182","author":"Pappagallo","year":"2001","journal-title":"Am J Surg"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2014\/141737","volume":"2014","author":"Kumar","year":"2014","journal-title":"Gastroenterol Res Pract"},{"key":"ref9","first-page":"39","volume":"7","author":"Slatkin","year":"2009","journal-title":"J Support Oncol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/S0009-9236(96)90117-4","volume":"59","author":"Yuan","year":"1996","journal-title":"Clin Pharmacol Ther"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1038\/ajgsup.2014.5","volume":"2","author":"Galligan","year":"2014","journal-title":"Am J Gastroenterol Suppl"},{"key":"ref12","first-page":"149","volume":"8","author":"Wickham","year":"2017","journal-title":"J Adv Pract Oncol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1932","DOI":"10.1093\/pm\/pnw240","volume":"18","author":"Emmanuel","year":"2017","journal-title":"Pain Med"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.2147\/DDDT.S221278","volume":"14","author":"Pergolizzi","year":"2020","journal-title":"Drug Des Devel Ther"},{"key":"ref15","unstructured":"Relistor [package insert]. Bridgewater, NJ: Salix Pharmaceuticals; 2018."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1089\/jpm.2014.0362","volume":"18","author":"Bull","year":"2015","journal-title":"J Palliat Med"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"2332","DOI":"10.1056\/NEJMoa0707377","volume":"358","author":"Thomas","year":"2008","journal-title":"N Engl J Med"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"2687","DOI":"10.2147\/JPR.S312731","volume":"14","author":"Chamberlain","year":"2021","journal-title":"J Pain Res"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"e6829","DOI":"10.7759\/cureus.6829","volume":"12","author":"Saini","year":"2020","journal-title":"Cureus"},{"key":"ref20","unstructured":"What is a serious adverse event? 2016. Available from: https:\/\/www.fda.gov\/safety\/reporting-serious-problems-fda\/what-serious-adverse-event. Accessed February 15, 2022."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"771","DOI":"10.2147\/JPR.S88203","volume":"8","author":"Webster","year":"2015","journal-title":"J Pain Res"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1016\/j.jpain.2010.11.008","volume":"12","author":"Michna","year":"2011","journal-title":"J Pain"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s12904-019-0416-7","volume":"18","author":"Neefjes","year":"2019","journal-title":"BMC Palliat Care"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"11b","DOI":"10.1155\/2011\/974573","volume":"25","author":"Sanchez","year":"2011","journal-title":"Can J Gastroenterol"}],"container-title":["Journal of Pain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=87385","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=87385","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T12:15:16Z","timestamp":1675944916000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/subcutaneous-methylnaltrexone-as-treatment-for-opioid-induced-constipa-peer-reviewed-fulltext-article-JPR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":24,"URL":"https:\/\/doi.org\/10.2147\/jpr.s366460","relation":{},"ISSN":["1178-7090"],"issn-type":[{"value":"1178-7090","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2]]}}}